EKS-HOS-00476

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00476

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	378.5	1.0E-112	14	304	291

Status

Reviewed

Ensembl Protein

ENSP00000337691

UniProt Accession

Q8TD08; Q2TCF9; Q8N362;

Protein Name

Mitogen-activated protein kinase 15

Protein Synonyms/Alias

MAP kinase 15; MAPK 15; Extracellular signal-regulated kinase 7; ERK-7; Extracellular signal-regulated kinase 8; ERK-8;

Gene Name

MAPK15

Gene Synonyms/Alias

MAPK15; ERK7, ERK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000181085	ENSP00000337691	ENST00000338033
ENSG00000181085	ENSP00000378539	ENST00000395107
ENSG00000181085	ENSP00000378540	ENST00000395108

Organism

Homo sapiens

Functional Description

In vitro, phosphorylates MBP.

Protein Length

544

Protein Sequence
(FASTA)

MCTVVDPRIV RRYLLRRQLG QGAYGIVWKA VDRRTGEVVA IKKIFDAFRD KTDAQRTFRE 60

ITLLQEFGDH PNIISLLDVI RAENDRDIYL VFEFMDTDLN AVIRKGGLLQ DVHVRSIFYQ 120

LLRATRFLHS GHVVHRDQKP SNVLLDANCT VKLCDFGLAR SLGDLPEGPE DQAVTEYVAT 180

RWYRAPEVLL SSHRYTLGVD MWSLGCILGE MLRGRPLFPG TSTLHQLELI LETIPPPSEE 240

DLLALGSGCR ASVLHQLGSR PRQTLDALLP PDTSPEALDL LRRLLVFAPD KRLSATQALQ 300

HPYVQRFHCP SDEWAREADV RPRAHEGVQL SVPEYRSRVY QMILECGGSS GTSREKGPEG 360

VSPSQAHLHK PRADPQLPSR TPVQGPRPRP QSSPGHDPAE HESPRAAKNV PRQNSAPLLQ 420

TALLGNGERP PGAKEAPPLT LSLVKPSGRG AAPSLTSQAA AQVANQALIR GDWNRGGGVR 480

VASVQQVPPR LPPEARPGRR MFSTSALQGA QGGARALLGG YSQAYGTVCH SALGHLPLLE 540

GHHV 544

Nucleotide Sequence
(FASTA)

ATGTGCACCG TAGTGGACCC TCGCATTGTC CGGAGATACC TACTCAGGCG GCAGCTCGGG 60

CAGGGGGCCT ATGGCATTGT GTGGAAGGCA GTGGACCGGA GGACTGGTGA GGTCGTGGCC 120

ATCAAGAAAA TCTTTGATGC TTTTAGGGAT AAGACAGATG CCCAGAGAAC ATTCCGGGAA 180

ATCACGCTCC TCCAGGAGTT TGGGGACCAT CCCAACATCA TCAGCCTCCT TGACGTGATC 240

CGGGCAGAGA ACGACAGGGA CATTTACCTG GTGTTTGAGT TTATGGACAC TGACCTGAAC 300

GCAGTCATCC GGAAGGGCGG CCTGCTGCAG GACGTCCACG TGCGCTCCAT CTTCTACCAG 360

CTCCTGCGGG CCACCCGGTT CCTCCACTCG GGGCACGTTG TGCACCGGGA CCAGAAGCCG 420

TCCAATGTGC TCCTGGATGC CAACTGCACA GTGAAGCTGT GTGACTTTGG CCTGGCCCGC 480

TCCCTGGGCG ACCTCCCCGA GGGGCCTGAG GACCAGGCCG TGACAGAGTA CGTGGCCACA 540

CGCTGGTACC GAGCACCGGA GGTGCTGCTC TCTTCGCACC GATACACCCT TGGGGTGGAC 600

ATGTGGAGTC TGGGCTGTAT CCTGGGGGAG ATGCTGCGGG GGAGACCCCT GTTCCCCGGC 660

ACGTCCACCC TCCACCAGCT GGAGCTGATC CTGGAGACCA TCCCACCGCC ATCTGAGGAG 720

GACCTCCTGG CTCTCGGCTC AGGCTGCCGT GCCTCTGTGC TGCACCAGCT GGGGTCCCGG 780

CCACGACAGA CGCTGGATGC CCTCCTACCG CCAGACACCT CCCCAGAGGC CTTGGACCTC 840

CTTAGGCGAC TCCTGGTGTT CGCCCCGGAC AAGCGGTTAA GCGCGACCCA GGCACTGCAG 900

CACCCCTACG TGCAGAGGTT CCACTGCCCC AGCGACGAGT GGGCACGAGA GGCAGATGTG 960

CGGCCCCGGG CACACGAAGG GGTCCAGCTC TCTGTGCCTG AGTACCGCAG CCGCGTCTAT 1020

CAGATGATCC TGGAGTGTGG AGGCAGCAGC GGCACCTCGA GAGAGAAGGG CCCGGAGGGT 1080

GTCTCCCCAA GCCAGGCACA CCTGCACAAA CCCAGAGCCG ACCCTCAGCT GCCTTCTAGG 1140

ACACCTGTGC AGGGTCCCAG ACCCAGGCCC CAGAGCAGCC CAGGCCATGA CCCTGCCGAG 1200

CACGAGTCCC CCCGTGCAGC CAAGAACGTT CCCAGGCAGA ACTCCGCTCC CCTGCTCCAA 1260

ACTGCTCTCC TAGGGAATGG GGAAAGGCCC CCTGGGGCGA AGGAAGCGCC CCCCTTGACA 1320

CTCTCGCTGG TGAAGCCAAG CGGGAGGGGA GCTGCGCCCT CCCTGACCTC CCAGGCTGCG 1380

GCTCAGGTGG CCAACCAGGC CCTGATCCGG GGTGACTGGA ACCGGGGCGG TGGGGTGAGG 1440

GTGGCCAGCG TACAACAGGT CCCTCCCCGG CTTCCTCCGG AGGCCCGGCC CGGCCGGAGG 1500

ATGTTCAGCA CCTCTGCCTT GCAGGGTGCC CAGGGGGGTG CCAGGGCTTT GCTTGGAGGC 1560

TACTCCCAAG CCTACGGGAC TGTCTGCCAC TCGGCACTGG GCCACCTGCC CCTGCTGGAG 1620

GGGCACCATG TGTGA 1635

Domain Profile

S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkel.kheNi  60

           +++lg+Gayg+v++avd+rt+e vaikk++++f+++t+a+rt+RE++ll+e+ +h+Ni

Q: 14    LLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFgDHPNI  73

         56799*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119

         i+lldv+++e+     +d+Ylv+e+m+tdL++vi++   l+d h+++++yq+lr++++lH

Q: 74    ISLLDVIRAEN----DRDIYLVFEFMDTDLNAVIRKGgLLQDVHVRSIFYQLLRATRFLH  129

         ********999....9********************999*********************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk....lteyvatrwYraPeil  175

         s +v+HrD+KPsN+l++++c++k++dFGlars  +  e      +teyvatrwYraPe+l

Q: 130   SGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPedqaVTEYVATRWYRAPEVL  189

         ********************************766554444566****************

S: 176   lslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiesee  235

         ls+++yt  vD+Ws+GCIl+E+l+g+plfpg+++++qle+ile+++ psee+l ++ s +

Q: 190   LSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGC  249

         ************************************************************

S: 236   arnyikslpkkkkkdfeelfpk.aseealdLleklLvldpdkRisveeaLehpYl  289

          ++++++l +++++++++l+p  +s+ealdLl++lLv++pdkR+s+++aL+hpY+

Q: 250   RASVLHQLGSRPRQTLDALLPPdTSPEALDLLRRLLVFAPDKRLSATQALQHPYV  304

         *******************986599*****************************7

Domain Sequence
(FASTA)

LLRRQLGQGA YGIVWKAVDR RTGEVVAIKK IFDAFRDKTD AQRTFREITL LQEFGDHPNI 60

ISLLDVIRAE NDRDIYLVFE FMDTDLNAVI RKGGLLQDVH VRSIFYQLLR ATRFLHSGHV 120

VHRDQKPSNV LLDANCTVKL CDFGLARSLG DLPEGPEDQA VTEYVATRWY RAPEVLLSSH 180

RYTLGVDMWS LGCILGEMLR GRPLFPGTST LHQLELILET IPPPSEEDLL ALGSGCRASV 240

LHQLGSRPRQ TLDALLPPDT SPEALDLLRR LLVFAPDKRL SATQALQHPY V 291

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005576	; C:extracellular region
GO:0005622	; C:intracellular
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0017124	; F:SH3 domain binding
GO:0008156	; P:negative regulation of DNA replication
GO:0045732	; P:positive regulation of protein catabolic process
GO:0001934	; P:positive regulation of protein phosphorylation
GO:0031398	; P:positive regulation of protein ubiquitination
GO:0046777	; P:protein autophosphorylation
GO:0032355	; P:response to estradiol stimulus

KEGG

hsa:225689

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013