EKS-HOS-00369
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00369
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Lmr536.93.9E-161125398274
StatusReviewed
Ensembl ProteinENSP00000363924
UniProt AccessionQ6ZMQ8; O75136; Q6ZN31; Q86X28;
Protein NameSerine/threonine-protein kinase LMTK1
Protein Synonyms/Alias Apoptosis-associated tyrosine kinase; AATYK; Brain apoptosis-associated tyrosine kinase; CDK5-binding protein; Lemur tyrosine kinase 1; p35-binding protein; p35BP;
Gene NameAATK
Gene Synonyms/Alias AATK; AATYK, KIAA0641, LMR1, LMTK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000181409ENSP00000363924ENST00000374792
ENSG00000181409ENSP00000460202ENST00000575363
ENSG00000181409ENSP00000324196ENST00000326724
ENSG00000181409ENSP00000398796ENST00000417379
ENSG00000181409ENSP00000460986ENST00000570932
OrganismHomo sapiens
Functional DescriptionMay be involved in neuronal differentiation.
Protein Length879
Protein Sequence
(FASTA)
MSSSFFNPSF AFSSHFDPDG APLSELSWPS SLAVVAVSFS GLFAVIVLML ACLCCKKGGI 60
GFKEFENAEG DEYAADLAQG SPATAAQNGP DVYVLPLTEV SLPMAKQPGR SVQLLKSTDV 120
GRHSLLYLKE IGRGWFGKVF LGEVNSGISS AQVVVKELQA SASVQEQMQF LEEVQPYRAL 180
KHSNLLQCLA QCAEVTPYLL VMEFCPLGDL KGYLRSCRVA ESMAPDPRTL QRMACEVACG 240
VLHLHRNNFV HSDLALRNCL LTADLTVKIG DYGLAHCKYR EDYFVTADQL WVPLRWIAPE 300
LVDEVHSNLL VVDQTKSGNV WSLGVTIWEL FELGTQPYPQ HSDQQVLAYT VREQQLKLPK 360
PQLQLTLSDR WYEVMQFCWL QPEQRPTAEE VHLLLSYLCA KGATEAEEEF ERRWRSLRPG 420
GGGVGPGPGA AGPMLGGVVE LAAASSFPLL EQFAGDGFHA DGDDVLTELC APDGAPPGVV 480
PVLSAHSPSL GSEYFIRLEE AAPAAGHDPD CAGCAPSPPA TADQDDDSDG STAASLAMEP 540
LLGHGPPVDV PWGRGDHYPR RSLARDPLCP SRSPSPSAGP LSLAEGGAED ADWGVAAFCP 600
AFFEDPLGTS PLGSSGAPPL PLTGEDELEE VGARRAAQRG HWRSNVSANN NSGSRCPESW 660
DPVSAGGHAE GCPSPKQTPR ASPEPGYPGE PLLGLQAASA QEPGCCPGLP HLCSAQGLAP 720
APCLVTPSWT ETASSGGDHP QAEPKLATEA EGTTGPRLPL PSVPSPSQEG APLPSEEASA 780
PDAPDALPDS PTPATGGEVS AIKLASALNG SSSSPEVEAP SSEDEDTAEA TSGIFTDTSS 840
DGLQARRPDV VPAFRSLQKQ WPQREESLPR LCLLLRPRG 879
Nucleotide Sequence
(FASTA)
ATGTCGTCGT CCTTCTTCAA CCCCAGCTTC GCCTTCAGCT CGCACTTCGA CCCCGACGGC 60
GCCCCGCTCA GCGAGCTGTC CTGGCCATCC TCCCTCGCCG TGGTGGCTGT GTCTTTCTCC 120
GGGCTCTTCG CCGTCATCGT CCTCATGCTG GCCTGCCTGT GCTGTAAGAA GGGCGGTATC 180
GGGTTCAAGG AGTTTGAGAA TGCGGAGGGG GACGAGTACG CAGCCGACCT GGCGCAGGGC 240
TCCCCGGCCA CGGCAGCACA GAACGGGCCC GACGTGTACG TCCTGCCACT CACGGAGGTC 300
TCCTTGCCCA TGGCCAAGCA GCCTGGGCGC TCAGTGCAGC TCCTCAAGTC CACAGACGTG 360
GGCCGGCACA GCCTCCTGTA CCTGAAGGAA ATCGGCCGTG GCTGGTTCGG GAAGGTGTTC 420
CTGGGGGAGG TGAACTCTGG CATCAGCAGT GCCCAGGTGG TGGTGAAGGA GCTGCAGGCT 480
AGTGCCAGCG TGCAGGAGCA GATGCAGTTC CTGGAGGAGG TGCAGCCCTA CAGGGCCCTG 540
AAGCACAGCA ACCTGCTCCA GTGCCTGGCC CAGTGCGCCG AGGTGACGCC CTACCTGCTG 600
GTGATGGAGT TCTGCCCACT GGGGGACCTC AAGGGCTACC TGCGGAGCTG CCGGGTGGCG 660
GAGTCCATGG CTCCCGACCC CCGGACCCTG CAGCGCATGG CCTGTGAGGT GGCCTGTGGC 720
GTCCTGCACC TTCATCGCAA CAATTTCGTG CACAGCGACC TGGCCCTGCG GAACTGCCTG 780
CTCACGGCTG ACCTGACGGT GAAGATTGGT GACTATGGCC TGGCTCACTG CAAGTACAGA 840
GAGGACTACT TCGTGACTGC CGACCAGCTG TGGGTGCCTC TGCGCTGGAT CGCGCCAGAG 900
CTGGTGGACG AGGTGCATAG CAACCTGCTC GTCGTGGACC AGACCAAGAG CGGGAATGTG 960
TGGTCCCTGG GCGTGACCAT CTGGGAGCTC TTTGAGCTGG GCACGCAGCC CTATCCCCAG 1020
CACTCGGACC AGCAGGTGCT GGCGTACACG GTCCGGGAGC AGCAGCTCAA GCTGCCCAAG 1080
CCCCAGCTGC AGCTGACCCT GTCGGACCGC TGGTACGAGG TGATGCAGTT CTGCTGGCTG 1140
CAGCCCGAGC AGCGGCCCAC AGCCGAGGAG GTGCACCTGC TGCTGTCCTA CCTGTGTGCC 1200
AAGGGCGCCA CCGAAGCAGA GGAGGAGTTT GAACGGCGCT GGCGCTCTCT GCGGCCCGGC 1260
GGGGGCGGCG TGGGGCCCGG GCCCGGTGCG GCGGGGCCCA TGCTGGGCGG CGTGGTGGAG 1320
CTCGCCGCTG CCTCGTCCTT CCCGCTGCTG GAGCAGTTCG CGGGCGACGG CTTCCACGCG 1380
GACGGCGACG ACGTGCTGAC GGAGCTGTGC GCCCCCGACG GCGCGCCCCC GGGCGTGGTT 1440
CCGGTGCTCA GCGCGCACAG CCCGTCGCTG GGCAGCGAGT ACTTCATCCG CCTAGAGGAG 1500
GCCGCACCCG CCGCCGGCCA CGACCCTGAC TGCGCCGGCT GCGCCCCCAG TCCACCTGCC 1560
ACCGCGGACC AGGACGACGA CTCTGACGGC AGCACCGCCG CCTCGCTGGC CATGGAGCCG 1620
CTGCTGGGCC ACGGGCCACC CGTCGACGTC CCCTGGGGCC GCGGCGACCA CTACCCTCGC 1680
AGAAGCTTGG CGCGGGACCC GCTCTGCCCC TCACGCTCTC CCTCGCCCTC GGCGGGGCCC 1740
CTGAGTCTGG CGGAGGGAGG AGCGGAGGAT GCAGACTGGG GCGTGGCCGC CTTCTGTCCT 1800
GCCTTCTTCG AGGACCCACT GGGCACGTCC CCTTTGGGGA GCTCAGGGGC GCCCCCGCTG 1860
CCGCTGACTG GCGAGGATGA GCTAGAGGAG GTGGGAGCGC GGAGGGCCGC CCAGCGCGGG 1920
CACTGGCGCT CCAACGTGTC AGCCAACAAC AACAGCGGCA GCCGCTGTCC AGAGTCCTGG 1980
GACCCCGTCT CTGCGGGCGG CCACGCTGAG GGCTGCCCCA GTCCAAAGCA GACCCCACGG 2040
GCCTCCCCCG AGCCGGGGTA CCCTGGAGAG CCTCTGCTTG GGCTCCAGGC AGCCTCTGCC 2100
CAGGAGCCAG GCTGCTGCCC CGGCCTCCCT CATCTATGCT CTGCCCAGGG CCTGGCACCT 2160
GCTCCCTGCC TGGTTACACC CTCCTGGACA GAGACAGCCA GTAGTGGGGG TGACCACCCG 2220
CAGGCAGAGC CCAAGCTTGC CACGGAGGCT GAGGGCACTA CCGGACCCCG CCTGCCCCTT 2280
CCTTCCGTCC CCTCCCCATC CCAGGAGGGA GCCCCACTTC CCTCGGAGGA GGCCAGTGCC 2340
CCCGACGCCC CTGATGCCCT GCCTGACTCT CCCACGCCTG CTACTGGTGG CGAGGTGTCT 2400
GCCATCAAGC TGGCTTCTGC CCTGAATGGC AGCAGCAGCT CTCCCGAGGT GGAGGCACCC 2460
AGCAGTGAGG ATGAGGACAC GGCCGAGGCC ACCTCAGGCA TCTTCACCGA CACGTCCAGC 2520
GACGGCCTGC AGGCCAGGAG GCCGGATGTG GTGCCAGCCT TCCGCTCTCT GCAGAAGCAG 2580
TGGCCTCAAC GAGAAGAATC CCTACCGAGA CTCTGCCTAC TTCTCAGACC TCGAGGCTGA 2640
Domain Profile
S: 1     lsylkeigsgwfgkvllgevfsdvssaqvvvkelkasaspkeqrkfleeaqpyralqhpn  60
         l ylkeig+gwfgkv+lgev+s++ssaqvvvkel+asas++eq++flee+qpyral+h+n
Q: 125   LLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSN  184
         78**********************************************************
S: 61    vlqclgqcvealpyllvlefcdlgdlkaylraereaeslspdlrtlqrmalevaaglahl  120
         +lqcl+qc+e++pyllv+efc+lgdlk+ylr++r+aes++pd+rtlqrma+eva+g++hl
Q: 185   LLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVACGVLHL  244
         ************************************************************
S: 121   hklnyvhsdlalrnclltsdltvkvgdyglahskykedylltadklvvplrwaapelvde  180
         h++n+vhsdlalrncllt+dltvk+gdyglah+ky+edy++tad+l+vplrw+apelvde
Q: 245   HRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDE  304
         ************************************************************
S: 181   lhdrllvvdqtkesnvwslgvtlwelfelgaqpyrklsdeevlafvvreqdvklakprlk  240
         +h++llvvdqtk++nvwslgvt+welfelg+qpy+++sd++vla++vreq++kl+kp+l+
Q: 305   VHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQ  364
         ************************************************************
S: 241   lpysdrwyevlqfcwlppekrpaaedvhllltyl  274
         l++sdrwyev+qfcwl+pe+rp+ae+vhlll+yl
Q: 365   LTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYL  398
         *********************************8
Domain Sequence
(FASTA)
LLYLKEIGRG WFGKVFLGEV NSGISSAQVV VKELQASASV QEQMQFLEEV QPYRALKHSN 60
LLQCLAQCAE VTPYLLVMEF CPLGDLKGYL RSCRVAESMA PDPRTLQRMA CEVACGVLHL 120
HRNNFVHSDL ALRNCLLTAD LTVKIGDYGL AHCKYREDYF VTADQLWVPL RWIAPELVDE 180
VHSNLLVVDQ TKSGNVWSLG VTIWELFELG TQPYPQHSDQ QVLAYTVREQ QLKLPKPQLQ 240
LTLSDRWYEV MQFCWLQPEQ RPTAEEVHLL LSYL 274
KeywordAlternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00338
EKS-ANC-00351
EKS-BOT-00363
EKS-CAJ-00367
EKS-CAP-00396
EKS-DAR-00739
EKS-EQC-00356
EKS-FEC-00351
EKS-GAM-00215
EKS-GAA-00442
EKS-GOG-00356
EKS-ICT-00344
EKS-LAC-00377
EKS-LOA-00371
EKS-MAM-00363
EKS-MEG-00298
EKS-MOD-00352
EKS-MUM-00395
EKS-MUP-00358
EKS-NOL-00333
EKS-ORN-00467
EKS-ORL-00429
EKS-POA-00352
EKS-RAN-00377
EKS-SAH-00335
EKS-SUS-00321
EKS-TAR-00462
EKS-TEN-00458
EKS-XET-00479
EKS-XIM-00457
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005739; C:mitochondrion
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0046777; P:protein autophosphorylation
KEGG
hsa:9625;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013