EKS-HOS-00231
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00231
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/Haspin317.43.5E-94485755271
StatusReviewed
Ensembl ProteinENSP00000325290
UniProt AccessionQ8TF76; Q5U5K3; Q96MN1; Q9BXS7;
Protein NameSerine/threonine-protein kinase haspin
Protein Synonyms/Alias Germ cell-specific gene 2 protein; H-haspin; Haploid germ cell-specific nuclear protein kinase;
Gene NameGSG2
Gene Synonyms/Alias GSG2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000177602ENSP00000325290ENST00000325418
OrganismHomo sapiens
Functional DescriptionSerine/threonine-protein kinase that phosphorylateshistone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
Protein Length798
Protein Sequence
(FASTA)
MAASLPGPGS RLFRTYGAAD GRRQRRPGRE AAQWFPPQDR RRFFNSSGSS DASIGDPSQS 60
DDPDDPDDPD FPGSPVRRRR RRPGGRVPKD RPSLTVTPKR WKLRARPSLT VTPRRLGLRA 120
RPPQKCSTPC GPLRLPPFPS RDSGRLSPDL SVCGQPRDGD ELGISASLFS SLASPCPGSP 180
TPRDSVISIG TSACLVAASA VPSGLHLPEV SLDRASLPCS QEEATGGAKD TRMVHQTRAS 240
LRSVLFGLMN SGTPEDSEFR ADGKNMRESC CKRKLVVGNG PEGPGLSSTG KRRATGQDSC 300
QERGLQEAVR REHQEASVPK GRIVPRGIDR LERTRSSRKS KHQEATETSL LHSHRFKKGQ 360
KLGKDSFPTQ DLTPLQNVCF WTKTRASFSF HKKKIVTDVS EVCSIYTTAT SLSGSLLSEC 420
SNRPVMNRTS GAPSSWHSSS MYLLSPLNTL SISNKKASDA EKVYGECSQK GPVPFSHCLP 480
TEKLQRCEKI GEGVFGEVFQ TIADHTPVAI KIIAIEGPDL VNGSHQKTFE EILPEIIISK 540
ELSLLSGEVC NRTEGFIGLN SVHCVQGSYP PLLLKAWDHY NSTKGSANDR PDFFKDDQLF 600
IVLEFEFGGI DLEQMRTKLS SLATAKSILH QLTASLAVAE ASLRFEHRDL HWGNVLLKKT 660
SLKKLHYTLN GKSSTIPSCG LQVSIIDYTL SRLERDGIVV FCDVSMDEDL FTGDGDYQFD 720
IYRLMKKENN NRWGEYHPYS NVLWLHYLTD KMLKQMTFKT KCNTPAMKQI KRKIQEFHRT 780
MLNFSSATDL LCQHSLFK 798
Nucleotide Sequence
(FASTA)
ATGGCGGCTT CGCTCCCGGG ACCTGGGAGC CGGCTTTTCC GCACATATGG GGCTGCGGAC 60
GGCAGGAGAC AGCGGCGGCC GGGCCGGGAA GCCGCGCAGT GGTTCCCGCC GCAGGACCGG 120
AGGCGTTTCT TCAACAGCAG CGGCAGCAGC GACGCCAGCA TCGGCGACCC CTCGCAGTCC 180
GACGATCCTG ACGATCCCGA CGACCCCGAC TTCCCCGGCA GCCCGGTGAG GCGGCGGCGG 240
AGGCGTCCCG GCGGCCGAGT GCCCAAGGAC CGGCCCAGCC TGACCGTGAC CCCAAAGCGC 300
TGGAAGCTGC GAGCTCGCCC AAGCCTAACC GTGACCCCAA GACGCCTGGG GCTGCGAGCT 360
CGGCCCCCGC AGAAGTGCAG CACACCCTGC GGCCCGCTCC GACTTCCGCC CTTCCCCAGC 420
CGCGACTCCG GCCGCCTCAG CCCGGACCTC AGCGTGTGCG GCCAGCCCAG GGACGGCGAC 480
GAGCTGGGCA TCAGTGCCTC CCTGTTCAGC TCTCTGGCCT CGCCCTGCCC CGGGTCCCCA 540
ACGCCAAGGG ACAGTGTCAT CTCGATCGGC ACCTCCGCCT GTCTGGTTGC AGCCTCAGCC 600
GTCCCGAGCG GCCTCCACCT CCCAGAAGTC TCCCTGGACC GAGCATCTCT CCCCTGCTCC 660
CAGGAGGAAG CGACAGGAGG AGCCAAGGAC ACCAGGATGG TCCACCAAAC CCGCGCCAGC 720
CTCAGGTCAG TTCTCTTTGG CCTTATGAAC TCAGGAACCC CTGAGGATTC TGAGTTTCGG 780
GCAGATGGGA AGAATATGAG AGAGTCCTGC TGTAAAAGGA AACTGGTGGT GGGAAATGGA 840
CCAGAGGGTC CAGGTCTGTC AAGCACAGGC AAGAGGAGGG CCACAGGCCA GGACTCTTGT 900
CAAGAGAGAG GGCTTCAAGA GGCCGTCCGG AGAGAGCATC AGGAGGCCAG TGTTCCCAAG 960
GGCCGCATTG TGCCAAGGGG AATAGACAGG CTGGAGAGAA CTAGATCAAG CCGGAAGAGC 1020
AAACATCAGG AGGCAACGGA AACCTCTCTC CTCCATTCCC ACCGCTTTAA AAAGGGCCAA 1080
AAGCTGGGAA AAGATTCGTT CCCCACCCAG GACCTGACTC CTTTACAGAA TGTCTGCTTT 1140
TGGACCAAAA CCAGGGCTTC CTTCAGTTTC CACAAGAAGA AAATTGTGAC TGATGTGTCA 1200
GAGGTCTGCA GCATCTATAC CACTGCCACT TCTCTCTCTG GATCCCTCCT ATCAGAATGT 1260
TCAAACCGGC CTGTCATGAA CAGAACAAGT GGTGCTCCGT CCTCTTGGCA CTCCTCCTCT 1320
ATGTATTTGC TAAGCCCCTT AAACACTCTA AGTATTTCAA ACAAAAAGGC ATCTGATGCT 1380
GAAAAGGTTT ATGGGGAATG CAGTCAGAAG GGTCCTGTCC CCTTTAGCCA TTGCCTTCCC 1440
ACAGAAAAAC TGCAACGCTG TGAGAAGATT GGGGAAGGGG TGTTTGGCGA AGTGTTTCAA 1500
ACAATTGCTG ATCACACACC CGTAGCCATA AAAATCATTG CTATTGAAGG ACCAGATTTA 1560
GTCAATGGAT CCCATCAGAA AACCTTTGAG GAAATCCTGC CAGAGATCAT CATCTCCAAA 1620
GAGTTGAGCC TCTTATCCGG TGAAGTGTGC AACCGCACAG AAGGCTTTAT CGGGCTGAAC 1680
TCAGTGCACT GTGTCCAGGG ATCTTACCCT CCCTTGCTCC TCAAAGCCTG GGATCACTAT 1740
AATTCAACCA AAGGCTCTGC AAATGACCGG CCTGATTTTT TTAAAGACGA CCAGCTCTTC 1800
ATTGTGCTGG AATTTGAGTT TGGAGGGATT GACTTAGAGC AAATGCGAAC CAAGTTGTCT 1860
TCCTTGGCTA CTGCAAAGAG CATTCTACAC CAGCTCACAG CCTCCCTCGC AGTGGCAGAG 1920
GCATCACTGC GCTTTGAGCA CCGAGACTTA CACTGGGGGA ACGTGCTCTT AAAGAAAACC 1980
AGCCTCAAAA AACTCCACTA CACCCTCAAT GGGAAGAGCA GCACTATCCC CAGCTGTGGG 2040
TTGCAAGTGA GCATCATTGA CTACACCCTG TCGCGCTTGG AACGGGATGG GATTGTGGTT 2100
TTCTGTGACG TTTCCATGGA TGAGGACCTG TTTACCGGTG ACGGTGACTA CCAGTTTGAC 2160
ATCTACAGGC TCATGAAGAA GGAGAATAAC AACCGCTGGG GTGAATATCA CCCTTATAGT 2220
AATGTGCTCT GGTTACATTA CCTGACAGAC AAGATGCTGA AACAAATGAC CTTCAAGACT 2280
AAATGTAACA CTCCTGCCAT GAAGCAAATT AAGAGAAAAA TCCAGGAGTT CCACAGGACA 2340
ATGCTGAACT TCAGCTCTGC CACTGACTTG CTCTGCCAGC ACAGTCTGTT TAAGTAA 2397
Domain Profile
S: 2     ekvkklGeGayGevfsvtwkgkevvlKiiplegsdv........keealkEliilkklsk  53
         ++++k+GeG++Gevf+++ ++++v++Kii++eg+d+        +ee+l+E+ii+k+ls 
Q: 485   QRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLvngshqktFEEILPEIIISKELSL  544
         79**********************************************************
S: 54    lske..nstpnFlellgakvvkgdvpkellkawdkydkekes..........dqlylvll  101
         ls e  n+t++F+ l+++++v+g++p++llkawd+y+++k+s          dql++vl+
Q: 545   LSGEvcNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSandrpdffkdDQLFIVLE  604
         ************************************************************
S: 102   leeggtsldni..klksesqllsilqqlvlslaiaekelkfeHrDlhlgNvLikktkkke  159
         +e+gg++l+++  kl+s ++++sil+ql++sla+ae++l+feHrDlh+gNvL+kkt+ k+
Q: 605   FEFGGIDLEQMrtKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKK  664
         ************************************************************
S: 160   leYtldgkkiklkskgvlvtiIDftksrlvkkdkevvyedlevdeelfegkgdkqfdvyr  219
         l+Ytl+gk+++++s+g++v+iID+t+sr  ++d+ vv++d+++de+lf+g+gd+qfd+yr
Q: 665   LHYTLNGKSSTIPSCGLQVSIIDYTLSR-LERDGIVVFCDVSMDEDLFTGDGDYQFDIYR  723
         ****************************.9******************************
S: 220   lmranvknewkefepktnllwltylsskllkk  251
         lm+++++n+w e++p++n+lwl+yl++k+lk+
Q: 724   LMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQ  755
         ******************************85
Domain Sequence
(FASTA)
QRCEKIGEGV FGEVFQTIAD HTPVAIKIIA IEGPDLVNGS HQKTFEEILP EIIISKELSL 60
LSGEVCNRTE GFIGLNSVHC VQGSYPPLLL KAWDHYNSTK GSANDRPDFF KDDQLFIVLE 120
FEFGGIDLEQ MRTKLSSLAT AKSILHQLTA SLAVAEASLR FEHRDLHWGN VLLKKTSLKK 180
LHYTLNGKSS TIPSCGLQVS IIDYTLSRLE RDGIVVFCDV SMDEDLFTGD GDYQFDIYRL 240
MKKENNNRWG EYHPYSNVLW LHYLTDKMLK Q 271
Keyword3D-structure; Alternative splicing; ATP-binding; Cell cycle; Chromatin regulator; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Magnesium; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-BOT-00224
EKS-CAE-00189
EKS-CAJ-00231
EKS-CAF-00231
EKS-CAP-00250
EKS-CII-00132
EKS-DAR-00536
EKS-DRM-00114
EKS-FEC-00210
EKS-GAM-00128
EKS-GAA-00276
EKS-GOG-00221
EKS-LOA-00221
EKS-MAM-00226
EKS-MIM-00002
EKS-MUM-00229
EKS-MUP-00223
EKS-MYL-00225
EKS-NOL-00208
EKS-ORA-00196
EKS-ORC-00201
EKS-OTG-00230
EKS-PAT-00213
EKS-PEM-00115
EKS-POA-00217
EKS-PRC-00005
EKS-RAN-00222
EKS-TAS-00003
EKS-TUB-00007
EKS-XIM-00283
EKS-SCP-00006
Gene Ontology
GO:0005813; C:centrosome
GO:0005694; C:chromosome
GO:0031965; C:nuclear membrane
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0003677; F:DNA binding
GO:0072354; F:histone kinase activity (H3-T3 specific)
GO:0007243; P:intracellular protein kinase cascade
GO:0007064; P:mitotic sister chromatid cohesion
GO:0071459; P:protein localization to chromosome, centromeric region
GO:0090231; P:regulation of spindle checkpoint
KEGG
hsa:83903;
InterPros
IPR024604; DUF3635.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
Pfam
PF12330; DUF3635; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
Prints
Created Date20-Feb-2013