EKS-HOS-00124

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00124

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	371.1	1.5E-110	1884	2131	248

Status

Reviewed

Ensembl Protein

ENSP00000298910

UniProt Accession

Q5S007; A6NJU2; Q6ZS50; Q8NCX9;

Protein Name

Leucine-rich repeat serine/threonine-protein kinase 2

Protein Synonyms/Alias

Dardarin;

Gene Name

LRRK2

Gene Synonyms/Alias

LRRK2; PARK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000188906	ENSP00000398726	ENST00000416796
ENSG00000188906	ENSP00000341930	ENST00000343742
ENSG00000188906	ENSP00000298910	ENST00000298910
ENSG00000188906	ENSP00000410821	ENST00000430804

Organism

Homo sapiens

Functional Description

May play a role in the phosphorylation of proteinscentral to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes.

Protein Length

2527

Protein Sequence
(FASTA)

MASGSCQGCE EDEETLKKLI VRLNNVQEGK QIETLVQILE DLLVFTYSER ASKLFQGKNI 60

HVPLLIVLDS YMRVASVQQV GWSLLCKLIE VCPGTMQSLM GPQDVGNDWE VLGVHQLILK 120

MLTVHNASVN LSVIGLKTLD LLLTSGKITL LILDEESDIF MLIFDAMHSF PANDEVQKLG 180

CKALHVLFER VSEEQLTEFV ENKDYMILLS ALTNFKDEEE IVLHVLHCLH SLAIPCNNVE 240

VLMSGNVRCY NIVVEAMKAF PMSERIQEVS CCLLHRLTLG NFFNILVLNE VHEFVVKAVQ 300

QYPENAALQI SALSCLALLT ETIFLNQDLE EKNENQENDD EGEEDKLFWL EACYKALTWH 360

RKNKHVQEAA CWALNNLLMY QNSLHEKIGD EDGHFPAHRE VMLSMLMHSS SKEVFQASAN 420

ALSTLLEQNV NFRKILLSKG IHLNVLELMQ KHIHSPEVAE SGCKMLNHLF EGSNTSLDIM 480

AAVVPKILTV MKRHETSLPV QLEALRAILH FIVPGMPEES REDTEFHHKL NMVKKQCFKN 540

DIHKLVLAAL NRFIGNPGIQ KCGLKVISSI VHFPDALEML SLEGAMDSVL HTLQMYPDDQ 600

EIQCLGLSLI GYLITKKNVF IGTGHLLAKI LVSSLYRFKD VAEIQTKGFQ TILAILKLSA 660

SFSKLLVHHS FDLVIFHQMS SNIMEQKDQQ FLNLCCKCFA KVAMDDYLKN VMLERACDQN 720

NSIMVECLLL LGADANQAKE GSSLICQVCE KESSPKLVEL LLNSGSREQD VRKALTISIG 780

KGDSQIISLL LRRLALDVAN NSICLGGFCI GKVEPSWLGP LFPDKTSNLR KQTNIASTLA 840

RMVIRYQMKS AVEEGTASGS DGNFSEDVLS KFDEWTFIPD SSMDSVFAQS DDLDSEGSEG 900

SFLVKKKSNS ISVGEFYRDA VLQRCSPNLQ RHSNSLGPIF DHEDLLKRKR KILSSDDSLR 960

SSKLQSHMRH SDSISSLASE REYITSLDLS ANELRDIDAL SQKCCISVHL EHLEKLELHQ 1020

NALTSFPQQL CETLKSLTHL DLHSNKFTSF PSYLLKMSCI ANLDVSRNDI GPSVVLDPTV 1080

KCPTLKQFNL SYNQLSFVPE NLTDVVEKLE QLILEGNKIS GICSPLRLKE LKILNLSKNH 1140

ISSLSENFLE ACPKVESFSA RMNFLAAMPF LPPSMTILKL SQNKFSCIPE AILNLPHLRS 1200

LDMSSNDIQY LPGPAHWKSL NLRELLFSHN QISILDLSEK AYLWSRVEKL HLSHNKLKEI 1260

PPEIGCLENL TSLDVSYNLE LRSFPNEMGK LSKIWDLPLD ELHLNFDFKH IGCKAKDIIR 1320

FLQQRLKKAV PYNRMKLMIV GNTGSGKTTL LQQLMKTKKS DLGMQSATVG IDVKDWPIQI 1380

RDKRKRDLVL NVWDFAGREE FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA 1440

RASSSPVILV GTHLDVSDEK QRKACMSKIT KELLNKRGFP AIRDYHFVNA TEESDALAKL 1500

RKTIINESLN FKIRDQLVVG QLIPDCYVEL EKIILSERKN VPIEFPVIDR KRLLQLVREN 1560

QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP KWLCKIMAQI LTVKVEGCPK 1620

HPKGIISRRD VEKFLSKKRK FPKNYMSQYF KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI 1680

ELPHCENSEI IIRLYEMPYF PMGFWSRLIN RLLEISPYML SGRERALRPN RMYWRQGIYL 1740

NWSPEAYCLV GSEVLDNHPE SFLKITVPSC RKGCILLGQV VDHIDSLMEE WFPGLLEIDI 1800

CGEGETLLKK WALYSFNDGE EHQKILLDDL MKKAEEGDLL VNPDQPRLTI PISQIAPDLI 1860

LADLPRNIML NNDELEFEQA PEFLLGDGSF GSVYRAAYEG EEVAVKIFNK HTSLRLLRQE 1920

LVVLCHLHHP SLISLLAAGI RPRMLVMELA SKGSLDRLLQ QDKASLTRTL QHRIALHVAD 1980

GLRYLHSAMI IYRDLKPHNV LLFTLYPNAA IIAKIADYGI AQYCCRMGIK TSEGTPGFRA 2040

PEVARGNVIY NQQADVYSFG LLLYDILTTG GRIVEGLKFP NEFDELEIQG KLPDPVKEYG 2100

CAPWPMVEKL IKQCLKENPQ ERPTSAQVFD ILNSAELVCL TRRILLPKNV IVECMVATHH 2160

NSRNASIWLG CGHTDRGQLS FLDLNTEGYT SEEVADSRIL CLALVHLPVE KESWIVSGTQ 2220

SGTLLVINTE DGKKRHTLEK MTDSVTCLYC NSFSKQSKQK NFLLVGTADG KLAIFEDKTV 2280

KLKGAAPLKI LNIGNVSTPL MCLSESTNST ERNVMWGGCG TKIFSFSNDF TIQKLIETRT 2340

SQLFSYAAFS DSNIITVVVD TALYIAKQNS PVVEVWDKKT EKLCGLIDCV HFLREVMVKE 2400

NKESKHKMSY SGRVKTLCLQ KNTALWIGTG GGHILLLDLS TRRLIRVIYN FCNSVRVMMT 2460

AQLGSLKNVM LVLGYNRKNT EGTQKQKEIQ SCLTVWDINL PHEVQNLEKH IEVRKELAEK 2520

MRRTSVE 2527

Nucleotide Sequence
(FASTA)

ATGGCTAGTG GCAGCTGTCA GGGGTGCGAA GAGGACGAGG AAACTCTGAA GAAGTTGATA 60

GTCAGGCTGA ACAATGTCCA GGAAGGAAAA CAGATAGAAA CGCTGGTCCA AATCCTGGAG 120

GATCTGCTGG TGTTCACGTA CTCCGAGCGC GCCTCCAAGT TATTTCAAGG CAAAAATATC 180

CATGTGCCTC TGTTGATCGT CTTGGACTCC TATATGAGAG TCGCGAGTGT GCAGCAGGTG 240

GGTTGGTCAC TTCTGTGCAA ATTAATAGAA GTCTGTCCAG GTACAATGCA AAGCTTAATG 300

GGACCCCAGG ATGTTGGAAA TGATTGGGAA GTCCTTGGTG TTCACCAATT GATTCTTAAA 360

ATGCTAACAG TTCATAATGC CAGTGTAAAC TTGTCAGTGA TTGGACTGAA GACCTTAGAT 420

CTCCTCCTAA CTTCAGGTAA AATCACCTTG CTGATATTGG ATGAAGAAAG TGATATTTTC 480

ATGTTAATTT TTGATGCCAT GCACTCATTT CCAGCCAATG ATGAAGTCCA GAAACTTGGA 540

TGCAAAGCTT TACATGTGCT GTTTGAGAGA GTCTCAGAGG AGCAACTGAC TGAATTTGTT 600

GAGAACAAAG ATTATATGAT ATTGTTAAGT GCGTTAACAA ATTTTAAAGA TGAAGAGGAA 660

ATTGTGCTTC ATGTGCTGCA TTGTTTACAT TCCCTAGCGA TTCCTTGCAA TAATGTGGAA 720

GTCCTCATGA GTGGCAATGT CAGGTGTTAT AATATTGTGG TGGAAGCTAT GAAAGCATTC 780

CCTATGAGTG AAAGAATTCA AGAAGTGAGT TGCTGTTTGC TCCATAGGCT TACATTAGGT 840

AATTTTTTCA ATATCCTGGT ATTAAACGAA GTCCATGAGT TTGTGGTGAA AGCTGTGCAG 900

CAGTACCCAG AGAATGCAGC ATTGCAGATC TCAGCGCTCA GCTGTTTGGC CCTCCTCACT 960

GAGACTATTT TCTTAAATCA AGATTTAGAG GAAAAGAATG AGAATCAAGA GAATGATGAT 1020

GAGGGGGAAG AAGATAAATT GTTTTGGCTG GAAGCCTGTT ACAAAGCATT AACGTGGCAT 1080

AGAAAGAACA AGCACGTGCA GGAGGCCGCA TGCTGGGCAC TAAATAATCT CCTTATGTAC 1140

CAAAACAGTT TACATGAGAA GATTGGAGAT GAAGATGGCC ATTTCCCAGC TCATAGGGAA 1200

GTGATGCTCT CCATGCTGAT GCATTCTTCA TCAAAGGAAG TTTTCCAGGC ATCTGCGAAT 1260

GCATTGTCAA CTCTCTTAGA ACAAAATGTT AATTTCAGAA AAATACTGTT ATCAAAAGGA 1320

ATACACCTGA ATGTTTTGGA GTTAATGCAG AAGCATATAC ATTCTCCTGA AGTGGCTGAA 1380

AGTGGCTGTA AAATGCTAAA TCATCTTTTT GAAGGAAGCA ACACTTCCCT GGATATAATG 1440

GCAGCAGTGG TCCCCAAAAT ACTAACAGTT ATGAAACGTC ATGAGACATC ATTACCAGTG 1500

CAGCTGGAGG CGCTTCGAGC TATTTTACAT TTTATAGTGC CTGGCATGCC AGAAGAATCC 1560

AGGGAGGATA CAGAATTTCA TCATAAGCTA AATATGGTTA AAAAACAGTG TTTCAAGAAT 1620

GATATTCACA AACTGGTCCT AGCAGCTTTG AACAGGTTCA TTGGAAATCC TGGGATTCAG 1680

AAATGTGGAT TAAAAGTAAT TTCTTCTATT GTACATTTTC CTGATGCATT AGAGATGTTA 1740

TCCCTGGAAG GTGCTATGGA TTCAGTGCTT CACACACTGC AGATGTATCC AGATGACCAA 1800

GAAATTCAGT GTCTGGGTTT AAGTCTTATA GGATACTTGA TTACAAAGAA GAATGTGTTC 1860

ATAGGAACTG GACATCTGCT GGCAAAAATT CTGGTTTCCA GCTTATACCG ATTTAAGGAT 1920

GTTGCTGAAA TACAGACTAA AGGATTTCAG ACAATCTTAG CAATCCTCAA ATTGTCAGCA 1980

TCTTTTTCTA AGCTGCTGGT GCATCATTCA TTTGACTTAG TAATATTCCA TCAAATGTCT 2040

TCCAATATCA TGGAACAAAA GGATCAACAG TTTCTAAACC TCTGTTGCAA GTGTTTTGCA 2100

AAAGTAGCTA TGGATGATTA CTTAAAAAAT GTGATGCTAG AGAGAGCGTG TGATCAGAAT 2160

AACAGCATCA TGGTTGAATG CTTGCTTCTA TTGGGAGCAG ATGCCAATCA AGCAAAGGAG 2220

GGATCTTCTT TAATTTGTCA GGTATGTGAG AAAGAGAGCA GTCCCAAATT GGTGGAACTC 2280

TTACTGAATA GTGGATCTCG TGAACAAGAT GTACGAAAAG CGTTGACGAT AAGCATTGGG 2340

AAAGGTGACA GCCAGATCAT CAGCTTGCTC TTAAGGAGGC TGGCCCTGGA TGTGGCCAAC 2400

AATAGCATTT GCCTTGGAGG ATTTTGTATA GGAAAAGTTG AACCTTCTTG GCTTGGTCCT 2460

TTATTTCCAG ATAAGACTTC TAATTTAAGG AAACAAACAA ATATAGCATC TACACTAGCA 2520

AGAATGGTGA TCAGATATCA GATGAAAAGT GCTGTGGAAG AAGGAACAGC CTCAGGCAGC 2580

GATGGAAATT TTTCTGAAGA TGTGCTGTCT AAATTTGATG AATGGACCTT TATTCCTGAC 2640

TCTTCTATGG ACAGTGTGTT TGCTCAAAGT GATGACCTGG ATAGTGAAGG AAGTGAAGGC 2700

TCATTTCTTG TGAAAAAGAA ATCTAATTCA ATTAGTGTAG GAGAATTTTA CCGAGATGCC 2760

GTATTACAGC GTTGCTCACC AAATTTGCAA AGACATTCCA ATTCCTTGGG GCCCATTTTT 2820

GATCATGAAG ATTTACTGAA GCGAAAAAGA AAAATATTAT CTTCAGATGA TTCACTCAGG 2880

TCATCAAAAC TTCAATCCCA TATGAGGCAT TCAGACAGCA TTTCTTCTCT GGCTTCTGAG 2940

AGAGAATATA TTACATCACT AGACCTTTCA GCAAATGAAC TAAGAGATAT TGATGCCCTA 3000

AGCCAGAAAT GCTGTATAAG TGTTCATTTG GAGCATCTTG AAAAGCTGGA GCTTCACCAG 3060

AATGCACTCA CGAGCTTTCC ACAACAGCTA TGTGAAACTC TGAAGAGTTT GACACATTTG 3120

GACTTGCACA GTAATAAATT TACATCATTT CCTTCTTATT TGTTGAAAAT GAGTTGTATT 3180

GCTAATCTTG ATGTCTCTCG AAATGACATT GGACCCTCAG TGGTTTTAGA TCCTACAGTG 3240

AAATGTCCAA CTCTGAAACA GTTTAACCTG TCATATAACC AGCTGTCTTT TGTACCTGAG 3300

AACCTCACTG ATGTGGTAGA GAAACTGGAG CAGCTCATTT TAGAAGGAAA TAAAATATCA 3360

GGGATATGCT CCCCCTTGAG ACTGAAGGAA CTGAAGATTT TAAACCTTAG TAAGAACCAC 3420

ATTTCATCCC TATCAGAGAA CTTTCTTGAG GCTTGTCCTA AAGTGGAGAG TTTCAGTGCC 3480

AGAATGAATT TTCTTGCTGC TATGCCTTTC TTGCCTCCTT CTATGACAAT CCTAAAATTA 3540

TCTCAGAACA AATTTTCCTG TATTCCAGAA GCAATTTTAA ATCTTCCACA CTTGCGGTCT 3600

TTAGATATGA GCAGCAATGA TATTCAGTAC CTACCAGGTC CCGCACACTG GAAATCTTTG 3660

AACTTAAGGG AACTCTTATT TAGCCATAAT CAGATCAGCA TCTTGGACTT GAGTGAAAAA 3720

GCATATTTAT GGTCTAGAGT AGAGAAACTG CATCTTTCTC ACAATAAACT GAAAGAGATT 3780

CCTCCTGAGA TTGGCTGTCT TGAAAATCTG ACATCTCTGG ATGTCAGTTA CAACTTGGAA 3840

CTAAGATCCT TTCCCAATGA AATGGGGAAA TTAAGCAAAA TATGGGATCT TCCTTTGGAT 3900

GAACTGCATC TTAACTTTGA TTTTAAACAT ATAGGATGTA AAGCCAAAGA CATCATAAGG 3960

TTTCTTCAAC AGCGATTAAA AAAGGCTGTG CCTTATAACC GAATGAAACT TATGATTGTG 4020

GGAAATACTG GGAGTGGTAA AACCACCTTA TTGCAGCAAT TAATGAAAAC CAAGAAATCA 4080

GATCTTGGAA TGCAAAGTGC CACAGTTGGC ATAGATGTGA AAGACTGGCC TATCCAAATA 4140

AGAGACAAAA GAAAGAGAGA TCTCGTCCTA AATGTGTGGG ATTTTGCAGG TCGTGAGGAA 4200

TTCTATAGTA CTCATCCCCA TTTTATGACG CAGCGAGCAT TGTACCTTGC TGTCTATGAC 4260

CTCAGCAAGG GACAGGCTGA AGTTGATGCC ATGAAGCCTT GGCTCTTCAA TATAAAGGCT 4320

CGCGCTTCTT CTTCCCCTGT GATTCTCGTT GGCACACATT TGGATGTTTC TGATGAGAAG 4380

CAACGCAAAG CCTGCATGAG TAAAATCACC AAGGAACTCC TGAATAAGCG AGGGTTCCCT 4440

GCCATACGAG ATTACCACTT TGTGAATGCC ACCGAGGAAT CTGATGCTTT GGCAAAACTT 4500

CGGAAAACCA TCATAAACGA GAGCCTTAAT TTCAAGATCC GAGATCAGCT TGTTGTTGGA 4560

CAGCTGATTC CAGACTGCTA TGTAGAACTT GAAAAAATCA TTTTATCGGA GCGTAAAAAT 4620

GTGCCAATTG AATTTCCCGT AATTGACCGG AAACGATTAT TACAACTAGT GAGAGAAAAT 4680

CAGCTGCAGT TAGATGAAAA TGAGCTTCCT CACGCAGTTC ACTTTCTAAA TGAATCAGGA 4740

GTCCTTCTTC ATTTTCAAGA CCCAGCACTG CAGTTAAGTG ACTTGTACTT TGTGGAACCC 4800

AAGTGGCTTT GTAAAATCAT GGCACAGATT TTGACAGTGA AAGTGGAAGG TTGTCCAAAA 4860

CACCCTAAGG GCATTATTTC GCGTAGAGAT GTGGAAAAAT TTCTTTCAAA AAAAAGGAAA 4920

TTTCCAAAGA ACTACATGTC ACAGTATTTT AAGCTCCTAG AAAAATTCCA GATTGCTTTG 4980

CCAATAGGAG AAGAATATTT GCTGGTTCCA AGCAGTTTGT CTGACCACAG GCCTGTGATA 5040

GAGCTTCCCC ATTGTGAGAA CTCTGAAATT ATCATCCGAC TATATGAAAT GCCTTATTTT 5100

CCAATGGGAT TTTGGTCAAG ATTAATCAAT CGATTACTTG AGATTTCACC TTACATGCTT 5160

TCAGGGAGAG AACGAGCACT TCGCCCAAAC AGAATGTATT GGCGACAAGG CATTTACTTA 5220

AATTGGTCTC CTGAAGCTTA TTGTCTGGTA GGATCTGAAG TCTTAGACAA TCATCCAGAG 5280

AGTTTCTTAA AAATTACAGT TCCTTCTTGT AGAAAAGGCT GTATTCTTTT GGGCCAAGTT 5340

GTGGACCACA TTGATTCTCT CATGGAAGAA TGGTTTCCTG GGTTGCTGGA GATTGATATT 5400

TGTGGTGAAG GAGAAACTCT GTTGAAGAAA TGGGCATTAT ATAGTTTTAA TGATGGTGAA 5460

GAACATCAAA AAATCTTACT TGATGACTTG ATGAAGAAAG CAGAGGAAGG AGATCTCTTA 5520

GTAAATCCAG ATCAACCAAG GCTCACCATT CCAATATCTC AGATTGCCCC TGACTTGATT 5580

TTGGCTGACC TGCCTAGAAA TATTATGTTG AATAATGATG AGTTGGAATT TGAACAAGCT 5640

CCAGAGTTTC TCCTAGGTGA TGGCAGTTTT GGATCAGTTT ACCGAGCAGC CTATGAAGGA 5700

GAAGAAGTGG CTGTGAAGAT TTTTAATAAA CATACATCAC TCAGGCTGTT AAGACAAGAG 5760

CTTGTGGTGC TTTGCCACCT CCACCACCCC AGTTTGATAT CTTTGCTGGC AGCTGGGATT 5820

CGTCCCCGGA TGTTGGTGAT GGAGTTAGCC TCCAAGGGTT CCTTGGATCG CCTGCTTCAG 5880

CAGGACAAAG CCAGCCTCAC TAGAACCCTA CAGCACAGGA TTGCACTCCA CGTAGCTGAT 5940

GGTTTGAGAT ACCTCCACTC AGCCATGATT ATATACCGAG ACCTGAAACC CCACAATGTG 6000

CTGCTTTTCA CACTGTATCC CAATGCTGCC ATCATTGCAA AGATTGCTGA CTACGGCATT 6060

GCTCAGTACT GCTGTAGAAT GGGGATAAAA ACATCAGAGG GCACACCAGG GTTTCGTGCA 6120

CCTGAAGTTG CCAGAGGAAA TGTCATTTAT AACCAACAGG CTGATGTTTA TTCATTTGGT 6180

TTACTACTCT ATGACATTTT GACAACTGGA GGTAGAATAG TAGAGGGTTT GAAGTTTCCA 6240

AATGAGTTTG ATGAATTAGA AATACAAGGA AAATTACCTG ATCCAGTTAA AGAATATGGT 6300

TGTGCCCCAT GGCCTATGGT TGAGAAATTA ATTAAACAGT GTTTGAAAGA AAATCCTCAA 6360

GAAAGGCCTA CTTCTGCCCA GGTCTTTGAC ATTTTGAATT CAGCTGAATT AGTCTGTCTG 6420

ACGAGACGCA TTTTATTACC TAAAAACGTA ATTGTTGAAT GCATGGTTGC TACACATCAC 6480

AACAGCAGGA ATGCAAGCAT TTGGCTGGGC TGTGGGCACA CCGACAGAGG ACAGCTCTCA 6540

TTTCTTGACT TAAATACTGA AGGATACACT TCTGAGGAAG TTGCTGATAG TAGAATATTG 6600

TGCTTAGCCT TGGTGCATCT TCCTGTTGAA AAGGAAAGCT GGATTGTGTC TGGGACACAG 6660

TCTGGTACTC TCCTGGTCAT CAATACCGAA GATGGGAAAA AGAGACATAC CCTAGAAAAG 6720

ATGACTGATT CTGTCACTTG TTTGTATTGC AATTCCTTTT CCAAGCAAAG CAAACAAAAA 6780

AATTTTCTTT TGGTTGGAAC CGCTGATGGC AAGTTAGCAA TTTTTGAAGA TAAGACTGTT 6840

AAGCTTAAAG GAGCTGCTCC TTTGAAGATA CTAAATATAG GAAATGTCAG TACTCCATTG 6900

ATGTGTTTGA GTGAATCCAC AAATTCAACG GAAAGAAATG TAATGTGGGG AGGATGTGGC 6960

ACAAAGATTT TCTCCTTTTC TAATGATTTC ACCATTCAGA AACTCATTGA GACAAGAACA 7020

AGCCAACTGT TTTCTTATGC AGCTTTCAGT GATTCCAACA TCATAACAGT GGTGGTAGAC 7080

ACTGCTCTCT ATATTGCTAA GCAAAATAGC CCTGTTGTGG AAGTGTGGGA TAAGAAAACT 7140

GAAAAACTCT GTGGACTAAT AGACTGCGTG CACTTTTTAA GGGAGGTAAT GGTAAAAGAA 7200

AACAAGGAAT CAAAACACAA AATGTCTTAT TCTGGGAGAG TGAAAACCCT CTGCCTTCAG 7260

AAGAACACTG CTCTTTGGAT AGGAACTGGA GGAGGCCATA TTTTACTCCT GGATCTTTCA 7320

ACTCGTCGAC TTATACGTGT AATTTACAAC TTTTGTAATT CGGTCAGAGT CATGATGACA 7380

GCACAGCTAG GAAGCCTTAA AAATGTCATG CTGGTATTGG GCTACAACCG GAAAAATACT 7440

GAAGGTACAC AAAAGCAGAA AGAGATACAA TCTTGCTTGA CCGTTTGGGA CATCAATCTT 7500

CCACATGAAG TGCAAAATTT AGAAAAACAC ATTGAAGTGA GAAAAGAATT AGCTGAAAAA 7560

ATGAGACGAA CATCTGTTGA GTAA 7584

Domain Profile

S: 6     llGrGafGsvyraavkGeevavkafkiaadklkrdslelalkayselrqelsvLlalkhP  65

         llG+G+fGsvyraa++Geevavk+f+      k++sl+l       lrqel+vL++l+hP

Q: 1884  LLGDGSFGSVYRAAYEGEEVAVKIFN------KHTSLRL-------LRQELVVLCHLHHP  1930

         79************************......*******.......**************

S: 66    sivsLvgisikPlalvleLaplgsLdrlLsedkksssklgrtltkkialqvargleyLhk  125

         s++sL++++i+P++lv+eLa++gsLdrlL++dk+s   l+rtl+++ial+va+gl+yLh+

Q: 1931  SLISLLAAGIRPRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHS  1987

         *********************************99...**********************

S: 126   kkiiyrdLksenvLvwslspkeailikladyGisrqslrsGakgveGteGfraPeivrge  185

         ++iiyrdLk++nvL+++l+p++ai++k+adyGi+++++r+G+k++eGt+GfraPe++rg+

Q: 1988  AMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGN  2047

         ************************************************************

S: 186   vvydekvdvfsfGlllyell.sgkrpvegeeqlkivekl.lkGkrPvlvkeeevlptpll  243

         v+y++++dv+sfGllly++l +g r+veg ++++++++l ++Gk+P++vke++++p+p++

Q: 2048  VIYNQQADVYSFGLLLYDILtTGGRIVEGLKFPNEFDELeIQGKLPDPVKEYGCAPWPMV  2107

         ********************999*************************************

S: 244   d.LlveCwkekPekrPtasqvvsi  266

         + L+++C+ke+P++rPt++qv++i

Q: 2108  EkLIKQCLKENPQERPTSAQVFDI  2131

         99********************96

Domain Sequence
(FASTA)

LLGDGSFGSV YRAAYEGEEV AVKIFNKHTS LRLLRQELVV LCHLHHPSLI SLLAAGIRPR 60

MLVMELASKG SLDRLLQQDK ASLTRTLQHR IALHVADGLR YLHSAMIIYR DLKPHNVLLF 120

TLYPNAAIIA KIADYGIAQY CCRMGIKTSE GTPGFRAPEV ARGNVIYNQQ ADVYSFGLLL 180

YDILTTGGRI VEGLKFPNEF DELEIQGKLP DPVKEYGCAP WPMVEKLIKQ CLKENPQERP 240

TSAQVFDI 248

Keyword

3D-structure; ATP-binding; Autophagy; Coiled coil; Complete proteome; Cytoplasm; Disease mutation; GTP-binding; GTPase activation; Kinase; Leucine-rich repeat; Membrane; Mitochondrion; Neurodegeneration; Nucleotide-binding; Parkinson disease; Parkinsonism; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0032839	; C:dendrite cytoplasm
GO:0032473	; C:external side of mitochondrial outer membrane
GO:0045121	; C:membrane raft
GO:0043025	; C:neuronal cell body
GO:0005886	; C:plasma membrane
GO:0008021	; C:synaptic vesicle
GO:0005802	; C:trans-Golgi network
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0034211	; F:GTP-dependent protein kinase activity
GO:0005096	; F:GTPase activator activity
GO:0003924	; F:GTPase activity
GO:0004708	; F:MAP kinase kinase activity
GO:0015631	; F:tubulin binding
GO:0000186	; P:activation of MAPKK activity
GO:0006914	; P:autophagy
GO:0008340	; P:determination of adult lifespan
GO:0035640	; P:exploration behavior
GO:0048312	; P:intracellular distribution of mitochondria
GO:2000173	; P:negative regulation of branching morphogenesis of a nerve
GO:0061002	; P:negative regulation of dendritic spine morphogenesis
GO:0034260	; P:negative regulation of GTPase activity
GO:0007406	; P:negative regulation of neuroblast proliferation
GO:0014043	; P:negative regulation of neuron maturation
GO:0007528	; P:neuromuscular junction development
GO:0070997	; P:neuron death
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0010508	; P:positive regulation of autophagy
GO:0060161	; P:positive regulation of dopamine receptor signaling pathway
GO:0043068	; P:positive regulation of programmed cell death
GO:0032436	; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	; P:positive regulation of protein ubiquitination
GO:0046777	; P:protein autophosphorylation
GO:0035564	; P:regulation of kidney size
GO:0040012	; P:regulation of locomotion
GO:0042391	; P:regulation of membrane potential
GO:0006979	; P:response to oxidative stress
GO:0007264	; P:small GTPase mediated signal transduction
GO:0022028	; P:tangential migration from the subventricular zone to the olfactory bulb

KEGG

hsa:120892

;

InterPros

IPR020683	; Ankyrin_rpt-contain_dom.
IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR013684	; MIRO-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020859	; ROC_GTPase.
IPR008271	; Ser/Thr_kinase_AS.
IPR005225	; Small_GTP-bd_dom.
IPR001806	; Small_GTPase.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR017986	; WD40_repeat_dom.

Pfam

PF00560	; LRR_1; 1.
PF12799	; LRR_4; 1.
PF08477	; Miro; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00369	; LRR_TYP; 1.
SM00320	; WD40; 1.

Prosites

PS51450	; LRR; 11.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS51424	; ROC; 1.

Prints

PR00449

; RASTRNSFRMNG.

Created Date

20-Feb-2013