EKS-HOS-00189
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00189
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKA452.52.0E-13549303255
StatusReviewed
Ensembl ProteinENSP00000262848
UniProt AccessionP51817;
Protein NamecAMP-dependent protein kinase catalytic subunit PRKX
Protein Synonyms/Alias PrKX; Protein kinase X; Protein kinase X-linked; Serine/threonine-protein kinase PRKX; Protein kinase PKX1;
Gene NamePRKX
Gene Synonyms/Alias PRKX; PKX1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000183943ENSP00000262848ENST00000262848
OrganismHomo sapiens
Functional DescriptionSerine/threonine protein kinase regulated by andmediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.
Protein Length358
Protein Sequence
(FASTA)
MEAPGLAQAA AAESDSRKVA EETPDGAPAL CPSPEALSPE PPVYSLQDFD TLATVGTGTF 60
GRVHLVKEKT AKHFFALKVM SIPDVIRLKQ EQHVHNEKSV LKEVSHPFLI RLFWTWHDER 120
FLYMLMEYVP GGELFSYLRN RGRFSSTTGL FYSAEIICAI EYLHSKEIVY RDLKPENILL 180
DRDGHIKLTD FGFAKKLVDR TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG 240
FPPFFDDNPF GIYQKILAGK IDFPRHLDFH VKDLIKKLLV VDRTRRLGNM KNGANDVKHH 300
RWFRSVDWEA VPQRKLKPPI VPKIAGDGDT SNFETYPEND WDTAAPVPQK DLEIFKNF 358
Nucleotide Sequence
(FASTA)
ATGGAGGCGC CCGGGCTGGC CCAGGCGGCC GCGGCGGAGA GCGACTCCCG CAAGGTGGCG 60
GAGGAGACCC CCGACGGGGC GCCCGCGCTC TGCCCCAGCC CTGAGGCGCT GTCGCCGGAG 120
CCGCCTGTGT ACAGCCTGCA GGACTTTGAC ACGCTGGCCA CCGTGGGCAC TGGGACGTTC 180
GGGCGGGTGC ACCTGGTGAA GGAGAAGACA GCCAAGCATT TCTTCGCCCT CAAGGTGATG 240
AGCATTCCCG ACGTCATCCG CCTAAAGCAG GAGCAACACG TACACAATGA GAAGTCTGTC 300
CTGAAGGAAG TCAGCCACCC GTTCCTCATC AGGCTGTTCT GGACGTGGCA TGACGAGCGC 360
TTCCTCTACA TGCTCATGGA GTACGTGCCG GGCGGCGAGC TCTTCAGCTA CCTGCGCAAC 420
CGGGGGCGCT TCTCCAGCAC CACGGGGCTC TTCTACTCTG CAGAGATCAT CTGTGCCATC 480
GAGTACCTGC ACTCCAAAGA GATCGTCTAC AGGGACTTGA AGCCAGAGAA CATCCTGCTG 540
GATAGGGATG GCCACATTAA GCTCACGGAC TTTGGGTTCG CCAAGAAGCT GGTAGACAGG 600
ACTTGGACCC TCTGTGGAAC ACCCGAGTAC CTAGCCCCCG AAGTCATTCA GAGCAAGGGC 660
CACGGAAGGG CCGTGGACTG GTGGGCCCTC GGCATCCTGA TATTCGAGAT GCTTTCGGGG 720
TTTCCTCCGT TTTTTGATGA CAACCCGTTT GGCATTTATC AGAAAATTCT TGCAGGCAAA 780
ATAGATTTCC CCAGACATTT GGATTTCCAT GTAAAAGACC TCATTAAGAA ACTGCTCGTG 840
GTTGACAGAA CAAGGCGATT AGGAAACATG AAGAACGGGG CGAATGATGT GAAGCATCAT 900
CGGTGGTTCC GCTCCGTGGA CTGGGAAGCT GTTCCGCAGA GAAAACTGAA GCCTCCCATC 960
GTGCCCAAGA TAGCTGGTGA CGGCGACACT TCCAACTTCG AAACTTACCC TGAGAATGAC 1020
TGGGACACAG CCGCGCCCGT GCCGCAGAAG GATTTAGAAA TCTTCAAGAA TTTCTGA 1077
Domain Profile
S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60
         f++l+t+GtG+fGrv+lv+ek++k+++alkv+s+ +v++lkq +hv+nek+vlk+v++pf
Q: 49    FDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPF  108
         7899********************************************************
S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120
         l++l+++++de++ly+++eyv+GGelfsylr+++rfs++++ fy+aei++a+eylhs+++
Q: 109   LIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEI  168
         ************************************************************
S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180
         +yrdlkpen+lld++G+ik+tdfGfakk+ drtwtlcGtpeylape+iqskg+++avdww
Q: 169   VYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWW  228
         ************************************************************
S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240
         alG+li+e+l+G+ppffdd+p+ iy+ki++gk++fp++l+ ++kdl+kkll+vd+t+rlg
Q: 229   ALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLG  288
         ************************************************************
S: 241   nlkngvedikehkwf  255
         n+kng++d+k+h+wf
Q: 289   NMKNGANDVKHHRWF  303
         **************9
Domain Sequence
(FASTA)
FDTLATVGTG TFGRVHLVKE KTAKHFFALK VMSIPDVIRL KQEQHVHNEK SVLKEVSHPF 60
LIRLFWTWHD ERFLYMLMEY VPGGELFSYL RNRGRFSSTT GLFYSAEIIC AIEYLHSKEI 120
VYRDLKPENI LLDRDGHIKL TDFGFAKKLV DRTWTLCGTP EYLAPEVIQS KGHGRAVDWW 180
ALGILIFEML SGFPPFFDDN PFGIYQKILA GKIDFPRHLD FHVKDLIKKL LVVDRTRRLG 240
NMKNGANDVK HHRWF 255
KeywordAngiogenesis; ATP-binding; cAMP; Chromosomal rearrangement; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00174
EKS-BOT-00182
EKS-CAE-00174
EKS-CAJ-00187
EKS-CAF-00189
EKS-CHH-00029
EKS-CII-00118
EKS-CIS-00210
EKS-DAR-00482
EKS-DRM-00092
EKS-EQC-00179
EKS-FEC-00171
EKS-GAM-00101
EKS-GAG-00156
EKS-GAA-00225
EKS-GOG-00180
EKS-ICT-00177
EKS-LAC-00193
EKS-LOA-00181
EKS-MAM-00183
EKS-MEG-00142
EKS-MOD-00181
EKS-MUM-00187
EKS-MUP-00185
EKS-NOL-00174
EKS-ORN-00233
EKS-ORA-00160
EKS-ORL-00219
EKS-OTG-00189
EKS-PAT-00173
EKS-PES-00160
EKS-PTV-00153
EKS-RAN-00178
EKS-SAH-00176
EKS-SUS-00158
EKS-TAG-00209
EKS-TAR-00239
EKS-TEN-00236
EKS-TUT-00158
EKS-XET-00215
EKS-XIM-00229
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004691; F:cAMP-dependent protein kinase activity
GO:0001525; P:angiogenesis
GO:0031589; P:cell-substrate adhesion
GO:0043542; P:endothelial cell migration
GO:0001935; P:endothelial cell proliferation
GO:0060562; P:epithelial tube morphogenesis
GO:0060993; P:kidney morphogenesis
GO:0030099; P:myeloid cell differentiation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0046777; P:protein autophosphorylation
GO:0030155; P:regulation of cell adhesion
GO:0030334; P:regulation of cell migration
GO:2000696; P:regulation of epithelial cell differentiation involved in kidney development
KEGG
hsa:5613;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013