EKS-HOS-00069

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00069

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	369.1	6.7E-110	39	323	285

Status

Reviewed

Ensembl Protein

ENSP00000338673

UniProt Accession

Q15131; A8MXU6; B7Z420; D3DX82; D3DX83; Q0VGZ7; Q15130; Q6PJC0;

Protein Name

Cyclin-dependent kinase 10

Protein Synonyms/Alias

Cell division protein kinase 10; Serine/threonine-protein kinase PISSLRE;

Gene Name

CDK10

Gene Synonyms/Alias

CDK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000185324	ENSP00000426102	ENST00000511415
ENSG00000185324	ENSP00000424415	ENST00000505473
ENSG00000185324	ENSP00000423370	ENST00000508723
ENSG00000185324	ENSP00000338673	ENST00000353379
ENSG00000185324	ENSP00000426264	ENST00000512912
ENSG00000185324	ENSP00000421597	ENST00000502547
ENSG00000185324	ENSP00000457055	ENST00000564192
ENSG00000185324	ENSP00000456788	ENST00000565470
ENSG00000185324	ENSP00000455976	ENST00000510811
ENSG00000185324	ENSP00000329957	ENST00000331006

Organism

Homo sapiens

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ 60

TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC 120

EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHRNFII HRDLKVSNLL MTDKGCVKTA 180

DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHRPLLP 240

GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LVGQYSLRKQ PYNNLKHKFP WLSEAGLRLL 300

HFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAT SEGQSKRCKP 360

Nucleotide Sequence
(FASTA)

ATGGCGGAGC CAGATCTGGA GTGCGAGCAG ATCCGTCTGA AGTGTATTCG TAAGGAGGGC 60

TTCTTCACGG TGCCTCCGGA ACACAGGCTG GGACGATGCC GGAGTGTGAA GGAGTTTGAG 120

AAGCTGAACC GCATTGGAGA GGGTACCTAC GGCATTGTGT ATCGGGCCCG GGACACCCAG 180

ACAGATGAGA TTGTCGCACT GAAGAAGGTG CGGATGGACA AGGAGAAGGA TGGCATCCCC 240

ATCAGCAGCT TGCGGGAGAT CACGCTGCTG CTCCGCCTGC GTCATCCGAA CATCGTGGAG 300

CTGAAGGAGG TGGTTGTGGG GAACCACCTG GAGAGCATCT TCCTGGTGAT GGGTTACTGT 360

GAGCAGGACC TGGCCAGCCT CCTGGAGAAT ATGCCAACAC CCTTCTCGGA GGCTCAGGTC 420

AAGTGCATCG TGCTGCAGGT GCTCCGGGGC CTCCAGTATC TGCACAGGAA CTTCATTATC 480

CACAGGGACC TGAAGGTTTC CAACTTGCTC ATGACCGACA AGGGTTGTGT GAAGACAGCG 540

GATTTCGGCC TGGCCCGGGC CTATGGTGTC CCAGTAAAGC CAATGACCCC CAAGGTGGTC 600

ACTCTCTGGT ACCGAGCCCC TGAACTGCTG TTGGGAACCA CCACGCAGAC CACCAGCATC 660

GACATGTGGG CTGTGGGCTG CATACTGGCC GAGCTGCTGG CGCACAGGCC TCTTCTCCCC 720

GGCACTTCCG AGATCCACCA GATCGACTTG ATCGTGCAGC TGCTGGGCAC GCCCAGTGAG 780

AACATCTGGC CGGGCTTTTC CAAGCTGCCA CTGGTCGGCC AGTACAGCCT CCGGAAGCAG 840

CCCTACAACA ACCTGAAGCA CAAGTTCCCA TGGCTGTCGG AGGCCGGGCT GCGCCTGCTG 900

CACTTCCTGT TCATGTACGA CCCTAAGAAA AGGGCGACGG CCGGGGACTG CCTGGAGAGC 960

TCCTATTTCA AGGAGAAGCC CCTACCCTGT GAGCCGGAGC TCATGCCGAC CTTTCCCCAC 1020

CACCGCAACA AGCGGGCCGC CCCAGCCACC TCCGAGGGCC AGAGCAAGCG CTGTAAACCC 1080

TGA 1083

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d++t+e+vAlKk+r++kek+g+pi++lrEi+ll +l+h+ni

Q: 39    FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNI  98

         89**********************************************************

S: 61    vkLlevvakdk.kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++++Lv+ ++eqdL++ll+++++  +s+++vk ++lq+l+gl+ylH+n

Q: 99    VELKEVVVGNHlESIFLVMGYCEQDLASLLENMPT-PFSEAQVKCIVLQVLRGLQYLHRN  157

         ********5555***********************.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          i+HRDlK +NlL++++g++k aDfGlara+++p+k +t++vvTlwYraPelLlg+++ +

Q: 158   FIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQT  217

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         t++D+W+vgcilaell+++pl++g+sei+q++ i++llgtpse++wp++sklp +  +s+

Q: 218   TSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGqYSL  277

         *******************************************************988**

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk+k++ l+e++l+ll+ l+++dpkkR +a ++l+++yf

Q: 278   RKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF  323

         *********************************************8

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD TQTDEIVALK KVRMDKEKDG IPISSLREIT LLLRLRHPNI 60

VELKEVVVGN HLESIFLVMG YCEQDLASLL ENMPTPFSEA QVKCIVLQVL RGLQYLHRNF 120

IIHRDLKVSN LLMTDKGCVK TADFGLARAY GVPVKPMTPK VVTLWYRAPE LLLGTTTQTT 180

SIDMWAVGCI LAELLAHRPL LPGTSEIHQI DLIVQLLGTP SENIWPGFSK LPLVGQYSLR 240

KQPYNNLKHK FPWLSEAGLR LLHFLFMYDP KKRATAGDCL ESSYF 285

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0008285	; P:negative regulation of cell proliferation
GO:0007089	; P:traversing start control point of mitotic cell cycle

KEGG

hsa:8558

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013