EKS-HOS-00225
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00225
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF1409.52.7E-12253313261
StatusReviewed
Ensembl ProteinENSP00000343248
UniProt AccessionQ52WX2;
Protein NameSerine/threonine-protein kinase SBK1
Protein Synonyms/Alias SH3-binding kinase 1;
Gene NameSBK1
Gene Synonyms/Alias SBK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000188322ENSP00000343248ENST00000341901
OrganismHomo sapiens
Functional DescriptionMay be involved in signal-transduction pathways relatedto the control of brain development (By similarity).
Protein Length424
Protein Sequence
(FASTA)
MSVGCPEPEP PRSLTCCGPG TAPGPGAGVP LLTEDMQALT LRTLAASDVT KHYELVRELG 60
KGTYGKVDLV VYKGTGTKMA LKFVNKSKTK LKNFLREVSI TNSLSSSPFI IKVFDVVFET 120
EDCYVFAQEY APAGDLFDII PPQVGLPEDT VKRCVQQLGL ALDFMHGRQL VHRDIKPENV 180
LLFDRECRRV KLADFGMTRR VGCRVKRVSG TIPYTAPEVC QAGRADGLAV DTGVDVWAFG 240
VLIFCVLTGN FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP 300
ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRPPAA GPLRLEAPGP LKRTVLTESG 360
SGSRPAPPAV GSVPLPVPVP VPVPVPVPVP EPGLAPQGPP GRTDGRADKS KGQVVLATAI 420
EICV 424
Nucleotide Sequence
(FASTA)
ATGAGCGTGG GCTGCCCAGA GCCTGAGCCG CCCCGCTCCC TGACCTGCTG TGGGCCGGGG 60
ACTGCCCCTG GGCCTGGTGC CGGTGTGCCC CTTCTCACTG AAGACATGCA GGCCCTGACT 120
CTCCGCACAC TGGCCGCCAG CGACGTCACC AAGCACTACG AACTAGTCCG GGAGCTGGGC 180
AAAGGCACCT ATGGGAAGGT TGACCTGGTG GTCTACAAGG GCACAGGCAC AAAAATGGCA 240
CTGAAGTTTG TGAACAAGAG CAAAACCAAG CTGAAGAACT TCCTACGGGA GGTGAGCATC 300
ACCAACAGCC TCTCCTCCAG CCCCTTCATC ATCAAGGTCT TTGACGTGGT CTTTGAGACA 360
GAGGACTGCT ACGTCTTTGC CCAGGAGTAC GCACCTGCTG GGGACCTGTT TGACATCATC 420
CCTCCCCAGG TGGGGCTCCC TGAGGACACG GTGAAGCGCT GTGTGCAGCA GCTGGGCCTG 480
GCGCTGGACT TCATGCACGG GCGGCAGCTG GTGCACCGCG ACATCAAGCC CGAGAACGTG 540
CTGCTGTTCG ACCGCGAGTG CCGCCGCGTA AAGCTGGCCG ACTTCGGCAT GACGCGCCGC 600
GTGGGCTGCC GCGTCAAGCG CGTGAGCGGC ACCATCCCTT ACACGGCGCC TGAGGTGTGC 660
CAGGCGGGCC GCGCCGACGG GCTGGCGGTG GACACGGGCG TGGACGTGTG GGCCTTCGGC 720
GTGCTCATCT TCTGCGTGCT CACCGGCAAC TTCCCGTGGG AGGCGGCGTC GGGCGCCGAC 780
GCCTTCTTCG AGGAGTTCGT GCGCTGGCAG CGGGGCCGCC TGCCGGGGCT GCCTTCGCAG 840
TGGCGCCGCT TCACCGAGCC CGCGCTGCGC ATGTTCCAGC GCTTACTGGC CCTGGAGCCC 900
GAGCGCCGCG GCCCAGCCAA GGAGGTGTTC CGCTTCCTCA AGCACGAGCT CACGTCCGAG 960
CTGCGCCGCC GGCCCTCGCA CCGCGCGCGC AAGCCCCCCG GGGACCGCCC GCCCGCCGCC 1020
GGGCCACTGC GCCTCGAGGC GCCTGGGCCG CTCAAGCGGA CGGTGCTGAC CGAGAGCGGC 1080
AGCGGCTCCC GGCCCGCGCC CCCCGCCGTC GGGTCGGTGC CCTTGCCCGT GCCGGTGCCG 1140
GTGCCAGTGC CCGTGCCGGT GCCTGTGCCC GAGCCCGGCC TAGCTCCCCA GGGGCCCCCC 1200
GGCCGGACCG ACGGCCGCGC GGACAAGAGC AAAGGGCAGG TGGTGCTGGC CACGGCCATC 1260
GAGATCTGCG TCTGA 1275
Domain Profile
S: 1     yelvrklgeGsfgkvlLvehrqsgtkvalKllpkektklkdFlrEfsvglslsshsaivk  60
         yelvr+lg+G++gkv+Lv ++++gtk+alK+++k+ktklk+FlrE+s+++slss+++i+k
Q: 53    YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIK  112
         9***********************************************************
S: 61    tydvaletadayvFaqEyaplgdLaeaiqekvGlpeaavkrvvaqlasAldflHsrnlvh  120
         ++dv++et+d+yvFaqEyap+gdL+++i+++vGlpe++vkr+v+ql+ Aldf+H+r+lvh
Q: 113   VFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVH  172
         ************************************************************
S: 121   rdlKpenvLvfdpdcsrvkltDfGltrkkgslvkkkeevipytapelcelvkeeklkvdp  180
         rd+KpenvL+fd++c+rvkl+DfG+tr++g++vk+++ +ipytape+c++ ++++l+vd+
Q: 173   RDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDT  232
         ************************************************************
S: 181   svDvWalGvllfvvltgkfPWdkasleadpfyeeflkwqkrklrklPkkfkrlsekalrl  240
         +vDvWa+Gvl+f+vltg+fPW++a + ad+f+eef++wq+++l+ lP++++r++e+alr+
Q: 233   GVDVWAFGVLIFCVLTGNFPWEAA-SGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRM  291
         ************************.9**********************************
S: 241   lkklldlepedrskakevakfl  262
         +++ll+lepe+r +akev++fl
Q: 292   FQRLLALEPERRGPAKEVFRFL  313
         *******************997
Domain Sequence
(FASTA)
YELVRELGKG TYGKVDLVVY KGTGTKMALK FVNKSKTKLK NFLREVSITN SLSSSPFIIK 60
VFDVVFETED CYVFAQEYAP AGDLFDIIPP QVGLPEDTVK RCVQQLGLAL DFMHGRQLVH 120
RDIKPENVLL FDRECRRVKL ADFGMTRRVG CRVKRVSGTI PYTAPEVCQA GRADGLAVDT 180
GVDVWAFGVL IFCVLTGNFP WEAASGADAF FEEFVRWQRG RLPGLPSQWR RFTEPALRMF 240
QRLLALEPER RGPAKEVFRF L 261
KeywordATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00209
EKS-BOT-00219
EKS-CAE-00185
EKS-CAJ-00226
EKS-CAF-00227
EKS-CAP-00242
EKS-DAR-00529
EKS-DRM-00111
EKS-EQC-00211
EKS-GAG-00183
EKS-GAA-00268
EKS-GOG-00216
EKS-ICT-00209
EKS-LAC-00229
EKS-LOA-00219
EKS-MAM-00219
EKS-MAE-00081
EKS-MEG-00167
EKS-MIM-00101
EKS-MOD-00216
EKS-MUM-00221
EKS-NOL-00202
EKS-OCP-00142
EKS-ORN-00284
EKS-ORA-00194
EKS-ORL-00259
EKS-OTG-00223
EKS-PAT-00209
EKS-PEM-00114
EKS-POA-00211
EKS-PTV-00189
EKS-RAN-00211
EKS-SUS-00191
EKS-TAG-00237
EKS-TAR-00277
EKS-TEN-00277
EKS-XET-00241
EKS-XIM-00271
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007420; P:brain development
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
KEGG
hsa:388228;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR016234; Ser/Thr_kinase_Sbk1.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013