EPS-HOS-00008

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00008

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	152.5	3.7E-44	133	278	146

Status

Reviewed

Ensembl Protein

ENSP00000271385

UniProt Accession

Q5VZP5; A0AUM4; Q9C074;

Protein Name

Inactive dual specificity phosphatase 27

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000198842	ENSP00000404874	ENST00000443333
ENSG00000198842	ENSP00000354483	ENST00000361200
ENSG00000198842	ENSP00000271385	ENST00000271385

Organism

Homo sapiens

Functional Description

Protein Length

1158

Protein Sequence
(FASTA)

MATRKDTEEE QVVPSEEDEA NVRAVQAHYL RSPSPSQYSM VSDAETESIF MEPIHLSSAI 60

AAKQIINEEL KPPGVRADAE CPGMLESAEQ LLVEDLYNRV REKMDDTSLY NTPCVLDLQR 120

ALVQDRQEAP WNEVDEVWPN VFIAEKSVAV NKGRLKRLGI THILNAAHGT GVYTGPEFYT 180

GLEIQYLGVE VDDFPEVDIS QHFRKASEFL DEALLTYRGK VLVSSEMGIS RSAVLVVAYL 240

MIFHNMAILE ALMTVRKKRA IYPNEGFLKQ LRELNEKLME EREEDYGREG GSAEAEEGEG 300

TGSMLGARVH ALTVEEEDDS ASHLSGSSLG KATQASKPLT LIDEEEEEKL YEQWKKGQGL 360

LSDKVPQDGG GWRSASSGQG GEELEDEDVE RIIQEWQSRN ERYQAEGYRR WGREEEKEEE 420

SDAGSSVGRR RRTLSESSAW ESVSSHDIWV LKQQLELNRP DHGRRRRADS MSSESTWDAW 480

NERLLEIEKE ASRRYHAKSK REEAADRSSE AGSRVREDDE DSVGSEASSF YNFCSRNKDK 540

LTALERWKIK RIQFGFHKKD LGAGDSSGEP GAEEAVGEKN PSDVSLTAYQ AWKLKHQKKV 600

GSENKEEVVE LSKGEDSALA KKRQRRLELL ERSRQTLEES QSMASWEADS STASGSIPLS 660

AFWSADPSVS ADGDTTSVLS TQSHRSHLSQ AASNIAGCST SNPTTPLPNL PVGPGDTISI 720

ASIQNWIANV VSETLAQKQN EMLLLSRSPS VASMKAVPAA SCLGDDQVSM LSGHSSSSLG 780

GCLLPQSQAR PSSDMQSVLS CNTTLSSPAE SCRSKVRGTS KPIFSLFADN VDLKELGRKE 840

KEMQMELREK MSEYKMEKLA SDNKRSSLFK KKKVKEDEDD GVGDGDEDTD SAIGSFRYSS 900

RSNSQKPETD TCSSLAVCDH YASGSRVGKE MDSSINKWLS GLRTEEKPPF QSDWSGSSRG 960

KYTRSSLLRE TESKSSSYKF SKSQSEEQDT SSYHEANGNS VRSTSRFSSS STREGREMHK 1020

FSRSTYNETS SSREESPEPY FFRRTPESSE REESPEPQRP NWARSRDWED VEESSKSDFS 1080

EFGAKRKFTQ SFMRSEEEGE KERTENREEG RFASGRRSQY RRSTDREEEE EMDDEAIIAA 1140

WRRRQEETRT KLQKRRED 1158

Nucleotide Sequence
(FASTA)

ATGGCGACCA GAAAGGACAC AGAGGAGGAG CAGGTAGTCC CAAGCGAGGA GGACGAAGCC 60

AACGTGAGGG CGGTGCAGGC CCACTACCTC CGAAGCCCCT CCCCTAGCCA GTATTCGATG 120

GTCTCAGATG CAGAAACAGA AAGCATTTTC ATGGAACCCA TTCACCTCTC CTCAGCCATT 180

GCAGCCAAAC AGATCATCAA TGAAGAACTC AAGCCACCGG GGGTCAGAGC AGACGCAGAG 240

TGTCCAGGCA TGCTGGAGTC TGCTGAACAG CTGCTGGTGG AGGACCTGTA CAACCGCGTC 300

AGGGAGAAGA TGGATGACAC CAGCCTCTAT AATACGCCCT GTGTCCTGGA CCTACAGCGG 360

GCCCTGGTTC AGGATCGCCA AGAGGCGCCC TGGAATGAGG TGGATGAGGT CTGGCCCAAT 420

GTCTTCATAG CTGAGAAGAG TGTGGCTGTG AACAAGGGGA GGCTGAAGAG GCTGGGAATC 480

ACCCACATTC TGAATGCTGC GCATGGCACC GGCGTTTACA CTGGCCCCGA ATTCTACACT 540

GGCCTGGAGA TCCAGTACCT GGGTGTAGAG GTGGATGACT TTCCTGAGGT GGACATTTCC 600

CAGCATTTCC GGAAGGCGTC TGAGTTCCTG GATGAGGCGC TGCTGACTTA CAGAGGGAAA 660

GTCCTGGTCA GCAGCGAAAT GGGCATCAGC CGGTCAGCAG TGCTGGTGGT CGCCTACCTG 720

ATGATCTTCC ACAACATGGC CATCCTGGAG GCTTTGATGA CCGTGCGTAA GAAGCGGGCC 780

ATCTACCCCA ATGAGGGCTT CCTGAAGCAG CTGCGGGAGC TCAATGAGAA GTTGATGGAG 840

GAGAGAGAAG AGGACTATGG CCGGGAGGGG GGATCAGCTG AGGCTGAGGA GGGCGAGGGC 900

ACTGGGAGCA TGCTCGGGGC CAGAGTGCAC GCCCTGACGG TGGAAGAGGA GGACGACAGC 960

GCCAGCCACC TGAGTGGCTC CTCCCTGGGG AAGGCCACCC AGGCCTCCAA GCCCCTCACC 1020

CTCATAGACG AGGAGGAGGA GGAGAAACTG TACGAGCAGT GGAAGAAGGG GCAGGGCCTC 1080

CTCTCAGACA AGGTCCCCCA GGATGGAGGT GGCTGGCGCT CAGCCTCCTC TGGCCAGGGT 1140

GGGGAGGAGC TCGAGGACGA GGACGTGGAG AGGATCATCC AGGAGTGGCA GAGCCGAAAC 1200

GAGAGGTACC AAGCAGAAGG GTACCGGAGG TGGGGAAGGG AGGAGGAGAA GGAGGAGGAG 1260

AGCGACGCTG GCTCCTCGGT GGGGAGGCGG CGGCGCACCC TGAGCGAGAG CAGCGCCTGG 1320

GAGAGCGTGA GCAGCCACGA CATCTGGGTC CTGAAGCAGC AGCTGGAGCT GAACCGCCCG 1380

GACCACGGCA GGAGGCGCCG CGCAGACTCG ATGTCCTCGG AGAGCACCTG GGACGCATGG 1440

AACGAGAGGC TGCTGGAGAT TGAGAAGGAG GCTTCCCGGA GGTACCACGC CAAGAGCAAG 1500

AGAGAGGAGG CGGCAGACAG GAGCTCAGAA GCAGGGAGCA GGGTGCGGGA GGATGATGAG 1560

GACAGCGTGG GCTCTGAGGC CAGTTCCTTC TACAACTTCT GCAGCAGGAA CAAGGACAAG 1620

CTCACTGCCC TGGAAAGATG GAAGATCAAG AGAATCCAAT TTGGATTTCA CAAGAAAGAC 1680

TTGGGAGCGG GAGACAGCAG CGGTGAGCCC GGTGCAGAGG AGGCAGTAGG GGAGAAGAAC 1740

CCCTCCGACG TCAGCCTGAC AGCCTACCAG GCCTGGAAGC TGAAACACCA GAAGAAGGTG 1800

GGCAGTGAGA ACAAGGAGGA GGTGGTGGAG CTCAGCAAGG GGGAGGACTC GGCCTTGGCT 1860

AAGAAGAGAC AACGGAGGCT GGAGCTGCTG GAGAGAAGCC GGCAGACGCT GGAGGAGAGC 1920

CAGTCTATGG CAAGCTGGGA GGCGGACAGC TCCACGGCCA GCGGGAGCAT TCCCCTGTCT 1980

GCGTTCTGGT CTGCAGACCC CTCAGTCAGC GCTGATGGGG ACACGACGTC AGTACTGAGC 2040

ACCCAGAGCC ACCGCTCCCA CCTGTCTCAG GCTGCAAGCA ACATAGCGGG GTGTTCAACC 2100

TCCAACCCCA CCACACCCCT GCCTAACCTG CCAGTGGGGC CTGGAGACAC CATTTCCATT 2160

GCCAGTATCC AGAACTGGAT TGCCAATGTA GTCAGTGAGA CCCTTGCTCA GAAGCAAAAT 2220

GAAATGCTGC TGTTGTCCCG CTCACCGTCT GTTGCAAGCA TGAAGGCAGT ACCAGCGGCT 2280

AGCTGCCTGG GGGATGACCA AGTCTCCATG CTTAGTGGAC ACAGCAGCTC CTCCTTGGGT 2340

GGCTGCCTGT TGCCTCAGAG CCAGGCAAGA CCCAGCTCTG ACATGCAGTC TGTGCTGTCC 2400

TGCAACACCA CACTGAGCTC ACCCGCGGAA AGTTGCAGAA GCAAAGTGAG GGGGACCAGC 2460

AAGCCCATCT TCAGCCTCTT TGCTGACAAT GTGGACCTAA AGGAACTTGG CCGGAAGGAG 2520

AAGGAGATGC AGATGGAGCT TAGGGAGAAG ATGTCTGAGT ACAAAATGGA AAAGCTGGCC 2580

TCAGACAACA AACGCAGCTC CCTCTTCAAG AAGAAGAAGG TCAAGGAAGA TGAGGATGAT 2640

GGTGTGGGTG ATGGGGATGA GGACACTGAC AGTGCCATAG GGAGCTTCCG ATATTCTTCC 2700

CGCAGTAATT CCCAGAAACC TGAAACAGAC ACATGCTCCT CCCTGGCTGT CTGTGATCAC 2760

TATGCAAGTG GCAGCAGAGT TGGCAAAGAG ATGGATAGCA GTATTAATAA GTGGCTCAGT 2820

GGCCTCAGGA CGGAGGAAAA ACCTCCTTTC CAAAGTGACT GGTCTGGAAG TTCCAGAGGG 2880

AAGTACACCA GATCGTCCCT GCTCAGGGAG ACAGAGTCTA AATCCTCCAG TTACAAGTTT 2940

TCCAAATCCC AGTCAGAGGA ACAGGACACC TCCTCCTACC ACGAGGCAAA TGGCAACTCT 3000

GTAAGAAGCA CTTCACGGTT CTCATCTTCC TCCACCAGGG AGGGCAGAGA GATGCACAAG 3060

TTCTCCAGGT CCACGTACAA CGAGACCTCA AGTTCCCGAG AGGAGAGCCC AGAGCCCTAC 3120

TTCTTCCGCC GGACCCCAGA GTCCTCAGAA AGGGAAGAGT CCCCAGAACC ACAGCGCCCA 3180

AATTGGGCCA GGTCCAGGGA CTGGGAAGAT GTGGAAGAGT CATCCAAGTC AGACTTCTCT 3240

GAATTTGGAG CCAAGAGGAA GTTCACCCAG AGCTTTATGA GGTCTGAAGA AGAGGGAGAG 3300

AAAGAGAGGA CAGAAAACAG AGAAGAAGGG AGGTTTGCAT CTGGACGGCG GTCCCAGTAT 3360

CGGAGAAGCA CTGACAGGGA GGAAGAGGAA GAAATGGACG ATGAAGCCAT CATTGCTGCT 3420

TGGAGACGCC GGCAAGAAGA AACCAGGACC AAGCTGCAGA AAAGGAGGGA GGACTGA 3477

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe+++  +i+y++++v

Q: 133   EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGVEV  191

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++a ef+dea  + +gkvlv +++G+sRSa+lv+aYLm+++++++ +A

Q: 192   DDFPEVDISQHFRKASEFLDEAlLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEA  251

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         +++v++kr +i+pnegfl+QL+el++kl

Q: 252   LMTVRKKR-AIYPNEGFLKQLRELNEKL  278

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNVF IAEKSVAVNK GRLKRLGITH ILNAAHGTGV YTGPEFYTGL EIQYLGVEVD 60

DFPEVDISQH FRKASEFLDE ALLTYRGKVL VSSEMGISRS AVLVVAYLMI FHNMAILEAL 120

MTVRKKRAIY PNEGFLKQLR ELNEKL 146

Keyword

Complete proteome; Polymorphism; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

hsa:92235

;

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS00383	; TYR_PHOSPHATASE_1; FALSE_NEG.
PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013