EKS-HOS-00293
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00293
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/IRE485.12.6E-145571832262
StatusReviewed
Ensembl ProteinENSP00000401445
UniProt AccessionO75460; A1L457; A8K8N8; A8MXS7; Q59EE2;
Protein NameEndoribonuclease
Protein Synonyms/Alias Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a;
Gene NameERN1
Gene Synonyms/Alias ERN1; IRE1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000178607ENSP00000401445ENST00000433197
OrganismHomo sapiens
Functional DescriptionSenses unfolded proteins in the lumen of the endoplasmicreticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Protein Length977
Protein Sequence
(FASTA)
MPARRLLLLL TLLLPGLGIF GSTSTVTLPE TLLFVSTLDG SLHAVSKRTG SIKWTLKEDP 60
VLQVPTHVEE PAFLPDPNDG SLYTLGSKNN EGLTKLPFTI PELVQASPCR SSDGILYMGK 120
KQDIWYVIDL LTGEKQQTLS SAFADSLCPS TSLLYLGRTE YTITMYDTKT RELRWNATYF 180
DYAASLPEDD VDYKMSHFVS NGDGLVVTVD SESGDVLWIQ NYASPVVAFY VWQREGLRKV 240
MHINVAVETL RYLTFMSGEV GRITKWKYPF PKETEAKSKL TPTLYVGKYS TSLYASPSMV 300
HEGVAVVPRG STLPLLEGPQ TDGVTIGDKG ECVITPSTDV KFDPGLKSKN KLNYLRNYWL 360
LIGHHETPLS ASTKMLERFP NNLPKHRENV IPADSEKKSF EEVINLVDQT SENAPTTVSR 420
DVEEKPAHAP ARPEAPVDSM LKDMATIILS TFLLIGWVAF IITYPLSMHQ QQQLQHQQFQ 480
KELEKIQLLQ QQQQQLPFHP PGDTAQDGEL LDTSGPYSES SGTSSPSTSP RASNHSLCSG 540
SSASKAGSSP SLEQDDGDEE TSVVIVGKIS FCPKDVLGHG AEGTIVYRGM FDNRDVAVKR 600
ILPECFSFAD REVQLLRESD EHPNVIRYFC TEKDRQFQYI AIELCAATLQ EYVEQKDFAH 660
LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK PHNILISMPN AHGKIKAMIS DFGLCKKLAV 720
GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ 780
RQANILLGAC SLDCLHPEKH EDVIARELIE KMIAMDPQKR PSAKHVLKHP FFWSLEKQLQ 840
FFQDVSDRIE KESLDGPIVK QLERGGRAVV KMDWRENITV PLQTDLRKFR TYKGGSVRDL 900
LRAMRNKKHH YRELPAEVRE TLGSLPDDFV CYFTSRFPHL LAHTYRAMEL CSHERLFQPY 960
YFHEPPEPQP PVTPDAL 977
Nucleotide Sequence
(FASTA)
ATGCCGGCCC GGCGGCTGCT GCTGCTGCTG ACGCTGCTGC TGCCCGGCCT CGGGATTTTT 60
GGAAGTACCA GCACAGTGAC GCTTCCTGAA ACCTTGTTGT TTGTGTCAAC GCTGGATGGA 120
AGTTTGCATG CTGTCAGCAA GAGGACAGGC TCAATCAAAT GGACTTTAAA AGAAGATCCA 180
GTCCTGCAGG TCCCAACACA TGTGGAAGAG CCTGCCTTTC TCCCAGATCC TAATGATGGC 240
AGCCTGTATA CGCTTGGAAG CAAGAATAAT GAAGGCCTGA CGAAACTTCC TTTTACCATC 300
CCAGAATTGG TGCAGGCATC CCCATGCCGA AGTTCAGATG GAATCCTCTA CATGGGTAAA 360
AAGCAGGACA TCTGGTATGT TATTGACCTC CTGACCGGAG AGAAGCAGCA GACTTTGTCA 420
TCGGCCTTTG CAGATAGTCT CTGCCCATCA ACCTCTCTTC TGTATCTTGG GCGAACAGAA 480
TACACCATCA CCATGTACGA CACCAAAACC CGAGAGCTCC GGTGGAATGC CACCTACTTT 540
GACTATGCGG CCTCACTGCC TGAGGACGAC GTGGACTACA AGATGTCCCA CTTTGTGTCC 600
AATGGTGATG GGCTGGTGGT GACTGTGGAC AGTGAATCTG GGGACGTCCT GTGGATCCAA 660
AACTACGCCT CCCCTGTGGT GGCCTTTTAT GTCTGGCAGC GGGAGGGTCT GAGGAAGGTG 720
ATGCACATCA ATGTCGCTGT GGAGACCCTG CGCTATCTGA CCTTCATGTC TGGGGAGGTG 780
GGGCGCATCA CAAAGTGGAA GTACCCGTTC CCCAAGGAGA CAGAGGCCAA GAGCAAGCTG 840
ACGCCCACTC TGTATGTTGG GAAATACTCT ACCAGCCTCT ATGCCTCTCC CTCAATGGTA 900
CACGAGGGGG TTGCTGTCGT GCCCCGCGGC AGCACACTTC CTTTGCTGGA AGGGCCCCAG 960
ACTGATGGCG TCACCATTGG GGACAAGGGG GAGTGTGTGA TCACGCCCAG CACGGACGTC 1020
AAGTTTGATC CCGGACTCAA AAGCAAGAAC AAGCTCAACT ACTTGAGGAA TTACTGGCTT 1080
CTGATAGGAC ACCATGAAAC CCCACTGTCT GCGTCTACCA AGATGCTGGA GAGATTTCCC 1140
AACAATCTAC CCAAACATCG GGAAAATGTG ATTCCTGCTG ATTCAGAGAA AAAGAGCTTT 1200
GAGGAAGTTA TCAACCTGGT TGACCAGACT TCAGAAAACG CACCTACCAC CGTGTCTCGG 1260
GATGTGGAGG AGAAGCCCGC CCATGCCCCT GCCCGGCCCG AGGCCCCCGT GGACTCCATG 1320
CTTAAGGACA TGGCTACCAT CATCCTGAGC ACCTTCCTGC TGATTGGCTG GGTGGCCTTC 1380
ATCATCACCT ATCCCCTGAG CATGCATCAG CAGCAGCAGC TCCAGCACCA GCAGTTCCAG 1440
AAGGAACTGG AGAAGATCCA GCTCCTGCAG CAGCAGCAGC AGCAGCTGCC CTTCCACCCA 1500
CCTGGAGACA CGGCTCAGGA CGGCGAGCTC CTGGACACGT CTGGCCCGTA CTCAGAGAGC 1560
TCGGGCACCA GCAGCCCCAG CACGTCCCCC AGGGCCTCCA ACCACTCGCT CTGCTCCGGC 1620
AGCTCTGCCT CCAAGGCTGG CAGCAGCCCC TCCCTGGAAC AAGACGATGG AGATGAGGAA 1680
ACCAGCGTGG TGATAGTTGG GAAAATTTCC TTCTGTCCCA AGGATGTCCT GGGCCATGGA 1740
GCTGAGGGCA CAATTGTGTA CCGGGGCATG TTTGACAACC GCGACGTGGC CGTGAAGAGG 1800
ATCCTCCCCG AGTGTTTTAG CTTCGCAGAC CGTGAGGTCC AGCTGTTGCG AGAATCGGAT 1860
GAGCACCCGA ACGTGATCCG CTACTTCTGC ACGGAGAAGG ACCGGCAATT CCAGTACATT 1920
GCCATCGAGC TGTGTGCAGC CACCCTGCAA GAGTATGTGG AGCAGAAGGA CTTTGCGCAT 1980
CTCGGCCTGG AGCCCATCAC CTTGCTGCAG CAGACCACCT CGGGCCTGGC CCACCTCCAC 2040
TCCCTCAACA TCGTTCACAG AGACCTAAAG CCACACAACA TCCTCATATC CATGCCCAAT 2100
GCACACGGCA AGATCAAGGC CATGATCTCC GACTTTGGCC TCTGCAAGAA GCTGGCAGTG 2160
GGCAGACACA GTTTCAGCCG CCGATCTGGG GTGCCTGGCA CAGAAGGCTG GATCGCTCCA 2220
GAGATGCTGA GCGAAGACTG TAAGGAGAAC CCTACCTACA CGGTGGACAT CTTTTCTGCA 2280
GGCTGCGTCT TTTACTACGT AATCTCTGAG GGCAGCCACC CTTTTGGCAA GTCCCTGCAG 2340
CGGCAGGCCA ACATCCTCCT GGGTGCCTGC AGCCTTGACT GCTTGCACCC AGAGAAGCAC 2400
GAAGACGTCA TTGCACGTGA ATTGATAGAG AAGATGATTG CGATGGATCC TCAGAAACGC 2460
CCCTCAGCGA AGCATGTGCT CAAACACCCG TTCTTCTGGA GCCTAGAGAA GCAGCTCCAG 2520
TTCTTCCAGG ACGTGAGCGA CAGAATAGAA AAGGAATCCC TGGATGGCCC GATCGTGAAG 2580
CAGTTAGAGA GAGGCGGGAG AGCCGTGGTG AAGATGGACT GGCGGGAGAA CATCACTGTC 2640
CCCCTCCAGA CAGACCTGCG TAAATTCAGG ACCTATAAAG GTGGTTCTGT CAGAGATCTC 2700
CTCCGAGCCA TGAGAAATAA GAAGCACCAC TACCGGGAGC TGCCTGCAGA GGTGCGGGAG 2760
ACGCTGGGGT CCCTCCCCGA CGACTTCGTG TGCTACTTCA CATCTCGCTT CCCCCACCTC 2820
CTCGCACACA CCTACCGGGC CATGGAGCTG TGCAGCCACG AGAGACTCTT CCAGCCCTAC 2880
TACTTCCACG AGCCCCCAGA GCCCCAGCCC CCAGTGACTC CAGACGCCCT CTGA 2934
Domain Profile
S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60
         f+pkdvlG+GaeGt+v+rG+f++r+vavkr+l+e++++a+rev+llresdehpnviryfc
Q: 571   FCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFC  630
         79**********************************************************
S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120
         tekdrqf+yia+elcaa+lq+yve+kd++ + +lepi+ll+q++sGlahlhsl+ivhrdl
Q: 631   TEKDRQFQYIAIELCAATLQEYVEQKDFA-HLGLEPITLLQQTTSGLAHLHSLNIVHRDL  689
         *****************************.******************************
S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180
         kp+nilis+p+a+gk++++isdfGlckkl+vG++sfsrrsgv+GteGwiape+l+e++ke
Q: 690   KPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKE  749
         ************************************************************
S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240
         ++t++vdifs+Gcvfyyv+s+G+hpfG+sl+rqanil g++sld+l++ek+e+via++li
Q: 750   NPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELI  809
         ************************************************************
S: 241   skmidkdplkrpsakkvlkhplf  263
         +kmi++dp+krpsak+vlkhp+f
Q: 810   EKMIAMDPQKRPSAKHVLKHPFF  832
         **********************9
Domain Sequence
(FASTA)
FCPKDVLGHG AEGTIVYRGM FDNRDVAVKR ILPECFSFAD REVQLLRESD EHPNVIRYFC 60
TEKDRQFQYI AIELCAATLQ EYVEQKDFAH LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK 120
PHNILISMPN AHGKIKAMIS DFGLCKKLAV GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN 180
PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ RQANILLGAC SLDCLHPEKH EDVIARELIE 240
KMIAMDPQKR PSAKHVLKHP FF 262
Keyword3D-structure; ADP-ribosylation; Alternative splicing; Apoptosis; ATP-binding; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Kinase; Magnesium; Membrane; Metal-binding; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Signal; Transcription; Transcription regulation; Transferase; Transmembrane; Transmembrane helix; Unfolded protein response.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00269
EKS-ANC-00277
EKS-BOT-00287
EKS-CAE-00246
EKS-CAJ-00294
EKS-CAF-00293
EKS-CAP-00322
EKS-CII-00169
EKS-CIS-00050
EKS-DAR-00632
EKS-DRM-00146
EKS-EQC-00279
EKS-FEC-00273
EKS-GAM-00181
EKS-GAG-00240
EKS-GAA-00355
EKS-GOG-00286
EKS-ICT-00272
EKS-LAC-00301
EKS-LOA-00297
EKS-MAM-00290
EKS-MEG-00229
EKS-MOD-00282
EKS-MUM-00318
EKS-MUP-00283
EKS-MYL-00289
EKS-NOL-00265
EKS-ORN-00373
EKS-ORA-00253
EKS-ORC-00269
EKS-ORL-00345
EKS-OTG-00293
EKS-PAT-00272
EKS-PES-00256
EKS-POA-00279
EKS-RAN-00303
EKS-SAH-00269
EKS-SUS-00253
EKS-TAG-00301
EKS-TAR-00376
EKS-XET-00360
EKS-XIM-00366
EKS-SAC-00054
EKS-SCP-00051
Gene Ontology
GO:0030176; C:integral to endoplasmic reticulum membrane
GO:0005637; C:nuclear inner membrane
GO:0005524; F:ATP binding
GO:0004521; F:endoribonuclease activity
GO:0016891; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006987; P:activation of signaling protein activity involved in unfolded protein response
GO:0006915; P:apoptotic process
GO:0007050; P:cell cycle arrest
GO:0006917; P:induction of apoptosis
GO:0006397; P:mRNA processing
GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response
GO:0046777; P:protein autophosphorylation
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0006351; P:transcription, DNA-dependent
KEGG
hsa:2081;
InterPros
IPR010513; KEN_RNase_activator.
IPR011009; Kinase-like_dom.
IPR018391; PQQ_beta_propeller_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR006567; PUG-dom.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF06479; Ribonuc_2-5A; 1.
SMARTs
SM00564; PQQ; 5.
SM00580; PUG; 1.
Prosites
PS51392; KEN; 1.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013