EKS-HOS-00399

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00399

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	342.8	8.4E-102	243	506	264

Status

Reviewed

Ensembl Protein

ENSP00000365004

UniProt Accession

Q56UN5; B2RP57; Q56UN1; Q56UN2; Q56UN3; Q56UN4; Q8N4E9; Q9H5T2;

Protein Name

Mitogen-activated protein kinase kinase kinase 19

Protein Synonyms/Alias

Regulated in COPD, protein kinase; SPS1/STE20-related protein kinase YSK4;

Gene Name

MAP3K19

Gene Synonyms/Alias

MAP3K19; RCK, YSK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000176601	ENSP00000321160	ENST00000315513
ENSG00000176601	ENSP00000376649	ENST00000392917
ENSG00000176601	ENSP00000376647	ENST00000392915
ENSG00000176601	ENSP00000376650	ENST00000392918
ENSG00000176601	ENSP00000392827	ENST00000437365
ENSG00000176601	ENSP00000365004	ENST00000375844
ENSG00000176601	ENSP00000351140	ENST00000358371
ENSG00000176601	ENSP00000365005	ENST00000375845
ENSG00000176601	ENSP00000416345	ENST00000414343
ENSG00000176601	ENSP00000390940	ENST00000425952

Organism

Homo sapiens

Functional Description

Protein Length

510

Protein Sequence
(FASTA)

MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ DGDCSHSTLV 60

NEEEDPSGGR QDWQPRTEGV EITVTFPRDV SPPQEMSQED LKEKNLINSS LQEWAQAHAV 120

SHPNEIETVE LRKKKLTMRP LVLQKEESSR ELCNVNLGFL LPRSCLELNI SKSVTREDAP 180

HFLKEQQRKS EEFSTSHMKY SGRSIKRHSS GLRIYDREEK FLISNEKKIF SENSLKSEEP 240

ILWTKGEILG KGAYGTVYCG LTSQGQLIAV KQVALDTSNK LAAEKEYRKL QEEVDLLKAL 300

KHVNIVAYLG TCLQENTVSI FMEFVPGGSI SSIINRFGPL PEMVFCKYTK QILQGVAYLH 360

ENCVVHRDIK GNNVMLMPTG IIKLIDFGCA RRLAWAGLNG THSDMLKSMH GTPYWMAPEV 420

INESGYGRKS DIWSIGCTVF EMATGKPPLA SMDRMAAMFY IGAHRGLMPP LPDHFSENAA 480

DFVRMCLTRD QHERPSALQL LKHSFLERSH 510

Nucleotide Sequence
(FASTA)

ATGAGTTCTA TGCCAAAACC AGAAAGACAT GCTGAGTCAT TGCTTGACAT TTGTCATGAT 60

ACAAACTCTT CTCCAACTGA TTTGATGACA GTTACCAAAA ATCAAAACAT CATCTTGCAA 120

AGCATCAGCA GAAGTGAGGA GTTCGACCAA GATGGTGACT GCAGTCATTC CACACTGGTT 180

AATGAAGAAG AAGATCCCAG TGGTGGTAGA CAGGACTGGC AACCCAGGAC AGAAGGTGTT 240

GAGATCACTG TAACTTTTCC AAGAGATGTC AGTCCTCCCC AAGAAATGAG CCAAGAAGAC 300

TTAAAAGAAA AGAATCTGAT AAACTCATCG CTTCAAGAAT GGGCACAAGC ACATGCAGTT 360

TCTCATCCAA ATGAAATAGA AACGGTGGAG CTCAGGAAAA AGAAGCTGAC CATGCGGCCC 420

TTAGTTTTGC AAAAAGAGGA AAGTTCCAGG GAGCTCTGCA ATGTGAACTT GGGCTTTTTG 480

CTACCAAGAT CTTGTTTAGA ACTGAACATT TCCAAGTCTG TAACCAGAGA AGATGCTCCT 540

CATTTTCTGA AGGAGCAGCA AAGAAAATCT GAAGAGTTTT CGACCTCTCA TATGAAGTAC 600

AGTGGCCGAA GCATCAAGAG GCATAGTAGT GGGCTCAGGA TATATGACAG GGAGGAGAAA 660

TTTCTCATCT CAAATGAAAA GAAGATATTT TCTGAAAATA GTTTAAAGTC TGAAGAACCT 720

ATCCTATGGA CCAAGGGTGA GATTCTTGGA AAGGGAGCCT ACGGCACAGT ATACTGTGGT 780

CTCACTAGTC AAGGACAGCT AATAGCTGTA AAACAGGTGG CTTTGGATAC CTCTAATAAA 840

TTAGCTGCTG AAAAGGAATA CCGGAAACTA CAGGAAGAAG TAGATTTGCT CAAAGCACTG 900

AAACATGTCA ACATTGTGGC CTATTTGGGG ACATGCTTGC AAGAGAACAC TGTGAGCATT 960

TTCATGGAGT TTGTTCCTGG TGGCTCAATC TCTAGTATTA TAAACCGTTT TGGGCCATTG 1020

CCTGAGATGG TGTTCTGTAA ATATACGAAA CAAATACTTC AAGGTGTTGC TTATCTCCAT 1080

GAGAACTGTG TGGTACATCG CGATATCAAA GGAAATAATG TTATGCTCAT GCCAACTGGA 1140

ATAATAAAGC TGATTGACTT TGGCTGTGCC AGGCGTTTGG CCTGGGCAGG TTTAAATGGC 1200

ACCCACAGTG ACATGCTTAA GTCCATGCAT GGGACTCCAT ATTGGATGGC CCCAGAAGTC 1260

ATCAATGAGT CTGGCTATGG ACGGAAATCA GATATCTGGA GCATTGGTTG TACTGTGTTT 1320

GAGATGGCTA CAGGGAAGCC TCCACTGGCT TCCATGGACA GGATGGCCGC CATGTTTTAC 1380

ATCGGAGCAC ACCGAGGGCT GATGCCTCCT TTACCAGACC ACTTCTCAGA AAATGCAGCA 1440

GACTTTGTGC GCATGTGCCT GACCAGGGAC CAGCATGAGC GACCTTCTGC TCTCCAGCTC 1500

CTGAAGCACT CCTTCTTGGA GAGAAGTCAC TGA 1533

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekk.sekkevkalkeEikllkelk  59

         w+k+e++gkG++g+vy++l+ ++g+l+avK+v++++ +k +++ke+++l+eE++llk+lk

Q: 243   WTKGEILGKGAYGTVYCGLT-SQGQLIAVKQVALDTSNKlAAEKEYRKLQEEVDLLKALK  301

         89*****************8.89***********8765515667****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G++ +e++++if+E+v+gGs+ss+++++g+l e+v++kytkqil+g+ayLHe

Q: 302   HVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHE  361

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG+++rla++  + ++   l+s++Gt+++maPEvi

Q: 362   NCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHsdmLKSMHGTPYWMAPEVI  421

         **********************************999988877899**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a+mf +ga++  +P++p+++se+

Q: 422   NES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRgLMPPLPDHFSEN  478

         988..****************************.9**********9979***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa +LLkh+fl

Q: 479   AADFVRMCLTRDQHERPSALQLLKHSFL  506

         **************************96

Domain Sequence
(FASTA)

WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSNKLA AEKEYRKLQE EVDLLKALKH 60

VNIVAYLGTC LQENTVSIFM EFVPGGSISS IINRFGPLPE MVFCKYTKQI LQGVAYLHEN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCARR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENAADF 240

VRMCLTRDQH ERPSALQLLK HSFL 264

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

hsa:80122

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013