Tag | Content |
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EKPD ID | EKS-HOS-00189 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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AGC/PKA | 452.5 | 2.0E-135 | 49 | 303 | 255 |
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Status | Reviewed |
Ensembl Protein | ENSP00000262848 |
UniProt Accession | P51817; |
Protein Name | cAMP-dependent protein kinase catalytic subunit PRKX |
Protein Synonyms/Alias | PrKX; Protein kinase X; Protein kinase X-linked; Serine/threonine-protein kinase PRKX; Protein kinase PKX1; |
Gene Name | PRKX |
Gene Synonyms/Alias | PRKX; PKX1; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | Serine/threonine protein kinase regulated by andmediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. |
Protein Length | 358 |
Protein Sequence (FASTA) | MEAPGLAQAA AAESDSRKVA EETPDGAPAL CPSPEALSPE PPVYSLQDFD TLATVGTGTF 60 | GRVHLVKEKT AKHFFALKVM SIPDVIRLKQ EQHVHNEKSV LKEVSHPFLI RLFWTWHDER 120 | FLYMLMEYVP GGELFSYLRN RGRFSSTTGL FYSAEIICAI EYLHSKEIVY RDLKPENILL 180 | DRDGHIKLTD FGFAKKLVDR TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG 240 | FPPFFDDNPF GIYQKILAGK IDFPRHLDFH VKDLIKKLLV VDRTRRLGNM KNGANDVKHH 300 | RWFRSVDWEA VPQRKLKPPI VPKIAGDGDT SNFETYPEND WDTAAPVPQK DLEIFKNF 358 |
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Nucleotide Sequence (FASTA) | ATGGAGGCGC CCGGGCTGGC CCAGGCGGCC GCGGCGGAGA GCGACTCCCG CAAGGTGGCG 60 | GAGGAGACCC CCGACGGGGC GCCCGCGCTC TGCCCCAGCC CTGAGGCGCT GTCGCCGGAG 120 | CCGCCTGTGT ACAGCCTGCA GGACTTTGAC ACGCTGGCCA CCGTGGGCAC TGGGACGTTC 180 | GGGCGGGTGC ACCTGGTGAA GGAGAAGACA GCCAAGCATT TCTTCGCCCT CAAGGTGATG 240 | AGCATTCCCG ACGTCATCCG CCTAAAGCAG GAGCAACACG TACACAATGA GAAGTCTGTC 300 | CTGAAGGAAG TCAGCCACCC GTTCCTCATC AGGCTGTTCT GGACGTGGCA TGACGAGCGC 360 | TTCCTCTACA TGCTCATGGA GTACGTGCCG GGCGGCGAGC TCTTCAGCTA CCTGCGCAAC 420 | CGGGGGCGCT TCTCCAGCAC CACGGGGCTC TTCTACTCTG CAGAGATCAT CTGTGCCATC 480 | GAGTACCTGC ACTCCAAAGA GATCGTCTAC AGGGACTTGA AGCCAGAGAA CATCCTGCTG 540 | GATAGGGATG GCCACATTAA GCTCACGGAC TTTGGGTTCG CCAAGAAGCT GGTAGACAGG 600 | ACTTGGACCC TCTGTGGAAC ACCCGAGTAC CTAGCCCCCG AAGTCATTCA GAGCAAGGGC 660 | CACGGAAGGG CCGTGGACTG GTGGGCCCTC GGCATCCTGA TATTCGAGAT GCTTTCGGGG 720 | TTTCCTCCGT TTTTTGATGA CAACCCGTTT GGCATTTATC AGAAAATTCT TGCAGGCAAA 780 | ATAGATTTCC CCAGACATTT GGATTTCCAT GTAAAAGACC TCATTAAGAA ACTGCTCGTG 840 | GTTGACAGAA CAAGGCGATT AGGAAACATG AAGAACGGGG CGAATGATGT GAAGCATCAT 900 | CGGTGGTTCC GCTCCGTGGA CTGGGAAGCT GTTCCGCAGA GAAAACTGAA GCCTCCCATC 960 | GTGCCCAAGA TAGCTGGTGA CGGCGACACT TCCAACTTCG AAACTTACCC TGAGAATGAC 1020 | TGGGACACAG CCGCGCCCGT GCCGCAGAAG GATTTAGAAA TCTTCAAGAA TTTCTGA 1077 |
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Domain Profile | S: 1 ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf 60 | f++l+t+GtG+fGrv+lv+ek++k+++alkv+s+ +v++lkq +hv+nek+vlk+v++pf | Q: 49 FDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPF 108 | 7899******************************************************** |
| S: 61 lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl 120 | l++l+++++de++ly+++eyv+GGelfsylr+++rfs++++ fy+aei++a+eylhs+++ | Q: 109 LIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEI 168 | ************************************************************ |
| S: 121 iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww 180 | +yrdlkpen+lld++G+ik+tdfGfakk+ drtwtlcGtpeylape+iqskg+++avdww | Q: 169 VYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWW 228 | ************************************************************ |
| S: 181 alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg 240 | alG+li+e+l+G+ppffdd+p+ iy+ki++gk++fp++l+ ++kdl+kkll+vd+t+rlg | Q: 229 ALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLG 288 | ************************************************************ |
| S: 241 nlkngvedikehkwf 255 | n+kng++d+k+h+wf | Q: 289 NMKNGANDVKHHRWF 303 | **************9 |
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Domain Sequence (FASTA) | FDTLATVGTG TFGRVHLVKE KTAKHFFALK VMSIPDVIRL KQEQHVHNEK SVLKEVSHPF 60 | LIRLFWTWHD ERFLYMLMEY VPGGELFSYL RNRGRFSSTT GLFYSAEIIC AIEYLHSKEI 120 | VYRDLKPENI LLDRDGHIKL TDFGFAKKLV DRTWTLCGTP EYLAPEVIQS KGHGRAVDWW 180 | ALGILIFEML SGFPPFFDDN PFGIYQKILA GKIDFPRHLD FHVKDLIKKL LVVDRTRRLG 240 | NMKNGANDVK HHRWF 255 |
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Keyword | Angiogenesis; ATP-binding; cAMP; Chromosomal rearrangement; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |