EKS-HOS-00156

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00156

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	520.8	4.7E-156	90	383	294

Status

Reviewed

Ensembl Protein

ENSP00000373684

UniProt Accession

Q9Y2H1; A8K4U0; Q8TBX7;

Protein Name

Serine/threonine-protein kinase 38-like

Protein Synonyms/Alias

NDR2 protein kinase; Nuclear Dbf2-related kinase 2;

Gene Name

STK38L

Gene Synonyms/Alias

STK38L; KIAA0965, NDR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000211455	ENSP00000446386	ENST00000539577
ENSG00000211455	ENSP00000385174	ENST00000407753
ENSG00000211455	ENSP00000442253	ENST00000543246
ENSG00000211455	ENSP00000439457	ENST00000545470
ENSG00000211455	ENSP00000443961	ENST00000536093
ENSG00000211455	ENSP00000443838	ENST00000540996
ENSG00000211455	ENSP00000445898	ENST00000544367
ENSG00000211455	ENSP00000437856	ENST00000541191
ENSG00000211455	ENSP00000373684	ENST00000389032
ENSG00000211455	ENSP00000443456	ENST00000546286
ENSG00000211455	ENSP00000440279	ENST00000544969

Organism

Homo sapiens

Functional Description

Involved in the regulation of structural processes indifferentiating and mature neuronal cells (By similarity).

Protein Length

464

Protein Sequence
(FASTA)

MAMTAGTTTT FPMSNHTRER VTVAKLTLEN FYSNLILQHE ERETRQKKLE VAMEEEGLAD 60

EEKKLRRSQH ARKETEFLRL KRTRLGLDDF ESLKVIGRGA FGEVRLVQKK DTGHIYAMKI 120

LRKSDMLEKE QVAHIRAERD ILVEADGAWV VKMFYSFQDK RNLYLIMEFL PGGDMMTLLM 180

KKDTLTEEET QFYISETVLA IDAIHQLGFI HRDIKPDNLL LDAKGHVKLS DFGLCTGLKK 240

AHRTEFYRNL THNPPSDFSF QNMNSKRKAE TWKKNRRQLA YSTVGTPDYI APEVFMQTGY 300

NKLCDWWSLG VIMYEMLIGY PPFCSETPQE TYRKVMNWKE TLVFPPEVPI SEKAKDLILR 360

FCIDSENRIG NSGVEEIKGH PFFEGVDWEH IRERPAAIPI EIKSIDDTSN FDDFPESDIL 420

QPVPNTTEPD YKSKDWVFLN YTYKRFEGLT QRGSIPTYMK AGKL 464

Nucleotide Sequence
(FASTA)

ATGGCAATGA CGGCAGGGAC TACAACAACC TTTCCTATGA GCAACCATAC CCGGGAAAGA 60

GTGACTGTAG CCAAGCTCAC ATTGGAGAAT TTTTATAGCA ACCTAATTTT ACAGCATGAA 120

GAGAGAGAAA CCAGGCAGAA GAAATTAGAA GTGGCCATGG AAGAAGAAGG ATTAGCAGAT 180

GAAGAGAAAA AGTTACGTCG ATCACAACAC GCTCGCAAAG AAACAGAGTT CTTACGGCTC 240

AAAAGGACCA GACTTGGCTT GGATGACTTT GAGTCTCTGA AAGTTATAGG AAGAGGAGCT 300

TTTGGAGAGG TGCGGTTGGT CCAGAAGAAA GATACAGGCC ATATCTATGC AATGAAGATA 360

TTGAGAAAGT CTGATATGCT TGAAAAAGAG CAGGTGGCCC ATATCCGAGC AGAAAGAGAT 420

ATTTTGGTAG AAGCAGATGG TGCCTGGGTG GTGAAGATGT TTTACAGTTT TCAGGATAAG 480

AGGAATCTTT ATCTAATCAT GGAATTTCTC CCTGGAGGTG ACATGATGAC ATTGCTAATG 540

AAGAAAGACA CCTTGACAGA AGAGGAAACA CAGTTCTACA TTTCAGAGAC TGTTCTGGCA 600

ATAGATGCGA TCCACCAGTT GGGTTTCATC CATCGGGATA TTAAGCCAGA CAACCTTTTA 660

TTGGATGCCA AGGGTCATGT AAAATTATCT GATTTTGGTT TATGTACGGG ATTAAAGAAA 720

GCTCACAGGA CTGAATTTTA TAGAAATCTC ACACACAACC CACCAAGTGA CTTCTCATTT 780

CAGAACATGA ACTCAAAGAG GAAAGCAGAA ACTTGGAAGA AGAACAGGAG ACAACTGGCA 840

TATTCCACAG TTGGGACACC AGATTACATT GCTCCAGAAG TATTCATGCA GACTGGTTAC 900

AACAAATTGT GTGACTGGTG GTCTTTGGGA GTGATTATGT ATGAAATGCT AATAGGATAT 960

CCACCTTTCT GCTCTGAAAC ACCTCAAGAA ACGTACAGAA AAGTGATGAA CTGGAAAGAA 1020

ACTCTGGTAT TTCCTCCAGA GGTACCTATA TCTGAGAAAG CCAAGGACTT AATTCTCAGA 1080

TTTTGTATTG ATTCTGAAAA CAGAATTGGA AATAGTGGAG TAGAAGAAAT AAAAGGTCAT 1140

CCCTTTTTTG AAGGTGTCGA CTGGGAGCAC ATAAGGGAAA GGCCAGCAGC AATCCCTATA 1200

GAAATCAAAA GCATTGATGA TACTTCAAAT TTTGATGACT TCCCTGAATC TGATATTTTA 1260

CAACCAGTGC CAAATACCAC AGAACCGGAC TACAAATCCA AAGACTGGGT TTTTCTCAAT 1320

TATACCTATA AAAGGTTTGA AGGGTTGACT CAACGTGGCT CTATCCCCAC CTACATGAAA 1380

GCTGGGAAGT TATGA 1395

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt+++ya+kilrk+d+l+k+qvah++aerdil+ead +w

Q: 90    FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAW  149

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvk++ysfqdk+nlyl+me+lPGGd+mtll+kk++l+ee+++fyi+e+vla++++h+lGf

Q: 150   VVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGF  209

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180

         ihrd+kPdnll+dakGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+++++  ++ +

Q: 210   IHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKA  269

         *************************************************65555555555

S: 181   rkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPflaetpq  240

            kknrr+lays+vGtpdyiapev++++gynklcdwWslGvi+yeml+GypPf++etpq

Q: 270   ETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQ  329

         555*********************************************************

S: 241   etykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         ety+kv+nwketl fp+ev++se+akdli r+++d+e+r+g++Gv+eik hpff

Q: 330   ETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFF  383

         *****************************************************9

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHIYAMK ILRKSDMLEK EQVAHIRAER DILVEADGAW 60

VVKMFYSFQD KRNLYLIMEF LPGGDMMTLL MKKDTLTEEE TQFYISETVL AIDAIHQLGF 120

IHRDIKPDNL LLDAKGHVKL SDFGLCTGLK KAHRTEFYRN LTHNPPSDFS FQNMNSKRKA 180

ETWKKNRRQL AYSTVGTPDY IAPEVFMQTG YNKLCDWWSL GVIMYEMLIG YPPFCSETPQ 240

ETYRKVMNWK ETLVFPPEVP ISEKAKDLIL RFCIDSENRI GNSGVEEIKG HPFF 294

Keyword

Acetylation; Actin-binding; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Kinase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0051128	; P:regulation of cellular component organization

KEGG

hsa:23012

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013