EKS-GAA-00068

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00068

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	399.5	1.1E-119	332	588	257

Status

Unreviewed

Ensembl Protein

ENSGACP00000000078

UniProt Accession

G3N460;

Protein Name

Protein Synonyms/Alias

Gene Name

RAF1

Gene Synonyms/Alias

RAF1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000000060	ENSGACP00000000078	ENSGACT00000000078

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

629

Protein Sequence
(FASTA)

MEHLQGAWKT LSNGFGMKDT AFEGPCLSPT LVQGFSCQRR SSDDGKMPDS KTSSTIRVYL 60

PNQQRTVVNV RPGMTLYSCL IKALKVRGLQ PQCCAVFRLH PGQRRSPPMC VESEATSDHS 120

CKEEPLCNTS TLSFILKPAD VLAFLSPCLY INLSDDLTLT PFYGFCMLRI VAYLVIIGGN 180

PRMSVGCVRR PGDSGASSLR PLTSRRMRES LTRFPREMHF ICCGSPDNVS EPLAVGGGKQ 240

PIRLRKHREP NTSTVSSTLL LHASHLQDAM RDHDSGGSSP SQSPTGWSQS KAPAPAQRER 300

APSFNNHEKN KIRPRDKRDS SYYWEIEASE VHLSSRIGSG SFGTVYKGKW HGDVAVKILK 360

VTDPTPEQFQ AFRNEVAVLR KTRHVNILLF MGYMTEDNLA IVTQWCEGSS LYKHLHVLET 420

NFKIIQLIDI ARQTAQGMDY LHAKNIIHRD MKSNNIFLHE GLTVKIGDFG LATVKARWSG 480

SHQVEQPSGS ILWMAPEVIR MQDNNPYSFQ SDVYSYGIVL FEILTGELPY SLIATRDQII 540

FMVGRGYLSP DLSKLYKNCP KAMKRLVADC IKKSKDERPL FPQILSSIEL LQHALPKINR 600

STSEPSLHRA AHTEDINICT LTSTRLPCF 629

Nucleotide Sequence
(FASTA)

ATGGAGCACC TCCAGGGAGC GTGGAAGACC CTGAGCAACG GCTTCGGAAT GAAGGACACC 60

GCCTTCGAGG GCCCGTGCCT CTCGCCGACC TTGGTCCAGG GCTTCTCCTG CCAGCGCCGC 120

TCCTCCGACG ACGGCAAGAT GCCCGACTCC AAGACCAGCA GCACCATCCG CGTCTACCTC 180

CCGAACCAGC AGCGCACTGT GGTGAACGTA CGACCAGGTA TGACTCTGTA CAGTTGCCTG 240

ATTAAAGCAT TAAAGGTGAG AGGTCTGCAA CCGCAGTGCT GCGCCGTCTT CAGGCTGCAT 300

CCGGGACAGA GGAGGTCACC TCCCATGTGT GTGGAATCGG AAGCAACATC AGATCACTCC 360

TGTAAAGAGG AACCTCTGTG CAATACATCC ACGTTGTCGT TCATTTTAAA ACCTGCAGAC 420

GTCCTTGCCT TCCTAAGTCC GTGTCTGTAC ATTAATCTTT CTGATGACTT GACCCTGACC 480

CCTTTTTATG GATTTTGCAT GCTGAGAATA GTAGCTTATT TGGTAATCAT TGGAGGAAAT 540

CCACGCATGA GCGTCGGTTG TGTCCGACGC CCCGGCGACA GCGGCGCCTC GTCGCTGCGC 600

CCGCTGACGT CTCGGCGGAT GAGAGAGTCC TTAACGCGGT TCCCAAGAGA AATGCATTTT 660

ATTTGTTGTG GGTCACCGGA TAATGTATCT GAGCCACTGG CAGTGGGGGG GGGGAAGCAG 720

CCAATACGGC TCCGCAAACA CCGAGAGCCA AATACCTCGA CGGTGTCAAG TACACTTCTT 780

CTTCATGCAT CACACCTTCA GGATGCAATG CGTGATCACG ACTCGGGGGG GAGCTCCCCC 840

AGCCAGAGCC CTACAGGCTG GTCCCAGTCC AAAGCGCCTG CGCCTGCCCA GCGGGAGAGG 900

GCCCCGTCCT TCAACAACCA CGAGAAAAAC AAAATAAGGC CTCGGGACAA GCGCGACTCC 960

AGTTACTACT GGGAGATCGA GGCCAGCGAA GTGCACCTGA GCTCCCGCAT CGGATCGGGC 1020

TCGTTTGGGA CGGTGTACAA AGGGAAATGG CACGGTGACG TAGCGGTGAA GATTCTAAAG 1080

GTCACCGACC CCACGCCGGA GCAGTTCCAG GCATTCAGGA ATGAAGTGGC AGTCTTGAGG 1140

AAGACACGGC ATGTCAACAT CCTGCTGTTC ATGGGCTACA TGACGGAGGA CAACCTGGCC 1200

ATTGTGACCC AGTGGTGTGA AGGCAGCAGC CTCTACAAAC ACCTCCACGT CCTGGAGACC 1260

AACTTCAAGA TCATCCAGCT CATAGACATC GCCCGGCAGA CGGCCCAGGG GATGGACTAT 1320

CTGCACGCGA AGAACATCAT TCACCGGGAC ATGAAGTCCA ACAACATCTT CCTGCATGAA 1380

GGGCTAACGG TGAAAATCGG CGACTTCGGT CTGGCAACGG TGAAGGCCAG GTGGAGCGGC 1440

TCGCATCAGG TGGAGCAGCC TTCCGGATCC ATCCTCTGGA TGGCTCCTGA GGTCATCCGG 1500

ATGCAGGATA ACAACCCGTA CAGCTTCCAG TCTGATGTCT ATTCCTATGG AATCGTTCTC 1560

TTCGAGATCC TGACCGGGGA GCTCCCGTAC TCCCTGATAG CCACCAGAGA TCAGATCATC 1620

TTCATGGTGG GAAGAGGCTA TTTGTCCCCA GACCTCAGCA AGCTCTATAA AAACTGCCCC 1680

AAAGCCATGA AGAGGTTGGT GGCCGACTGC ATCAAGAAGT CCAAAGACGA GAGGCCGCTC 1740

TTCCCCCAGA TCTTGTCCTC CATTGAGCTT CTCCAGCACG CCCTACCGAA GATAAACCGC 1800

AGTACCTCAG AGCCGTCCCT GCACCGAGCC GCCCACACCG AGGATATCAA TATCTGCACT 1860

CTGACCTCCA CCAGACTGCC TTGTTTCTAG 1890

Domain Profile

S: 2     elaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLFm  61

         +l+++iGsG+fGtvy+gkwhGdvavk+l+v+++++eq++aF++eva+++ktRh+ni+LFm

Q: 332   HLSSRIGSGSFGTVYKGKWHGDVAVKILKVTDPTPEQFQAFRNEVAVLRKTRHVNILLFM  391

         6889********************************************************

S: 62    GyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkDl  121

         Gy+++++laivt++c+gssLyk+lh+ et++++ +lidiarq+aqgmdYLhak+i+h+D+

Q: 392   GYMTEDNLAIVTQWCEGSSLYKHLHVLETNFKIIQLIDIARQTAQGMDYLHAKNIIHRDM  451

         ************************************************************

S: 122   ksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleqd  181

         ks+ni+l+egl+v+i+DFgl++vk ++sg  ++q+e+p+g+il++apevir+      qd

Q: 452   KSNNIFLHEGLTVKIGDFGLATVKARWSG--SHQVEQPSGSILWMAPEVIRM------QD  503

         *****************************..*********************......**

S: 182   elpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpkel  239

         ++p+s++sDvy++Givl+e+l++elpy+   ++dqi+f+vgrG l+pdlsk+++++pk++

Q: 504   NNPYSFQSDVYSYGIVLFEILTGELPYSLiATRDQIIFMVGRGyLSPDLSKLYKNCPKAM  563

         ****************************99******************************

S: 240   kellleClkfekeeRPlftqilkkl  264

         k+l+++C+k++k+eRPlf+qil+++

Q: 564   KRLVADCIKKSKDERPLFPQILSSI  588

         *********************9875

Domain Sequence
(FASTA)

HLSSRIGSGS FGTVYKGKWH GDVAVKILKV TDPTPEQFQA FRNEVAVLRK TRHVNILLFM 60

GYMTEDNLAI VTQWCEGSSL YKHLHVLETN FKIIQLIDIA RQTAQGMDYL HAKNIIHRDM 120

KSNNIFLHEG LTVKIGDFGL ATVKARWSGS HQVEQPSGSI LWMAPEVIRM QDNNPYSFQS 180

DVYSYGIVLF EILTGELPYS LIATRDQIIF MVGRGYLSPD LSKLYKNCPK AMKRLVADCI 240

KKSKDERPLF PQILSSI 257

Keyword

Complete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005057	; F:receptor signaling protein activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR003116	; Raf-like_ras-bd.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF02196	; RBD; 1.

SMARTs

SM00455

; RBD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50898	; RBD; 1.

Prints

Created Date

20-Feb-2013