Tag | Content |
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EKPD ID | EKS-HOS-00459 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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CK1/CK1 | 491.5 | 2.4E-147 | 9 | 269 | 261 |
|
Status | Reviewed |
Ensembl Protein | ENSP00000384426 |
UniProt Accession | P49674; |
Protein Name | Casein kinase I isoform epsilon |
Protein Synonyms/Alias | CKI-epsilon; CKIe; |
Gene Name | CSNK1E |
Gene Synonyms/Alias | CSNK1E; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | Casein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation. |
Protein Length | 311 |
Protein Sequence (FASTA) | MELRVGNKYR LGRKIGSGSF GDIYLGANIA SGEEVAIKLE CVKTKHPQLH IESKFYKMMQ 60 | GGVGIPSIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH 120 | SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA 180 | SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL 240 | CKGYPSEFST YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFTDTVQ 300 | DGSHWPHATH F 311 |
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Nucleotide Sequence (FASTA) | ATGGAGCTAC GTGTGGGGAA CAAGTACCGC CTGGGACGGA AGATCGGGAG CGGGTCCTTC 60 | GGAGATATCT ACCTGGGTGC CAACATCGCC TCTGGTGAGG AAGTCGCCAT CAAGCTGGAG 120 | TGTGTGAAGA CAAAGCACCC CCAGCTGCAC ATCGAGAGCA AGTTCTACAA GATGATGCAG 180 | GGTGGCGTGG GGATCCCGTC CATCAAGTGG TGCGGAGCTG AGGGCGACTA CAACGTGATG 240 | GTCATGGAGC TGCTGGGGCC TAGCCTCGAG GACCTGTTCA ACTTCTGTTC CCGCAAATTC 300 | AGCCTCAAGA CGGTGCTGCT CTTGGCCGAC CAGATGATCA GCCGCATCGA GTATATCCAC 360 | TCCAAGAACT TCATCCACCG GGACGTCAAG CCCGACAACT TCCTCATGGG GCTGGGGAAG 420 | AAGGGCAACC TGGTCTACAT CATCGACTTC GGCCTGGCCA AGAAGTACCG GGACGCCCGC 480 | ACCCACCAGC ACATTCCCTA CCGGGAAAAC AAGAACCTGA CCGGCACGGC CCGCTACGCT 540 | TCCATCAACA CGCACCTGGG CATTGAGCAA AGCCGTCGAG ATGACCTGGA GAGCCTGGGC 600 | TACGTGCTCA TGTACTTCAA CCTGGGCTCC CTGCCCTGGC AGGGGCTCAA AGCAGCCACC 660 | AAGCGCCAGA AGTATGAACG GATCAGCGAG AAGAAGATGT CAACGCCCAT CGAGGTCCTC 720 | TGCAAAGGCT ATCCCTCCGA ATTCTCAACA TACCTCAACT TCTGCCGCTC CCTGCGGTTT 780 | GACGACAAGC CCGACTACTC TTACCTACGT CAGCTCTTCC GCAACCTCTT CCACCGGCAG 840 | GGCTTCTCCT ATGACTACGT CTTTGACTGG AACATGCTGA AATTCACGGA CACTGTCCAA 900 | GATGGTAGCC ATTGGCCACA TGCGACACAT TTTTAA 936 |
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Domain Profile | S: 1 yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev 60 | yr+++kiGsGsfGdiylg+n+asgeevaikle++k+k+pql++es++yk++qggvgiP++ | Q: 9 YRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSI 68 | 89********************************************************** |
| S: 61 ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd 120 | +++g+e++ynv+v++llGpsledlf++c+rkfslktvllladq+isriey+hsk++i+rd | Q: 69 KWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRD 128 | ************************************************************ |
| S: 121 ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk 180 | +kPdnfl+g+g+kg+ vy+idfGlakkyrda+t++hipyre+k+ltGtaryasinthlg+ | Q: 129 VKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGI 188 | ************************************************************ |
| S: 181 eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef 240 | eqsrrddleslgyvl+yf+ gslPWqglkaatk+qkye+isekk+st+ievlc+g+P+ef | Q: 189 EQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEF 248 | ************************************************************ |
| S: 241 atylkyvrklkfeekPdyeyl 261 | +tyl+++r+l+f++kPdy+yl | Q: 249 STYLNFCRSLRFDDKPDYSYL 269 | *******************97 |
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Domain Sequence (FASTA) | YRLGRKIGSG SFGDIYLGAN IASGEEVAIK LECVKTKHPQ LHIESKFYKM MQGGVGIPSI 60 | KWCGAEGDYN VMVMELLGPS LEDLFNFCSR KFSLKTVLLL ADQMISRIEY IHSKNFIHRD 120 | VKPDNFLMGL GKKGNLVYII DFGLAKKYRD ARTHQHIPYR ENKNLTGTAR YASINTHLGI 180 | EQSRRDDLES LGYVLMYFNL GSLPWQGLKA ATKRQKYERI SEKKMSTPIE VLCKGYPSEF 240 | STYLNFCRSL RFDDKPDYSY L 261 |
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Keyword | ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |