EKS-HOS-00018

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00018

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	535.6	9.7E-161	1011	1278	268

Status

Reviewed

Ensembl Protein

ENSP00000342838

UniProt Accession

P06213; Q17RW0; Q59H98; Q9UCB7; Q9UCB8; Q9UCB9;

Protein Name

Insulin receptor subunit beta

Protein Synonyms/Alias

IR;

Gene Name

INSR

Gene Synonyms/Alias

INSR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000171105	ENSP00000342838	ENST00000341500
ENSG00000171105	ENSP00000473170	ENST00000600492
ENSG00000171105	ENSP00000303830	ENST00000302850

Organism

Homo sapiens

Functional Description

Receptor tyrosine kinase which mediates the pleiotropicactions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src- homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti- apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K- AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Protein Length

1370

Protein Sequence
(FASTA)

MATGGRRGAA AAPLLVAVAA LLLGAAGHLY PGEVCPGMDI RNNLTRLHEL ENCSVIEGHL 60

QILLMFKTRP EDFRDLSFPK LIMITDYLLL FRVYGLESLK DLFPNLTVIR GSRLFFNYAL 120

VIFEMVHLKE LGLYNLMNIT RGSVRIEKNN ELCYLATIDW SRILDSVEDN YIVLNKDDNE 180

ECGDICPGTA KGKTNCPATV INGQFVERCW THSHCQKVCP TICKSHGCTA EGLCCHSECL 240

GNCSQPDDPT KCVACRNFYL DGRCVETCPP PYYHFQDWRC VNFSFCQDLH HKCKNSRRQG 300

CHQYVIHNNK CIPECPSGYT MNSSNLLCTP CLGPCPKVCH LLEGEKTIDS VTSAQELRGC 360

TVINGSLIIN IRGGNNLAAE LEANLGLIEE ISGYLKIRRS YALVSLSFFR KLRLIRGETL 420

EIGNYSFYAL DNQNLRQLWD WSKHNLTITQ GKLFFHYNPK LCLSEIHKME EVSGTKGRQE 480

RNDIALKTNG DQASCENELL KFSYIRTSFD KILLRWEPYW PPDFRDLLGF MLFYKEAPYQ 540

NVTEFDGQDA CGSNSWTVVD IDPPLRSNDP KSQNHPGWLM RGLKPWTQYA IFVKTLVTFS 600

DERRTYGAKS DIIYVQTDAT NPSVPLDPIS VSNSSSQIIL KWKPPSDPNG NITHYLVFWE 660

RQAEDSELFE LDYCLKGLKL PSRTWSPPFE SEDSQKHNQS EYEDSAGECC SCPKTDSQIL 720

KELEESSFRK TFEDYLHNVV FVPRPSRKRR SLGDVGNVTV AVPTVAAFPN TSSTSVPTSP 780

EEHRPFEKVV NKESLVISGL RHFTGYRIEL QACNQDTPEE RCSVAAYVSA RTMPEAKADD 840

IVGPVTHEIF ENNVVHLMWQ EPKEPNGLIV LYEVSYRRYG DEELHLCVSR KHFALERGCR 900

LRGLSPGNYS VRIRATSLAG NGSWTEPTYF YVTDYLDVPS NIAKIIIGPL IFVFLFSVVI 960

GSIYLFLRKR QPDGPLGPLY ASSNPEYLSA SDVFPCSVYV PDEWEVSREK ITLLRELGQG 1020

SFGMVYEGNA RDIIKGEAET RVAVKTVNES ASLRERIEFL NEASVMKGFT CHHVVRLLGV 1080

VSKGQPTLVV MELMAHGDLK SYLRSLRPEA ENNPGRPPPT LQEMIQMAAE IADGMAYLNA 1140

KKFVHRDLAA RNCMVAHDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW MAPESLKDGV 1200

FTTSSDMWSF GVVLWEITSL AEQPYQGLSN EQVLKFVMDG GYLDQPDNCP ERVTDLMRMC 1260

WQFNPKMRPT FLEIVNLLKD DLHPSFPEVS FFHSEENKAP ESEELEMEFE DMENVPLDRS 1320

SHCQREEAGG RDGGSSLGFK RSYEEHIPYT HMNGGKKNGR ILTLPRSNPS 1370

Nucleotide Sequence
(FASTA)

ATGGCCACCG GGGGCCGGCG GGGGGCGGCG GCCGCGCCGC TGCTGGTGGC GGTGGCCGCG 60

CTGCTACTGG GCGCCGCGGG CCACCTGTAC CCCGGAGAGG TGTGTCCCGG CATGGATATC 120

CGGAACAACC TCACTAGGTT GCATGAGCTG GAGAATTGCT CTGTCATCGA AGGACACTTG 180

CAGATACTCT TGATGTTCAA AACGAGGCCC GAAGATTTCC GAGACCTCAG TTTCCCCAAA 240

CTCATCATGA TCACTGATTA CTTGCTGCTC TTCCGGGTCT ATGGGCTCGA GAGCCTGAAG 300

GACCTGTTCC CCAACCTCAC GGTCATCCGG GGATCACGAC TGTTCTTTAA CTACGCGCTG 360

GTCATCTTCG AGATGGTTCA CCTCAAGGAA CTCGGCCTCT ACAACCTGAT GAACATCACC 420

CGGGGTTCTG TCCGCATCGA GAAGAACAAT GAGCTCTGTT ACTTGGCCAC TATCGACTGG 480

TCCCGTATCC TGGATTCCGT GGAGGATAAT TACATCGTGT TGAACAAAGA TGACAACGAG 540

GAGTGTGGAG ACATCTGTCC GGGTACCGCG AAGGGCAAGA CCAACTGCCC CGCCACCGTC 600

ATCAACGGGC AGTTTGTCGA ACGATGTTGG ACTCATAGTC ACTGCCAGAA AGTTTGCCCG 660

ACCATCTGTA AGTCACACGG CTGCACCGCC GAAGGCCTCT GTTGCCACAG CGAGTGCCTG 720

GGCAACTGTT CTCAGCCCGA CGACCCCACC AAGTGCGTGG CCTGCCGCAA CTTCTACCTG 780

GACGGCAGGT GTGTGGAGAC CTGCCCGCCC CCGTACTACC ACTTCCAGGA CTGGCGCTGT 840

GTGAACTTCA GCTTCTGCCA GGACCTGCAC CACAAATGCA AGAACTCGCG GAGGCAGGGC 900

TGCCACCAGT ACGTCATTCA CAACAACAAG TGCATCCCTG AGTGTCCCTC CGGGTACACG 960

ATGAATTCCA GCAACTTGCT GTGCACCCCA TGCCTGGGTC CCTGTCCCAA GGTGTGCCAC 1020

CTCCTAGAAG GCGAGAAGAC CATCGACTCG GTGACGTCTG CCCAGGAGCT CCGAGGATGC 1080

ACCGTCATCA ACGGGAGTCT GATCATCAAC ATTCGAGGAG GCAACAATCT GGCAGCTGAG 1140

CTAGAAGCCA ACCTCGGCCT CATTGAAGAA ATTTCAGGGT ATCTAAAAAT CCGCCGATCC 1200

TACGCTCTGG TGTCACTTTC CTTCTTCCGG AAGTTACGTC TGATTCGAGG AGAGACCTTG 1260

GAAATTGGGA ACTACTCCTT CTATGCCTTG GACAACCAGA ACCTAAGGCA GCTCTGGGAC 1320

TGGAGCAAAC ACAACCTCAC CATCACTCAG GGGAAACTCT TCTTCCACTA TAACCCCAAA 1380

CTCTGCTTGT CAGAAATCCA CAAGATGGAA GAAGTTTCAG GAACCAAGGG GCGCCAGGAG 1440

AGAAACGACA TTGCCCTGAA GACCAATGGG GACCAGGCAT CCTGTGAAAA TGAGTTACTT 1500

AAATTTTCTT ACATTCGGAC ATCTTTTGAC AAGATCTTGC TGAGATGGGA GCCGTACTGG 1560

CCCCCCGACT TCCGAGACCT CTTGGGGTTC ATGCTGTTCT ACAAAGAGGC CCCTTATCAG 1620

AATGTGACGG AGTTCGACGG GCAGGATGCG TGTGGTTCCA ACAGTTGGAC GGTGGTAGAC 1680

ATTGACCCAC CCCTGAGGTC CAACGACCCC AAATCACAGA ACCACCCAGG GTGGCTGATG 1740

CGGGGTCTCA AGCCCTGGAC CCAGTATGCC ATCTTTGTGA AGACCCTGGT CACCTTTTCG 1800

GATGAACGCC GGACCTATGG GGCCAAGAGT GACATCATTT ATGTCCAGAC AGATGCCACC 1860

AACCCCTCTG TGCCCCTGGA TCCAATCTCA GTGTCTAACT CATCATCCCA GATTATTCTG 1920

AAGTGGAAAC CACCCTCCGA CCCCAATGGC AACATCACCC ACTACCTGGT TTTCTGGGAG 1980

AGGCAGGCGG AAGACAGTGA GCTGTTCGAG CTGGATTATT GCCTCAAAGG GCTGAAGCTG 2040

CCCTCGAGGA CCTGGTCTCC ACCATTCGAG TCTGAAGATT CTCAGAAGCA CAACCAGAGT 2100

GAGTATGAGG ATTCGGCCGG CGAATGCTGC TCCTGTCCAA AGACAGACTC TCAGATCCTG 2160

AAGGAGCTGG AGGAGTCCTC GTTTAGGAAG ACGTTTGAGG ATTACCTGCA CAACGTGGTT 2220

TTCGTCCCCA GGCCATCTCG GAAACGCAGG TCCCTTGGCG ATGTTGGGAA TGTGACGGTG 2280

GCCGTGCCCA CGGTGGCAGC TTTCCCCAAC ACTTCCTCGA CCAGCGTGCC CACGAGTCCG 2340

GAGGAGCACA GGCCTTTTGA GAAGGTGGTG AACAAGGAGT CGCTGGTCAT CTCCGGCTTG 2400

CGACACTTCA CGGGCTATCG CATCGAGCTG CAGGCTTGCA ACCAGGACAC CCCTGAGGAA 2460

CGGTGCAGTG TGGCAGCCTA CGTCAGTGCG AGGACCATGC CTGAAGCCAA GGCTGATGAC 2520

ATTGTTGGCC CTGTGACGCA TGAAATCTTT GAGAACAACG TCGTCCACTT GATGTGGCAG 2580

GAGCCGAAGG AGCCCAATGG TCTGATCGTG CTGTATGAAG TGAGTTATCG GCGATATGGT 2640

GATGAGGAGC TGCATCTCTG CGTCTCCCGC AAGCACTTCG CTCTGGAACG GGGCTGCAGG 2700

CTGCGTGGGC TGTCACCGGG GAACTACAGC GTGCGAATCC GGGCCACCTC CCTTGCGGGC 2760

AACGGCTCTT GGACGGAACC CACCTATTTC TACGTGACAG ACTATTTAGA CGTCCCGTCA 2820

AATATTGCAA AAATTATCAT CGGCCCCCTC ATCTTTGTCT TTCTCTTCAG TGTTGTGATT 2880

GGAAGTATTT ATCTATTCCT GAGAAAGAGG CAGCCAGATG GGCCGCTGGG ACCGCTTTAC 2940

GCTTCTTCAA ACCCTGAGTA TCTCAGTGCC AGTGATGTGT TTCCATGCTC TGTGTACGTG 3000

CCGGACGAGT GGGAGGTGTC TCGAGAGAAG ATCACCCTCC TTCGAGAGCT GGGGCAGGGC 3060

TCCTTCGGCA TGGTGTATGA GGGCAATGCC AGGGACATCA TCAAGGGTGA GGCAGAGACC 3120

CGCGTGGCGG TGAAGACGGT CAACGAGTCA GCCAGTCTCC GAGAGCGGAT TGAGTTCCTC 3180

AATGAGGCCT CGGTCATGAA GGGCTTCACC TGCCATCACG TGGTGCGCCT CCTGGGAGTG 3240

GTGTCCAAGG GCCAGCCCAC GCTGGTGGTG ATGGAGCTGA TGGCTCACGG AGACCTGAAG 3300

AGCTACCTCC GTTCTCTGCG GCCAGAGGCT GAGAATAATC CTGGCCGCCC TCCCCCTACC 3360

CTTCAAGAGA TGATTCAGAT GGCGGCAGAG ATTGCTGACG GGATGGCCTA CCTGAACGCC 3420

AAGAAGTTTG TGCATCGGGA CCTGGCAGCG AGAAACTGCA TGGTCGCCCA TGATTTTACT 3480

GTCAAAATTG GAGACTTTGG AATGACCAGA GACATCTATG AAACGGATTA CTACCGGAAA 3540

GGGGGCAAGG GTCTGCTCCC TGTACGGTGG ATGGCACCGG AGTCCCTGAA GGATGGGGTC 3600

TTCACCACTT CTTCTGACAT GTGGTCCTTT GGCGTGGTCC TTTGGGAAAT CACCAGCTTG 3660

GCAGAACAGC CTTACCAAGG CCTGTCTAAT GAACAGGTGT TGAAATTTGT CATGGATGGA 3720

GGGTATCTGG ATCAACCCGA CAACTGTCCA GAGAGAGTCA CTGACCTCAT GCGCATGTGC 3780

TGGCAATTCA ACCCCAAGAT GAGGCCAACC TTCCTGGAGA TTGTCAACCT GCTCAAGGAC 3840

GACCTGCACC CCAGCTTTCC AGAGGTGTCG TTCTTCCACA GCGAGGAGAA CAAGGCTCCC 3900

GAGAGTGAGG AGCTGGAGAT GGAGTTTGAG GACATGGAGA ATGTGCCCCT GGACCGTTCC 3960

TCGCACTGTC AGAGGGAGGA GGCGGGGGGC CGGGATGGAG GGTCCTCGCT GGGTTTCAAG 4020

CGGAGCTACG AGGAACACAT CCCTTACACA CACATGAACG GAGGCAAGAA AAACGGGCGG 4080

ATTCTGACCT TGCCTCGGTC CAATCCTTCC TAA 4113

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+llrelGqGsfGmvyeG+a+d++kge+etrva+ktvne+as reriefl+easvmk f+

Q: 1011  ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFT  1070

         789*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvskgqp+lvvmelm++Gdlksylrslrpe+en+++++pp+l+++iqmaae

Q: 1071  CHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAE  1130

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+akkfvhrdlaarncmva+d+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1131  IADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1190

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdGvft++sd+wsfGvvlwei++laeqpyqGlsneqvlkfv+dgg+l++p+ncp

Q: 1191  MAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP  1250

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         e++t+lmr+cwq+npk+rp+fleiv+ll

Q: 1251  ERVTDLMRMCWQFNPKMRPTFLEIVNLL  1278

         *************************976

Domain Sequence
(FASTA)

ITLLRELGQG SFGMVYEGNA RDIIKGEAET RVAVKTVNES ASLRERIEFL NEASVMKGFT 60

CHHVVRLLGV VSKGQPTLVV MELMAHGDLK SYLRSLRPEA ENNPGRPPPT LQEMIQMAAE 120

IADGMAYLNA KKFVHRDLAA RNCMVAHDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MAPESLKDGV FTTSSDMWSF GVVLWEITSL AEQPYQGLSN EQVLKFVMDG GYLDQPDNCP 240

ERVTDLMRMC WQFNPKMRPT FLEIVNLL 268

Keyword

3D-structure; Acetylation; Alternative splicing; ATP-binding; Carbohydrate metabolism; Cleavage on pair of basic residues; Complete proteome; Diabetes mellitus; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005829	; C:cytosol
GO:0010008	; C:endosome membrane
GO:0005899	; C:insulin receptor complex
GO:0005634	; C:nucleus
GO:0045202	; C:synapse
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0043559	; F:insulin binding
GO:0005009	; F:insulin-activated receptor activity
GO:0005159	; F:insulin-like growth factor receptor binding
GO:0031405	; F:lipoic acid binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0032148	; P:activation of protein kinase B activity
GO:0005975	; P:carbohydrate metabolic process
GO:0071363	; P:cellular response to growth factor stimulus
GO:0031017	; P:exocrine pancreas development
GO:0045444	; P:fat cell differentiation
GO:0007186	; P:G-protein coupled receptor signaling pathway
GO:0042593	; P:glucose homeostasis
GO:0003007	; P:heart morphogenesis
GO:0030238	; P:male sex determination
GO:0010629	; P:negative regulation of gene expression
GO:0001933	; P:negative regulation of protein phosphorylation
GO:0032410	; P:negative regulation of transporter activity
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0030335	; P:positive regulation of cell migration
GO:0008284	; P:positive regulation of cell proliferation
GO:0048639	; P:positive regulation of developmental growth
GO:0045740	; P:positive regulation of DNA replication
GO:0046326	; P:positive regulation of glucose import
GO:0045725	; P:positive regulation of glycogen biosynthetic process
GO:0045821	; P:positive regulation of glycolysis
GO:0010560	; P:positive regulation of glycoprotein biosynthetic process
GO:0043410	; P:positive regulation of MAPK cascade
GO:0045840	; P:positive regulation of mitosis
GO:0045429	; P:positive regulation of nitric oxide biosynthetic process
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060267	; P:positive regulation of respiratory burst
GO:0046777	; P:protein autophosphorylation
GO:0051290	; P:protein heterotetramerization
GO:0045995	; P:regulation of embryonic development
GO:0010310	; P:regulation of hydrogen peroxide metabolic process
GO:0006355	; P:regulation of transcription, DNA-dependent
GO:0014823	; P:response to activity
GO:0032355	; P:response to estradiol stimulus
GO:0045471	; P:response to ethanol
GO:0051384	; P:response to glucocorticoid stimulus
GO:0009749	; P:response to glucose stimulus
GO:0010042	; P:response to manganese ion
GO:0033574	; P:response to testosterone stimulus
GO:0034612	; P:response to tumor necrosis factor
GO:0033280	; P:response to vitamin D
GO:0019087	; P:transformation of host cell by virus

KEGG

hsa:3643

;

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 2.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013