EPS-HOS-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	208.1	9.8E-61	67	324	258

Status

Reviewed

Ensembl Protein

ENSP00000397050

UniProt Accession

Q8N819; Q6P662;

Protein Name

Probable protein phosphatase 1N

Protein Synonyms/Alias

Gene Name

PPM1N

Gene Synonyms/Alias

PPM1N;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000213889	ENSP00000397050	ENST00000451287
ENSG00000213889	ENSP00000321761	ENST00000324688
ENSG00000213889	ENSP00000384809	ENST00000401593
ENSG00000213889	ENSP00000379961	ENST00000396735
ENSG00000213889	ENSP00000379963	ENST00000396737
ENSG00000213889	ENSP00000379962	ENST00000396736
ENSG00000213889	ENSP00000389871	ENST00000456399
ENSG00000213889	ENSP00000409511	ENST00000415077
ENSG00000213889	ENSP00000384318	ENST00000401705

Organism

Homo sapiens

Functional Description

Protein Length

430

Protein Sequence
(FASTA)

MAVLARQLQR LLWTACKKKE REKEGREEEE EEEAGRRAPE GPRSLLTAPR RAQRPHGGAE 60

ASGGLRFGAS AAQGWRARME DAHCTWLSLP GLPPGWALFA VLDGHGGARA ARFGARHLPG 120

HVLQELGPEP SEPEGVREAL RRAFLSADER LRSLWPRVET GGCTAVVLLV SPRFLYLAHC 180

GDSRAVLSRA GAVAFSTEDH RPLRPRERER IHAAGGTIRR RRVEGSLAVS RALGDFTYKE 240

APGRPPELQL VSAEPEVAAL ARQAEDEFML LASDGVWDTV SGAALAGLVA SRLRLGLAPE 300

LLCAQLLDTC LCKGSLDNMT CILVCFPGAP RPSEEAIRRE LALDAALGCR IAELCASAQK 360

PPSLNTVFRT LASEDIPDLP PGGGLDCKAT VIAEVYSQIC QVSEECGEKG QDGAGKSNPT 420

HLGSALDMEA 430

Nucleotide Sequence
(FASTA)

ATGGCGGTCC TGGCCCGCCA GCTGCAGCGT CTCCTCTGGA CCGCTTGCAA GAAAAAGGAG 60

AGGGAGAAGG AGGGGAGGGA GGAAGAGGAG GAGGAGGAGG CGGGGCGCAG GGCCCCCGAA 120

GGGCCTCGGT CTCTGTTGAC AGCGCCGCGC CGCGCCCAGC GGCCGCACGG GGGTGCCGAG 180

GCGTCTGGGG GCCTGCGCTT CGGGGCGAGC GCAGCGCAAG GCTGGCGCGC GCGCATGGAG 240

GATGCTCACT GCACTTGGCT TTCGTTACCT GGTCTGCCCC CGGGCTGGGC CTTGTTTGCC 300

GTCCTCGACG GCCACGGTGG GGCTCGAGCT GCCCGCTTCG GTGCACGCCA TTTGCCAGGC 360

CATGTGCTCC AGGAGCTGGG CCCGGAGCCT AGCGAGCCCG AGGGCGTGCG CGAGGCGCTG 420

CGCCGAGCCT TCTTGAGCGC CGACGAGCGC CTGCGCTCCC TCTGGCCCCG CGTGGAAACG 480

GGCGGCTGCA CGGCCGTGGT GTTGCTGGTC TCCCCGCGGT TTCTGTACCT GGCGCACTGC 540

GGTGACTCCC GCGCGGTGCT GAGCCGCGCT GGCGCCGTGG CCTTCAGCAC AGAGGACCAC 600

CGGCCCCTTC GACCCCGGGA ACGCGAGCGC ATCCACGCCG CTGGCGGCAC CATCCGCCGC 660

CGCCGCGTCG AGGGCTCTCT GGCCGTGTCG CGAGCGTTGG GCGACTTTAC CTACAAGGAG 720

GCTCCGGGGA GGCCCCCCGA GCTACAGCTC GTTTCTGCGG AGCCAGAGGT GGCCGCACTG 780

GCACGCCAGG CTGAGGACGA GTTCATGCTC CTGGCCTCTG ATGGCGTCTG GGACACTGTG 840

TCTGGTGCTG CCCTGGCGGG ACTGGTGGCT TCACGCCTCC GCTTGGGCCT GGCCCCAGAG 900

CTTCTCTGCG CGCAGCTGTT GGACACGTGT CTGTGCAAGG GCAGCCTGGA CAACATGACC 960

TGCATCCTGG TCTGCTTCCC TGGGGCCCCT AGGCCTTCTG AGGAGGCGAT CAGGAGGGAG 1020

CTAGCACTGG ACGCAGCCCT GGGCTGCAGA ATCGCTGAAC TGTGTGCCTC TGCTCAGAAG 1080

CCCCCCAGCC TGAACACAGT TTTCAGGACT CTGGCCTCAG AGGACATCCC AGATTTACCT 1140

CCTGGGGGAG GGCTGGACTG CAAGGCCACT GTCATTGCTG AAGTTTATTC TCAGATCTGC 1200

CAGGTCTCAG AAGAGTGCGG AGAGAAGGGG CAGGATGGGG CTGGGAAGTC CAACCCCACG 1260

CATTTGGGCT CAGCCTTGGA CATGGAGGCC TGA 1293

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         +g ++ +g+r  meda+ +  ++   p     +a+f+v DGhgg ++a+f + +l  ++

Q: 67    FGASAAQGWRARMEDAHCTWLSLPGLPPG---WALFAVLDGHGGARAARFGARHLPGHVL  123

         68899************875555555554...****************************

S: 63    eelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvanv  122

         +el  + se + v++al++aFls de+l    +   + ++ G+tavv l+++  ly a++

Q: 124   QELGPEPSEPEGVREALRRAFLSADERL---RSLWPRVETGGCTAVVLLVSPRFLYLAHC  180

         ****999*********************...444456999********************

S: 123   GdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalGdly  182

         GdSravL+r g +   ++dH+p r++E+eRi +agg++ ++   Rv G+LavsRalGd+

Q: 181   GDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRR---RVEGSLAVSRALGDFT  237

         ************9**************************99...****************

S: 183   lk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

         +k         ++v++ePev    ++ edef+ LasDG+wd+vs  ++  lv ++l+ +

Q: 238   YKeapgrppelQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGL  297

         ************************************************************

S: 234   aeqeaakkLvklalargskdnvsaivv  260

         a++  + +L++++l +gs dn++ i+v

Q: 298   APELLCAQLLDTCLCKGSLDNMTCILV  324

         **********************99876

Domain Sequence
(FASTA)

FGASAAQGWR ARMEDAHCTW LSLPGLPPGW ALFAVLDGHG GARAARFGAR HLPGHVLQEL 60

GPEPSEPEGV REALRRAFLS ADERLRSLWP RVETGGCTAV VLLVSPRFLY LAHCGDSRAV 120

LSRAGAVAFS TEDHRPLRPR ERERIHAAGG TIRRRRVEGS LAVSRALGDF TYKEAPGRPP 180

ELQLVSAEPE VAALARQAED EFMLLASDGV WDTVSGAALA GLVASRLRLG LAPELLCAQL 240

LDTCLCKGSL DNMTCILV 258

Keyword

Alternative splicing; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0008152	; P:metabolic process

KEGG

hsa:147699

;

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; FALSE_NEG.

Prints

Created Date

20-Feb-2013