| Tag | Content |
|---|
| EKPD ID | EPS-HOS-00132 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| PPP/PP1 | 413.2 | 7.6E-124 | 57 | 250 | 194 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000296122 |
| UniProt Accession | P62140; B2R5V4; D6W565; P37140; Q5U087; Q6FG45; |
| Protein Name | Serine/threonine-protein phosphatase PP1-beta catalytic subunit |
| Protein Synonyms/Alias | PP-1B; PPP1CD; |
| Gene Name | PPP1CB |
| Gene Synonyms/Alias | PPP1CB; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Protein phosphatase that associates with over 200regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. |
| Protein Length | 327 |
Protein Sequence
(FASTA) | | MADGELNVDS LITRLLEVRG CRPGKIVQMT EAEVRGLCIK SREIFLSQPI LLELEAPLKI 60 | | CGDIHGQYTD LLRLFEYGGF PPEANYLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFLL 120 | | RGNHECASIN RIYGFYDECK RRFNIKLWKT FTDCFNCLPI AAIVDEKIFC CHGGLSPDLQ 180 | | SMEQIRRIMR PTDVPDTGLL CDLLWSDPDK DVQGWGENDR GVSFTFGADV VSKFLNRHDL 240 | | DLICRAHQVV EDGYEFFAKR QLVTLFSAPN YCGEFDNAGG MMSVDETLMC SFQILKPSEK 300 | | KAKYQYGGLN SGRPVTPPRT ANPPKKR 327 |
|
Nucleotide Sequence
(FASTA) | | ATGGCGGACG GGGAGCTGAA CGTGGACAGC CTCATCACCC GGCTGCTGGA GGTACGAGGA 60 | | TGTCGTCCAG GAAAGATTGT GCAGATGACT GAAGCAGAAG TTCGAGGCTT ATGTATCAAG 120 | | TCTCGGGAGA TCTTTCTCAG CCAGCCTATT CTTTTGGAAT TGGAAGCACC GCTGAAAATT 180 | | TGTGGAGATA TTCATGGACA ATATACAGAT TTACTGAGAT TATTTGAATA TGGAGGTTTC 240 | | CCACCAGAAG CCAACTATCT TTTCTTAGGA GATTATGTGG ACAGAGGAAA GCAGTCTTTG 300 | | GAAACCATTT GTTTGCTATT GGCTTATAAA ATCAAATATC CAGAGAACTT CTTTCTCTTA 360 | | AGAGGAAACC ATGAGTGTGC TAGCATCAAT CGCATTTATG GATTCTATGA TGAATGCAAA 420 | | CGAAGATTTA ATATTAAATT GTGGAAGACC TTCACTGATT GTTTTAACTG TCTGCCTATA 480 | | GCAGCCATTG TGGATGAGAA GATCTTCTGT TGTCATGGAG GATTGTCACC AGACCTGCAA 540 | | TCTATGGAGC AGATTCGGAG AATTATGAGA CCTACTGATG TCCCTGATAC AGGTTTGCTC 600 | | TGTGATTTGC TATGGTCTGA TCCAGATAAG GATGTGCAAG GCTGGGGAGA AAATGATCGT 660 | | GGTGTTTCCT TTACTTTTGG AGCTGATGTA GTCAGTAAAT TTCTGAATCG TCATGATTTA 720 | | GATTTGATTT GTCGAGCTCA TCAGGTGGTG GAAGATGGAT ATGAATTTTT TGCTAAACGA 780 | | CAGTTGGTAA CCTTATTTTC AGCCCCAAAT TACTGTGGCG AGTTTGATAA TGCTGGTGGA 840 | | ATGATGAGTG TGGATGAAAC TTTGATGTGT TCATTTCAGA TATTGAAACC ATCTGAAAAG 900 | | AAAGCTAAAT ACCAGTATGG TGGACTGAAT TCTGGACGTC CTGTCACTCC ACCTCGAACA 960 | | GCTAATCCGC CGAAGAAAAG GTGA 984 |
|
| Domain Profile | S: 1 pvkicgdihgqykdllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypen 60 | p+kicgdihgqy+dllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypen | Q: 57 PLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPEN 116 | 89********************************************************** |
| S: 61 ffllrgnhesasinriygfydeckrrynvklwktftdcfnclpvaaiidekilcvhggls 120 | ffllrgnhe+asinriygfydeckrr+n+klwktftdcfnclp+aai+deki+c+hggls | Q: 117 FFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLS 176 | ************************************************************ |
| S: 121 pdlksleqirrikrptdvpdegllcdllwsdpdkdvkgwgendrgvsftfgadvvakflk 180 | pdl+s+eqirri+rptdvpd+gllcdllwsdpdkdv+gwgendrgvsftfgadvv+kfl+ | Q: 177 PDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLN 236 | ************************************************************ |
| S: 181 khdldlicrahqvv 194 | +hdldlicrahqvv | Q: 237 RHDLDLICRAHQVV 250 | *************8 |
|
Domain Sequence
(FASTA) | | PLKICGDIHG QYTDLLRLFE YGGFPPEANY LFLGDYVDRG KQSLETICLL LAYKIKYPEN 60 | | FFLLRGNHEC ASINRIYGFY DECKRRFNIK LWKTFTDCFN CLPIAAIVDE KIFCCHGGLS 120 | | PDLQSMEQIR RIMRPTDVPD TGLLCDLLWS DPDKDVQGWG ENDRGVSFTF GADVVSKFLN 180 | | RHDLDLICRA HQVV 194 |
|
| Keyword | Acetylation; Carbohydrate metabolism; Cell cycle; Cell division; Complete proteome; Cytoplasm; Direct protein sequencing; Glycogen metabolism; Hydrolase; Iron; Manganese; Metal-binding; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |