EKS-HOS-00349

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00349

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DCAMKL	456.6	1.3E-136	393	650	258

Status

Reviewed

Ensembl Protein

ENSP00000401916

UniProt Accession

Q8N568; C9J5Q9; Q59GC8; Q8N399;

Protein Name

Serine/threonine-protein kinase DCLK2

Protein Synonyms/Alias

CaMK-like CREB regulatory kinase 2; CL2; CLICK-II; CLICK2; Doublecortin domain-containing protein 3B; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2;

Gene Name

DCLK2

Gene Synonyms/Alias

DCLK2; DCAMKL2, DCDC3B, DCK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000170390	ENSP00000427235	ENST00000506325
ENSG00000170390	ENSP00000303887	ENST00000302176
ENSG00000170390	ENSP00000296550	ENST00000296550
ENSG00000170390	ENSP00000401916	ENST00000411937

Organism

Homo sapiens

Functional Description

Protein kinase with a significantly reduced C(a2+)/CAMaffinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).

Protein Length

695

Protein Sequence
(FASTA)

MASTRSIELE HFEERDKRPR PGSRRGAPSS SGGSSSSGPK GNGLIPSPAH SAHCSFYRTR 60

TLQALSSEKK AKKARFYRNG DRYFKGLVFA ISSDRFRSFD ALLIELTRSL SDNVNLPQGV 120

RTIYTIDGSR KVTSLDELLE GESYVCASNE PFRKVDYTKN INPNWSVNIK GGTSRALAAA 180

SSVKSEVKES KDFIKPKLVT VIRSGVKPRK AVRILLNKKT AHSFEQVLTD ITEAIKLDSG 240

VVKRLCTLDG KQVTCLQDFF GDDDVFIACG PEKFRYAQDD FVLDHSECRV LKSSYSRSSA 300

VKYSGSKSPG PSRRSKSPAS VNGTPSSQLS TPKSTKSSSS SPTSPGSFRG LKISAHGRSS 360

SNVNGGPELD RCISPEGVNG NRCSESSTLL EKYKIGKVIG DGNFAVVKEC IDRSTGKEFA 420

LKIIDKAKCC GKEHLIENEV SILRRVKHPN IIMLVEEMET ATELFLVMEL VKGGDLFDAI 480

TSSTKYTERD GSAMVYNLAN ALRYLHGLSI VHRDIKPENL LVCEYPDGTK SLKLGDFGLA 540

TVVEGPLYTV CGTPTYVAPE IIAETGYGLK VDIWAAGVIT YILLCGFPPF RSENNLQEDL 600

FDQILAGKLE FPAPYWDNIT DSAKELISQM LQVNVEARCT AGQILSHPWV SDDASQENNM 660

QAEVTGKLKQ HFNNALPKQN STTTGVSVIM FDLTV 695

Nucleotide Sequence
(FASTA)

ATGGCCAGCA CCAGGAGTAT CGAGCTGGAG CACTTTGAGG AACGGGACAA AAGGCCGCGG 60

CCGGGGTCGC GGAGAGGGGC CCCCAGCTCC TCCGGGGGCA GCAGCAGCTC GGGCCCCAAG 120

GGGAACGGGC TCATCCCCAG TCCGGCGCAC AGTGCCCACT GCAGCTTCTA CCGCACGCGG 180

ACCCTGCAGG CCCTCAGCTC GGAGAAGAAG GCCAAGAAGG CGCGCTTCTA CCGGAACGGG 240

GACCGCTACT TCAAGGGCCT GGTGTTTGCC ATCTCCAGCG ACCGCTTCCG GTCCTTCGAT 300

GCGCTCCTCA TAGAGCTCAC CCGCTCCCTG TCGGACAACG TGAACCTGCC CCAGGGTGTC 360

CGCACTATCT ACACCATCGA CGGCAGCCGG AAGGTCACCA GCCTGGACGA GCTGCTGGAA 420

GGTGAGAGTT ACGTGTGTGC ATCCAATGAA CCATTTCGTA AAGTCGATTA CACCAAAAAT 480

ATTAATCCAA ACTGGTCTGT GAACATCAAG GGTGGGACAT CCCGAGCGCT GGCTGCTGCC 540

TCCTCTGTGA AAAGTGAAGT AAAAGAAAGT AAAGATTTCA TCAAACCCAA GTTAGTGACT 600

GTGATTCGAA GTGGAGTGAA GCCTAGAAAA GCCGTGCGGA TCCTTCTGAA TAAAAAGACT 660

GCTCATTCCT TTGAACAAGT CTTAACAGAT ATCACCGAAG CCATTAAACT AGACTCAGGA 720

GTCGTCAAGA GGCTCTGCAC CCTGGATGGA AAGCAGGTTA CTTGTCTGCA AGACTTTTTT 780

GGTGATGACG ATGTTTTTAT TGCATGTGGA CCAGAAAAAT TTCGTTATGC CCAAGATGAC 840

TTTGTCCTGG ATCATAGTGA ATGTCGTGTC CTGAAGTCAT CTTATTCTCG ATCCTCAGCT 900

GTTAAGTATT CTGGATCCAA AAGCCCTGGG CCCTCTCGAC GCAGCAAATC ACCAGCTTCA 960

GTTAATGGAA CTCCCAGCAG CCAACTTTCT ACTCCTAAAT CTACGAAATC CTCCAGTTCC 1020

TCTCCAACTA GTCCAGGAAG TTTCAGAGGA TTAAAGATTT CTGCTCATGG CAGATCTTCT 1080

TCCAATGTAA ACGGTGGACC TGAGCTTGAC CGTTGCATAA GTCCTGAAGG TGTGAATGGA 1140

AACAGATGCT CTGAATCATC AACTCTTCTT GAGAAATACA AAATTGGAAA GGTCATTGGT 1200

GATGGCAATT TTGCAGTAGT CAAAGAGTGT ATAGACAGGT CCACTGGAAA GGAGTTTGCC 1260

CTAAAGATTA TAGACAAAGC CAAATGTTGT GGAAAGGAAC ACCTGATTGA GAATGAAGTG 1320

TCAATACTGC GCCGAGTGAA ACATCCCAAT ATCATTATGC TGGTCGAGGA GATGGAAACA 1380

GCAACTGAGC TCTTTCTGGT GATGGAATTG GTCAAAGGTG GAGATCTCTT TGATGCAATT 1440

ACTTCGTCGA CCAAGTACAC TGAGAGAGAT GGCAGTGCCA TGGTGTACAA CTTAGCCAAT 1500

GCCCTCAGGT ATCTCCATGG CCTCAGCATC GTGCACAGAG ACATCAAACC AGAGAATCTC 1560

TTGGTGTGTG AATATCCTGA TGGAACCAAG TCTTTGAAAC TGGGAGACTT TGGGCTTGCG 1620

ACTGTGGTAG AAGGCCCTTT ATACACAGTC TGTGGCACAC CCACTTATGT GGCTCCAGAA 1680

ATCATTGCTG AAACTGGCTA TGGCCTGAAG GTGGACATTT GGGCAGCTGG TGTGATCACA 1740

TACATACTTC TCTGTGGATT CCCACCATTC CGAAGTGAGA ACAATCTCCA GGAAGATCTC 1800

TTCGACCAGA TCTTGGCTGG GAAGCTGGAG TTTCCGGCCC CCTACTGGGA TAACATCACG 1860

GACTCTGCCA AGGAATTAAT CAGTCAAATG CTTCAGGTAA ATGTTGAAGC TCGGTGTACC 1920

GCGGGACAAA TCCTGAGTCA CCCCTGGGTG TCAGATGATG CCTCCCAGGA GAATAACATG 1980

CAAGCTGAGG TGACAGGTAA ACTAAAACAG CACTTTAATA ATGCGCTCCC CAAACAGAAC 2040

AGCACTACCA CCGGGGTCTC CGTCATCATG TTTGATTTGA CAGTTTGA 2088

Domain Profile

S: 1     yeigrviGdGnfavvkevreretgkeyalkiidksklkGkehlidneveilkkvkhpniv  60

         y+ig+viGdGnfavvke+++r+tgke+alkiidk+k++Gkehli+nev+il++vkhpni+

Q: 393   YKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNII  452

         9***********************************************************

S: 61    klieeletetelylvlelvkgGdlfdaitkstkleerdaaimilelakalkylhelnivh  120

         +l+ee+et+tel+lv+elvkgGdlfdait+stk++erd+++m+++la+al+ylh l+ivh

Q: 453   MLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVH  512

         ************************************************************

S: 121   rdvkpenllvvekedgskslkladfGlaaevegplytvcGtPtyvaPeilaetGyglkvd  180

         rd+kpenllv+e+ dg+kslkl+dfGla++vegplytvcGtPtyvaPei+aetGyglkvd

Q: 513   RDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVD  572

         ************************************************************

S: 181   iWaaGvilyillvGfpPfrssdedqeelfdlilsgklefpsPyWdnisdkakdlvsrlle  240

         iWaaGvi+yill+GfpPfrs+++ qe+lfd+il+gklefp+PyWdni+d+ak+l+s++l+

Q: 573   IWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQ  632

         ************************************************************

S: 241   vdeekrltaeqilehpwv  258

         v++e+r+ta qil+hpwv

Q: 633   VNVEARCTAGQILSHPWV  650

         *****************8

Domain Sequence
(FASTA)

YKIGKVIGDG NFAVVKECID RSTGKEFALK IIDKAKCCGK EHLIENEVSI LRRVKHPNII 60

MLVEEMETAT ELFLVMELVK GGDLFDAITS STKYTERDGS AMVYNLANAL RYLHGLSIVH 120

RDIKPENLLV CEYPDGTKSL KLGDFGLATV VEGPLYTVCG TPTYVAPEII AETGYGLKVD 180

IWAAGVITYI LLCGFPPFRS ENNLQEDLFD QILAGKLEFP APYWDNITDS AKELISQMLQ 240

VNVEARCTAG QILSHPWV 258

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

hsa:166614

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR003533	; Doublecortin_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF03607	; DCX; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00537	; DCX; 2.
SM00220	; S_TKc; 1.

Prosites

PS50309	; DC; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013