Tag | Content |
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EKPD ID | EKS-HOS-00488 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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CAMK/CAMK1 | 447.3 | 8.2E-134 | 23 | 279 | 257 |
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Status | Reviewed |
Ensembl Protein | ENSP00000368122 |
UniProt Accession | Q8IU85; B0YIY0; Q9HD31; |
Protein Name | Calcium/calmodulin-dependent protein kinase type 1D |
Protein Synonyms/Alias | CaM kinase I delta; CaM kinase ID; CaM-KI delta; CaMKI delta; CaMKID; CaMKI-like protein kinase; CKLiK; |
Gene Name | CAMK1D |
Gene Synonyms/Alias | CAMK1D; CAMKID; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | Calcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. |
Protein Length | 357 |
Protein Sequence (FASTA) | MARENGESSS SWKKQAEDIK KIFEFKETLG TGAFSEVVLA EEKATGKLFA VKCIPKKALK 60 | GKESSIENEI AVLRKIKHEN IVALEDIYES PNHLYLVMQL VSGGELFDRI VEKGFYTEKD 120 | ASTLIRQVLD AVYYLHRMGI VHRDLKPENL LYYSQDEESK IMISDFGLSK MEGKGDVMST 180 | ACGTPGYVAP EVLAQKPYSK AVDCWSIGVI AYILLCGYPP FYDENDSKLF EQILKAEYEF 240 | DSPYWDDISD SAKDFIRNLM EKDPNKRYTC EQAARHPWIA GDTALNKNIH ESVSAQIRKN 300 | FAKSKWRQAF NATAVVRHMR KLHLGSSLDS SNASVSSSLS LASQKDCAYV AKPESLS 357 |
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Nucleotide Sequence (FASTA) | ATGGCCCGGG AGAACGGCGA GAGCAGCTCC TCCTGGAAAA AGCAAGCTGA AGACATCAAG 60 | AAGATCTTCG AGTTCAAAGA GACCCTCGGA ACCGGGGCCT TTTCCGAAGT GGTTTTAGCT 120 | GAAGAGAAGG CAACTGGCAA GCTCTTTGCT GTGAAGTGTA TCCCTAAGAA GGCGCTGAAG 180 | GGCAAGGAAA GCAGCATAGA GAATGAGATA GCCGTCCTGA GAAAGATTAA GCATGAAAAT 240 | ATTGTTGCCC TGGAAGACAT TTATGAAAGC CCAAATCACC TGTACTTGGT CATGCAGCTG 300 | GTGTCCGGTG GAGAGCTGTT TGACCGGATA GTGGAGAAGG GGTTTTATAC AGAGAAGGAT 360 | GCCAGCACTC TGATCCGCCA AGTCTTGGAC GCCGTGTACT ATCTCCACAG AATGGGCATC 420 | GTCCACAGAG ACCTCAAGCC CGAAAATCTC TTGTACTACA GTCAAGATGA GGAGTCCAAA 480 | ATAATGATCA GTGACTTTGG ATTGTCAAAA ATGGAGGGCA AAGGAGATGT GATGTCCACT 540 | GCCTGTGGAA CTCCAGGCTA TGTCGCTCCT GAAGTCCTCG CCCAGAAACC TTACAGCAAA 600 | GCCGTTGACT GCTGGTCCAT CGGAGTGATT GCCTACATCT TGCTCTGCGG CTACCCTCCT 660 | TTTTATGATG AAAATGACTC CAAGCTCTTT GAGCAGATCC TCAAGGCGGA ATATGAGTTT 720 | GACTCTCCCT ACTGGGATGA CATCTCCGAC TCTGCAAAAG ACTTCATTCG GAACCTGATG 780 | GAGAAGGACC CGAATAAAAG ATACACGTGT GAGCAGGCAG CTCGGCACCC ATGGATCGCT 840 | GGTGACACAG CCCTCAACAA AAACATCCAC GAGTCCGTCA GCGCCCAGAT CCGGAAAAAC 900 | TTTGCCAAGA GCAAATGGAG ACAAGCATTT AATGCCACGG CCGTCGTCAG ACATATGAGA 960 | AAACTACACC TCGGCAGCAG CCTGGACAGT TCAAATGCAA GTGTTTCGAG CAGCCTCAGT 1020 | TTGGCCAGCC AAAAAGACTG TGCGTATGTA GCAAAACCAG AATCCCTCAG CTGA 1074 |
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Domain Profile | S: 1 yklkeklGeGafsevlkakekktqkavaikvikkkalkgkeesveneiavlkklkhpniv 60 | +++ke+lG+Gafsev++a+ek+t+k +a+k+i kkalkgke+s+eneiavl+k+kh+niv | Q: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82 | 799********************************************************* |
| S: 61 alkdiyesksklylvlelvtGGelfdrivekgvytekdasevikqvleavkylhelgivh 120 | al+diyes+++lylv++lv+GGelfdrivekg+ytekdas++i+qvl+av ylh++givh | Q: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142 | ************************************************************ |
| S: 121 rdlkPenllylskeedskikiadfGlskleeke.llktacGtvgyvapevlkqkkyskkv 179 | rdlkPenlly+s++e+ski+i+dfGlsk+e k+ +++tacGt+gyvapevl+qk+ysk+v | Q: 143 RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGdVMSTACGTPGYVAPEVLAQKPYSKAV 202 | ********************************99************************** |
| S: 180 dvWsiGvityillcGyppfydekeekllekilkgeyefesPyWdeisesakdfikkllel 239 | d+WsiGvi+yillcGyppfyde+++kl+e+ilk+eyef+sPyWd+is+sakdfi++l+e+ | Q: 203 DCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEK 262 | ************************************************************ |
| S: 240 dpekrytieqaledpWi 256 | dp+kryt+eqa ++pWi | Q: 263 DPNKRYTCEQAARHPWI 279 | ****************8 |
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Domain Sequence (FASTA) | FEFKETLGTG AFSEVVLAEE KATGKLFAVK CIPKKALKGK ESSIENEIAV LRKIKHENIV 60 | ALEDIYESPN HLYLVMQLVS GGELFDRIVE KGFYTEKDAS TLIRQVLDAV YYLHRMGIVH 120 | RDLKPENLLY YSQDEESKIM ISDFGLSKME GKGDVMSTAC GTPGYVAPEV LAQKPYSKAV 180 | DCWSIGVIAY ILLCGYPPFY DENDSKLFEQ ILKAEYEFDS PYWDDISDSA KDFIRNLMEK 240 | DPNKRYTCEQ AARHPWI 257 |
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Keyword | 3D-structure; Allosteric enzyme; Alternative splicing; ATP-binding; Calcium; Calmodulin-binding; Complete proteome; Cytoplasm; Inflammatory response; Kinase; Neurogenesis; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |