EKS-HOS-00459
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00459
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CK1/CK1491.52.4E-1479269261
StatusReviewed
Ensembl ProteinENSP00000384426
UniProt AccessionP49674;
Protein NameCasein kinase I isoform epsilon
Protein Synonyms/Alias CKI-epsilon; CKIe;
Gene NameCSNK1E
Gene Synonyms/Alias CSNK1E;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000213923ENSP00000403057ENST00000451964
ENSG00000213923ENSP00000380044ENST00000396832
ENSG00000213923ENSP00000384426ENST00000405675
ENSG00000213923ENSP00000384074ENST00000403904
ENSG00000213923ENSP00000412194ENST00000431611
ENSG00000213923ENSP00000403610ENST00000431632
ENSG00000213923ENSP00000397460ENST00000442216
ENSG00000213923ENSP00000407235ENST00000413574
ENSG00000213923ENSP00000412335ENST00000430335
ENSG00000213923ENSP00000400494ENST00000366216
ENSG00000213923ENSP00000383067ENST00000400206
ENSG00000213923ENSP00000352929ENST00000359867
OrganismHomo sapiens
Functional DescriptionCasein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation.
Protein Length311
Protein Sequence
(FASTA)
MELRVGNKYR LGRKIGSGSF GDIYLGANIA SGEEVAIKLE CVKTKHPQLH IESKFYKMMQ 60
GGVGIPSIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH 120
SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA 180
SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL 240
CKGYPSEFST YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFTDTVQ 300
DGSHWPHATH F 311
Nucleotide Sequence
(FASTA)
ATGGAGCTAC GTGTGGGGAA CAAGTACCGC CTGGGACGGA AGATCGGGAG CGGGTCCTTC 60
GGAGATATCT ACCTGGGTGC CAACATCGCC TCTGGTGAGG AAGTCGCCAT CAAGCTGGAG 120
TGTGTGAAGA CAAAGCACCC CCAGCTGCAC ATCGAGAGCA AGTTCTACAA GATGATGCAG 180
GGTGGCGTGG GGATCCCGTC CATCAAGTGG TGCGGAGCTG AGGGCGACTA CAACGTGATG 240
GTCATGGAGC TGCTGGGGCC TAGCCTCGAG GACCTGTTCA ACTTCTGTTC CCGCAAATTC 300
AGCCTCAAGA CGGTGCTGCT CTTGGCCGAC CAGATGATCA GCCGCATCGA GTATATCCAC 360
TCCAAGAACT TCATCCACCG GGACGTCAAG CCCGACAACT TCCTCATGGG GCTGGGGAAG 420
AAGGGCAACC TGGTCTACAT CATCGACTTC GGCCTGGCCA AGAAGTACCG GGACGCCCGC 480
ACCCACCAGC ACATTCCCTA CCGGGAAAAC AAGAACCTGA CCGGCACGGC CCGCTACGCT 540
TCCATCAACA CGCACCTGGG CATTGAGCAA AGCCGTCGAG ATGACCTGGA GAGCCTGGGC 600
TACGTGCTCA TGTACTTCAA CCTGGGCTCC CTGCCCTGGC AGGGGCTCAA AGCAGCCACC 660
AAGCGCCAGA AGTATGAACG GATCAGCGAG AAGAAGATGT CAACGCCCAT CGAGGTCCTC 720
TGCAAAGGCT ATCCCTCCGA ATTCTCAACA TACCTCAACT TCTGCCGCTC CCTGCGGTTT 780
GACGACAAGC CCGACTACTC TTACCTACGT CAGCTCTTCC GCAACCTCTT CCACCGGCAG 840
GGCTTCTCCT ATGACTACGT CTTTGACTGG AACATGCTGA AATTCACGGA CACTGTCCAA 900
GATGGTAGCC ATTGGCCACA TGCGACACAT TTTTAA 936
Domain Profile
S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60
         yr+++kiGsGsfGdiylg+n+asgeevaikle++k+k+pql++es++yk++qggvgiP++
Q: 9     YRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSI  68
         89**********************************************************
S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120
         +++g+e++ynv+v++llGpsledlf++c+rkfslktvllladq+isriey+hsk++i+rd
Q: 69    KWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRD  128
         ************************************************************
S: 121   ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk  180
         +kPdnfl+g+g+kg+ vy+idfGlakkyrda+t++hipyre+k+ltGtaryasinthlg+
Q: 129   VKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGI  188
         ************************************************************
S: 181   eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef  240
         eqsrrddleslgyvl+yf+ gslPWqglkaatk+qkye+isekk+st+ievlc+g+P+ef
Q: 189   EQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEF  248
         ************************************************************
S: 241   atylkyvrklkfeekPdyeyl  261
         +tyl+++r+l+f++kPdy+yl
Q: 249   STYLNFCRSLRFDDKPDYSYL  269
         *******************97
Domain Sequence
(FASTA)
YRLGRKIGSG SFGDIYLGAN IASGEEVAIK LECVKTKHPQ LHIESKFYKM MQGGVGIPSI 60
KWCGAEGDYN VMVMELLGPS LEDLFNFCSR KFSLKTVLLL ADQMISRIEY IHSKNFIHRD 120
VKPDNFLMGL GKKGNLVYII DFGLAKKYRD ARTHQHIPYR ENKNLTGTAR YASINTHLGI 180
EQSRRDDLES LGYVLMYFNL GSLPWQGLKA ATKRQKYERI SEKKMSTPIE VLCKGYPSEF 240
STYLNFCRSL RFDDKPDYSY L 261
KeywordATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Sus scrofa"; ?>
EKS-GAA-00551
EKS-MAM-00451
EKS-MUM-00484
EKS-MUP-00445
EKS-SUS-00400
Gene Ontology
GO:0005829; C:cytosol
GO:0005634; C:nucleus
GO:0030529; C:ribonucleoprotein complex
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0034613; P:cellular protein localization
GO:0006281; P:DNA repair
GO:0000086; P:G2/M transition of mitotic cell cycle
GO:0030178; P:negative regulation of Wnt receptor signaling pathway
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0007165; P:signal transduction
KEGG
hsa:1454;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013