| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00230 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Other/Bud32 | 363.3 | 2.2E-108 | 34 | 252 | 219 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000361186 |
| UniProt Accession | Q96S44; B3KU44; Q3T977; Q5JZ01; Q6NZ60; Q96FM7; Q9NQE6; |
| Protein Name | TP53-regulating kinase |
| Protein Synonyms/Alias | Nori-2; p53-related protein kinase; |
| Gene Name | TP53RK |
| Gene Synonyms/Alias | TP53RK; C20orf64, PRPK; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Protein kinase that phosphorylates 'Ser-15' of p53/TP53protein and may therefore participate in its activation. |
| Protein Length | 253 |
Protein Sequence
(FASTA) | | MAAARATTPA DGEEPAPEAE ALAAARERSS RFLSGLELVK QGAEARVFRG RFQGRAAVIK 60 | | HRFPKGYRHP ALEARLGRRR TVQEARALLR CRRAGISAPV VFFVDYASNC LYMEEIEGSV 120 | | TVRDYIQSTM ETEKTPQGLS NLAKTIGQVL ARMHDEDLIH GDLTTSNMLL KPPLEQLNIV 180 | | LIDFGLSFIS ALPEDKGVDL YVLEKAFLST HPNTETVFEA FLKSYSTSSK KARPVLKKLD 240 | | EVRLRGRKRS MVG 253 |
|
Nucleotide Sequence
(FASTA) | | ATGGCGGCGG CCAGAGCTAC TACGCCGGCC GATGGCGAGG AGCCCGCCCC GGAGGCTGAG 60 | | GCTCTGGCCG CAGCCCGGGA GCGGAGCAGC CGCTTCTTGA GCGGCCTGGA GCTGGTGAAG 120 | | CAGGGTGCCG AGGCGCGCGT GTTCCGTGGC CGCTTCCAGG GCCGCGCGGC GGTGATCAAG 180 | | CACCGCTTCC CCAAGGGCTA CCGGCACCCG GCGCTGGAGG CGCGGCTTGG CAGACGGCGG 240 | | ACGGTGCAGG AGGCCCGGGC GCTCCTCCGC TGTCGCCGCG CTGGAATATC TGCCCCAGTT 300 | | GTCTTTTTTG TGGACTATGC TTCCAACTGC TTATATATGG AAGAAATTGA AGGCTCAGTG 360 | | ACTGTTCGAG ATTATATTCA GTCCACTATG GAGACTGAAA AAACTCCCCA GGGTCTCTCC 420 | | AACTTAGCCA AGACAATTGG GCAGGTTTTG GCTCGAATGC ACGATGAAGA CCTCATTCAT 480 | | GGTGATCTCA CCACCTCCAA CATGCTCCTG AAACCCCCCC TGGAACAGCT GAACATTGTG 540 | | CTCATAGACT TTGGGCTGAG TTTCATTTCA GCACTTCCAG AGGATAAGGG AGTAGACCTC 600 | | TATGTCCTGG AGAAGGCCTT CCTCAGTACC CATCCCAACA CTGAAACTGT GTTTGAAGCC 660 | | TTTCTGAAGA GCTACTCCAC CTCCTCCAAA AAGGCCAGGC CAGTGCTAAA AAAATTAGAT 720 | | GAAGTGCGCC TGAGAGGAAG AAAGAGGTCC ATGGTTGGGT AG 762 |
|
| Domain Profile | S: 2 vdlellkqGaearvfrakfkgrkaiikerfpkkyrhPeldaqltkrrtlqearalakale 61 | ++lel+kqGaearvfr++f+gr+a+ik+rfpk+yrhP+l+a+l++rrt+qearal+++++ | Q: 34 SGLELVKQGAEARVFRGRFQGRAAVIKHRFPKGYRHPALEARLGRRRTVQEARALLRCRR 93 | 5799******************************************************** |
| S: 62 aGilvPkvlfvdleknklyleflegsstvknfiqetdetdyedkvkktl.elarkvGekl 120 | aGi++P+v+fvd+++n+ly+e++egs+tv+++iq+t+et +k++++l +la+++G++l | Q: 94 AGISAPVVFFVDYASNCLYMEEIEGSVTVRDYIQSTMET---EKTPQGLsNLAKTIGQVL 150 | ***************************************...9***************** |
| S: 121 gklhsndlihGdLttsnillkrdgaqlkvvlidfGLssvsklvedkGvdLyvLerallst 180 | +++h++dlihGdLttsn+llk++ +ql++vlidfGLs++s+l+edkGvdLyvLe+a+lst | Q: 151 ARMHDEDLIHGDLTTSNMLLKPPLEQLNIVLIDFGLSFISALPEDKGVDLYVLEKAFLST 210 | ************************************************************ |
| S: 181 hsktaailegllesyraasakklkevlkkleevrlrGrkrsml 223 | h++t++++e++l+sy ++s+kk+++vlkkl+evrlrGrkrsm+ | Q: 211 HPNTETVFEAFLKSY-STSSKKARPVLKKLDEVRLRGRKRSMV 252 | ***************.9*************************7 |
|
Domain Sequence
(FASTA) | | SGLELVKQGA EARVFRGRFQ GRAAVIKHRF PKGYRHPALE ARLGRRRTVQ EARALLRCRR 60 | | AGISAPVVFF VDYASNCLYM EEIEGSVTVR DYIQSTMETE KTPQGLSNLA KTIGQVLARM 120 | | HDEDLIHGDL TTSNMLLKPP LEQLNIVLID FGLSFISALP EDKGVDLYVL EKAFLSTHPN 180 | | TETVFEAFLK SYSTSSKKAR PVLKKLDEVR LRGRKRSMV 219 |
|
| Keyword | ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |