EKS-HOS-00488
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00488
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CAMK1447.38.2E-13423279257
StatusReviewed
Ensembl ProteinENSP00000368122
UniProt AccessionQ8IU85; B0YIY0; Q9HD31;
Protein NameCalcium/calmodulin-dependent protein kinase type 1D
Protein Synonyms/Alias CaM kinase I delta; CaM kinase ID; CaM-KI delta; CaMKI delta; CaMKID; CaMKI-like protein kinase; CKLiK;
Gene NameCAMK1D
Gene Synonyms/Alias CAMK1D; CAMKID;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000183049ENSP00000368122ENST00000378845
ENSG00000183049ENSP00000368124ENST00000378847
OrganismHomo sapiens
Functional DescriptionCalcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.
Protein Length357
Protein Sequence
(FASTA)
MARENGESSS SWKKQAEDIK KIFEFKETLG TGAFSEVVLA EEKATGKLFA VKCIPKKALK 60
GKESSIENEI AVLRKIKHEN IVALEDIYES PNHLYLVMQL VSGGELFDRI VEKGFYTEKD 120
ASTLIRQVLD AVYYLHRMGI VHRDLKPENL LYYSQDEESK IMISDFGLSK MEGKGDVMST 180
ACGTPGYVAP EVLAQKPYSK AVDCWSIGVI AYILLCGYPP FYDENDSKLF EQILKAEYEF 240
DSPYWDDISD SAKDFIRNLM EKDPNKRYTC EQAARHPWIA GDTALNKNIH ESVSAQIRKN 300
FAKSKWRQAF NATAVVRHMR KLHLGSSLDS SNASVSSSLS LASQKDCAYV AKPESLS 357
Nucleotide Sequence
(FASTA)
ATGGCCCGGG AGAACGGCGA GAGCAGCTCC TCCTGGAAAA AGCAAGCTGA AGACATCAAG 60
AAGATCTTCG AGTTCAAAGA GACCCTCGGA ACCGGGGCCT TTTCCGAAGT GGTTTTAGCT 120
GAAGAGAAGG CAACTGGCAA GCTCTTTGCT GTGAAGTGTA TCCCTAAGAA GGCGCTGAAG 180
GGCAAGGAAA GCAGCATAGA GAATGAGATA GCCGTCCTGA GAAAGATTAA GCATGAAAAT 240
ATTGTTGCCC TGGAAGACAT TTATGAAAGC CCAAATCACC TGTACTTGGT CATGCAGCTG 300
GTGTCCGGTG GAGAGCTGTT TGACCGGATA GTGGAGAAGG GGTTTTATAC AGAGAAGGAT 360
GCCAGCACTC TGATCCGCCA AGTCTTGGAC GCCGTGTACT ATCTCCACAG AATGGGCATC 420
GTCCACAGAG ACCTCAAGCC CGAAAATCTC TTGTACTACA GTCAAGATGA GGAGTCCAAA 480
ATAATGATCA GTGACTTTGG ATTGTCAAAA ATGGAGGGCA AAGGAGATGT GATGTCCACT 540
GCCTGTGGAA CTCCAGGCTA TGTCGCTCCT GAAGTCCTCG CCCAGAAACC TTACAGCAAA 600
GCCGTTGACT GCTGGTCCAT CGGAGTGATT GCCTACATCT TGCTCTGCGG CTACCCTCCT 660
TTTTATGATG AAAATGACTC CAAGCTCTTT GAGCAGATCC TCAAGGCGGA ATATGAGTTT 720
GACTCTCCCT ACTGGGATGA CATCTCCGAC TCTGCAAAAG ACTTCATTCG GAACCTGATG 780
GAGAAGGACC CGAATAAAAG ATACACGTGT GAGCAGGCAG CTCGGCACCC ATGGATCGCT 840
GGTGACACAG CCCTCAACAA AAACATCCAC GAGTCCGTCA GCGCCCAGAT CCGGAAAAAC 900
TTTGCCAAGA GCAAATGGAG ACAAGCATTT AATGCCACGG CCGTCGTCAG ACATATGAGA 960
AAACTACACC TCGGCAGCAG CCTGGACAGT TCAAATGCAA GTGTTTCGAG CAGCCTCAGT 1020
TTGGCCAGCC AAAAAGACTG TGCGTATGTA GCAAAACCAG AATCCCTCAG CTGA 1074
Domain Profile
S: 1     yklkeklGeGafsevlkakekktqkavaikvikkkalkgkeesveneiavlkklkhpniv  60
         +++ke+lG+Gafsev++a+ek+t+k +a+k+i kkalkgke+s+eneiavl+k+kh+niv
Q: 23    FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV  82
         799*********************************************************
S: 61    alkdiyesksklylvlelvtGGelfdrivekgvytekdasevikqvleavkylhelgivh  120
         al+diyes+++lylv++lv+GGelfdrivekg+ytekdas++i+qvl+av ylh++givh
Q: 83    ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH  142
         ************************************************************
S: 121   rdlkPenllylskeedskikiadfGlskleeke.llktacGtvgyvapevlkqkkyskkv  179
         rdlkPenlly+s++e+ski+i+dfGlsk+e k+ +++tacGt+gyvapevl+qk+ysk+v
Q: 143   RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGdVMSTACGTPGYVAPEVLAQKPYSKAV  202
         ********************************99**************************
S: 180   dvWsiGvityillcGyppfydekeekllekilkgeyefesPyWdeisesakdfikkllel  239
         d+WsiGvi+yillcGyppfyde+++kl+e+ilk+eyef+sPyWd+is+sakdfi++l+e+
Q: 203   DCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEK  262
         ************************************************************
S: 240   dpekrytieqaledpWi  256
         dp+kryt+eqa ++pWi
Q: 263   DPNKRYTCEQAARHPWI  279
         ****************8
Domain Sequence
(FASTA)
FEFKETLGTG AFSEVVLAEE KATGKLFAVK CIPKKALKGK ESSIENEIAV LRKIKHENIV 60
ALEDIYESPN HLYLVMQLVS GGELFDRIVE KGFYTEKDAS TLIRQVLDAV YYLHRMGIVH 120
RDLKPENLLY YSQDEESKIM ISDFGLSKME GKGDVMSTAC GTPGYVAPEV LAQKPYSKAV 180
DCWSIGVIAY ILLCGYPPFY DENDSKLFEQ ILKAEYEFDS PYWDDISDSA KDFIRNLMEK 240
DPNKRYTCEQ AARHPWI 257
Keyword3D-structure; Allosteric enzyme; Alternative splicing; ATP-binding; Calcium; Calmodulin-binding; Complete proteome; Cytoplasm; Inflammatory response; Kinase; Neurogenesis; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00447
EKS-CAF-00479
EKS-CAP-00511
EKS-CHH-00038
EKS-CII-00268
EKS-CIS-00232
EKS-DAR-00901
EKS-DRM-00230
EKS-LOA-00486
EKS-MAM-00480
EKS-MOD-00472
EKS-MUM-00511
EKS-MUP-00471
EKS-NOL-00437
EKS-ORN-00611
EKS-ORA-00419
EKS-ORC-00455
EKS-ORL-00556
EKS-PAT-00451
EKS-PEM-00264
EKS-POA-00468
EKS-RAN-00494
EKS-TAR-00600
EKS-TEN-00605
EKS-TUT-00184
EKS-XIM-00604
EKS-SAC-00108
Gene Ontology
GO:0005954; C:calcium- and calmodulin-dependent protein kinase complex
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004683; F:calmodulin-dependent protein kinase activity
GO:0006954; P:inflammatory response
GO:0032793; P:positive regulation of CREB transcription factor activity
GO:0010976; P:positive regulation of neuron projection development
GO:0090023; P:positive regulation of neutrophil chemotaxis
GO:0050766; P:positive regulation of phagocytosis
GO:0060267; P:positive regulation of respiratory burst
GO:0042981; P:regulation of apoptotic process
GO:0050773; P:regulation of dendrite development
GO:0071622; P:regulation of granulocyte chemotaxis
KEGG
hsa:57118;
InterPros
IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013