EKS-HOS-00252

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00252

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	361.0	1.5E-107	20	271	252

Status

Reviewed

Ensembl Protein

ENSP00000305976

UniProt Accession

Q9H0K1; B0YJ94; O94878; Q17RV0; Q6AZE2; Q76N03; Q8NCV7; Q96CZ8;

Protein Name

Serine/threonine-protein kinase SIK2

Protein Synonyms/Alias

Qin-induced kinase; Salt-inducible kinase 2; SIK-2; Serine/threonine-protein kinase SNF1-like kinase 2;

Gene Name

SIK2

Gene Synonyms/Alias

SIK2; KIAA0781, QIK, SNF1LK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000170145	ENSP00000305976	ENST00000304987

Organism

Homo sapiens

Functional Description

Phosphorylates 'Ser-794' of IRS1 in insulin-stimulatedadipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Protein Length

926

Protein Sequence
(FASTA)

MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI IDKSQLDAVN 60

LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK NGEIFDYLAN HGRLNESEAR 120

RKFWQILSAV DYCHGRKIVH RDLKAENLLL DNNMNIKIAD FGFGNFFKSG ELLATWCGSP 180

PYAAPEVFEG QQYEGPQLDI WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM 240

SEDCEHLIRR MLVLDPSKRL TIAQIKEHKW MLIEVPVQRP VLYPQEQENE PSIGEFNEQV 300

LRLMHSLGID QQKTIESLQN KSYNHFAAIY FLLVERLKSH RSSFPVEQRL DGRQRRPSTI 360

AEQTVAKAQT VGLPVTMHSP NMRLLRSALL PQASNVEAFS FPASGCQAEA AFMEEECVDT 420

PKVNGCLLDP VPPVLVRKGC QSLPSNMMET SIDEGLETEG EAEEDPAHAF EAFQSTRSGQ 480

RRHTLSEVTN QLVVMPGAGK IFSMNDSPSL DSVDSEYDMG SVQRDLNFLE DNPSLKDIML 540

ANQPSPRMTS PFISLRPTNP AMQALSSQKR EVHNRSPVSF REGRRASDTS LTQGIVAFRQ 600

HLQNLARTKG ILELNKVQLL YEQIGPEADP NLAPAAPQLQ DLASSCPQEE VSQQQESVST 660

LPASVHPQLS PRQSLETQYL QHRLQKPSLL SKAQNTCQLY CKEPPRSLEQ QLQEHRLQQK 720

RLFLQKQSQL QAYFNQMQIA ESSYPQPSQQ LPLPRQETPP PSQQAPPFSL TQPLSPVLEP 780

SSEQMQYSPF LSQYQEMQLQ PLPSTSGPRA APPLPTQLQQ QQPPPPPPPP PPRQPGAAPA 840

PLQFSYQTCE LPSAASPAPD YPTPCQYPVD GAQQSDLTGP DCPRSPGLQE APSSYDPLAL 900

SELPGLFDCE MLDAVDPQHN GYVLVN 926

Nucleotide Sequence
(FASTA)

ATGGTCATGG CGGATGGCCC GAGGCACTTG CAGCGCGGGC CGGTCCGGGT GGGGTTCTAC 60

GACATCGAGG GCACGCTGGG CAAGGGCAAC TTCGCTGTGG TGAAGCTGGG GCGGCACCGG 120

ATCACCAAGA CGGAGGTGGC AATAAAAATA ATCGATAAGT CTCAGCTGGA TGCAGTGAAC 180

CTTGAGAAAA TCTACCGAGA AGTACAAATA ATGAAAATGT TAGACCACCC TCACATAATC 240

AAACTTTATC AGGTAATGGA GACCAAAAGT ATGTTGTACC TTGTGACAGA ATATGCCAAA 300

AATGGAGAAA TTTTTGACTA TCTTGCTAAT CATGGCCGGT TAAATGAGTC TGAAGCCAGG 360

CGAAAATTCT GGCAAATCCT GTCTGCTGTT GATTATTGTC ATGGTCGGAA GATTGTGCAC 420

CGTGACCTCA AAGCTGAAAA TCTCCTGCTG GATAACAACA TGAATATCAA AATAGCAGAT 480

TTCGGTTTTG GAAATTTCTT TAAAAGTGGT GAACTGCTGG CAACATGGTG TGGCAGCCCC 540

CCTTATGCAG CCCCAGAAGT CTTTGAAGGG CAGCAGTATG AAGGACCACA GCTGGACATC 600

TGGAGTATGG GAGTTGTTCT TTATGTCCTT GTCTGTGGAG CTCTGCCCTT TGATGGACCG 660

ACTCTTCCAA TTTTGAGGCA GAGGGTTCTG GAAGGAAGAT TCCGGATTCC GTATTTCATG 720

TCAGAAGATT GCGAGCACCT TATCCGAAGG ATGTTGGTCC TAGACCCATC CAAACGGCTA 780

ACCATAGCCC AAATCAAGGA GCATAAATGG ATGCTCATAG AAGTTCCTGT CCAGAGACCT 840

GTTCTCTATC CACAAGAGCA AGAAAATGAG CCATCCATCG GGGAGTTTAA TGAGCAGGTT 900

CTGCGACTGA TGCACAGCCT TGGAATAGAT CAGCAGAAAA CCATTGAGTC TTTGCAGAAC 960

AAGAGCTATA ACCACTTTGC TGCCATTTAT TTCTTGTTGG TGGAGCGCCT GAAATCACAT 1020

CGGAGCAGTT TCCCAGTGGA GCAGAGACTT GATGGCCGCC AGCGTCGGCC TAGCACCATT 1080

GCTGAGCAAA CAGTTGCCAA GGCACAGACT GTGGGGCTCC CAGTGACCAT GCATTCACCG 1140

AACATGAGGC TGCTGCGATC TGCCCTCCTC CCCCAGGCAT CCAACGTGGA GGCCTTTTCA 1200

TTTCCAGCAT CTGGCTGTCA GGCGGAAGCT GCATTCATGG AAGAAGAGTG TGTGGACACT 1260

CCAAAGGTCA ATGGCTGTCT GCTTGACCCT GTGCCTCCTG TCCTGGTGCG GAAGGGATGC 1320

CAGTCACTGC CCAGCAACAT GATGGAGACC TCCATTGACG AAGGGCTGGA GACAGAAGGA 1380

GAGGCCGAGG AAGACCCCGC TCATGCCTTT GAGGCATTTC AGTCCACACG CAGCGGGCAG 1440

AGACGGCACA CTCTGTCAGA AGTGACCAAT CAACTGGTCG TGATGCCTGG GGCAGGGAAA 1500

ATTTTCTCCA TGAATGACAG CCCCTCCCTT GACAGTGTGG ACTCTGAGTA TGATATGGGG 1560

TCTGTTCAGA GGGACCTGAA CTTTCTGGAA GACAACCCTT CCCTTAAGGA CATCATGTTA 1620

GCCAATCAGC CTTCACCCCG CATGACATCT CCCTTCATAA GCCTGAGACC TACCAACCCA 1680

GCCATGCAGG CTCTGAGCTC CCAGAAACGA GAGGTCCACA ACAGGTCTCC AGTGAGCTTC 1740

AGAGAGGGCC GCAGAGCATC AGATACCTCC CTCACCCAGG GAATTGTAGC ATTTAGACAA 1800

CATCTTCAGA ATCTGGCTAG AACCAAAGGA ATTCTAGAGT TGAACAAAGT GCAGTTGTTG 1860

TATGAACAAA TAGGACCGGA GGCAGACCCT AACCTGGCGC CGGCGGCTCC TCAGCTCCAG 1920

GACCTTGCTA GCAGCTGCCC TCAGGAAGAA GTTTCTCAGC AGCAGGAAAG CGTCTCCACT 1980

CTCCCTGCCA GCGTGCATCC CCAGCTGTCC CCACGGCAGA GCCTGGAGAC CCAGTACCTG 2040

CAGCACAGAC TCCAGAAGCC CAGCCTTCTG TCAAAGGCCC AGAACACCTG TCAGCTTTAT 2100

TGCAAAGAAC CACCGCGGAG CCTTGAGCAG CAGCTGCAGG AACATAGGCT CCAGCAGAAG 2160

CGACTCTTTC TTCAGAAGCA GTCTCAACTG CAGGCCTATT TTAATCAGAT GCAGATAGCA 2220

GAGAGCTCCT ACCCACAGCC AAGTCAGCAG CTGCCCCTTC CCCGCCAGGA GACTCCACCG 2280

CCTTCTCAGC AGGCCCCACC GTTCAGCCTG ACCCAGCCCC TGAGCCCCGT CCTGGAGCCT 2340

TCCTCCGAGC AGATGCAATA CAGCCCTTTC CTCAGCCAGT ACCAAGAGAT GCAGCTTCAG 2400

CCCCTGCCCT CCACTTCCGG TCCCCGGGCT GCTCCTCCTC TGCCCACGCA GCTACAGCAG 2460

CAGCAGCCGC CACCGCCACC ACCCCCTCCA CCACCACGAC AGCCAGGAGC TGCCCCAGCC 2520

CCCTTACAGT TCTCCTATCA GACTTGTGAG CTGCCAAGCG CTGCTTCCCC TGCGCCAGAC 2580

TATCCCACTC CCTGTCAGTA TCCTGTGGAT GGAGCCCAGC AGAGCGACCT AACGGGGCCA 2640

GACTGTCCCA GAAGCCCAGG ACTGCAAGAG GCCCCCTCCA GCTACGACCC ACTAGCCCTC 2700

TCTGAGCTAC CTGGACTCTT TGATTGTGAA ATGCTAGACG CTGTGGATCC ACAACACAAC 2760

GGGTATGTCC TGGTGAATTA G 2781

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++  tlG+g+f+ Vkl +h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 20    YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI  79

         89999*******************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya++ge+fdy+ ++grl+e+ear+ f q++sav+Y+h ++iv

Q: 80    IKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIV  139

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+fk+g+ll t+cGsppYaaPe+++g++Yegp++D

Q: 140   HRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLD  199

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +s+++e+L+r++Lv dp+kR

Q: 200   IWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKR  259

         ************************************************************

S: 241   atieeilkhewl  252

         +ti +i++h+w+

Q: 260   LTIAQIKEHKWM  271

         ***********8

Domain Sequence
(FASTA)

YDIEGTLGKG NFAVVKLGRH RITKTEVAIK IIDKSQLDAV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK SMLYLVTEYA KNGEIFDYLA NHGRLNESEA RRKFWQILSA VDYCHGRKIV 120

HRDLKAENLL LDNNMNIKIA DFGFGNFFKS GELLATWCGS PPYAAPEVFE GQQYEGPQLD 180

IWSMGVVLYV LVCGALPFDG PTLPILRQRV LEGRFRIPYF MSEDCEHLIR RMLVLDPSKR 240

LTIAQIKEHK WM 252

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008286	; P:insulin receptor signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0046777	; P:protein autophosphorylation
GO:0046626	; P:regulation of insulin receptor signaling pathway

KEGG

hsa:23235

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017090	; Ser/Thr_kinase_SIK1/2.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013