| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00461 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CK1/CK1 | 480.5 | 5.7E-144 | 17 | 277 | 261 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000369126 |
| UniProt Accession | Q8N752; Q5T2N2; |
| Protein Name | Casein kinase I isoform alpha-like |
| Protein Synonyms/Alias | CKI-alpha-like; CK1; |
| Gene Name | CSNK1A1L |
| Gene Synonyms/Alias | CSNK1A1L; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Casein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). |
| Protein Length | 337 |
Protein Sequence
(FASTA) | | MTNNSGSKAE LVVGGKYKLV RKIGSGSFGD VYLGITTTNG EDVAVKLESQ KVKHPQLLYE 60 | | SKLYTILQGG VGIPHMHWYG QEKDNNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM 120 | | ISRIEYVHTK NFLHRDIKPD NFLMGTGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKH 180 | | LIGTVRYASI NAHLGIEQSR RDDMESLGYV FMYFNRTSLP WQGLRAMTKK QKYEKISEKK 240 | | MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE VPDYMYLRQL FRILFRTLNH QYDYTFDWTM 300 | | LKQKAAQQAA SSSGQGQQAQ TQTGKQTEKN KNNVKDN 337 |
|
Nucleotide Sequence
(FASTA) | | ATGACAAACA ACAGCGGCTC CAAAGCCGAA CTCGTTGTGG GAGGGAAATA CAAACTGGTG 60 | | CGGAAGATCG GGTCTGGCTC CTTTGGAGAC GTTTATCTGG GCATCACCAC CACCAACGGC 120 | | GAGGACGTAG CAGTGAAGCT GGAATCTCAG AAGGTCAAGC ACCCCCAGTT GCTGTATGAG 180 | | AGCAAACTCT ACACGATTCT TCAAGGTGGG GTTGGCATCC CCCACATGCA CTGGTATGGT 240 | | CAGGAAAAAG ACAACAATGT GCTAGTCATG GACCTTCTGG GACCCAGCCT CGAAGACCTC 300 | | TTTAATTTCT GTTCAAGAAG GTTCACCATG AAAACTGTAC TTATGTTAGC CGACCAGATG 360 | | ATCAGCAGAA TTGAATACGT GCATACAAAG AATTTTCTAC ACCGAGACAT TAAACCAGAT 420 | | AACTTCCTGA TGGGTACTGG GCGTCACTGT AATAAGTTGT TCCTTATTGA TTTTGGTTTG 480 | | GCCAAAAAGT ACAGAGACAA CAGGACCAGG CAACACATAC CGTACAGAGA AGATAAACAC 540 | | CTCATTGGCA CTGTCCGATA TGCCAGCATC AATGCACATC TTGGTATTGA GCAGAGCCGC 600 | | CGAGATGACA TGGAATCCTT AGGCTACGTT TTCATGTATT TTAATAGAAC CAGCCTGCCG 660 | | TGGCAAGGAC TAAGGGCTAT GACAAAAAAA CAAAAATATG AAAAGATTAG TGAGAAGAAG 720 | | ATGTCCACCC CTGTTGAAGT TTTATGTAAG GGGTTTCCTG CAGAATTCGC CATGTACTTG 780 | | AACTACTGTC GTGGGCTGCG CTTTGAGGAA GTCCCAGATT ACATGTATCT GAGGCAGCTA 840 | | TTCCGCATTC TTTTCAGGAC CCTGAACCAC CAATATGACT ACACATTTGA TTGGACGATG 900 | | TTAAAGCAGA AAGCAGCACA GCAGGCAGCC TCTTCCAGTG GGCAGGGTCA GCAGGCCCAA 960 | | ACCCAGACAG GCAAGCAAAC TGAAAAAAAC AAGAATAATG TGAAAGATAA CTAA 1014 |
|
| Domain Profile | S: 1 yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev 60 | y++v+kiGsGsfGd+ylg++ ++ge+va+kles+k+k+pql +es++y ilqggvgiP++ | Q: 17 YKLVRKIGSGSFGDVYLGITTTNGEDVAVKLESQKVKHPQLLYESKLYTILQGGVGIPHM 76 | 89********************************************************** |
| S: 61 ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd 120 | +++g+ek+ nvlv+dllGpsledlf++c+r+f++ktvl+ladq+isrieyvh+k++++rd | Q: 77 HWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFLHRD 136 | ************************************************************ |
| S: 121 ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk 180 | ikPdnfl+g gr+++k++lidfGlakkyrd++t++hipyre+k+l Gt+ryasin+hlg+ | Q: 137 IKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYASINAHLGI 196 | ************************************************************ |
| S: 181 eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef 240 | eqsrrdd+eslgyv++yf+r+slPWqgl+a tkkqkyekisekk+st++evlc+gfP+ef | Q: 197 EQSRRDDMESLGYVFMYFNRTSLPWQGLRAMTKKQKYEKISEKKMSTPVEVLCKGFPAEF 256 | ************************************************************ |
| S: 241 atylkyvrklkfeekPdyeyl 261 | a+yl+y+r l+fee Pdy+yl | Q: 257 AMYLNYCRGLRFEEVPDYMYL 277 | *******************97 |
|
Domain Sequence
(FASTA) | | YKLVRKIGSG SFGDVYLGIT TTNGEDVAVK LESQKVKHPQ LLYESKLYTI LQGGVGIPHM 60 | | HWYGQEKDNN VLVMDLLGPS LEDLFNFCSR RFTMKTVLML ADQMISRIEY VHTKNFLHRD 120 | | IKPDNFLMGT GRHCNKLFLI DFGLAKKYRD NRTRQHIPYR EDKHLIGTVR YASINAHLGI 180 | | EQSRRDDMES LGYVFMYFNR TSLPWQGLRA MTKKQKYEKI SEKKMSTPVE VLCKGFPAEF 240 | | AMYLNYCRGL RFEEVPDYMY L 261 |
|
| Keyword | ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |