EPS-HOS-00131
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-HOS-00131
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
PPP/PP1413.94.5E-12458251194
StatusReviewed
Ensembl ProteinENSP00000448981
UniProt AccessionP36873;
Protein NameSerine/threonine-protein phosphatase PP1-gamma catalytic subunit
Protein Synonyms/Alias PP-1G; Protein phosphatase 1C catalytic subunit;
Gene NamePPP1CC
Gene Synonyms/Alias PPP1CC;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000186298ENSP00000449986ENST00000553024
ENSG00000186298ENSP00000448981ENST00000550991
ENSG00000186298ENSP00000447122ENST00000546933
ENSG00000186298ENSP00000448437ENST00000551676
ENSG00000186298ENSP00000341779ENST00000340766
ENSG00000186298ENSP00000447090ENST00000551582
ENSG00000186298ENSP00000447528ENST00000550261
ENSG00000186298ENSP00000335084ENST00000335007
OrganismHomo sapiens
Functional DescriptionProtein phosphatase that associates with over 200regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
Protein Length304
Protein Sequence
(FASTA)
MADLDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP ILLELEAPLK 60
ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL 120
LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL 180
QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD 240
LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQVEHAFN 300
MISF 304
Nucleotide Sequence
(FASTA)
ATGGCGGATT TAGATAAACT CAACATCGAC AGCATTATCC AACGGCTGCT GGAAGTGAGA 60
GGGTCCAAGC CTGGTAAGAA TGTCCAGCTT CAGGAGAATG AAATCAGAGG ACTGTGCTTA 120
AAGTCTCGTG AAATCTTTCT CAGTCAGCCT ATCCTACTAG AACTTGAAGC ACCACTCAAA 180
ATATGTGGTG ACATCCATGG ACAATACTAT GATTTGCTGC GACTTTTTGA GTACGGTGGT 240
TTCCCACCAG AAAGCAACTA CCTGTTTCTT GGGGACTATG TGGACAGGGG AAAGCAGTCA 300
TTGGAGACGA TCTGCCTCTT ACTGGCCTAC AAAATAAAAT ATCCTGAGAA TTTTTTTCTT 360
CTCAGAGGGA ACCATGAATG TGCCAGCATC AACAGAATTT ATGGATTTTA TGATGAATGT 420
AAAAGAAGAT ACAACATTAA ACTATGGAAA ACTTTCACAG ACTGTTTTAA CTGTTTACCG 480
ATAGCAGCCA TCGTGGATGA GAAGATATTC TGCTGTCATG GAGGTTTATC ACCAGATCTT 540
CAATCTATGG AGCAGATTCG GCGAATTATG CGACCAACTG ATGTACCAGA TCAAGGTCTT 600
CTTTGTGATC TTTTGTGGTC TGACCCCGAT AAAGATGTCT TAGGCTGGGG TGAAAATGAC 660
AGAGGAGTGT CCTTCACATT TGGTGCAGAA GTGGTTGCAA AATTTCTCCA TAAGCATGAT 720
TTGGATCTTA TATGTAGAGC CCATCAGGTG GTTGAAGATG GATATGAATT TTTTGCAAAG 780
AGGCAGTTGG TCACTCTGTT TTCTGCGCCC AATTATTGCG GAGAGTTTGA CAATGCAGGT 840
GCCATGATGA GTGTGGATGA AACACTAATG TGTTCTTTTC AGGTAGAGCA TGCTTTCAAC 900
ATGATTTCCT TTTAA 915
Domain Profile
S: 1     pvkicgdihgqykdllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypen  60
         p+kicgdihgqy+dllrlfeyggfppe+nylflgdyvdrgkqsleticlllaykikypen
Q: 58    PLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPEN  117
         89**********************************************************
S: 61    ffllrgnhesasinriygfydeckrrynvklwktftdcfnclpvaaiidekilcvhggls  120
         ffllrgnhe+asinriygfydeckrryn+klwktftdcfnclp+aai+deki+c+hggls
Q: 118   FFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLS  177
         ************************************************************
S: 121   pdlksleqirrikrptdvpdegllcdllwsdpdkdvkgwgendrgvsftfgadvvakflk  180
         pdl+s+eqirri+rptdvpd+gllcdllwsdpdkdv gwgendrgvsftfga+vvakfl+
Q: 178   PDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLH  237
         ************************************************************
S: 181   khdldlicrahqvv  194
         khdldlicrahqvv
Q: 238   KHDLDLICRAHQVV  251
         *************8
Domain Sequence
(FASTA)
PLKICGDIHG QYYDLLRLFE YGGFPPESNY LFLGDYVDRG KQSLETICLL LAYKIKYPEN 60
FFLLRGNHEC ASINRIYGFY DECKRRYNIK LWKTFTDCFN CLPIAAIVDE KIFCCHGGLS 120
PDLQSMEQIR RIMRPTDVPD QGLLCDLLWS DPDKDVLGWG ENDRGVSFTF GAEVVAKFLH 180
KHDLDLICRA HQVV 194
Keyword3D-structure; Acetylation; Alternative splicing; Carbohydrate metabolism; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Glycogen metabolism; Hydrolase; Iron; Kinetochore; Manganese; Metal-binding; Mitochondrion; Nucleus; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0032154; C:cleavage furrow
GO:0000777; C:condensed chromosome kinetochore
GO:0005829; C:cytosol
GO:0030496; C:midbody
GO:0005741; C:mitochondrial outer membrane
GO:0005739; C:mitochondrion
GO:0070688; C:MLL5-L complex
GO:0016607; C:nuclear speck
GO:0005730; C:nucleolus
GO:0072357; C:PTW/PP1 phosphatase complex
GO:0046872; F:metal ion binding
GO:0004722; F:protein serine/threonine phosphatase activity
GO:0051301; P:cell division
GO:0005977; P:glycogen metabolic process
GO:0000236; P:mitotic prometaphase
GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0006470; P:protein dephosphorylation
GO:0046822; P:regulation of nucleocytoplasmic transport
GO:0044281; P:small molecule metabolic process
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0019433; P:triglyceride catabolic process
KEGG
hsa:5501;
InterPros
IPR004843; Metallo_PEstase_dom.
IPR006186; Ser/Thr-sp_prot-phosphatase.
Pfam
PF00149; Metallophos; 1.
SMARTs
SM00156; PP2Ac; 1.
Prosites
PS00125; SER_THR_PHOSPHATASE; 1.
Prints
PR00114; STPHPHTASE.
Created Date20-Feb-2013