EKS-HOS-00219
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00219
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF3628.02.0E-1889921321330
StatusReviewed
Ensembl ProteinENSP00000330930
UniProt AccessionQ86YV5; Q8N3N5;
Protein NameTyrosine-protein kinase SgK223
Protein Synonyms/Alias Sugen kinase 223;
Gene NameSGK223
Gene Synonyms/Alias SGK223;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000182319ENSP00000330930ENST00000330777
ENSG00000182319ENSP00000428054ENST00000520004
OrganismHomo sapiens
Functional Description
Protein Length1402
Protein Sequence
(FASTA)
MHQTLCLNPE SLKMSACSDF VEHIWKPGSC KNCFCLRSDH QLVAGPPQPR AGSLPPPPRL 60
PPRPENCRLE DEGVNSSPYS KPTIAVKPTM MSSEASDVWT EANLSAEVSQ VIWRRAPGKL 120
PLPKQEDAPV VYLGSFRGVQ KPAGPSTSPD GNSRCPPAYT MVGLHNLEPR GERNIAFHPV 180
SFPEEKAVHK EKPSFPYQDR PSTQESFRQK LAAFAGTTSG CHQGPGPLRE SLPSEDDSDQ 240
RCSPSGDSEG GEYCSILDCC PGSPVAKAAS QTAGSRGRHG GRDCSPTCWE QGKCSGPAEQ 300
EKRGPSFPKE CCSQGPTAHP SCLGPKKLSL TSEAAISSDG LSCGSGSGSG ASSPFVPHLE 360
SDYCSLMKEP APEKQQDPGC PGVTPSRCLG LTGEPQPPAH PREATQPEPI YAESTKRKKA 420
APVPSKSQAK IEHAAAAQGQ GQVCTGNAWA QKAASGWGRD SPDPTPQVSA TITVMAAHPE 480
EDHRTIYLSS PDSAVGVQWP RGPVSQNSEV GEEETSAGQG LSSRESHAHS ASESKPKERP 540
AIPPKLSKSS PVGSPVSPSA GGPPVSPLAD LSDGSSGGSS IGPQPPSQGP ADPAPSCRTN 600
GVAISDPSRC PQPAASSASE QRRPRFQAGT WSRQCRIEEE EEVEQELLSH SWGRETKNGP 660
TDHSNSTTWH RLHPTDGSSG QNSKVGTGMS KSASFAFEFP KDRSGIETFS PPPPPPKSRH 720
LLKMNKSSSD LEKVSQGSAE SLSPSFRGVH VSFTTGSTDS LASDSRTCSD GGPSSELAHS 780
PTNSGKKLFA PVPFPSGSTE DVSPSGPQQP PPLPQKKIVS RAASSPDGFF WTQGSPKPGT 840
ASPKLNLSHS ETNVHDESHF SYSLSPGNRH HPVFSSSDPL EKAFKGSGHW LPAAGLAGNR 900
GGCGSPGLQC KGAPSASSSQ LSVSSQASTG STQLQLHGLL SNISSKEGTY AKLGGLYTQS 960
LARLVAKCED LFMGGQKKEL HFNENNWSLF KLTCNKPCCD SGDAIYYCAT CSEDPGSTYA 1020
VKICKAPEPK TVSYCSPSVP VHFNIQQDCG HFVASVPSSM LSSPDAPKDP VPALPTHPPA 1080
QEQDCVVVIT REVPHQTASD FVRDSAASHQ AEPEAYERRV CFLLLQLCNG LEHLKEHGII 1140
HRDLCLENLL LVHCTLQAGP GPAPAPAPAP AAAAPPCSSA APPAGGTLSP AAGPASPEGP 1200
REKQLPRLII SNFLKAKQKP GGTPNLQQKK SQARLAPEIV SASQYRKFDE FQTGILIYEL 1260
LHQPNPFEVR AQLRERDYRQ EDLPPLPALS LYSPGLQQLA HLLLEADPIK RIRIGEAKRV 1320
LQCLLWGPRR ELVQQPGTSE EALCGTLHNW IDMKRALMMM KFAEKAVDRR RGVELEDWLC 1380
CQYLASAEPG ALLQSLKLLQ LL 1402
Nucleotide Sequence
(FASTA)
ATGCACCAGA CCCTCTGCCT GAACCCCGAG AGCCTGAAAA TGTCTGCGTG CAGTGACTTT 60
GTGGAGCACA TCTGGAAACC CGGGTCCTGC AAGAACTGCT TCTGCCTGCG GAGCGACCAC 120
CAGCTGGTGG CCGGCCCTCC CCAGCCCAGA GCGGGCAGCC TGCCCCCTCC ACCGCGCCTG 180
CCTCCCAGGC CTGAGAACTG CCGCCTGGAA GATGAAGGTG TGAACAGCTC ACCTTACTCC 240
AAGCCCACAA TTGCCGTGAA GCCCACCATG ATGAGCTCCG AGGCCTCTGA TGTGTGGACA 300
GAGGCCAACC TGAGTGCCGA AGTCTCGCAG GTCATCTGGA GACGAGCCCC TGGCAAGCTC 360
CCCCTCCCGA AGCAGGAGGA TGCCCCCGTC GTCTACCTGG GCAGCTTCCG AGGTGTACAG 420
AAGCCTGCTG GTCCCTCTAC CTCCCCTGAT GGCAATTCTC GCTGTCCCCC AGCTTACACC 480
ATGGTCGGCC TGCACAACCT TGAGCCCCGC GGCGAGAGGA ACATTGCCTT CCACCCGGTG 540
AGCTTCCCGG AGGAGAAGGC TGTGCACAAA GAAAAACCCT CATTTCCTTA CCAAGACCGG 600
CCCTCCACCC AGGAGAGCTT CCGCCAGAAA CTGGCTGCCT TTGCTGGGAC CACATCTGGC 660
TGTCACCAGG GCCCTGGGCC CCTGCGGGAA TCCCTGCCCT CGGAGGATGA CAGTGATCAA 720
AGGTGCTCGC CCTCCGGGGA CAGCGAGGGT GGAGAGTACT GCTCCATCCT GGACTGCTGC 780
CCTGGGAGCC CTGTTGCCAA GGCTGCCTCC CAGACTGCAG GTTCCCGGGG CAGGCATGGT 840
GGCAGGGACT GCTCACCCAC GTGCTGGGAG CAGGGGAAGT GTTCCGGGCC CGCAGAGCAG 900
GAGAAGCGGG GCCCGAGCTT CCCCAAGGAG TGCTGTAGCC AGGGCCCCAC TGCCCACCCA 960
TCCTGCCTGG GCCCCAAGAA ACTGTCCCTC ACCTCGGAGG CTGCCATTTC TTCCGACGGC 1020
CTCTCTTGTG GCAGCGGCAG CGGCAGCGGC GCCAGTAGCC CCTTCGTCCC CCACCTCGAG 1080
AGTGATTACT GCTCCCTCAT GAAGGAACCT GCCCCAGAGA AGCAGCAGGA CCCTGGCTGC 1140
CCAGGGGTGA CCCCTAGCAG ATGCCTTGGG CTGACGGGGG AGCCCCAGCC CCCGGCCCAC 1200
CCCCGGGAGG CTACACAGCC TGAACCCATC TATGCTGAGA GCACCAAGAG GAAGAAGGCA 1260
GCTCCGGTGC CTTCCAAGTC ACAGGCCAAG ATAGAACATG CAGCTGCTGC CCAGGGCCAA 1320
GGCCAGGTAT GCACAGGTAA TGCCTGGGCC CAGAAAGCAG CATCTGGCTG GGGCCGGGAC 1380
AGCCCAGACC CAACTCCCCA GGTGTCAGCC ACCATCACAG TCATGGCGGC CCACCCGGAA 1440
GAGGACCATC GGACGATCTA CCTGAGCAGC CCTGACTCTG CAGTGGGGGT GCAGTGGCCA 1500
CGAGGGCCTG TGAGCCAGAA CTCCGAGGTA GGTGAAGAGG AGACTTCGGC TGGGCAGGGG 1560
CTGAGCTCCA GGGAAAGCCA TGCTCACAGT GCCAGCGAGA GCAAGCCCAA GGAGAGGCCC 1620
GCCATTCCCC CCAAGTTGTC CAAGAGTAGC CCTGTAGGGT CCCCGGTGTC ACCGTCTGCT 1680
GGAGGGCCCC CAGTGTCACC GCTGGCTGAC CTTAGTGATG GGAGCTCTGG CGGCAGCAGC 1740
ATTGGGCCCC AGCCTCCATC CCAAGGTCCT GCTGACCCCG CTCCTTCCTG CCGGACCAAC 1800
GGTGTCGCTA TCAGTGACCC ATCCAGGTGT CCCCAGCCTG CCGCCTCGTC AGCCTCGGAA 1860
CAGAGGCGGC CCAGGTTCCA GGCAGGCACC TGGAGTCGTC AGTGCCGGAT AGAGGAAGAA 1920
GAGGAGGTGG AGCAGGAATT GCTGAGTCAC AGCTGGGGAA GAGAGACCAA AAATGGCCCC 1980
ACGGACCATT CAAACTCCAC GACCTGGCAC CGTCTCCACC CCACAGATGG CTCCTCTGGG 2040
CAGAACAGCA AAGTTGGGAC CGGGATGAGC AAATCCGCCT CTTTTGCCTT TGAGTTCCCC 2100
AAGGACAGAA GTGGGATTGA GACATTCTCA CCTCCTCCTC CGCCTCCAAA GTCGCGGCAC 2160
CTTCTAAAAA TGAACAAGAG CAGCTCTGAT TTGGAAAAAG TGAGCCAGGG CTCTGCAGAA 2220
AGCCTCAGCC CATCCTTCAG GGGTGTCCAC GTCAGCTTCA CCACCGGCTC CACGGACAGC 2280
CTGGCCTCAG ACTCTAGGAC CTGCAGCGAT GGAGGTCCCT CGTCTGAGCT GGCTCACTCG 2340
CCCACCAACA GCGGGAAGAA GCTCTTTGCT CCCGTTCCGT TTCCTTCAGG CTCCACTGAG 2400
GACGTGTCCC CCAGTGGCCC CCAGCAGCCC CCTCCACTCC CCCAGAAAAA GATAGTGAGC 2460
CGGGCAGCCT CTTCACCGGA TGGCTTCTTC TGGACCCAAG GCTCCCCCAA GCCCGGAACA 2520
GCAAGCCCCA AGCTGAACCT AAGCCACTCG GAAACCAACG TCCACGACGA ATCTCACTTT 2580
AGCTATTCGT TGAGCCCCGG GAACCGCCAC CATCCTGTCT TCTCCTCTTC CGATCCTCTG 2640
GAGAAAGCTT TCAAAGGCAG TGGCCACTGG CTTCCGGCAG CAGGGCTGGC GGGCAACAGA 2700
GGCGGCTGCG GGAGCCCTGG CCTCCAGTGC AAAGGGGCCC CCTCCGCCTC ATCCTCCCAG 2760
CTGAGCGTGT CCAGTCAAGC CTCCACCGGG AGCACCCAGC TTCAGCTGCA CGGTCTCCTG 2820
AGCAACATCA GCAGCAAGGA GGGCACCTAT GCCAAGCTGG GGGGACTCTA CACCCAGTCC 2880
CTGGCCCGCC TTGTAGCCAA ATGTGAGGAC CTCTTCATGG GCGGCCAGAA AAAGGAGCTC 2940
CACTTCAATG AGAATAACTG GTCGCTCTTC AAGCTGACTT GTAACAAGCC CTGCTGTGAC 3000
TCGGGGGATG CCATTTATTA CTGTGCCACC TGCTCTGAGG ACCCCGGCAG CACCTATGCT 3060
GTGAAAATCT GCAAAGCCCC TGAGCCCAAA ACAGTCTCCT ACTGCAGCCC GTCCGTGCCC 3120
GTGCACTTTA ACATCCAGCA GGACTGCGGC CACTTCGTCG CCTCGGTGCC GTCCAGCATG 3180
CTCAGCTCCC CCGACGCGCC CAAGGACCCT GTGCCTGCCC TGCCCACACA CCCCCCTGCC 3240
CAGGAGCAGG ACTGCGTGGT GGTCATCACC CGAGAGGTGC CACATCAGAC CGCCTCCGAC 3300
TTCGTGCGGG ACTCGGCGGC CAGCCACCAG GCGGAGCCCG AGGCGTACGA GCGGCGCGTG 3360
TGCTTCCTGC TTCTGCAACT CTGCAACGGG CTGGAGCACC TGAAGGAGCA CGGGATCATC 3420
CACCGGGACC TGTGCCTGGA GAACCTGCTG CTGGTGCACT GCACCCTCCA GGCCGGCCCC 3480
GGGCCCGCCC CCGCCCCGGC TCCCGCCCCC GCCGCCGCCG CGCCTCCCTG CTCCTCTGCC 3540
GCCCCGCCTG CTGGTGGCAC TCTCAGCCCC GCAGCCGGCC CCGCCTCCCC GGAAGGGCCC 3600
CGGGAGAAGC AGCTGCCCCG GCTCATCATC AGCAACTTTT TGAAGGCCAA GCAGAAGCCG 3660
GGCGGCACCC CAAACCTGCA GCAGAAGAAG AGCCAGGCCC GGCTGGCCCC CGAGATCGTG 3720
TCTGCTTCCC AGTACCGCAA GTTCGATGAG TTCCAGACAG GCATCCTCAT CTACGAGCTG 3780
CTGCACCAAC CCAACCCGTT CGAGGTGCGC GCCCAGCTGC GGGAGAGAGA CTACCGGCAG 3840
GAGGACCTGC CGCCGCTGCC CGCGCTGTCC CTCTACTCAC CCGGCCTGCA GCAGCTGGCA 3900
CATCTGCTAC TGGAGGCCGA CCCCATCAAG CGTATCCGCA TCGGCGAGGC CAAGCGCGTG 3960
CTGCAGTGCC TGCTGTGGGG GCCTCGGCGC GAGCTGGTGC AGCAGCCGGG CACCTCGGAG 4020
GAGGCGCTGT GCGGCACGCT GCACAACTGG ATCGACATGA AGCGGGCCCT GATGATGATG 4080
AAGTTTGCGG AGAAGGCGGT GGATCGCAGG CGGGGCGTGG AGCTGGAGGA CTGGCTTTGC 4140
TGCCAGTACC TGGCGTCTGC GGAGCCCGGG GCCCTCTTAC AGTCGCTGAA GCTCCTGCAG 4200
CTTCTGTGA 4209
Domain Profile
S: 1     ltsdkpcceagdavyytasyakdplsnyavkickskekksqsyvrqslpvhfniqqdcGh  60
         lt++kpcc++gda+yy+a++++dp+s+yavkick++e+k++sy+++s+pvhfniqqdcGh
Q: 992   LTCNKPCCDSGDAIYYCATCSEDPGSTYAVKICKAPEPKTVSYCSPSVPVHFNIQQDCGH  1051
         79**********************************************************
S: 61    flaevpsrlladpdapekdpkpasetepsakerdhvvvitrevphltvadfvrdslashr  120
         f+a+vps++l++pdap++ p+pa++t+p+a+e+d+vvvitrevph+t++dfvrds+ash+
Q: 1052  FVASVPSSMLSSPDAPKD-PVPALPTHPPAQEQDCVVVITREVPHQTASDFVRDSAASHQ  1110
         ****************98.*****************************************
S: 121   aepelyerrvcllllqlcsGlehlkeygvihrdlrlenlllvhlqpqagaaqaaapaepa  180
         aepe+yerrvc+lllqlc+Glehlke+g+ihrdl+lenlllvh+++qag+++a+apa pa
Q: 1111  AEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCTLQAGPGPAPAPA-PA  1169
         *********************************************************.**
S: 181   ptsaapsa...........apaattasqegprekqltrlivsnflkakqksgglvdlqik  229
         p++aap++           +paa++as+egprekql+rli+snflkakqk+gg+++lq+k
Q: 1170  PAAAAPPCssaappaggtlSPAAGPASPEGPREKQLPRLIISNFLKAKQKPGGTPNLQQK  1229
         ************************************************************
S: 230   kdqarlapeivsasqykkfdefqtGiliyellhlpnpfevraelkereyrredlprlpll  289
         k+qarlapeivsasqy+kfdefqtGiliyellh+pnpfevra+l+er+yr+edlp+lp+l
Q: 1230  KSQARLAPEIVSASQYRKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRQEDLPPLPAL  1289
         ************************************************************
S: 290   slysrGlqqlasllleadpikriliseakrvl  321
         slys+Glqqla+llleadpikri+i+eakrvl
Q: 1290  SLYSPGLQQLAHLLLEADPIKRIRIGEAKRVL  1321
         ******************************98
Domain Sequence
(FASTA)
LTCNKPCCDS GDAIYYCATC SEDPGSTYAV KICKAPEPKT VSYCSPSVPV HFNIQQDCGH 60
FVASVPSSML SSPDAPKDPV PALPTHPPAQ EQDCVVVITR EVPHQTASDF VRDSAASHQA 120
EPEAYERRVC FLLLQLCNGL EHLKEHGIIH RDLCLENLLL VHCTLQAGPG PAPAPAPAPA 180
AAAPPCSSAA PPAGGTLSPA AGPASPEGPR EKQLPRLIIS NFLKAKQKPG GTPNLQQKKS 240
QARLAPEIVS ASQYRKFDEF QTGILIYELL HQPNPFEVRA QLRERDYRQE DLPPLPALSL 300
YSPGLQQLAH LLLEADPIKR IRIGEAKRVL 330
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00199
EKS-ANC-00207
EKS-BOT-00213
EKS-CAJ-00219
EKS-CAF-00219
EKS-CAP-00238
EKS-DAR-00519
EKS-ECT-00081
EKS-EQC-00208
EKS-ERE-00062
EKS-FEC-00200
EKS-GAA-00262
EKS-GOG-00209
EKS-ICT-00203
EKS-LOA-00210
EKS-MAM-00215
EKS-MAE-00078
EKS-MEG-00165
EKS-MOD-00213
EKS-MUM-00216
EKS-MYL-00216
EKS-NOL-00199
EKS-OCP-00139
EKS-ORC-00195
EKS-ORL-00254
EKS-OTG-00220
EKS-PAT-00202
EKS-PES-00191
EKS-POA-00207
EKS-PTV-00185
EKS-RAN-00208
EKS-TAR-00274
EKS-TAS-00076
EKS-TUT-00198
EKS-XET-00238
EKS-XIM-00266
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
KEGG
hsa:157285;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
Created Date20-Feb-2013