EKS-HOS-00161

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00161

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	362.6	7.1E-108	67	328	262

Status

Reviewed

Ensembl Protein

ENSP00000308413

UniProt Accession

Q9UBS0; B2RMZ9; O94809; Q9UEC1;

Protein Name

Ribosomal protein S6 kinase beta-2

Protein Synonyms/Alias

S6K-beta-2; S6K2; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70 S6 kinase beta; p70 S6K-beta; p70 S6KB; p70-beta;

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2; STK14B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000175634	ENSP00000410175	ENST00000420069
ENSG00000175634	ENSP00000442949	ENST00000539188
ENSG00000175634	ENSP00000308413	ENST00000312629
ENSG00000175634	ENSP00000450621	ENST00000556575
ENSG00000175634	ENSP00000432847	ENST00000528964
ENSG00000175634	ENSP00000436811	ENST00000524934
ENSG00000175634	ENSP00000435716	ENST00000530623
ENSG00000175634	ENSP00000431615	ENST00000524814

Organism

Homo sapiens

Functional Description

Phosphorylates specifically ribosomal protein S6.

Protein Length

482

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEGE PELSPADACP LAELRAAGLE PVGHYEEVEL TETSVNVGPE 60

RIGPHCFELL RVLGKGGYGK VFQVRKVQGT NLGKIYAMKV LRKAKIVRNA KDTAHTRAER 120

NILESVKHPF IVELAYAFQT GGKLYLILEC LSGGELFTHL EREGIFLEDT ACFYLAEITL 180

ALGHLHSQGI IYRDLKPENI MLSSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI 240

LVRSGHNRAV DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIRGKLALPP YLTPDARDLV 300

KKFLKRNPSQ RIGGGPGDAA DVQRHPFFRH MNWDDLLAWR VDPPFRPCLQ SEEDVSQFDT 360

RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE GFSFQPKLRS PRRLNSSPRA 420

PVSPLKFSPF EGFRPSPSLP EPTELPLPPL LPPPPPSTTA PLPIRPPSGT KKSKRGRGRP 480

GR 482

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TGTTTGATTT GGATTTGGAG ACGGAGGAAG GCAGCGAGGG CGAGGGCGAG 60

CCAGAGCTCA GCCCCGCGGA CGCATGTCCC CTTGCCGAGT TGAGGGCAGC TGGCCTAGAG 120

CCTGTGGGAC ACTATGAAGA GGTGGAGCTG ACTGAGACCA GCGTGAACGT TGGCCCAGAG 180

CGCATCGGGC CCCACTGCTT TGAGCTGCTG CGTGTGCTGG GCAAGGGGGG CTATGGCAAG 240

GTGTTCCAGG TGCGAAAGGT GCAAGGCACC AACTTGGGCA AAATATATGC CATGAAAGTC 300

CTAAGGAAGG CCAAAATTGT GCGCAATGCC AAGGACACAG CACACACACG GGCTGAGCGG 360

AACATTCTAG AGTCAGTGAA GCACCCCTTT ATTGTGGAAC TGGCCTATGC CTTCCAGACT 420

GGTGGCAAAC TCTACCTCAT CCTTGAGTGC CTCAGTGGTG GCGAGCTCTT CACGCATCTG 480

GAGCGAGAGG GCATCTTCCT GGAAGATACG GCCTGCTTCT ACCTGGCTGA GATCACGCTG 540

GCCCTGGGCC ATCTCCACTC CCAGGGCATC ATCTACCGGG ACCTCAAGCC CGAGAACATC 600

ATGCTCAGCA GCCAGGGCCA CATCAAACTG ACCGACTTTG GACTCTGCAA GGAGTCTATC 660

CATGAGGGCG CCGTCACTCA CACCTTCTGC GGCACCATTG AGTACATGGC CCCTGAGATT 720

CTGGTGCGCA GTGGCCACAA CCGGGCTGTG GACTGGTGGA GCCTGGGGGC CCTGATGTAC 780

GACATGCTCA CTGGATCGCC GCCCTTCACC GCAGAGAACC GGAAGAAAAC CATGGATAAG 840

ATCATCAGGG GCAAGCTGGC ACTGCCCCCC TACCTCACCC CAGATGCCCG GGACCTTGTC 900

AAAAAGTTTC TGAAACGGAA TCCCAGCCAG CGGATTGGGG GTGGCCCAGG GGATGCTGCT 960

GATGTGCAGA GACATCCCTT TTTCCGGCAC ATGAATTGGG ACGACCTTCT GGCCTGGCGT 1020

GTGGACCCCC CTTTCAGGCC CTGTCTGCAG TCAGAGGAGG ACGTGAGCCA GTTTGATACC 1080

CGCTTCACAC GGCAGACGCC GGTGGACAGT CCTGATGACA CAGCCCTCAG CGAGAGTGCC 1140

AACCAGGCCT TCCTGGGCTT CACATACGTG GCGCCGTCTG TCCTGGACAG CATCAAGGAG 1200

GGCTTCTCCT TCCAGCCCAA GCTGCGCTCA CCCAGGCGCC TCAACAGTAG CCCCCGGGCC 1260

CCCGTCAGCC CCCTCAAGTT CTCCCCTTTT GAGGGGTTTC GGCCCAGCCC CAGCCTGCCG 1320

GAGCCCACGG AGCTACCTCT ACCTCCACTC CTGCCACCGC CGCCGCCCTC GACCACCGCC 1380

CCTCTCCCCA TCCGTCCCCC CTCAGGGACC AAGAAGTCCA AGAGGGGCCG TGGGCGTCCA 1440

GGGCGCTAG 1449

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 67    FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRnaKDTAHTRAERNILESV  126

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 127   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  186

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+g

Q: 187   SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGAVTHTFCGTIEYMAPEILVRSG  245

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i +gk  l lp +  l+++a+dlvk

Q: 246   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGK--LALPPY--LTPDARDLVK  301

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 302   KFLKRNPSQRIGGgpgDAADVQRHPFF  328

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNLGKIY AMKVLRKAKI VRNAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLSSQG HIKLTDFGLC KESIHEGAVT HTFCGTIEYM APEILVRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIRGKL ALPPYLTPDA RDLVKKFLKR 240

NPSQRIGGGP GDAADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005654	; C:nucleoplasm
GO:0005524	; F:ATP binding
GO:0042277	; F:peptide binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004711	; F:ribosomal protein S6 kinase activity
GO:0007173	; P:epidermal growth factor receptor signaling pathway
GO:0008543	; P:fibroblast growth factor receptor signaling pathway
GO:0048011	; P:nerve growth factor receptor signaling pathway
GO:0048015	; P:phosphatidylinositol-mediated signaling
GO:0045948	; P:positive regulation of translational initiation
GO:0043491	; P:protein kinase B signaling cascade
GO:0006412	; P:translation

KEGG

hsa:6199

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013