EKS-HOS-00339

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00339

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	320.6	3.9E-95	63	337	275

Status

Reviewed

Ensembl Protein

ENSP00000348278

UniProt Accession

Q9UEW8; O14774; Q53S90; Q53SL7; Q53SS1; Q9UER4;

Protein Name

STE20/SPS1-related proline-alanine-rich protein kinase

Protein Synonyms/Alias

Ste-20-related kinase; DCHT; Serine/threonine-protein kinase 39;

Gene Name

STK39

Gene Synonyms/Alias

STK39; SPAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000198648	ENSP00000348278	ENST00000355999

Organism

Homo sapiens

Functional Description

May act as a mediator of stress-activated signals.

Protein Length

545

Protein Sequence
(FASTA)

MAEPSGSPVH VQLPQQAAPV TAAAAAAPAA ATAAPAPAAP AAPAPAPAPA AQAVGWPICR 60

DAYELQEVIG SGATAVVQAA LCKPRQERVA IKRINLEKCQ TSMDELLKEI QAMSQCSHPN 120

VVTYYTSFVV KDELWLVMKL LSGGSMLDII KYIVNRGEHK NGVLEEAIIA TILKEVLEGL 180

DYLHRNGQIH RDLKAGNILL GEDGSVQIAD FGVSAFLATG GDVTRNKVRK TFVGTPCWMA 240

PEVMEQVRGY DFKADMWSFG ITAIELATGA APYHKYPPMK VLMLTLQNDP PTLETGVEDK 300

EMMKKYGKSF RKLLSLCLQK DPSKRPTAAE LLKCKFFQKA KNREYLIEKL LTRTPDIAQR 360

AKKVRRVPGS SGHLHKTEDG DWEWSDDEMD EKSEEGKAAF SQEKSRRVKE ENPEIAVSAS 420

TIPEQIQSLS VHDSQGPPNA NEDYREASSC AVNLVLRLRN SRKELNDIRF EFTPGRDTAD 480

GVSQELFSAG LVDGHDVVIV AANLQKIVDD PKALKTLTFK LASGCDGSEI PDEVKLIGFA 540

QLSVS 545

Nucleotide Sequence
(FASTA)

ATGGCGGAGC CGAGCGGCTC GCCCGTGCAC GTCCAGCTTC CCCAGCAGGC GGCCCCGGTG 60

ACAGCGGCGG CGGCGGCGGC CCCGGCGGCC GCGACAGCAG CGCCGGCCCC GGCAGCTCCC 120

GCGGCCCCGG CCCCGGCCCC GGCCCCGGCG GCACAGGCTG TCGGCTGGCC CATCTGCAGG 180

GACGCGTACG AGCTGCAGGA GGTTATCGGC AGTGGAGCTA CTGCTGTGGT TCAGGCAGCC 240

CTATGCAAAC CCAGGCAAGA ACGTGTAGCA ATAAAACGGA TCAACTTGGA AAAATGCCAG 300

ACCAGTATGG ATGAACTATT AAAAGAAATT CAAGCCATGA GTCAGTGCAG CCATCCCAAC 360

GTAGTGACCT ATTACACCTC TTTTGTGGTC AAAGATGAAC TTTGGCTGGT CATGAAATTA 420

CTAAGTGGAG GTTCAATGTT GGATATCATA AAATACATTG TCAACCGAGG AGAACACAAG 480

AATGGAGTTC TGGAAGAGGC AATAATAGCA ACAATTCTTA AAGAGGTTTT GGAAGGCTTA 540

GACTATCTAC ACAGAAACGG TCAGATTCAC AGGGATTTGA AAGCTGGTAA TATTCTTCTG 600

GGTGAGGATG GTTCAGTACA AATAGCAGAT TTTGGGGTAA GTGCGTTCCT AGCAACAGGG 660

GGTGATGTTA CCCGAAATAA AGTAAGAAAA ACATTCGTTG GCACCCCATG TTGGATGGCT 720

CCTGAAGTCA TGGAACAGGT GAGAGGCTAT GACTTCAAGG CTGACATGTG GAGTTTTGGA 780

ATAACTGCCA TTGAATTAGC AACAGGAGCA GCGCCTTATC ACAAATATCC TCCCATGAAA 840

GTGTTAATGT TGACTTTGCA AAATGATCCA CCCACTTTGG AAACAGGGGT AGAGGATAAA 900

GAAATGATGA AAAAGTACGG CAAGTCCTTT AGAAAATTAC TTTCACTGTG TCTTCAGAAA 960

GATCCTTCCA AAAGGCCCAC AGCAGCAGAA CTTTTAAAAT GCAAATTCTT CCAGAAAGCC 1020

AAGAACAGAG AGTACCTGAT TGAGAAGCTG CTTACAAGAA CACCAGACAT AGCCCAAAGA 1080

GCCAAAAAGG TAAGAAGAGT TCCTGGGTCA AGTGGTCACC TTCATAAAAC CGAAGACGGG 1140

GACTGGGAGT GGAGTGACGA CGAGATGGAT GAGAAGAGCG AAGAAGGGAA AGCAGCTTTT 1200

TCTCAGGAAA AGTCACGAAG AGTAAAAGAA GAAAATCCAG AGATTGCAGT GAGTGCCAGC 1260

ACCATCCCCG AACAAATACA GTCCCTCTCT GTGCACGACT CTCAGGGCCC ACCCAATGCT 1320

AATGAAGACT ACAGAGAAGC TTCTTCTTGT GCCGTGAACC TCGTTTTGAG ATTAAGAAAC 1380

TCCAGAAAGG AACTTAATGA CATACGATTT GAGTTTACTC CAGGAAGAGA TACAGCAGAT 1440

GGTGTATCTC AGGAGCTCTT CTCTGCTGGC TTGGTGGATG GTCACGATGT AGTTATAGTG 1500

GCTGCTAATT TACAGAAGAT TGTAGATGAT CCCAAAGCTT TAAAAACATT GACATTTAAG 1560

TTGGCTTCTG GCTGTGATGG GTCGGAGATT CCTGATGAAG TGAAGCTGAT TGGGTTTGCT 1620

CAGTTGAGTG TCAGCTGA 1638

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.ekleelqkeisvlkklkhpniv  59

         yel+e+ig+Ga++ v++a +k+++e vaik+inlek+ ++++el kei+++++++hpn+v

Q: 63    YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCqTSMDELLKEIQAMSQCSHPNVV  122

         99***********************************8899*******************

S: 60    eylesflkeeelwlvmeylagGslsdlvk......eelkselkEeqiayilrevlkaLey  113

         +y++sf++++elwlvm++l+gGs+ d++k      e+++  l+E  ia+il+evl++L+y

Q: 123   TYYTSFVVKDELWLVMKLLSGGSMLDIIKyivnrgEHKNGVLEEAIIATILKEVLEGLDY  182

         **********************************999***********************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlek....trkk.rktvvgtpywmAPE  168

         lH++++iHrd+ka+niLl e+g+V+++dfgv+a l++    tr+k rkt+vgtp+wmAPE

Q: 183   LHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATggdvTRNKvRKTFVGTPCWMAPE  242

         ***********************************99888888899**************

S: 169   viaqeekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklksk.....  223

         v++q  +gYd kaD+ws+GItaiela+g++P+++++p+k+l+++l+n+pp+l++

Q: 243   VMEQ-VRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGvedke  301

         ***5.9**********************************************66666777

S: 224   ..kkfskefkefvekclqknpekRpsasellkhkFl  257

           kk++k+f+++++ clqk+p+kRp+a+ellk kF+

Q: 302   mmKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFF  337

         7799******************************97

Domain Sequence
(FASTA)

YELQEVIGSG ATAVVQAALC KPRQERVAIK RINLEKCQTS MDELLKEIQA MSQCSHPNVV 60

TYYTSFVVKD ELWLVMKLLS GGSMLDIIKY IVNRGEHKNG VLEEAIIATI LKEVLEGLDY 120

LHRNGQIHRD LKAGNILLGE DGSVQIADFG VSAFLATGGD VTRNKVRKTF VGTPCWMAPE 180

VMEQVRGYDF KADMWSFGIT AIELATGAAP YHKYPPMKVL MLTLQNDPPT LETGVEDKEM 240

MKKYGKSFRK LLSLCLQKDP SKRPTAAELL KCKFF 275

Keyword

Acetylation; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016324	; C:apical plasma membrane
GO:0016323	; C:basolateral plasma membrane
GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0043268	; P:positive regulation of potassium ion transport
GO:0006950	; P:response to stress

KEGG

hsa:27347

;

InterPros

IPR011009	; Kinase-like_dom.
IPR024678	; Kinase_OSR1/WNK_CCT.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF12202	; OSR1_C; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013