| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00057 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CMGC/CDK | 437.5 | 9.8E-131 | 4 | 286 | 283 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000400088 |
| UniProt Accession | Q00526; |
| Protein Name | Cyclin-dependent kinase 3 |
| Protein Synonyms/Alias | Cell division protein kinase 3; |
| Gene Name | CDK3 |
| Gene Synonyms/Alias | CDK3; CDKN3; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Serine/threonine-protein kinase that plays a criticalrole in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1- independent manner. |
| Protein Length | 305 |
Protein Sequence
(FASTA) | | MDMFQKVEKI GEGTYGVVYK AKNRETGQLV ALKKIRLDLE MEGVPSTAIR EISLLKELKH 60 | | PNIVRLLDVV HNERKLYLVF EFLSQDLKKY MDSTPGSELP LHLIKSYLFQ LLQGVSFCHS 120 | | HRVIHRDLKP QNLLINELGA IKLADFGLAR AFGVPLRTYT HEVVTLWYRA PEILLGSKFY 180 | | TTAVDIWSIG CIFAEMVTRK ALFPGDSEID QLFRIFRMLG TPSEDTWPGV TQLPDYKGSF 240 | | PKWTRKGLEE IVPNLEPEGR DLLMQLLQYD PSQRITAKTA LAHPYFSSPE PSPAARQYVL 300 | | QRFRH 305 |
|
Nucleotide Sequence
(FASTA) | | ATGGATATGT TCCAGAAGGT AGAGAAGATC GGAGAGGGCA CCTATGGGGT GGTGTACAAG 60 | | GCCAAGAACA GGGAGACAGG GCAGCTGGTG GCCCTGAAGA AGATCAGACT GGATTTGGAG 120 | | ATGGAGGGGG TCCCAAGCAC TGCCATCAGG GAGATCTCGC TGCTCAAGGA ACTGAAGCAC 180 | | CCCAACATCG TCCGACTGCT GGACGTGGTG CACAACGAGA GGAAGCTCTA TCTGGTGTTT 240 | | GAGTTCCTCA GCCAGGACCT GAAGAAGTAC ATGGACTCCA CCCCAGGCTC AGAGCTCCCC 300 | | CTGCACCTCA TCAAGAGCTA CCTCTTCCAG CTGCTGCAGG GGGTGAGTTT CTGCCACTCA 360 | | CATCGGGTCA TCCACCGAGA CCTGAAGCCC CAGAACCTGC TCATCAATGA GTTGGGTGCC 420 | | ATCAAGCTGG CTGACTTCGG CCTGGCTCGC GCCTTCGGGG TGCCCCTGCG CACCTACACC 480 | | CATGAGGTGG TGACACTGTG GTATCGCGCC CCCGAGATTC TCTTGGGCAG CAAGTTCTAT 540 | | ACCACAGCTG TGGATATCTG GAGCATTGGT TGCATCTTTG CAGAGATGGT GACTCGAAAA 600 | | GCCCTGTTTC CTGGTGACTC TGAGATTGAC CAGCTCTTTC GTATCTTTCG TATGCTGGGG 660 | | ACACCCAGCG AAGACACATG GCCCGGGGTC ACCCAGCTGC CTGACTATAA GGGCAGCTTC 720 | | CCTAAGTGGA CCAGGAAGGG ACTGGAAGAG ATTGTGCCCA ATCTGGAGCC AGAGGGCAGG 780 | | GACCTGCTCA TGCAACTCCT GCAGTATGAC CCCAGCCAGC GGATCACAGC CAAGACTGCC 840 | | CTGGCCCACC CGTACTTCTC ATCCCCTGAG CCCTCCCCAG CTGCCCGCCA GTATGTGCTG 900 | | CAGCGATTCC GCCATTGA 918 |
|
| Domain Profile | S: 1 yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni 60 | ++k+ekigeGtyg+vykak++etg++vAlKkirl+ e egvp+ta+rEisllkelkh+ni | Q: 4 FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNI 63 | 89********************************************************** |
| S: 61 vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk 120 | v+Ll+vv+ +++klyLvfefl+qdLkk++++++ ++l+l+ +ks+l+qll+g++++Hs++ | Q: 64 VRLLDVVH-NERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHR 122 | ********.99************************************************* |
| S: 121 ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst 180 | ++HRDlKpqNlLi++ g +klaDfGlaraf++pl+tyt+evvTlwYraPe+Llg+k Y+t | Q: 123 VIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTT 182 | ************************************************************ |
| S: 181 avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfpk 240 | avDiWs+gci+ae++trk+lf+g+seidql+rif++lgtpse++wp+v++lp+yk sfpk | Q: 183 AVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPK 242 | ************************************************************ |
| S: 241 kkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf 284 | +++k l+e v++l+ +++dll +ll++dp++Ri+ak+al+h+yf | Q: 243 WTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF 286 | *******************************************9 |
|
Domain Sequence
(FASTA) | | FQKVEKIGEG TYGVVYKAKN RETGQLVALK KIRLDLEMEG VPSTAIREIS LLKELKHPNI 60 | | VRLLDVVHNE RKLYLVFEFL SQDLKKYMDS TPGSELPLHL IKSYLFQLLQ GVSFCHSHRV 120 | | IHRDLKPQNL LINELGAIKL ADFGLARAFG VPLRTYTHEV VTLWYRAPEI LLGSKFYTTA 180 | | VDIWSIGCIF AEMVTRKALF PGDSEIDQLF RIFRMLGTPS EDTWPGVTQL PDYKGSFPKW 240 | | TRKGLEEIVP NLEPEGRDLL MQLLQYDPSQ RITAKTALAH PYF 283 |
|
| Keyword | 3D-structure; ATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Mitosis; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |