| Tag | Content |
|---|
| EKPD ID | EPS-HOS-00111 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| PTPLA/PTPLA | 144.2 | 1.6E-41 | 65 | 223 | 159 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000419503 |
| UniProt Accession | Q5VWC8; Q7Z385; |
| Protein Name | Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 4 |
| Protein Synonyms/Alias | 3-hydroxyacyl-CoA dehydratase 4; HACD4; Protein tyrosine phosphatase-like protein PTPLAD2; Protein-tyrosine phosphatase-like A domain-containing protein 2; |
| Gene Name | PTPLAD2 |
| Gene Synonyms/Alias | PTPLAD2; HACD4; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Responsible for the dehydration step in very long-chainfatty acids (VLCFAs) synthesis. |
| Protein Length | 232 |
Protein Sequence
(FASTA) | | MGPLALPAWL QPRYRKNAYL FIYYLIQFCG HSWIFTNMTV RFFSFGKDSM VDTFYAIGLV 60 | | MRLCQSVSLL ELLHIYVGIE SNHLLPRFLQ LTERIIILFV VITSQEEVQE KYVVCVLFVF 120 | | WNLLDMVRYT YSMLSVIGIS YAVLTWLSQT LWMPIYPLCV LAEAFAIYQS LPYFESFGTY 180 | | STKLPFDLSI YFPYVLKIYL MMLFIGMYFT YSHLYSERRD ILGIFPIKKK KM 232 |
|
Nucleotide Sequence
(FASTA) | | ATGGGGCCCT TGGCGCTGCC CGCCTGGCTG CAGCCCAGGT ATAGGAAGAA TGCGTATCTT 60 | | TTCATCTATT ACTTAATCCA GTTCTGTGGC CACTCTTGGA TATTTACAAA TATGACAGTC 120 | | AGATTCTTTT CATTTGGAAA AGATTCAATG GTTGACACTT TTTATGCTAT TGGACTTGTG 180 | | ATGCGACTTT GCCAATCCGT ATCTCTCCTG GAACTGCTGC ACATATATGT TGGCATTGAG 240 | | TCAAACCATC TTCTCCCAAG GTTTTTGCAG CTCACAGAAA GAATAATCAT CCTTTTTGTG 300 | | GTGATCACCA GTCAAGAGGA AGTCCAAGAG AAATATGTGG TGTGTGTTTT ATTCGTCTTT 360 | | TGGAATCTAT TGGATATGGT TAGGTACACT TATAGCATGT TATCAGTCAT AGGAATATCC 420 | | TATGCTGTCT TGACATGGCT CAGTCAAACA CTATGGATGC CAATTTATCC TTTGTGTGTT 480 | | CTTGCTGAAG CATTTGCCAT CTATCAATCG CTGCCTTATT TTGAATCATT TGGCACTTAT 540 | | TCCACCAAGC TGCCCTTTGA CTTATCCATC TATTTCCCAT ATGTGCTGAA AATATATCTC 600 | | ATGATGCTCT TTATAGGTAT GTATTTTACC TACAGTCATC TATACTCAGA AAGAAGAGAC 660 | | ATCCTCGGAA TCTTTCCCAT TAAAAAAAAG AAGATGTGA 699 |
|
| Domain Profile | S: 1 qtlavlEivhallglvrspvlttllQvasRllivwvvveslpevqnspvvlllllaWslt 60 | q++++lE++h+++g+ ++++l+ +lQ+++R++i++vv++s +evq+++vv++l++ W+l | Q: 65 QSVSLLELLHIYVGIESNHLLPRFLQLTERIIILFVVITSQEEVQEKYVVCVLFVFWNLL 124 | 8999******************************************************** |
| S: 61 EviRYsfyalkllgtepklltwlRYslFivLYPlGvlsEavlvyqslpvlketkrfslkl 120 | +++RY++ +l+++g+++++ltwl +l++++YPl+vl+Ea+++yqslp++++ ++s+kl | Q: 125 DMVRYTYSMLSVIGISYAVLTWLSQTLWMPIYPLCVLAEAFAIYQSLPYFESFGTYSTKL 184 | ************************************************************ |
| S: 121 paalnfslsfsyflilvlllyipglyvlytymlkqrkkvlk 161 | p +++s++f y+l+++l++ ++g+y+ y++++++r+ +l+ | Q: 185 P--FDLSIYFPYVLKIYLMMLFIGMYFTYSHLYSERRDILG 223 | *..6789999***************************9986 |
|
Domain Sequence
(FASTA) | | QSVSLLELLH IYVGIESNHL LPRFLQLTER IIILFVVITS QEEVQEKYVV CVLFVFWNLL 60 | | DMVRYTYSML SVIGISYAVL TWLSQTLWMP IYPLCVLAEA FAIYQSLPYF ESFGTYSTKL 120 | | PFDLSIYFPY VLKIYLMMLF IGMYFTYSHL YSERRDILG 159 |
|
| Keyword | Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Lyase; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |