EKS-HOS-00508
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00508
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/BRDN/AN/AN/AN/AN/A
StatusReviewed
Ensembl ProteinENSP00000372588
UniProt AccessionP25440; A2AAU0; B0S7P0; B1AZT1; O00699; O00700; Q15310; Q5STC9; Q6P3U2; Q969U4;
Protein NameBromodomain-containing protein 2
Protein Synonyms/Alias O27.1.1; Really interesting new gene 3 protein;
Gene NameBRD2
Gene Synonyms/Alias BRD2; KIAA9001, RING3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000234507ENSP00000410994ENST00000442863
ENSG00000234507ENSP00000448867ENST00000549843
ENSG00000234507ENSP00000401791ENST00000438194
ENSG00000234507ENSP00000391758ENST00000412535
ENSG00000234507ENSP00000434978ENST00000492172
ENSG00000234507ENSP00000446894ENST00000552513
ENSG00000234507ENSP00000432478ENST00000496177
ENSG00000234507ENSP00000447736ENST00000547895
ENSG00000234507ENSP00000434843ENST00000493063
ENSG00000234507ENSP00000404221ENST00000446150
ENSG00000234507ENSP00000372588ENST00000383108
OrganismHomo sapiens
Functional DescriptionMay play a role in spermatogenesis or folliculogenesis(By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.
Protein Length801
Protein Sequence
(FASTA)
MLQNVTPHNK LPGEGNAGLL GLGPEAAAPG KRIRKPSLLY EGFESPTMAS VPALQLTPAN 60
PPPPEVSNPK KPGRVTNQLQ YLHKVVMKAL WKHQFAWPFR QPVDAVKLGL PDYHKIIKQP 120
MDMGTIKRRL ENNYYWAASE CMQDFNTMFT NCYIYNKPTD DIVLMAQTLE KIFLQKVASM 180
PQEEQELVVT IPKNSHKKGA KLAALQGSVT SAHQVPAVSS VSHTALYTPP PEIPTTVLNI 240
PHPSVISSPL LKSLHSAGPP LLAVTAAPPA QPLAKKKGVK RKADTTTPTP TAILAPGSPA 300
SPPGSLEPKA ARLPPMRRES GRPIKPPRKD LPDSQQQHQS SKKGKLSEQL KHCNGILKEL 360
LSKKHAAYAW PFYKPVDASA LGLHDYHDII KHPMDLSTVK RKMENRDYRD AQEFAADVRL 420
MFSNCYKYNP PDHDVVAMAR KLQDVFEFRY AKMPDEPLEP GPLPVSTAMP PGLAKSSSES 480
SSEESSSESS SEEEEEEDEE DEEEEESESS DSEEERAHRL AELQEQLRAV HEQLAALSQG 540
PISKPKRKRE KKEKKKKRKA EKHRGRAGAD EDDKGPRAPR PPQPKKSKKA SGSGGGSAAL 600
GPSGFGPSGG SGTKLPKKAT KTAPPALPTG YDSEEEEESR PMSYDEKRQL SLDINKLPGE 660
KLGRVVHIIQ AREPSLRDSN PEEIEIDFET LKPSTLRELE RYVLSCLRKK PRKPYTIKKP 720
VGKTKEELAL EKKRELEKRL QDVSGQLNST KKPPKKANEK TESSSAQQVA VSRLSASSSS 780
SDSSSSSSSS SSSDTSDSDS G 801
Nucleotide Sequence
(FASTA)
ATGCTGCAAA ACGTGACTCC CCACAATAAG CTCCCTGGGG AAGGGAATGC AGGGTTGCTG 60
GGGCTGGGCC CAGAAGCAGC AGCACCAGGG AAGAGGATTC GAAAACCCTC TCTCTTGTAT 120
GAGGGCTTTG AGAGCCCCAC AATGGCTTCG GTGCCTGCTT TGCAACTTAC CCCTGCCAAC 180
CCACCACCCC CGGAGGTGTC CAATCCCAAA AAGCCAGGAC GAGTTACCAA CCAGCTGCAA 240
TACCTACACA AGGTAGTGAT GAAGGCTCTG TGGAAACATC AGTTCGCATG GCCATTCCGG 300
CAGCCTGTGG ATGCTGTCAA ACTGGGTCTA CCGGATTATC ACAAAATTAT AAAACAGCCT 360
ATGGACATGG GTACTATTAA GAGGAGACTT GAAAACAATT ATTATTGGGC TGCTTCAGAG 420
TGTATGCAAG ATTTTAATAC CATGTTCACC AACTGTTACA TTTACAACAA GCCCACTGAT 480
GATATTGTCC TAATGGCACA AACGCTGGAA AAGATATTCC TACAGAAGGT TGCATCAATG 540
CCACAAGAAG AACAAGAGCT GGTAGTGACC ATCCCTAAGA ACAGCCACAA GAAGGGGGCC 600
AAGTTGGCAG CGCTCCAGGG CAGTGTTACC AGTGCCCATC AGGTGCCTGC CGTCTCTTCT 660
GTGTCACACA CAGCCCTCTA TACTCCTCCA CCTGAGATAC CTACCACTGT CCTCAACATT 720
CCCCACCCAT CAGTCATTTC CTCTCCACTT CTCAAGTCCT TGCACTCTGC TGGACCCCCG 780
CTCCTTGCTG TTACTGCAGC TCCTCCAGCC CAGCCCCTTG CCAAGAAAAA AGGCGTAAAG 840
CGGAAAGCAG ATACTACCAC CCCTACACCT ACAGCCATCT TGGCTCCTGG TTCTCCAGCT 900
AGCCCTCCTG GGAGTCTTGA GCCTAAGGCA GCACGGCTTC CCCCTATGCG TAGAGAGAGT 960
GGTCGCCCCA TCAAGCCCCC ACGCAAAGAC TTGCCTGACT CTCAGCAACA ACACCAGAGC 1020
TCTAAGAAAG GAAAGCTTTC AGAACAGTTA AAACATTGCA ATGGCATTTT GAAGGAGTTA 1080
CTCTCTAAGA AGCATGCTGC CTATGCTTGG CCTTTCTATA AACCAGTGGA TGCTTCTGCA 1140
CTTGGCCTGC ATGACTACCA TGACATCATT AAGCACCCCA TGGACCTCAG CACTGTCAAG 1200
CGGAAGATGG AGAACCGTGA TTACCGGGAT GCACAGGAGT TTGCTGCTGA TGTACGGCTT 1260
ATGTTCTCCA ACTGCTATAA GTACAATCCC CCAGATCACG ATGTTGTGGC AATGGCACGA 1320
AAGCTACAGG ATGTATTTGA GTTCCGTTAT GCCAAGATGC CAGATGAACC ACTAGAACCA 1380
GGGCCTTTAC CAGTCTCTAC TGCCATGCCC CCTGGCTTGG CCAAATCGTC TTCAGAGTCC 1440
TCCAGTGAGG AAAGTAGCAG TGAGAGCTCC TCTGAGGAAG AGGAGGAGGA AGATGAGGAG 1500
GACGAGGAGG AAGAAGAGAG TGAAAGCTCA GACTCAGAGG AAGAAAGGGC TCATCGCTTA 1560
GCAGAACTAC AGGAACAGCT TCGGGCAGTA CATGAACAAC TGGCTGCTCT GTCCCAGGGT 1620
CCAATATCCA AGCCCAAGAG GAAAAGAGAG AAAAAAGAGA AAAAGAAGAA ACGGAAGGCA 1680
GAGAAGCATC GAGGCCGAGC TGGGGCCGAT GAAGATGACA AGGGGCCTAG GGCACCCCGC 1740
CCACCTCAAC CTAAGAAGTC CAAGAAAGCA AGTGGCAGTG GGGGTGGCAG TGCTGCTTTA 1800
GGCCCTTCTG GCTTTGGACC TTCTGGAGGA AGTGGCACCA AGCTCCCCAA AAAGGCCACA 1860
AAGACAGCCC CACCTGCCCT GCCTACAGGT TATGATTCAG AGGAGGAGGA AGAGAGCAGG 1920
CCCATGAGTT ACGATGAGAA GCGGCAGCTG AGCCTGGACA TCAACAAATT ACCTGGGGAG 1980
AAGCTGGGCC GAGTTGTGCA TATAATCCAA GCCAGGGAGC CCTCTTTACG TGATTCAAAC 2040
CCAGAAGAGA TTGAGATTGA TTTTGAAACA CTCAAGCCAT CCACACTTAG AGAGCTTGAG 2100
CGCTATGTCC TTTCCTGCCT ACGTAAGAAA CCCCGGAAGC CCTACACCAT TAAGAAGCCT 2160
GTGGGAAAGA CAAAGGAGGA ACTGGCTTTG GAGAAAAAGC GGGAATTAGA AAAGCGGTTA 2220
CAAGATGTCA GCGGACAGCT CAATTCTACT AAAAAGCCCC CCAAGAAAGC GAATGAGAAA 2280
ACAGAGTCAT CCTCTGCACA GCAAGTAGCA GTGTCACGCC TTAGCGCTTC CAGCTCTAGC 2340
TCAGATTCCA GCTCCTCCTC TTCCTCGTCG TCGTCTTCAG ACACCAGTGA TTCAGACTCA 2400
GGCTAA 2406
Domain Profile
N/A
Domain Sequence
(FASTA)
N/A
Keyword3D-structure; Acetylation; Alternative splicing; Bromodomain; Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Dipodomys ordii"; ?>Latimeria chalumnae"; ?>Oryzias latipes"; ?>Sorex araneus"; ?>Takifugu rubripes"; ?>
EKS-CAE-00440
EKS-DIO-00116
EKS-LAC-00519
EKS-ORL-00580
EKS-SOA-00068
EKS-TAR-00620
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0003682; F:chromatin binding
GO:0070577; F:histone acetyl-lysine binding
GO:0016568; P:chromatin modification
GO:0006334; P:nucleosome assembly
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0007283; P:spermatogenesis
GO:0006351; P:transcription, DNA-dependent
KEGG
hsa:6046;
InterPros
IPR001487; Bromodomain.
IPR018359; Bromodomain_CS.
Pfam
PF00439; Bromodomain; 2.
SMARTs
SM00297; BROMO; 2.
Prosites
PS00633; BROMODOMAIN_1; 2.
PS50014; BROMODOMAIN_2; 2.
PS51525; NET; 1.
Prints
PR00503; BROMODOMAIN.
Created Date20-Feb-2013