EKS-HOS-00394
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00394
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11368.11.5E-10989343255
StatusReviewed
Ensembl ProteinENSP00000352093
UniProt AccessionQ6ZN16; A2AI49; A2AI50; A6NJ61; Q5JPR4; Q6ZMV3;
Protein NameMitogen-activated protein kinase kinase kinase 15
Protein Synonyms/Alias Apoptosis signal-regulating kinase 3; MAPK/ERK kinase kinase 15; MEK kinase 15; MEKK 15;
Gene NameMAP3K15
Gene Synonyms/Alias MAP3K15; ASK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000180815ENSP00000428356ENST00000469203
ENSG00000180815ENSP00000345629ENST00000338883
ENSG00000180815ENSP00000352093ENST00000359173
OrganismHomo sapiens
Functional DescriptionMay function in a signal transduction pathway that isactivated by various cell stresses and leads to apoptosis.
Protein Length748
Protein Sequence
(FASTA)
MKQMHEWNFT ASSIKGISLS KFDERCCFLY VHDNSDDFQI YFSTEEQCSR FFSLVKEMIT 60
NTAGSTVELE GETDGDTLEY EYDHDANGER VVLGKGTYGI VYAGRDLSNQ VRIAIKEIPE 120
RDSRYSQPLH EEIALHKYLK HRNIVQYLGS VSENGYIKIF MEQVPGGSLS ALLRSKWGPM 180
KEPTIKFYTK QILEGLKYLH ENQIVHRDIK GDNVLVNTYS GVVKISDFGT SKRLAGVNPC 240
TETFTGTLQY MAPEIIDQGP RGYGAPADIW SLGCTIIEMA TSKPPFHELG EPQAAMFKVG 300
MFKIHPEIPE ALSAEARAFI LSCFEPDPHK RATTAELLRE GFLRQVNKGK KNRIAFKPSE 360
GPRGVVLALP TQGEPMATSS SEHGSVSPDS DAQPDALFER TRAPRHHLGH LLSVPDESSA 420
LEDRGLASSP EDRDQGLFLL RKDSERRAIL YKILWEEQNQ VASNLQECVA QSSEELHLSV 480
GHIKQIIGIL RDFIRSPEHR VMATTISKLK VDLDFDSSSI SQIHLVLFGF QDAVNKILRN 540
HLIRPHWMFA MDNIIRRAVQ AAVTILIPEL RAHFEPTCET EGVDKDMDEA EEGYPPATGP 600
GQEAQPHQQH LSLQLGELRQ ETNRLLEHLV EKEREYQNLL RQTLEQKTQE LYHLQLKLKS 660
NCITENPAGP YGQRTDKELI DWLRLQGADA KTIEKIVEEG YTLSDILNEI TKEDLRYLRL 720
RGGLLCRLWS AVSQYRRAQE ASETKDKA 748
Nucleotide Sequence
(FASTA)
ATGAAACAGA TGCACGAATG GAATTTTACA GCCTCTTCCA TAAAGGGAAT AAGCCTATCA 60
AAGTTTGATG AAAGGTGTTG TTTTCTTTAT GTCCATGATA ATTCTGATGA CTTTCAAATC 120
TACTTTTCCA CCGAAGAGCA GTGCAGTAGA TTTTTCTCTT TGGTCAAAGA GATGATAACC 180
AATACAGCAG GCAGTACGGT GGAGCTGGAG GGAGAGACCG ATGGAGACAC CTTGGAGTAT 240
GAGTATGACC ATGATGCAAA TGGTGAGAGA GTTGTCTTGG GGAAAGGCAC GTATGGGATT 300
GTGTATGCTG GCCGAGATCT GAGCAATCAA GTGCGAATAG CCATCAAAGA AATCCCGGAG 360
AGAGATAGCA GGTATTCTCA GCCTCTGCAC GAGGAGATAG CCCTGCACAA GTACCTTAAG 420
CACCGCAATA TCGTTCAGTA CCTGGGCTCT GTTTCAGAGA ACGGCTACAT TAAGATATTT 480
ATGGAGCAGG TGCCTGGAGG AAGCCTTTCT GCTCTTCTGC GATCCAAATG GGGGCCGATG 540
AAGGAACCGA CAATCAAGTT TTACACCAAA CAGATCCTGG AGGGCCTTAA GTATCTTCAT 600
GAAAACCAGA TCGTGCACAG AGACATAAAG GGCGATAATG TTCTGGTGAA CACCTACAGC 660
GGAGTGGTGA AAATCTCCGA TTTTGGAACC TCGAAACGTC TTGCGGGTGT GAACCCCTGC 720
ACAGAGACTT TTACTGGCAC CCTGCAGTAC ATGGCACCTG AGATAATTGA CCAAGGGCCT 780
CGCGGATATG GTGCCCCAGC CGATATCTGG TCCCTGGGCT GCACCATCAT TGAGATGGCC 840
ACCAGCAAGC CTCCGTTCCA TGAGCTTGGT GAGCCGCAGG CAGCCATGTT CAAAGTGGGC 900
ATGTTTAAGA TCCACCCTGA GATTCCAGAA GCCCTTTCAG CTGAAGCCCG AGCCTTCATT 960
TTATCCTGTT TCGAGCCTGA CCCCCACAAA CGTGCCACCA CTGCTGAGCT ACTGAGAGAG 1020
GGTTTCTTAA GGCAGGTGAA CAAGGGCAAG AAGAACCGAA TTGCCTTCAA GCCCTCAGAA 1080
GGTCCCCGCG GTGTCGTCCT GGCCCTGCCC ACACAGGGAG AGCCCATGGC CACCAGCAGC 1140
AGCGAGCACG GCTCTGTCTC CCCAGACTCC GACGCCCAGC CTGACGCACT CTTTGAGAGG 1200
ACCCGGGCGC CCAGGCACCA CCTTGGCCAC CTCCTCAGTG TTCCAGACGA GAGCTCAGCC 1260
TTGGAAGACC GGGGCTTGGC CTCGTCCCCG GAGGACAGGG ACCAGGGCCT CTTCCTGCTA 1320
CGCAAGGACA GTGAGCGCCG TGCCATCCTG TACAAAATCC TCTGGGAGGA GCAGAACCAG 1380
GTGGCTTCCA ACCTGCAGGA GTGTGTGGCC CAGAGTTCCG AAGAGTTGCA TCTCTCAGTT 1440
GGACACATCA AGCAAATCAT TGGGATCCTG AGGGACTTCA TCCGCTCCCC AGAGCACCGG 1500
GTGATGGCGA CCACAATATC AAAGCTCAAG GTGGACCTGG ACTTTGACAG CTCGTCCATC 1560
AGTCAGATTC ACCTGGTGCT GTTCGGATTT CAGGATGCCG TAAATAAAAT TTTGAGGAAC 1620
CACTTAATTA GGCCCCACTG GATGTTCGCG ATGGACAACA TCATCCGCCG AGCGGTGCAG 1680
GCCGCGGTCA CCATTCTCAT CCCAGAGCTC CGAGCCCACT TTGAGCCTAC CTGTGAGACT 1740
GAAGGGGTAG ATAAGGACAT GGATGAAGCG GAAGAGGGCT ATCCCCCAGC CACCGGACCT 1800
GGCCAGGAGG CCCAGCCCCA CCAGCAGCAC CTGAGCCTCC AGCTGGGTGA GCTCAGACAG 1860
GAGACCAACA GACTTTTGGA ACACCTAGTT GAAAAAGAGA GAGAGTACCA GAATCTTCTG 1920
CGGCAAACTC TAGAACAGAA AACTCAAGAA TTGTATCACC TTCAGTTAAA ATTAAAATCG 1980
AATTGTATTA CAGAGAACCC AGCAGGCCCC TACGGGCAGA GAACAGATAA AGAGCTTATA 2040
GACTGGTTGC GGCTGCAAGG AGCTGATGCA AAGACAATTG AAAAGATTGT TGAAGAGGGT 2100
TATACACTTT CGGATATTCT TAATGAGATC ACTAAGGAAG ATCTAAGATA CCTTCGACTA 2160
CGGGGTGGTC TCCTCTGCAG ACTCTGGAGT GCGGTCTCCC AGTACAGAAG GGCTCAGGAG 2220
GCCTCAGAAA CCAAAGACAA GGCTTGA 2247
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k lkH+n
Q: 89    ERVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKYLKHRN  143
         6899**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121
         iv+y+G+ +e++++kif+E+v+gGsls+ll+ k+g+++e +ik+ytkqilegl+yLHe++
Q: 144   IVQYLGSVSENGYIKIFMEQVPGGSLSALLRsKWGPMKEPTIKFYTKQILEGLKYLHENQ  203
         *******************************9****************************
S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180
         ivHRDiKg+N+l+++ sgvvk+sDFG+skrla +n++   +e++tGtl+ymaPE+i+++ 
Q: 204   IVHRDIKGDNVLVNTySGVVKISDFGTSKRLAGVNPC---TETFTGTLQYMAPEIIDQGP  260
         *************************************...8*******************
S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240
         +gyg+ aDiWslgc++iem+t+k+Pf+el+e++a+mfkvg+ k++Peipe+ls+e+++f+
Q: 261   RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI  320
         ************************************************************
S: 241   ekcleldpkkrpsaeeLLkhefl  263
          +c+e dp+kr++++eLL++ fl
Q: 321   LSCFEPDPHKRATTAELLREGFL  343
         *******************9885
Domain Sequence
(FASTA)
ERVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKY LKHRNIVQYL 60
GSVSENGYIK IFMEQVPGGS LSALLRSKWG PMKEPTIKFY TKQILEGLKY LHENQIVHRD 120
IKGDNVLVNT YSGVVKISDF GTSKRLAGVN PCTETFTGTL QYMAPEIIDQ GPRGYGAPAD 180
IWSLGCTIIE MATSKPPFHE LGEPQAAMFK VGMFKIHPEI PEALSAEARA FILSCFEPDP 240
HKRATTAELL REGFL 255
KeywordAlternative splicing; ATP-binding; Coiled coil; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Nomascus leucogenys"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>
EKS-GOG-00379
EKS-ICT-00367
EKS-MAM-00387
EKS-MOD-00377
EKS-NOL-00359
EKS-ORL-00458
EKS-POA-00378
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0046872; F:metal ion binding
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
KEGG
hsa:389840;
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013