EKS-HOS-00093

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00093

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	457.0	2.0E-136	2229	2555	327

Status

Reviewed

Ensembl Protein

ENSP00000372581

UniProt Accession

Q13535; Q59HB2; Q7KYL3; Q93051; Q9BXK4;

Protein Name

Serine/threonine-protein kinase ATR

Protein Synonyms/Alias

Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1;

Gene Name

ATR

Gene Synonyms/Alias

ATR; FRP1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000175054	ENSP00000426595	ENST00000507148
ENSG00000175054	ENSP00000421870	ENST00000515810
ENSG00000175054	ENSP00000372581	ENST00000383101
ENSG00000175054	ENSP00000425897	ENST00000515149
ENSG00000175054	ENSP00000422553	ENST00000504521
ENSG00000175054	ENSP00000424754	ENST00000514393
ENSG00000175054	ENSP00000424355	ENST00000513291
ENSG00000175054	ENSP00000343741	ENST00000350721

Organism

Homo sapiens

Functional Description

Serine/threonine protein kinase which activatescheckpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Protein Length

2580

Protein Sequence
(FASTA)

MGEHGLELAS MIPALRELGS ATPEEYNTVV QKPRQILCQF IDRILTDVNV VAVELVKKTD 60

SQPTSVMLLD FIQHIMKSSP LMFVNVSGSH EAKGSCIEFS NWIITRLLRI AATPSCHLLH 120

KKICEVICSL LFLFKSKSPA IFGVLTKELL QLFEDLVYLH RRNVMGHAVE WPVVMSRFLS 180

QLDEHMGYLQ SAPLQLMSMQ NLEFIEVTLL MVLTRIIAIV FFRRQELLLW QIGCVLLEYG 240

SPKIKSLAIS FLTELFQLGG LPAQPASTFF SSFLELLKHL VEMDTDQLKL YEEPLSKLIK 300

TLFPFEAEAY RNIEPVYLNM LLEKLCVMFE DGVLMRLKSD LLKAALCHLL QYFLKFVPAG 360

YESALQVRKV YVRNICKALL DVLGIEVDAE YLLGPLYAAL KMESMEIIEE IQCQTQQENL 420

SSNSDGISPK RRRLSSSLNP SKRAPKQTED RTFKDCQHKS KKKPSVVITW MSLDFYTKVL 480

KSCRSLLESV QKLDLEATID KVVKIYDALI YMQVNSSFED HILEDLCGML SLPWIYSHSD 540

DGCLKLTTFA ANLLTLSCRI SDSYSPQAQS RCVFLLTLFP RRIFLEWRTA VYNWALQSSH 600

EVIRASCVSG FFILLQQQNS CNRVPKILID KVKDDSDIVK KEFASILGQL VCTLHGMFYL 660

TSSLTEPFSE HGHVDLFCRN LKATSQHECS SSQLKASVCK PFLFLLKKKI PSPVKLAFID 720

NLHHLCKHLD FREDETDVKA VLGTLLNLME DPDKDVRVAF SGNIKHILES LDSEDGFIKE 780

LFVLRMKEAY THAQISRNNE LKDTLILTTG DIGRAAKGDL VPFALLHLLH CLLSKSASVS 840

GAAYTEIRAL VAAKSVKLQS FFSQYKKPIC QFLVESLHSS QMTALPNTPC QNADVRKQDV 900

AHQREMALNT LSEIANVFDF PDLNRFLTRT LQVLLPDLAA KASPAASALI RTLGKQLNVN 960

RREILINNFK YIFSHLVCSC SKDELERALH YLKNETEIEL GSLLRQDFQG LHNELLLRIG 1020

EHYQQVFNGL SILASFASSD DPYQGPRDII SPELMADYLQ PKLLGILAFF NMQLLSSSVG 1080

IEDKKMALNS LMSLMKLMGP KHVSSVRVKM MTTLRTGLRF KDDFPELCCR AWDCFVRCLD 1140

HACLGSLLSH VIVALLPLIH IQPKETAAIF HYLIIENRDA VQDFLHEIYF LPDHPELKKI 1200

KAVLQEYRKE TSESTDLQTT LQLSMKAIQH ENVDVRIHAL TSLKETLYKN QEKLIKYATD 1260

SETVEPIISQ LVTVLLKGCQ DANSQARLLC GECLGELGAI DPGRLDFSTT ETQGKDFTFV 1320

TGVEDSSFAY GLLMELTRAY LAYADNSRAQ DSAAYAIQEL LSIYDCREME TNGPGHQLWR 1380

RFPEHVREIL EPHLNTRYKS SQKSTDWSGV KKPIYLSKLG SNFAEWSASW AGYLITKVRH 1440

DLASKIFTCC SIMMKHDFKV TIYLLPHILV YVLLGCNQED QQEVYAEIMA VLKHDDQHTI 1500

NTQDIASDLC QLSTQTVFSM LDHLTQWARH KFQALKAEKC PHSKSNRNKV DSMVSTVDYE 1560

DYQSVTRFLD LIPQDTLAVA SFRSKAYTRA VMHFESFITE KKQNIQEHLG FLQKLYAAMH 1620

EPDGVAGVSA IRKAEPSLKE QILEHESLGL LRDATACYDR AIQLEPDQII HYHGVVKSML 1680

GLGQLSTVIT QVNGVHANRS EWTDELNTYR VEAAWKLSQW DLVENYLAAD GKSTTWSVRL 1740

GQLLLSAKKR DITAFYDSLK LVRAEQIVPL SAASFERGSY QRGYEYIVRL HMLCELEHSI 1800

KPLFQHSPGD SSQEDSLNWV ARLEMTQNSY RAKEPILALR RALLSLNKRP DYNEMVGECW 1860

LQSARVARKA GHHQTAYNAL LNAGESRLAE LYVERAKWLW SKGDVHQALI VLQKGVELCF 1920

PENETPPEGK NMLIHGRAML LVGRFMEETA NFESNAIMKK YKDVTACLPE WEDGHFYLAK 1980

YYDKLMPMVT DNKMEKQGDL IRYIVLHFGR SLQYGNQFIY QSMPRMLTLW LDYGTKAYEW 2040

EKAGRSDRVQ MRNDLGKINK VITEHTNYLA PYQFLTAFSQ LISRICHSHD EVFVVLMEII 2100

AKVFLAYPQQ AMWMMTAVSK SSYPMRVNRC KEILNKAIHM KKSLEKFVGD ATRLTDKLLE 2160

LCNKPVDGSS STLSMSTHFK MLKKLVEEAT FSEILIPLQS VMIPTLPSIL GTHANHASHE 2220

PFPGHWAYIA GFDDMVEILA SLQKPKKISL KGSDGKFYIM MCKPKDDLRK DCRLMEFNSL 2280

INKCLRKDAE SRRRELHIRT YAVIPLNDEC GIIEWVNNTA GLRPILTKLY KEKGVYMTGK 2340

ELRQCMLPKS AALSEKLKVF REFLLPRHPP IFHEWFLRTF PDPTSWYSSR SAYCRSTAVM 2400

SMVGYILGLG DRHGENILFD SLTGECVHVD FNCLFNKGET FEVPEIVPFR LTHNMVNGMG 2460

PMGTEGLFRR ACEVTMRLMR DQREPLMSVL KTFLHDPLVE WSKPVKGHSK APLNETGEVV 2520

NEKAKTHVLD IEQRLQGVIK TRNRVTGLPL SIEGHVHYLI QEATDENLLC QMYLGWTPYM 2580

Nucleotide Sequence
(FASTA)

ATGGGGGAAC ATGGCCTGGA GCTGGCTTCC ATGATCCCCG CCCTGCGGGA GCTGGGCAGT 60

GCCACACCAG AGGAATATAA TACAGTTGTA CAGAAGCCAA GACAAATTCT GTGTCAATTC 120

ATTGACCGGA TACTTACAGA TGTAAATGTT GTTGCTGTAG AACTTGTAAA GAAAACTGAC 180

TCTCAGCCAA CCTCCGTGAT GTTGCTTGAT TTCATCCAGC ATATCATGAA ATCCTCCCCA 240

CTTATGTTTG TAAATGTGAG TGGAAGCCAT GAGGCCAAAG GCAGTTGTAT TGAATTCAGT 300

AATTGGATCA TAACGAGACT TCTGCGGATT GCAGCAACTC CCTCCTGTCA TTTGTTACAC 360

AAGAAAATCT GTGAAGTCAT CTGTTCATTA TTATTTCTTT TTAAAAGCAA GAGTCCTGCT 420

ATTTTTGGGG TACTCACAAA AGAATTATTA CAACTTTTTG AAGACTTGGT TTACCTCCAT 480

AGAAGAAATG TGATGGGTCA TGCTGTGGAA TGGCCAGTGG TCATGAGCCG ATTTTTAAGT 540

CAATTAGATG AACACATGGG ATATTTACAA TCAGCTCCTT TGCAGTTGAT GAGTATGCAA 600

AATTTAGAAT TTATTGAAGT CACTTTATTA ATGGTTCTTA CTCGTATTAT TGCAATTGTG 660

TTTTTTAGAA GGCAAGAACT CTTACTTTGG CAGATAGGTT GTGTTCTGCT AGAGTATGGT 720

AGTCCAAAAA TTAAATCCCT AGCAATTAGC TTTTTAACAG AACTTTTTCA GCTTGGAGGA 780

CTACCAGCAC AACCAGCTAG CACTTTTTTC AGCTCATTTT TGGAATTATT AAAACACCTT 840

GTAGAAATGG ATACTGACCA ATTGAAACTC TATGAAGAGC CATTATCAAA GCTGATAAAG 900

ACACTATTTC CCTTTGAAGC AGAAGCTTAT AGAAATATTG AACCTGTCTA TTTAAATATG 960

CTGCTGGAAA AACTCTGTGT CATGTTTGAA GACGGTGTGC TCATGCGGCT TAAGTCTGAT 1020

TTGCTAAAAG CAGCTTTGTG CCATTTACTG CAGTATTTCC TTAAATTTGT GCCAGCTGGG 1080

TATGAATCTG CTTTACAAGT CAGGAAGGTC TATGTGAGAA ATATTTGTAA AGCTCTTTTG 1140

GATGTGCTTG GAATTGAGGT AGATGCAGAG TACTTGTTGG GCCCACTTTA TGCAGCTTTG 1200

AAAATGGAAA GTATGGAAAT CATTGAGGAG ATTCAATGCC AAACTCAACA GGAAAACCTC 1260

AGCAGTAATA GTGATGGAAT ATCACCCAAA AGGCGTCGTC TCAGCTCGTC TCTAAACCCT 1320

TCTAAAAGAG CACCAAAACA GACTGAGGAC CGTACTTTCA AGGACTGTCA ACATAAATCC 1380

AAGAAGAAAC CTTCTGTAGT GATAACTTGG ATGTCATTGG ATTTTTACAC AAAAGTGCTT 1440

AAGAGCTGTA GAAGTTTGTT AGAATCTGTT CAGAAACTGG ACCTGGAGGC AACCATTGAT 1500

AAGGTGGTGA AAATTTATGA TGCTTTGATT TATATGCAAG TAAACAGTTC ATTTGAAGAT 1560

CATATCCTGG AAGATTTATG TGGTATGCTC TCACTTCCAT GGATTTATTC CCATTCTGAT 1620

GATGGCTGTT TAAAGTTGAC CACATTTGCC GCTAATCTTC TAACATTAAG CTGTAGGATT 1680

TCAGATAGCT ATTCACCACA GGCACAATCA CGATGTGTGT TTCTTCTGAC TCTGTTTCCA 1740

AGAAGAATAT TCCTTGAGTG GAGAACAGCA GTTTACAACT GGGCCCTGCA GAGCTCCCAT 1800

GAAGTAATCC GGGCTAGTTG TGTTAGTGGA TTTTTTATCT TATTGCAGCA GCAGAATTCT 1860

TGTAACAGAG TTCCCAAGAT TCTTATAGAT AAAGTCAAAG ATGATTCTGA CATTGTCAAG 1920

AAAGAATTTG CTTCTATACT TGGTCAACTT GTCTGTACTC TTCACGGCAT GTTTTATCTG 1980

ACAAGTTCTT TAACAGAACC TTTCTCTGAA CACGGACATG TGGACCTCTT CTGTAGGAAC 2040

TTGAAAGCCA CTTCTCAACA TGAATGTTCA TCTTCTCAAC TAAAAGCTTC TGTCTGCAAG 2100

CCATTCCTTT TCCTACTGAA AAAAAAAATA CCTAGTCCAG TAAAACTTGC TTTCATAGAT 2160

AATCTACATC ATCTTTGTAA GCATCTTGAT TTTAGAGAAG ATGAAACAGA TGTAAAAGCA 2220

GTTCTTGGAA CTTTATTAAA TTTAATGGAA GATCCAGACA AAGATGTTAG AGTGGCTTTT 2280

AGTGGAAATA TCAAGCACAT ATTGGAATCC TTGGACTCTG AAGATGGATT TATAAAGGAG 2340

CTTTTTGTCT TAAGAATGAA GGAAGCATAT ACACATGCCC AAATATCAAG AAATAATGAG 2400

CTGAAGGATA CCTTGATTCT TACAACAGGG GATATTGGAA GGGCCGCAAA AGGAGATTTG 2460

GTACCATTTG CACTCTTACA CTTATTGCAT TGTTTGTTAT CCAAGTCAGC ATCTGTCTCT 2520

GGAGCAGCAT ACACAGAAAT TAGAGCTCTG GTTGCAGCTA AAAGTGTTAA ACTGCAAAGT 2580

TTTTTCAGCC AGTATAAGAA ACCCATCTGT CAGTTTTTGG TAGAATCCCT TCACTCTAGT 2640

CAGATGACAG CACTTCCGAA TACTCCATGC CAGAATGCTG ACGTGCGAAA ACAAGATGTG 2700

GCTCACCAGA GAGAAATGGC TTTAAATACG TTGTCTGAAA TTGCCAACGT TTTCGACTTT 2760

CCTGATCTTA ATCGTTTTCT TACTAGGACA TTACAAGTTC TACTACCTGA TCTTGCTGCC 2820

AAAGCAAGCC CTGCAGCTTC TGCTCTCATT CGAACTTTAG GAAAACAATT AAATGTCAAT 2880

CGTAGAGAGA TTTTAATAAA CAACTTCAAA TATATTTTTT CTCATTTGGT CTGTTCTTGT 2940

TCCAAAGATG AATTAGAACG TGCCCTTCAT TATCTGAAGA ATGAAACAGA AATTGAACTG 3000

GGGAGCCTGT TGAGACAAGA TTTCCAAGGA TTGCATAATG AATTATTGCT GCGTATTGGA 3060

GAACACTATC AACAGGTTTT TAATGGTTTG TCAATACTTG CCTCATTTGC ATCCAGTGAT 3120

GATCCATATC AGGGCCCGAG AGATATCATA TCACCTGAAC TGATGGCTGA TTATTTACAA 3180

CCCAAATTGT TGGGCATTTT GGCTTTTTTT AACATGCAGT TACTGAGCTC TAGTGTTGGC 3240

ATTGAAGATA AGAAAATGGC CTTGAACAGT TTGATGTCTT TGATGAAGTT AATGGGACCC 3300

AAACATGTCA GTTCTGTGAG GGTGAAGATG ATGACCACAC TGAGAACTGG CCTTCGATTC 3360

AAGGATGATT TTCCTGAATT GTGTTGCAGA GCTTGGGACT GCTTTGTTCG CTGCCTGGAT 3420

CATGCTTGTC TGGGCTCCCT TCTCAGTCAT GTAATAGTAG CTTTGTTACC TCTTATACAC 3480

ATCCAGCCTA AAGAAACTGC AGCTATCTTC CACTACCTCA TAATTGAAAA CAGGGATGCT 3540

GTGCAAGATT TTCTTCATGA AATATATTTT TTACCTGATC ATCCAGAATT AAAAAAGATA 3600

AAAGCCGTTC TCCAGGAATA CAGAAAGGAG ACCTCTGAGA GCACTGATCT TCAGACAACT 3660

CTTCAGCTCT CTATGAAGGC CATTCAACAT GAAAATGTCG ATGTTCGTAT TCATGCTCTT 3720

ACAAGCTTGA AGGAAACCTT GTATAAAAAT CAGGAAAAAC TGATAAAGTA TGCAACAGAC 3780

AGTGAAACAG TAGAACCTAT TATCTCACAG TTGGTGACAG TGCTTTTGAA AGGTTGCCAA 3840

GATGCAAACT CTCAAGCTCG GTTGCTCTGT GGGGAATGTT TAGGGGAATT GGGGGCGATA 3900

GATCCAGGTC GATTAGATTT CTCAACAACT GAAACTCAAG GAAAAGATTT TACATTTGTG 3960

ACTGGAGTAG AAGATTCAAG CTTTGCCTAT GGATTATTGA TGGAGCTAAC AAGAGCTTAC 4020

CTTGCGTATG CTGATAATAG CCGAGCTCAA GATTCAGCTG CCTATGCCAT TCAGGAGTTG 4080

CTTTCTATTT ATGACTGTAG AGAGATGGAG ACCAACGGCC CAGGTCACCA ATTGTGGAGG 4140

AGATTTCCTG AGCATGTTCG GGAAATACTA GAACCTCATC TAAATACCAG ATACAAGAGT 4200

TCTCAGAAGT CAACCGATTG GTCTGGAGTA AAGAAGCCAA TTTACTTAAG TAAATTGGGT 4260

AGTAACTTTG CAGAATGGTC AGCATCTTGG GCAGGTTATC TTATTACAAA GGTTCGACAT 4320

GATCTTGCCA GTAAAATTTT CACCTGCTGT AGCATTATGA TGAAGCATGA TTTCAAAGTG 4380

ACCATCTATC TTCTTCCACA TATTCTGGTG TATGTCTTAC TGGGTTGTAA TCAAGAAGAT 4440

CAGCAGGAGG TTTATGCAGA AATTATGGCA GTTCTAAAGC ATGACGATCA GCATACCATA 4500

AATACCCAAG ACATTGCATC TGATCTGTGT CAACTCAGTA CACAGACTGT GTTCTCCATG 4560

CTTGACCATC TCACACAGTG GGCAAGGCAC AAATTTCAGG CACTGAAAGC TGAGAAATGT 4620

CCACACAGCA AATCAAACAG AAATAAGGTA GACTCAATGG TATCTACTGT GGATTATGAA 4680

GACTATCAGA GTGTAACCCG TTTTCTAGAC CTCATACCCC AGGATACTCT GGCAGTAGCT 4740

TCCTTTCGCT CCAAAGCATA CACACGAGCT GTAATGCACT TTGAATCATT TATTACAGAA 4800

AAGAAGCAAA ATATTCAGGA ACATCTTGGA TTTTTACAGA AATTGTATGC TGCTATGCAT 4860

GAACCTGATG GAGTGGCCGG AGTCAGTGCA ATTAGAAAGG CAGAACCATC TCTAAAAGAA 4920

CAGATCCTTG AACATGAAAG CCTTGGCTTG CTGAGGGATG CCACTGCTTG TTATGACAGG 4980

GCTATTCAGC TAGAACCAGA CCAGATCATT CATTATCATG GTGTAGTAAA GTCCATGTTA 5040

GGTCTTGGTC AGCTGTCTAC TGTTATCACT CAGGTGAATG GAGTGCATGC TAACAGGTCC 5100

GAGTGGACAG ATGAATTAAA CACGTACAGA GTGGAAGCAG CTTGGAAATT GTCACAGTGG 5160

GATTTGGTGG AAAACTATTT GGCAGCAGAT GGAAAATCTA CAACATGGAG TGTCAGACTG 5220

GGACAGCTAT TATTATCAGC CAAAAAAAGA GATATCACAG CTTTTTATGA CTCACTGAAA 5280

CTAGTGAGAG CAGAACAAAT TGTACCTCTT TCAGCTGCAA GCTTTGAAAG AGGCTCCTAC 5340

CAACGAGGAT ATGAATATAT TGTGAGATTG CACATGTTAT GTGAGTTGGA GCATAGCATC 5400

AAACCACTTT TCCAGCATTC TCCAGGTGAC AGTTCTCAAG AAGATTCTCT AAACTGGGTA 5460

GCTCGACTAG AAATGACCCA GAATTCCTAC AGAGCCAAGG AGCCTATCCT GGCTCTCCGG 5520

AGGGCTTTAC TAAGCCTCAA CAAAAGACCA GATTACAATG AAATGGTTGG AGAATGCTGG 5580

CTGCAGAGTG CCAGGGTAGC TAGAAAGGCT GGTCACCACC AGACAGCCTA CAATGCTCTC 5640

CTTAATGCAG GGGAATCACG ACTCGCTGAA CTGTACGTGG AAAGGGCAAA GTGGCTCTGG 5700

TCCAAGGGTG ATGTTCACCA GGCACTAATT GTTCTTCAAA AAGGTGTTGA ATTATGTTTT 5760

CCTGAAAATG AAACCCCACC TGAGGGTAAG AACATGTTAA TCCATGGTCG AGCTATGCTA 5820

CTAGTGGGCC GATTTATGGA AGAAACAGCT AACTTTGAAA GCAATGCAAT TATGAAAAAA 5880

TATAAGGATG TGACCGCGTG CCTGCCAGAA TGGGAGGATG GGCATTTTTA CCTTGCCAAG 5940

TACTATGACA AATTGATGCC CATGGTCACA GACAACAAAA TGGAAAAGCA AGGTGATCTC 6000

ATCCGGTATA TAGTTCTTCA TTTTGGCAGA TCTCTACAAT ATGGAAATCA GTTCATATAT 6060

CAGTCAATGC CACGAATGTT AACTCTATGG CTTGATTATG GTACAAAGGC ATATGAATGG 6120

GAAAAAGCTG GCCGCTCCGA TCGTGTACAA ATGAGGAATG ATTTGGGTAA AATAAACAAG 6180

GTTATCACAG AGCATACAAA CTATTTAGCT CCATATCAAT TTTTGACTGC TTTTTCACAA 6240

TTGATCTCTC GAATTTGTCA TTCTCACGAT GAAGTTTTTG TTGTCTTGAT GGAAATAATA 6300

GCCAAAGTAT TTCTAGCCTA TCCTCAACAA GCAATGTGGA TGATGACAGC TGTGTCAAAG 6360

TCATCTTATC CCATGCGTGT GAACAGATGC AAGGAAATCC TCAATAAAGC TATTCATATG 6420

AAAAAATCCT TAGAGAAGTT TGTTGGAGAT GCAACTCGCC TAACAGATAA GCTTCTAGAA 6480

TTGTGCAATA AACCGGTTGA TGGAAGTAGT TCCACATTAA GCATGAGCAC TCATTTTAAA 6540

ATGCTTAAAA AGCTGGTAGA AGAAGCAACA TTTAGTGAAA TCCTCATTCC TCTACAATCA 6600

GTCATGATAC CTACACTTCC ATCAATTCTG GGTACCCATG CTAACCATGC TAGCCATGAA 6660

CCATTTCCTG GACATTGGGC CTATATTGCA GGGTTTGATG ATATGGTGGA AATTCTTGCT 6720

TCTCTTCAGA AACCAAAGAA GATTTCTTTA AAAGGCTCAG ATGGAAAGTT CTACATCATG 6780

ATGTGTAAGC CAAAAGATGA CCTGAGAAAG GATTGTAGAC TAATGGAATT CAATTCCTTG 6840

ATTAATAAGT GCTTAAGAAA AGATGCAGAG TCTCGTAGAA GAGAACTTCA TATTCGAACA 6900

TATGCAGTTA TTCCACTAAA TGATGAATGT GGGATTATTG AATGGGTGAA CAACACTGCT 6960

GGTTTGAGAC CTATTCTGAC CAAACTATAT AAAGAAAAGG GAGTGTATAT GACAGGAAAA 7020

GAACTTCGCC AGTGTATGCT ACCAAAGTCA GCAGCTTTAT CTGAAAAACT CAAAGTATTC 7080

CGAGAATTTC TCCTGCCCAG GCATCCTCCT ATTTTTCATG AGTGGTTTCT GAGAACATTC 7140

CCTGATCCTA CATCATGGTA CAGTAGTAGA TCAGCTTACT GCCGTTCCAC TGCAGTAATG 7200

TCAATGGTTG GTTATATTCT GGGGCTTGGA GACCGTCATG GTGAAAATAT TCTCTTTGAT 7260

TCTTTGACTG GTGAATGCGT ACATGTAGAT TTCAATTGTC TTTTCAATAA GGGAGAAACC 7320

TTTGAAGTTC CAGAAATTGT GCCATTTCGC CTGACTCATA ATATGGTTAA TGGAATGGGT 7380

CCTATGGGAA CAGAGGGTCT TTTTCGAAGA GCATGTGAAG TTACAATGAG GCTGATGCGT 7440

GATCAGCGAG AGCCTTTAAT GAGTGTCTTA AAGACTTTTC TACATGATCC TCTTGTGGAA 7500

TGGAGTAAAC CAGTGAAAGG GCATTCCAAA GCGCCACTGA ATGAAACTGG AGAAGTTGTC 7560

AATGAAAAGG CCAAGACCCA TGTTCTTGAC ATTGAGCAGC GACTACAAGG TGTAATCAAG 7620

ACTCGAAATA GAGTGACAGG ACTGCCGTTA TCTATTGAAG GACATGTGCA TTACCTTATA 7680

CAGGAAGCTA CTGATGAAAA CTTACTATGC CAGATGTATC TTGGTTGGAC TCCATATATG 7740

TGA 7743

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         iagfd++veilas+qkpkk++l+Gsdgk+y++++k+k+Dlr+d+r+++++sl+N++L+kd

Q: 2229  IAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKD  2288

         89**********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +e++rr+L+irty+V+pl++++g+iewv+nt++L+ +l+kl+++k+v++        + +

Q: 2289  AESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYM--------TGK  2340

         *************************************************........599

S: 121   stvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAv  180

         + +q++ pk+++l+++l+vf+e+l +++p+ ++++++l++fp+p++w+++r+ay+rs+Av

Q: 2341  ELRQCMLPKSAALSEKLKVFREFLLPRHPP-IFHEWFLRTFPDPTSWYSSRSAYCRSTAV  2399

         *****************************8.*****************************

S: 181   islvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivna  240

         +s+vgyiLgLgdrh en+l+d+ tge+vh+df++ f+k++t ++vpe+vPFRLT+n+vn+

Q: 2400  MSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGET-FEVPEIVPFRLTHNMVNG  2458

         *****************************************.******************

S: 241   lgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk.....kkktsketee  295

         +g++g+eG+fr++ce ++r++r+++e l+++L++fl+dplv+w+k     +k++ +et+e

Q: 2459  MGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKpvkghSKAPLNETGE  2518

         *************************************************99*********

S: 296   elaekakaealkikkllskvekaenavatrdllllee  332

         +++ekak++ l+i+++l++v k++n+v+ ++l+++++

Q: 2519  VVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGH  2555

         ********************************99987

Domain Sequence
(FASTA)

IAGFDDMVEI LASLQKPKKI SLKGSDGKFY IMMCKPKDDL RKDCRLMEFN SLINKCLRKD 60

AESRRRELHI RTYAVIPLND ECGIIEWVNN TAGLRPILTK LYKEKGVYMT GKELRQCMLP 120

KSAALSEKLK VFREFLLPRH PPIFHEWFLR TFPDPTSWYS SRSAYCRSTA VMSMVGYILG 180

LGDRHGENIL FDSLTGECVH VDFNCLFNKG ETFEVPEIVP FRLTHNMVNG MGPMGTEGLF 240

RRACEVTMRL MRDQREPLMS VLKTFLHDPL VEWSKPVKGH SKAPLNETGE VVNEKAKTHV 300

LDIEQRLQGV IKTRNRVTGL PLSIEGH 327

Keyword

Alternative splicing; ATP-binding; Chromosome; Complete proteome; Disease mutation; DNA damage; DNA repair; DNA-binding; Dwarfism; Kinase; Manganese; Mental retardation; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005694	; C:chromosome
GO:0005654	; C:nucleoplasm
GO:0016605	; C:PML body
GO:0001741	; C:XY body
GO:0005524	; F:ATP binding
GO:0003677	; F:DNA binding
GO:0032405	; F:MutLalpha complex binding
GO:0032407	; F:MutSalpha complex binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007049	; P:cell cycle
GO:0071480	; P:cellular response to gamma radiation
GO:0034644	; P:cellular response to UV
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0006260	; P:DNA replication
GO:0007275	; P:multicellular organismal development
GO:0008156	; P:negative regulation of DNA replication
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043517	; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	; P:protein autophosphorylation
GO:0043393	; P:regulation of protein binding
GO:0090399	; P:replicative senescence

KEGG

hsa:545

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.
IPR012993	; UME.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08064	; UME; 1.

SMARTs

SM00146	; PI3Kc; 1.
SM00802	; UME; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; 1.
PS00915	; PI3_4_KINASE_1; FALSE_NEG.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013