EKS-HOS-00345
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00345
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK407.61.4E-121472956485
StatusReviewed
Ensembl ProteinENSP00000412076
UniProt AccessionQ9NZJ5; A0AVH1; A0AVH2; B2RCU9; O95846; Q53QY0; Q53SB1;
Protein NameEukaryotic translation initiation factor 2-alpha kinase 3
Protein Synonyms/Alias PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK;
Gene NameEIF2AK3
Gene Synonyms/Alias EIF2AK3; PEK, PERK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000172071ENSP00000307235ENST00000303236
ENSG00000172071ENSP00000408325ENST00000419748
ENSG00000172071ENSP00000412076ENST00000415570
OrganismHomo sapiens
Functional DescriptionPhosphorylates the alpha subunit of eukaryotictranslation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
Protein Length956
Protein Sequence
(FASTA)
MCYSEGGWST SGSRLQLLIT IILLKVFGNK MIIPSLDGAL FQWDQDRESM ETVPFTVESL 60
LESSYKFGDD VVLVGGKSLT TYGLSAYSGK VRYICSALGC RQWDSDEMEQ EEDILLLQRT 120
QKTVRAVGPR SGNEKWNFSV GHFELRYIPD METRAGFIES TFKPNENTEE SKIISDVEEQ 180
EAAIMDIVIK VSVADWKVMA FSKKGGHLEW EYQFCTPIAS AWLLKDGKVI PISLFDDTSY 240
TSNDDVLEDE EDIVEAARGA TENSVYLGMY RGQLYLQSSV RISEKFPSSP KALESVTNEN 300
AIIPLPTIKW KPLIHSPSRT PVLVGSDEFD KCLSNDKFSH EEYSNGALSI LQYPYDNGYY 360
LPYYKRERNK RSTQITVRFL DNPHYNKNIR KKDPVLLLHW WKEIVATILF CIIATTFIVR 420
RLFHPHPHRQ RKESETQCQT ENKYDSVSGE ANDSSWNDIK NSGYISRYLT DFEPIQCLGR 480
GGFGVVFEAK NKVDDCNYAI KRIRLPNREL AREKVMREVK ALAKLEHPGI VRYFNAWLEA 540
PPEKWQEKMD EIWLKDESTD WPLSSPSPMD APSVKIRRMD PFATKEHIEI IAPSPQRSRS 600
FSVGISCDQT SSSESQFSPL EFSGMDHEDI SESVDAAYNL QDSCLTDCDV EDGTMDGNDE 660
GHSFELCPSE ASPYVRSRER TSSSIVFEDS GCDNASSKEE PKTNRLHIGN HCANKLTAFK 720
PTSSKSSSEA TLSISPPRPT TLSLDLTKNT TEKLQPSSPK VYLYIQMQLC RKENLKDWMN 780
GRCTIEERER SVCLHIFLQI AEAVEFLHSK GLMHRDLKPS NIFFTMDDVV KVGDFGLVTA 840
MDQDEEEQTV LTPMPAYARH TGQVGTKLYM SPEQIHGNSY SHKVDIFSLG LILFELLYPF 900
STQMERVRTL TDVRNLKFPP LFTQKYPCEY VMVQDMLSPS PMERPEAINI IENAVF 956
Nucleotide Sequence
(FASTA)
ATGTGCTACT CAGAAGGAGG CTGGAGTACA TCAGGATCAA GACTCCAGCT CTTAATTACT 60
ATTATTCTTT TAAAGGTATT TGGGAATAAG ATGATCATTC CTTCCCTGGA TGGAGCCCTC 120
TTCCAGTGGG ACCAAGACCG TGAAAGCATG GAAACAGTTC CTTTCACAGT TGAATCACTT 180
CTTGAATCTT CTTATAAATT TGGAGATGAT GTTGTTTTGG TTGGAGGAAA ATCTCTGACT 240
ACATATGGAC TCAGTGCATA TAGTGGAAAG GTGAGGTATA TCTGTTCAGC TCTGGGTTGT 300
CGCCAATGGG ATAGTGACGA AATGGAACAA GAGGAAGACA TCCTGCTTCT ACAGCGTACC 360
CAAAAAACTG TTAGAGCTGT CGGACCTCGC AGTGGCAATG AGAAGTGGAA TTTCAGTGTT 420
GGCCACTTTG AACTTCGGTA TATTCCAGAC ATGGAAACGA GAGCCGGATT TATTGAAAGC 480
ACCTTTAAGC CCAATGAGAA CACAGAAGAG TCTAAAATTA TTTCAGATGT GGAAGAACAG 540
GAAGCTGCCA TAATGGACAT AGTGATAAAG GTTTCGGTTG CTGACTGGAA AGTTATGGCA 600
TTCAGTAAGA AGGGAGGACA TCTGGAATGG GAGTACCAGT TTTGTACTCC AATTGCATCT 660
GCCTGGTTAC TTAAGGATGG GAAAGTCATT CCCATCAGTC TTTTTGATGA TACAAGTTAT 720
ACATCTAATG ATGATGTTTT AGAAGATGAA GAAGACATTG TAGAAGCTGC CAGAGGAGCC 780
ACAGAAAACA GTGTTTACTT GGGAATGTAT AGAGGCCAGC TGTATCTGCA GTCATCAGTC 840
AGAATTTCAG AAAAGTTTCC TTCAAGTCCC AAGGCTTTGG AATCTGTCAC TAATGAAAAC 900
GCAATTATTC CTTTACCAAC AATCAAATGG AAACCCTTAA TTCATTCTCC TTCCAGAACT 960
CCTGTCTTGG TAGGATCTGA TGAATTTGAC AAATGTCTCA GTAATGATAA GTTTTCTCAT 1020
GAAGAATATA GTAATGGTGC ACTTTCAATC TTGCAGTATC CATATGATAA TGGTTATTAT 1080
CTACCATACT ACAAGAGGGA GAGGAACAAA CGAAGCACAC AGATTACAGT CAGATTCCTC 1140
GACAACCCAC ATTACAACAA GAATATCCGC AAAAAGGATC CTGTTCTTCT TTTACACTGG 1200
TGGAAAGAAA TAGTTGCAAC GATTTTGTTT TGTATCATAG CAACAACGTT TATTGTGCGC 1260
AGGCTTTTCC ATCCTCATCC TCACAGGCAA AGGAAGGAGT CTGAAACTCA GTGTCAAACT 1320
GAAAATAAAT ATGATTCTGT AAGTGGTGAA GCCAATGACA GTAGCTGGAA TGACATAAAA 1380
AACTCTGGAT ATATATCACG ATATCTAACT GATTTTGAGC CAATTCAATG CCTGGGACGT 1440
GGTGGCTTTG GAGTTGTTTT TGAAGCTAAA AACAAAGTAG ATGACTGCAA TTATGCTATC 1500
AAGAGGATCC GTCTCCCCAA TAGGGAATTG GCTCGGGAAA AGGTAATGCG AGAAGTTAAA 1560
GCCTTAGCCA AGCTTGAACA CCCGGGCATT GTTAGATATT TCAATGCCTG GCTCGAAGCA 1620
CCACCAGAGA AGTGGCAAGA AAAGATGGAT GAAATTTGGC TGAAAGATGA AAGCACAGAC 1680
TGGCCACTCA GCTCTCCTAG CCCAATGGAT GCACCATCAG TTAAAATACG CAGAATGGAT 1740
CCTTTCGCTA CAAAAGAACA TATTGAAATC ATAGCTCCTT CACCACAAAG AAGCAGGTCT 1800
TTTTCAGTAG GGATTTCCTG TGACCAGACA AGTTCATCTG AGAGCCAGTT CTCACCACTG 1860
GAATTCTCAG GAATGGACCA TGAGGACATC AGTGAGTCAG TGGATGCAGC ATACAACCTC 1920
CAGGACAGTT GCCTTACAGA CTGTGATGTG GAAGATGGGA CTATGGATGG CAATGATGAG 1980
GGGCACTCCT TTGAACTTTG TCCTTCTGAA GCTTCTCCTT ATGTAAGGTC AAGGGAGAGA 2040
ACCTCCTCTT CAATAGTATT TGAAGATTCT GGCTGTGATA ATGCTTCCAG TAAAGAAGAG 2100
CCGAAAACTA ATCGATTGCA TATTGGCAAC CATTGTGCTA ATAAACTAAC TGCTTTCAAG 2160
CCCACCAGTA GCAAATCTTC TTCTGAAGCT ACATTGTCTA TTTCTCCTCC AAGACCAACC 2220
ACTTTAAGTT TAGATCTCAC TAAAAACACC ACAGAAAAAC TCCAGCCCAG TTCACCAAAG 2280
GTGTATCTTT ACATTCAAAT GCAGCTGTGC AGAAAAGAAA ACCTCAAAGA CTGGATGAAT 2340
GGACGATGTA CCATAGAGGA GAGAGAGAGG AGCGTGTGTC TGCACATCTT CCTGCAGATC 2400
GCAGAGGCAG TGGAGTTTCT TCACAGTAAA GGACTGATGC ACAGGGACCT CAAGCCATCC 2460
AACATATTCT TTACAATGGA TGATGTGGTC AAGGTTGGAG ACTTTGGGTT AGTGACTGCA 2520
ATGGACCAGG ATGAGGAAGA GCAGACGGTT CTGACCCCAA TGCCAGCTTA TGCCAGACAC 2580
ACAGGACAAG TAGGGACCAA ACTGTATATG AGCCCAGAGC AGATTCATGG AAACAGCTAT 2640
TCTCATAAAG TGGACATCTT TTCTTTAGGC CTGATTCTAT TTGAATTGCT GTATCCATTC 2700
AGCACTCAGA TGGAGAGAGT CAGGACCTTA ACTGATGTAA GAAATCTCAA ATTTCCACCA 2760
TTATTTACTC AGAAATATCC TTGTGAGTAC GTGATGGTTC AAGACATGCT CTCTCCATCC 2820
CCCATGGAAC GACCTGAAGC TATAAACATC ATTGAAAATG CTGTATTTGA 2870
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60
         fe i++lG+GgfgvV++aknk+d+++yaikri+l++++ ++ekv+revkaLaklehp+iv
Q: 472   FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV  531
         799*********************************************************
S: 61    rYfaawleekeesl..............................................  74
         rYf+awle ++e++                                              
Q: 532   RYFNAWLEAPPEKWqekmdeiwlkdestdwplsspspmdapsvkirrmdpfatkehieii  591
         ************************************************************
S: 75    ............................................................  74
                                                                     
Q: 592   apspqrsrsfsvgiscdqtsssesqfsplefsgmdhedisesvdaaynlqdscltdcdve  651
         ************************************************************
S: 75    ..td.sseveaeaeleesesseesdtk.................................  98
           t+ ++++ +++el++se+s++++++                                 
Q: 652   dgTMdGNDEGHSFELCPSEASPYVRSRertsssivfedsgcdnasskeepktnrlhignh  711
         **66699******************999********************************
S: 99    ..................................................llyiqmelce  108
                                                           +lyiqm+lc+
Q: 712   cankltafkptsskssseatlsispprpttlsldltkntteklqpsspkvYLYIQMQLCR  771
         ************************************************************
S: 109   ketLkdwiderkllesrselvm.rlfkqllegleylHskgliHrdLkpsniFldsddqvK  167
         ke+Lkdw++ r+++e+r++ v+ ++f q++e++e+lHskgl+HrdLkpsniF+++dd vK
Q: 772   KENLKDWMNGRCTIEERERSVClHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVK  831
         ************************************************************
S: 168   igDFgLatalaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGl  227
         +gDFgL+ta++++++e+++ ++++++a+htgqvgtklymsPeq+++++Y++kvDifsLGl
Q: 832   VGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGL  891
         ************************************************************
S: 228   ilfeLlypfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasell  287
         ilfeLlypfst+merv+tlt++r++k+p  f++k+p+e+ ++q++ls +p+eRp+a +++
Q: 892   ILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINII  951
         ************************************************************
S: 288   ksell  292
         +++++
Q: 952   ENAVF  956
         *9875
Domain Sequence
(FASTA)
FEPIQCLGRG GFGVVFEAKN KVDDCNYAIK RIRLPNRELA REKVMREVKA LAKLEHPGIV 60
RYFNAWLEAP PEKWQEKMDE IWLKDESTDW PLSSPSPMDA PSVKIRRMDP FATKEHIEII 120
APSPQRSRSF SVGISCDQTS SSESQFSPLE FSGMDHEDIS ESVDAAYNLQ DSCLTDCDVE 180
DGTMDGNDEG HSFELCPSEA SPYVRSRERT SSSIVFEDSG CDNASSKEEP KTNRLHIGNH 240
CANKLTAFKP TSSKSSSEAT LSISPPRPTT LSLDLTKNTT EKLQPSSPKV YLYIQMQLCR 300
KENLKDWMNG RCTIEERERS VCLHIFLQIA EAVEFLHSKG LMHRDLKPSN IFFTMDDVVK 360
VGDFGLVTAM DQDEEEQTVL TPMPAYARHT GQVGTKLYMS PEQIHGNSYS HKVDIFSLGL 420
ILFELLYPFS TQMERVRTLT DVRNLKFPPL FTQKYPCEYV MVQDMLSPSP MERPEAINII 480
ENAVF 485
Keyword3D-structure; ADP-ribosylation; ATP-binding; Complete proteome; Diabetes mellitus; Disease mutation; Endoplasmic reticulum; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Signal; Stress response; Transferase; Translation regulation; Transmembrane; Transmembrane helix; Unfolded protein response.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00317
EKS-ANC-00330
EKS-BOT-00338
EKS-CAE-00275
EKS-CAJ-00347
EKS-CAF-00346
EKS-CAP-00372
EKS-CII-00189
EKS-CIS-00091
EKS-DAR-00702
EKS-DRM-00166
EKS-EQC-00330
EKS-FEC-00329
EKS-GAG-00285
EKS-GAA-00421
EKS-GOG-00335
EKS-ICT-00322
EKS-LAC-00353
EKS-LOA-00350
EKS-MAM-00344
EKS-MEG-00279
EKS-MOD-00334
EKS-MUM-00373
EKS-MUP-00333
EKS-MYL-00337
EKS-NOL-00309
EKS-ORN-00442
EKS-ORA-00297
EKS-ORC-00317
EKS-ORL-00409
EKS-OTG-00343
EKS-PAT-00321
EKS-PES-00298
EKS-PEM-00179
EKS-POA-00331
EKS-PTV-00079
EKS-RAN-00353
EKS-SAH-00317
EKS-SUS-00302
EKS-TAG-00414
EKS-TAR-00445
EKS-TEN-00441
EKS-VIP-00041
EKS-XET-00434
EKS-XIM-00430
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006987; P:activation of signaling protein activity involved in unfolded protein response
GO:0030282; P:bone mineralization
GO:0019722; P:calcium-mediated signaling
GO:0002063; P:chondrocyte development
GO:0031018; P:endocrine pancreas development
GO:0007029; P:endoplasmic reticulum organization
GO:0006983; P:ER overload response
GO:0045444; P:fat cell differentiation
GO:0030073; P:insulin secretion
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0007595; P:lactation
GO:0031642; P:negative regulation of myelination
GO:0032057; P:negative regulation of translational initiation in response to stress
GO:0032092; P:positive regulation of protein binding
GO:0009967; P:positive regulation of signal transduction
GO:0046777; P:protein autophosphorylation
GO:0051260; P:protein homooligomerization
GO:0019217; P:regulation of fatty acid metabolic process
GO:0032933; P:SREBP signaling pathway
GO:0006412; P:translation
GO:0006926; P:virus-infected cell apoptotic process
KEGG
hsa:9451;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013