EKS-HOS-00291

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00291

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	391.1	1.5E-116	203	501	299

Status

Reviewed

Ensembl Protein

ENSP00000363702

UniProt Accession

Q13873; Q16569; Q4ZG08; Q53SA5; Q585T8;

Protein Name

Bone morphogenetic protein receptor type-2

Protein Synonyms/Alias

BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II;

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2; PPH1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000204217	ENSP00000363702	ENST00000374574
ENSG00000204217	ENSP00000363708	ENST00000374580

Organism

Homo sapiens

Functional Description

On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

Protein Length

530

Protein Sequence
(FASTA)

MTSSLQRPWR VPWLPWTILL VSTAAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC 60

SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV VTTTPPSIQN GTYRFCCCST 120

DLCNVNFTEN FPPPDTTPLS PPHSFNRDET IIIALASVSV LAVLIVALCF GYRMLTGDRK 180

QGLHSMNMME AAASEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF 240

INEKNIYRVP LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS 300

SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS DFGLSMRLTG 360

NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEIFMRC 420

TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI 480

EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MSTAMQNERR 530

Nucleotide Sequence
(FASTA)

ATGACTTCCT CGCTGCAGCG GCCCTGGCGG GTGCCCTGGC TACCATGGAC CATCCTGCTG 60

GTCAGCACTG CGGCTGCTTC GCAGAATCAA GAACGGCTAT GTGCGTTTAA AGATCCGTAT 120

CAGCAAGACC TTGGGATAGG TGAGAGTAGA ATCTCTCATG AAAATGGGAC AATATTATGC 180

TCGAAAGGTA GCACCTGCTA TGGCCTTTGG GAGAAATCAA AAGGGGACAT AAATCTTGTA 240

AAACAAGGAT GTTGGTCTCA CATTGGAGAT CCCCAAGAGT GTCACTATGA AGAATGTGTA 300

GTAACTACCA CTCCTCCCTC AATTCAGAAT GGAACATACC GTTTCTGCTG TTGTAGCACA 360

GATTTATGTA ATGTCAACTT TACTGAGAAT TTTCCACCTC CTGACACAAC ACCACTCAGT 420

CCACCTCATT CATTTAACCG AGATGAGACA ATAATCATTG CTTTGGCATC AGTCTCTGTA 480

TTAGCTGTTT TGATAGTTGC CTTATGCTTT GGATACAGAA TGTTGACAGG AGACCGTAAA 540

CAAGGTCTTC ACAGTATGAA CATGATGGAG GCAGCAGCAT CCGAACCCTC TCTTGATCTA 600

GATAATCTGA AACTGTTGGA GCTGATTGGC CGAGGTCGAT ATGGAGCAGT ATATAAAGGC 660

TCCTTGGATG AGCGTCCAGT TGCTGTAAAA GTGTTTTCCT TTGCAAACCG TCAGAATTTT 720

ATCAACGAAA AGAACATTTA CAGAGTGCCT TTGATGGAAC ATGACAACAT TGCCCGCTTT 780

ATAGTTGGAG ATGAGAGAGT CACTGCAGAT GGACGCATGG AATATTTGCT TGTGATGGAG 840

TACTATCCCA ATGGATCTTT ATGCAAGTAT TTAAGTCTCC ACACAAGTGA CTGGGTAAGC 900

TCTTGCCGTC TTGCTCATTC TGTTACTAGA GGACTGGCTT ATCTTCACAC AGAATTACCA 960

CGAGGAGATC ATTATAAACC TGCAATTTCC CATCGAGATT TAAACAGCAG AAATGTCCTA 1020

GTGAAAAATG ATGGAACCTG TGTTATTAGT GACTTTGGAC TGTCCATGAG GCTGACTGGA 1080

AATAGACTGG TGCGCCCAGG GGAGGAAGAT AATGCAGCCA TAAGCGAGGT TGGCACTATC 1140

AGATATATGG CACCAGAAGT GCTAGAAGGA GCTGTGAACT TGAGGGACTG TGAATCAGCT 1200

TTGAAACAAG TAGACATGTA TGCTCTTGGA CTAATCTATT GGGAGATATT TATGAGATGT 1260

ACAGACCTCT TCCCAGGGGA ATCCGTACCA GAGTACCAGA TGGCTTTTCA GACAGAGGTT 1320

GGAAACCATC CCACTTTTGA GGATATGCAG GTTCTCGTGT CTAGGGAAAA ACAGAGACCC 1380

AAGTTCCCAG AAGCCTGGAA AGAAAATAGC CTGGCAGTGA GGTCACTCAA GGAGACAATC 1440

GAAGACTGTT GGGACCAGGA TGCAGAGGCT CGGCTTACTG CACAGTGTGC TGAGGAAAGG 1500

ATGGCTGAAC TTATGATGAT TTGGGAAAGA AACAAATCTG TGAGCCCAAC AGTCAATCCA 1560

ATGTCTACTG CTATGCAGAA TGAACGTAGG TGA 1593

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+

Q: 203   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  262

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 263   GDErVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  322

         **9999**************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R

Q: 323   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  381

         .46***********************************999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg

Q: 382   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  441

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 442   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  501

         ***************************9999*************************9997

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60

GDERVTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

3D-structure; ATP-binding; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016324	; C:apical plasma membrane
GO:0009925	; C:basal plasma membrane
GO:0005901	; C:caveola
GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0030425	; C:dendrite
GO:0005887	; C:integral to plasma membrane
GO:0043025	; C:neuronal cell body
GO:0016362	; F:activin receptor activity, type II
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0060840	; P:artery development
GO:0001974	; P:blood vessel remodeling
GO:0030509	; P:BMP signaling pathway
GO:0007420	; P:brain development
GO:0009267	; P:cellular response to starvation
GO:0048286	; P:lung alveolus development
GO:0001946	; P:lymphangiogenesis
GO:0060836	; P:lymphatic endothelial cell differentiation
GO:0001707	; P:mesoderm formation
GO:0030308	; P:negative regulation of cell growth
GO:2000279	; P:negative regulation of DNA biosynthetic process
GO:0003085	; P:negative regulation of systemic arterial blood pressure
GO:0045906	; P:negative regulation of vasoconstriction
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0010595	; P:positive regulation of endothelial cell migration
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916	; P:regulation of lung blood pressure
GO:0061298	; P:retina vasculature development in camera-type eye
GO:0006366	; P:transcription from RNA polymerase II promoter
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway
GO:0060841	; P:venous blood vessel development

KEGG

hsa:659

;

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013