Tag | Content |
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EKPD ID | EPS-HOS-00131 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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PPP/PP1 | 413.9 | 4.5E-124 | 58 | 251 | 194 |
|
Status | Reviewed |
Ensembl Protein | ENSP00000448981 |
UniProt Accession | P36873; |
Protein Name | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit |
Protein Synonyms/Alias | PP-1G; Protein phosphatase 1C catalytic subunit; |
Gene Name | PPP1CC |
Gene Synonyms/Alias | PPP1CC; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | Protein phosphatase that associates with over 200regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. |
Protein Length | 304 |
Protein Sequence (FASTA) | MADLDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP ILLELEAPLK 60 | ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL 120 | LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL 180 | QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD 240 | LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQVEHAFN 300 | MISF 304 |
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Nucleotide Sequence (FASTA) | ATGGCGGATT TAGATAAACT CAACATCGAC AGCATTATCC AACGGCTGCT GGAAGTGAGA 60 | GGGTCCAAGC CTGGTAAGAA TGTCCAGCTT CAGGAGAATG AAATCAGAGG ACTGTGCTTA 120 | AAGTCTCGTG AAATCTTTCT CAGTCAGCCT ATCCTACTAG AACTTGAAGC ACCACTCAAA 180 | ATATGTGGTG ACATCCATGG ACAATACTAT GATTTGCTGC GACTTTTTGA GTACGGTGGT 240 | TTCCCACCAG AAAGCAACTA CCTGTTTCTT GGGGACTATG TGGACAGGGG AAAGCAGTCA 300 | TTGGAGACGA TCTGCCTCTT ACTGGCCTAC AAAATAAAAT ATCCTGAGAA TTTTTTTCTT 360 | CTCAGAGGGA ACCATGAATG TGCCAGCATC AACAGAATTT ATGGATTTTA TGATGAATGT 420 | AAAAGAAGAT ACAACATTAA ACTATGGAAA ACTTTCACAG ACTGTTTTAA CTGTTTACCG 480 | ATAGCAGCCA TCGTGGATGA GAAGATATTC TGCTGTCATG GAGGTTTATC ACCAGATCTT 540 | CAATCTATGG AGCAGATTCG GCGAATTATG CGACCAACTG ATGTACCAGA TCAAGGTCTT 600 | CTTTGTGATC TTTTGTGGTC TGACCCCGAT AAAGATGTCT TAGGCTGGGG TGAAAATGAC 660 | AGAGGAGTGT CCTTCACATT TGGTGCAGAA GTGGTTGCAA AATTTCTCCA TAAGCATGAT 720 | TTGGATCTTA TATGTAGAGC CCATCAGGTG GTTGAAGATG GATATGAATT TTTTGCAAAG 780 | AGGCAGTTGG TCACTCTGTT TTCTGCGCCC AATTATTGCG GAGAGTTTGA CAATGCAGGT 840 | GCCATGATGA GTGTGGATGA AACACTAATG TGTTCTTTTC AGGTAGAGCA TGCTTTCAAC 900 | ATGATTTCCT TTTAA 915 |
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Domain Profile | S: 1 pvkicgdihgqykdllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypen 60 | p+kicgdihgqy+dllrlfeyggfppe+nylflgdyvdrgkqsleticlllaykikypen | Q: 58 PLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPEN 117 | 89********************************************************** |
| S: 61 ffllrgnhesasinriygfydeckrrynvklwktftdcfnclpvaaiidekilcvhggls 120 | ffllrgnhe+asinriygfydeckrryn+klwktftdcfnclp+aai+deki+c+hggls | Q: 118 FFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLS 177 | ************************************************************ |
| S: 121 pdlksleqirrikrptdvpdegllcdllwsdpdkdvkgwgendrgvsftfgadvvakflk 180 | pdl+s+eqirri+rptdvpd+gllcdllwsdpdkdv gwgendrgvsftfga+vvakfl+ | Q: 178 PDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLH 237 | ************************************************************ |
| S: 181 khdldlicrahqvv 194 | khdldlicrahqvv | Q: 238 KHDLDLICRAHQVV 251 | *************8 |
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Domain Sequence (FASTA) | PLKICGDIHG QYYDLLRLFE YGGFPPESNY LFLGDYVDRG KQSLETICLL LAYKIKYPEN 60 | FFLLRGNHEC ASINRIYGFY DECKRRYNIK LWKTFTDCFN CLPIAAIVDE KIFCCHGGLS 120 | PDLQSMEQIR RIMRPTDVPD QGLLCDLLWS DPDKDVLGWG ENDRGVSFTF GAEVVAKFLH 180 | KHDLDLICRA HQVV 194 |
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Keyword | 3D-structure; Acetylation; Alternative splicing; Carbohydrate metabolism; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Glycogen metabolism; Hydrolase; Iron; Kinetochore; Manganese; Metal-binding; Mitochondrion; Nucleus; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |