EPS-HOS-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	116.8	7.1E-33	179	473	295

Status

Reviewed

Ensembl Protein

ENSP00000373702

UniProt Accession

A8MPX8; Q96LI7;

Protein Name

Protein phosphatase 2C-like domain-containing protein 1

Protein Synonyms/Alias

Gene Name

PP2D1

Gene Synonyms/Alias

PP2D1; C3orf48;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000183977	ENSP00000373702	ENST00000389050
ENSG00000183977	ENSP00000331295	ENST00000333083

Organism

Homo sapiens

Functional Description

Protein Length

630

Protein Sequence
(FASTA)

MSTNNALRVF WKSREWNMKT STFDSDEDIL LLPKRKRFRK KKSRPVRHTK RHEEEQVYEQ 60

GTTLPCSICK HEIDLTGIFL HKKQHVALAT LGFQWMGRKK PQPSVIAVQR QFMISKLLSS 120

FMFTEKTLQS INNAFELLWK KQIPAYYKIF DNIDRSVIYS QKICHLLIKG VGICEDRNST 180

WKADMNDKFT VVSNFGNKPN VCFFGLFDGH HGASAAELTS MELPVLLLHQ LSKFDPSYQM 240

TTDEQQIINS FYTVFREEYA AIEDLFSAIN KTEAVRCEYE DTHKAFAKAF WRMDRLLGLG 300

RKEVSRVQWS GCSAVTCILE GKPKSPYAHK NWKRKNTHDG LAESSPSQEM PKIISGILHV 360

ANTGNVQAVL CRNGKGFCLT KEHTTRNTNE RRRILQNGAV ISSNEPYGLV EGQVKTTRGL 420

GFHGNLKLKK SIIPAPQTIS VPIDDLCQFL IVATNGLWEV LDKEEVTALA MTTFHMYKET 480

YCPIIPNKSP SKGPLLFSTS EPNLTKSQSN IHVLFQYKSV SEVRVSTTNS KENLSDSNYS 540

KYCIYNPENV ETFPAETTHR KPCSEKVTDR PTSVNDVATN EKESDTKSFY EGAAEYVSHE 600

LVNAALLAGS RDNITVMVIF LNGSEYQLLT 630

Nucleotide Sequence
(FASTA)

ATGAGCACCA ATAATGCTTT AAGAGTGTTT TGGAAATCAA GAGAATGGAA TATGAAAACA 60

TCAACATTTG ATTCAGATGA GGATATTCTA CTTTTACCCA AAAGAAAACG TTTTAGAAAG 120

AAAAAGTCAA GACCAGTGAG ACACACCAAA CGCCATGAAG AGGAGCAGGT CTATGAGCAA 180

GGGACCACAT TACCCTGTTC CATATGCAAG CACGAAATTG ACCTAACTGG TATTTTTCTC 240

CATAAGAAGC AACATGTAGC TCTGGCCACG CTGGGTTTCC AATGGATGGG TAGAAAGAAA 300

CCACAGCCCT CAGTGATTGC TGTTCAGAGA CAGTTCATGA TTTCTAAACT ATTGTCATCT 360

TTTATGTTCA CTGAAAAAAC CCTACAGAGC ATTAATAATG CTTTTGAGCT GCTTTGGAAA 420

AAACAAATAC CAGCATACTA TAAGATTTTT GATAACATTG ACAGGAGTGT CATATATTCT 480

CAAAAAATAT GTCATCTGTT AATTAAAGGA GTGGGCATTT GTGAAGACAG GAATTCTACA 540

TGGAAAGCTG ACATGAATGA TAAATTCACT GTAGTGAGTA ATTTTGGTAA CAAACCTAAT 600

GTGTGTTTTT TTGGTTTGTT TGATGGACAT CACGGTGCCT CAGCGGCAGA GTTGACATCA 660

ATGGAACTCC CAGTTTTACT TCTCCATCAG CTTTCCAAAT TTGATCCTTC TTACCAAATG 720

ACAACTGATG AGCAACAAAT AATCAATTCC TTTTACACTG TGTTTAGAGA AGAATACGCA 780

GCAATAGAAG ACCTCTTTTC TGCCATAAAC AAAACAGAAG CAGTGAGGTG TGAGTATGAG 840

GACACACACA AAGCCTTTGC AAAAGCATTT TGGAGAATGG ATAGGCTTTT AGGTCTTGGA 900

AGAAAAGAAG TGTCCAGGGT TCAATGGAGT GGCTGCTCTG CAGTTACTTG TATATTGGAA 960

GGCAAACCTA AAAGTCCTTA TGCTCATAAG AATTGGAAAA GAAAAAATAC CCATGATGGG 1020

TTGGCAGAGA GCTCCCCTTC CCAGGAGATG CCAAAAATAA TTTCTGGAAT ATTACATGTT 1080

GCAAACACTG GTAATGTGCA AGCAGTCTTA TGCAGAAATG GGAAAGGTTT TTGCCTAACC 1140

AAAGAACATA CTACACGAAA CACAAATGAA AGAAGAAGAA TACTTCAGAA TGGAGCAGTC 1200

ATTAGTTCAA ATGAACCATA CGGGCTTGTA GAGGGGCAAG TAAAAACTAC ACGAGGACTT 1260

GGATTTCATG GAAATCTCAA GCTGAAAAAA TCCATTATCC CAGCACCTCA AACTATTTCT 1320

GTCCCTATAG ATGACCTATG TCAATTCCTT ATTGTAGCTA CTAATGGACT TTGGGAAGTT 1380

TTGGATAAAG AGGAAGTTAC TGCCCTGGCA ATGACAACAT TTCACATGTA TAAAGAAACA 1440

TACTGTCCTA TCATACCTAA CAAATCACCA TCCAAAGGGC CTCTGCTTTT TTCAACCAGT 1500

GAACCAAACC TTACTAAATC ACAGAGTAAT ATCCACGTAT TGTTTCAGTA TAAATCTGTA 1560

TCTGAAGTAC GTGTGTCAAC TACAAATTCC AAAGAAAATT TATCCGATTC AAACTATTCT 1620

AAATACTGTA TTTATAACCC TGAGAATGTA GAAACATTTC CAGCAGAAAC GACTCATCGT 1680

AAACCTTGCA GTGAAAAAGT AACTGACAGA CCAACTAGTG TAAATGATGT GGCAACAAAT 1740

GAAAAAGAAT CAGACACTAA GAGTTTCTAT GAAGGCGCAG CTGAGTATGT TAGCCATGAA 1800

CTTGTAAATG CTGCTTTACT GGCTGGCTCC AGAGACAACA TTACAGTTAT GGTAATATTT 1860

CTCAATGGAA GTGAATATCA GCTTCTGACA TAA 1893

Domain Profile

S: 9     ngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheilaeele..  66

         + ++ +m+d++t+++nf+++p+    + ffg +DGh+g ++a+  s +l  +l  +l+

Q: 179   STWKADMNDKFTVVSNFGNKPN----VCFFGLFDGHHGASAAELTSMELPVLLLHQLSkf  234

         56899***************99....68********************************

S: 67    .......................................sseseerkvkkalakaFlstd  87

                                                +   e ++  ka+akaF ++d

Q: 235   dpsyqmttdeqqiinsfytvfreeyaaiedlfsainkteAVRCEYEDTHKAFAKAFWRMD  294

         *****99999999999999999999999999977655444444445555***********

S: 88    eelkvleeksldidksGstavvalik..........................ds......  115

         + l    ++ ++ + sG++av+++++                          ++

Q: 295   RLLGLGRKEVSRVQWSGCSAVTCILEgkpkspyahknwkrknthdglaesspSQempkii  354

         ***555555566677***********8888888888888877777777666511566677

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvL  172

            l+van+G  +avLcrngk   l+++H++ +++E++Ri ++g+ +  ++    v G+

Q: 355   sgILHVANTGNVQAVLCRNGKGFCLTKEHTTRNTNERRRILQNGAVISSNEPYgLVEGQV  414

         779****************************************855555555579*****

S: 173   avsRalG...dlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdv  228

         + +R lG    l+lk+ ++p P++ s++++   +fli a+ Glw+v+++ee+ +l+  +

Q: 415   KTTRGLGfhgNLKLKKSIIPAPQTISVPIDDLCQFLIVATNGLWEVLDKEEVTALAMTT  473

         ******643378999*************************************9987655

Domain Sequence
(FASTA)

STWKADMNDK FTVVSNFGNK PNVCFFGLFD GHHGASAAEL TSMELPVLLL HQLSKFDPSY 60

QMTTDEQQII NSFYTVFREE YAAIEDLFSA INKTEAVRCE YEDTHKAFAK AFWRMDRLLG 120

LGRKEVSRVQ WSGCSAVTCI LEGKPKSPYA HKNWKRKNTH DGLAESSPSQ EMPKIISGIL 180

HVANTGNVQA VLCRNGKGFC LTKEHTTRNT NERRRILQNG AVISSNEPYG LVEGQVKTTR 240

GLGFHGNLKL KKSIIPAPQT ISVPIDDLCQ FLIVATNGLW EVLDKEEVTA LAMTT 295

Keyword

Alternative splicing; Complete proteome; Polymorphism; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>