EKS-HOS-00214

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00214

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	519.4	9.3E-156	4	286	283

Status

Reviewed

Ensembl Protein

ENSP00000368080

UniProt Accession

Q5MAI5;

Protein Name

Cyclin-dependent kinase-like 4

Protein Synonyms/Alias

Gene Name

CDKL4

Gene Synonyms/Alias

CDKL4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000205111	ENSP00000368080	ENST00000378803
ENSG00000205111	ENSP00000389833	ENST00000451199
ENSG00000205111	ENSP00000399213	ENST00000419111
ENSG00000205111	ENSP00000378476	ENST00000395035

Organism

Homo sapiens

Functional Description

Protein Length

315

Protein Sequence
(FASTA)

MEKYEKLAKT GEGSYGVVFK CRNKTSGQVV AVKKFVESED DPVVKKIALR EIRMLKQLKH 60

PNLVNLIEVF RRKRKMHLVF EYCDHTLLNE LERNPNGVAD GVIKSVLWQT LQALNFCHIH 120

NCIHRDIKPE NILITKQGII KICDFGFAQI LIPGDAYTDY VATRWYRAPE LLVGDTQYGS 180

SVDIWAIGCV FAELLTGQPL WPGKSDVDQL YLIIRTLGKL IPRHQSIFKS NGFFHGISIP 240

EPEDMETLEE KFSDVHPVAL NFMKGCLKMN PDDRLTCSQL LESSYFDSFQ EAQIKRKARN 300

EGRNRRRQQV LPLKS 315

Nucleotide Sequence
(FASTA)

ATGGAAAAGT ATGAAAAATT AGCTAAGACT GGAGAAGGGT CTTATGGGGT TGTATTCAAA 60

TGCAGAAACA AAACCTCTGG ACAAGTAGTA GCTGTTAAAA AATTTGTGGA ATCTGAAGAT 120

GATCCTGTTG TTAAGAAAAT AGCACTAAGA GAAATACGTA TGTTGAAGCA ATTAAAACAT 180

CCAAATCTTG TGAACCTCAT CGAGGTGTTC AGGAGAAAAA GGAAAATGCA TTTAGTTTTT 240

GAATACTGTG ATCATACACT TTTAAATGAG CTGGAAAGAA ACCCAAATGG AGTTGCTGAT 300

GGAGTGATCA AAAGCGTATT ATGGCAAACA CTTCAAGCTC TTAATTTCTG TCATATACAT 360

AACTGTATTC ACAGAGATAT AAAACCTGAA AATATTCTAA TAACTAAGCA AGGAATAATC 420

AAGATTTGTG ACTTCGGGTT TGCACAAATT CTGATTCCAG GAGATGCCTA CACCGATTAT 480

GTAGCTACGA GATGGTACCG AGCTCCTGAA CTTCTTGTGG GAGATACTCA GTATGGTTCT 540

TCAGTCGATA TATGGGCTAT TGGTTGTGTT TTTGCAGAGC TCCTGACAGG CCAGCCACTG 600

TGGCCTGGAA AATCAGATGT GGACCAACTT TATCTGATAA TCAGAACACT AGGAAAATTA 660

ATCCCAAGAC ATCAATCAAT CTTTAAAAGT AACGGGTTTT TCCATGGCAT CAGTATACCT 720

GAGCCAGAAG ACATGGAAAC TCTTGAGGAA AAGTTCTCAG ATGTTCATCC TGTGGCTCTG 780

AACTTCATGA AGGGGTGTCT GAAGATGAAT CCAGATGACA GATTAACCTG TTCCCAACTC 840

CTGGAGAGCT CCTACTTTGA TTCTTTTCAA GAGGCCCAAA TTAAAAGAAA AGCACGTAAT 900

GAAGGAAGAA ACAGAAGACG CCAACAGGTA CTTCCGCTCA AAAGTTAA 948

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         yekl+k GeGsyGvv+kcrnk++gq+va+kkf+esedd++vkkialrei++lkqlkh+nl

Q: 4     YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnl+evfrrk+k++lvfey+d+t+l+eler+pnGv + ++k++l+q+l+a++fch +n+i

Q: 64    VNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCI  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenili+k+g++k+cdfGfa++l+ pgd+ytdyvatrwyrapellvgdt+yG+sv

Q: 124   HRDIKPENILITKQGIIKICDFGFAQILI-PGDAYTDYVATRWYRAPELLVGDTQYGSSV  182

         *****************************.******************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         d+waiGc++aelltG+pl+pgksdvdqly+i++tlG+liprhq+if++n +f+G+++pe+

Q: 183   DIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPEP  242

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         ed+e+le+k++++++v+l+++k+clk++p++rl+c++ll+++yf

Q: 243   EDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF  286

         ******************************************99

Domain Sequence
(FASTA)

YEKLAKTGEG SYGVVFKCRN KTSGQVVAVK KFVESEDDPV VKKIALREIR MLKQLKHPNL 60

VNLIEVFRRK RKMHLVFEYC DHTLLNELER NPNGVADGVI KSVLWQTLQA LNFCHIHNCI 120

HRDIKPENIL ITKQGIIKIC DFGFAQILIP GDAYTDYVAT RWYRAPELLV GDTQYGSSVD 180

IWAIGCVFAE LLTGQPLWPG KSDVDQLYLI IRTLGKLIPR HQSIFKSNGF FHGISIPEPE 240

DMETLEEKFS DVHPVALNFM KGCLKMNPDD RLTCSQLLES SYF 283

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>