EKS-HOS-00272

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00272

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	464.9	7.3E-139	189	502	314

Status

Reviewed

Ensembl Protein

ENSP00000462982

UniProt Accession

O43781; D3DT79; Q7Z752; Q9HBY6; Q9HBY7;

Protein Name

Dual specificity tyrosine-phosphorylation-regulated kinase 3

Protein Synonyms/Alias

Regulatory erythroid kinase; REDK;

Gene Name

DYRK3

Gene Synonyms/Alias

DYRK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000265184	ENSP00000463633	ENST00000584909
ENSG00000265184	ENSP00000462982	ENST00000581534
ENSG00000265184	ENSP00000463587	ENST00000578483
ENSG00000265184	ENSP00000462743	ENST00000583372

Organism

Homo sapiens

Functional Description

Negative regulator of EPO-dependent erythropoiesis, mayplace an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.

Protein Length

568

Protein Sequence
(FASTA)

MKWKEKLGDG VYDTFMMIDE TKCPPCSNVL CNPSEPPPPR RLNMTTEQFT GDHTQHFLDG 60

GEMKVEQLFQ EFGNRKSNTI QSDGISDSEK CSPTVSQGKS SDCLNTVKSN SSSKAPKVVP 120

LTPEQALKQY KHHLTAYEKL EIINYPEIYF VGPNAKKRHG VIGGPNNGGY DDADGAYIHV 180

PRDHLAYRYE VLKIIGKGSF GQVARVYDHK LRQYVALKMV RNEKRFHRQA AEEIRILEHL 240

KKQDKTGSMN VIHMLESFTF RNHVCMAFEL LSIDLYELIK KNKFQGFSVQ LVRKFAQSIL 300

QSLDALHKNK IIHCDLKPEN ILLKHHGRSS TKVIDFGSSC FEYQKLYTYI QSRFYRAPEI 360

ILGSRYSTPI DIWSFGCILA ELLTGQPLFP GEDEGDQLAC MMELLGMPPP KLLEQSKRAK 420

YFINSKGIPR YCSVTTQADG RVVLVGGRSR RGKKRGPPGS KDWGTALKGC DDYLFIEFLK 480

RCLHWDPSAR LTPAQALRHP WISKSVPRPL TTIDKVSGKR VVNPASAFQG LGSKLPPVVG 540

IANKLKANLM SETNGSIPLC SVLPKLIS 568

Nucleotide Sequence
(FASTA)

ATGAAGTGGA AAGAGAAGTT GGGGGATGGT GTCTATGACA CCTTCATGAT GATAGATGAA 60

ACCAAATGTC CCCCCTGTTC AAATGTACTC TGCAATCCTT CTGAACCACC TCCACCCAGA 120

AGACTAAATA TGACCACTGA GCAGTTTACA GGAGATCATA CTCAGCACTT TTTGGATGGA 180

GGTGAGATGA AGGTAGAACA GCTGTTTCAA GAATTTGGCA ACAGAAAATC CAATACTATT 240

CAGTCAGATG GCATCAGTGA CTCTGAAAAA TGCTCTCCTA CTGTTTCTCA GGGTAAAAGT 300

TCAGATTGCT TGAATACAGT AAAATCCAAC AGTTCATCCA AGGCACCCAA AGTGGTGCCT 360

CTGACTCCAG AACAAGCCCT GAAGCAATAT AAACACCACC TCACTGCCTA TGAGAAACTG 420

GAAATAATTA ATTATCCAGA AATTTACTTT GTAGGTCCAA ATGCCAAGAA AAGACATGGA 480

GTTATTGGTG GTCCCAATAA TGGAGGGTAT GATGATGCAG ATGGGGCCTA TATTCATGTA 540

CCTCGAGACC ATCTAGCTTA TCGATATGAG GTGCTGAAAA TTATTGGCAA GGGGAGTTTT 600

GGGCAGGTGG CCAGGGTCTA TGATCACAAA CTTCGACAGT ACGTGGCCCT AAAAATGGTG 660

CGCAATGAGA AGCGCTTTCA TCGTCAAGCA GCTGAGGAGA TCCGGATTTT GGAGCATCTT 720

AAGAAACAGG ATAAAACTGG TAGTATGAAC GTTATCCACA TGCTGGAAAG TTTCACATTC 780

CGGAACCATG TTTGCATGGC CTTTGAATTG CTGAGCATAG ACCTTTATGA GCTGATTAAA 840

AAAAATAAGT TTCAGGGTTT TAGCGTCCAG TTGGTACGCA AGTTTGCCCA GTCCATCTTG 900

CAATCTTTGG ATGCCCTCCA CAAAAATAAG ATTATTCACT GCGATCTGAA GCCAGAAAAC 960

ATTCTCCTGA AACACCACGG GCGCAGTTCA ACCAAGGTCA TTGACTTTGG GTCCAGCTGT 1020

TTCGAGTACC AGAAGCTCTA CACATATATC CAGTCTCGGT TCTACAGAGC TCCAGAAATC 1080

ATCTTAGGAA GCCGCTACAG CACACCAATT GACATATGGA GTTTTGGCTG CATCCTTGCA 1140

GAACTTTTAA CAGGACAGCC TCTCTTCCCT GGAGAGGATG AAGGAGACCA GTTGGCCTGC 1200

ATGATGGAGC TTCTAGGGAT GCCACCACCA AAACTTCTGG AGCAATCCAA ACGTGCCAAG 1260

TACTTTATTA ATTCCAAGGG CATACCCCGC TACTGCTCTG TGACTACCCA GGCAGATGGG 1320

AGGGTTGTGC TTGTGGGGGG TCGCTCACGT AGGGGTAAAA AGCGGGGTCC CCCAGGCAGC 1380

AAAGACTGGG GGACAGCACT GAAAGGGTGT GATGACTACT TGTTTATAGA GTTCTTGAAA 1440

AGGTGTCTTC ACTGGGACCC CTCTGCCCGC TTGACCCCAG CTCAAGCATT AAGACACCCT 1500

TGGATTAGCA AGTCTGTCCC CAGACCTCTC ACCACCATAG ACAAGGTGTC AGGGAAACGG 1560

GTAGTTAATC CTGCAAGTGC TTTCCAGGGA TTGGGTTCTA AGCTGCCTCC AGTTGTTGGA 1620

ATAGCCAATA AGCTTAAAGC TAACTTAATG TCAGAAACCA ATGGTAGTAT ACCCCTATGC 1680

AGTGTATTGC CAAAACTGAT TAGCTAG 1707

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl++igkGsfgqV++++d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+ +

Q: 189   YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS  248

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le+f+frnh+c+ fells++Lyel+kknkf+g+s++lvrk+aq+il++L++L++

Q: 249   MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK  308

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNill++++rs+ kviDFGss+++ qk +ytyiqsrfYraPEiilg +y+

Q: 309   NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK-LYTYIQSRFYRAPEIILGSRYS  367

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iD+WS+Gc+laEl+tG+pLfpGe+e dqla+++e+lg+pp+klle++k+ak+f+++k+

Q: 368   TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKG  427

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

          p+y+ +t+++d +++lv ++++++kkr +p+sk++g+alk ++d+lf+++lkr+l++dp

Q: 428   IPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDP  487

         ************************************************************

S: 301   akRitpkealkhpfv  315

         ++R+tp++al+hp++

Q: 488   SARLTPAQALRHPWI  502

         **************7

Domain Sequence
(FASTA)

YEVLKIIGKG SFGQVARVYD HKLRQYVALK MVRNEKRFHR QAAEEIRILE HLKKQDKTGS 60

MNVIHMLESF TFRNHVCMAF ELLSIDLYEL IKKNKFQGFS VQLVRKFAQS ILQSLDALHK 120

NKIIHCDLKP ENILLKHHGR SSTKVIDFGS SCFEYQKLYT YIQSRFYRAP EIILGSRYST 180

PIDIWSFGCI LAELLTGQPL FPGEDEGDQL ACMMELLGMP PPKLLEQSKR AKYFINSKGI 240

PRYCSVTTQA DGRVVLVGGR SRRGKKRGPP GSKDWGTALK GCDDYLFIEF LKRCLHWDPS 300

ARLTPAQALR HPWI 314

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0030218	; P:erythrocyte differentiation

KEGG

hsa:8444

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013