EKS-GAA-00326

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00326

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	456.7	5.9E-137	193	506	314

Status

Unreviewed

Ensembl Protein

ENSGACP00000000494

UniProt Accession

G3N5C4;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK3

Gene Synonyms/Alias

DYRK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000000385	ENSGACP00000000494	ENSGACT00000000494

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

579

Protein Sequence
(FASTA)

MIISRKPEGP IATARHGDGL YDSYMRTDHI LKDEADTNSP AGLPPMPKHT VVSNKTVMRE 60

QVTVRGGQLK VKYMYEDSAN NRKINAISTA ATQNSSTEPS KGSGDPCGPN AVANGGGVGK 120

LCGPLTPDQA LRLYRSQLTT LEQAEIHSYP EIFFVGPNAK KRPAVAGGNN NCGYDDEQGG 180

YTHVAHDHLA YRYEFLKIIG KGSFGQVAKV YDHKLQQHLA LKMVRNEKRF HRQAQEEIRI 240

LEHLRKQDRN GTMNVVHMLE NFTFRNHICM TFELLSMNLY ELIKRNKFQG FSLPLVRKFA 300

HSILQCLEAL SKHRIIHCDL KPENILLKQQ GRSGIKVIDF GSSCFEHQRV YTYIQSRFYR 360

APEVILGSRY GLPIDMWSFG CILAELLTGY PLFPGEDEGD QLACVMELLG MPPQKVLEQA 420

KRAKNFINSK GHPRYCGANT LPTGATVLTG SRSRRGKMRG PPGSKEWSAA LKGCEDPTFT 480

DFIKKCLDWD PSSRLTPTQA LRHPWLYRRL PKPLPGAEKS YGAPVKRLPE HHSTSFPSIL 540

AKGGPGLSST AVNNKLRSNM LGDSGDGIPL RTVLPKLVS 579

Nucleotide Sequence
(FASTA)

ATGATAATAA GCAGAAAACC AGAGGGCCCG ATAGCAACAG CGCGCCACGG TGATGGTCTA 60

TATGACTCGT ACATGAGGAC AGACCACATC CTTAAGGACG AGGCGGATAC AAACAGTCCG 120

GCCGGCCTGC CCCCCATGCC CAAACACACA GTTGTCAGCA ACAAGACTGT GATGAGGGAG 180

CAGGTCACCG TGAGAGGTGG CCAGCTGAAG GTGAAGTACA TGTACGAAGA CTCCGCCAAC 240

AACCGAAAGA TTAACGCCAT AAGCACAGCG GCCACTCAGA ACAGCAGCAC TGAACCCAGT 300

AAGGGCTCCG GGGATCCCTG CGGCCCTAAC GCAGTTGCAA ATGGAGGGGG CGTTGGAAAG 360

CTGTGTGGGC CTCTGACTCC CGACCAGGCT CTGAGACTGT ACCGATCTCA GCTGACCACC 420

CTGGAGCAGG CGGAGATCCA CTCCTACCCA GAGATCTTCT TTGTGGGACC CAATGCCAAG 480

AAGAGGCCTG CAGTCGCCGG CGGCAACAAC AACTGCGGCT ACGATGATGA ACAGGGTGGA 540

TACACCCACG TCGCCCATGA CCACCTGGCT TACCGCTACG AGTTCCTAAA GATCATTGGT 600

AAAGGTAGCT TTGGCCAGGT GGCAAAGGTG TACGATCACA AACTGCAGCA GCACCTGGCT 660

CTCAAAATGG TGCGCAACGA GAAGCGCTTC CACCGGCAGG CGCAGGAGGA GATCCGCATC 720

CTGGAGCACC TTCGCAAGCA GGATCGCAAC GGCACGATGA ACGTTGTGCA CATGCTGGAA 780

AACTTCACCT TCCGCAACCA CATCTGCATG ACCTTTGAGC TGCTGAGCAT GAACCTGTAC 840

GAGCTTATCA AGCGCAACAA GTTCCAGGGC TTCAGCCTGC CACTGGTCAG GAAGTTTGCG 900

CACTCCATCC TGCAGTGCCT GGAGGCCCTG AGCAAGCACC GAATCATCCA CTGCGACCTC 960

AAGCCTGAGA ACATCCTGCT CAAGCAGCAG GGACGCAGCG GCATCAAGGT GATCGACTTT 1020

GGGTCCAGCT GCTTCGAGCA CCAGCGGGTG TACACTTACA TCCAGTCCCG TTTCTACCGG 1080

GCCCCGGAGG TGATCCTCGG CTCGCGCTAC GGCCTCCCTA TCGACATGTG GAGCTTCGGC 1140

TGCATACTGG CCGAGCTGCT GACCGGCTAC CCGCTGTTCC CTGGCGAGGA CGAGGGCGAC 1200

CAGCTGGCCT GCGTCATGGA ACTGCTGGGC ATGCCTCCGC AGAAGGTCCT GGAGCAGGCC 1260

AAAAGGGCCA AGAACTTCAT CAACTCCAAG GGCCACCCTC GCTACTGCGG CGCCAACACC 1320

TTGCCCACAG GGGCCACCGT GCTCACGGGG TCCCGCTCTC GCCGCGGCAA GATGAGGGGT 1380

CCCCCGGGCA GCAAGGAGTG GAGCGCTGCA CTCAAGGGCT GCGAGGACCC CACCTTTACT 1440

GACTTCATAA AGAAGTGTTT GGACTGGGAC CCATCGTCGC GTCTCACGCC GACCCAGGCC 1500

CTCAGGCACC CGTGGCTGTA TCGGCGCCTA CCCAAGCCCC TACCCGGAGC CGAGAAGAGC 1560

TACGGGGCCC CGGTGAAAAG GCTCCCCGAG CACCACAGCA CCTCCTTCCC CTCGATCCTG 1620

GCCAAAGGGG GGCCCGGCTT AAGCAGCACA GCCGTGAACA ACAAACTGCG GAGCAACATG 1680

TTGGGAGATT CAGGGGACGG CATACCTCTT CGCACAGTCC TACCCAAACT TGTCTCTTAA 1740

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye l++igkGsfgqV+k++d+k ++++a+k+++n+krf+rqaqeE++iLe+l+k+d++ +

Q: 193   YEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLRKQDRNGT  252

         999*********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nvv++le f+frnh+c++fells+nLyel+k+nkf+g+sl lvrk+a++il++L++L++

Q: 253   MNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSK  312

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg +y

Q: 313   HRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQR-VYTYIQSRFYRAPEVILGSRYG  371

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

           iDmWS+Gc+laEl+tG+pLfpGe+e dqla+++e+lg+pp+k+le+ak+ak+f+++k+

Q: 372   LPIDMWSFGCILAELLTGYPLFPGEDEGDQLACVMELLGMPPQKVLEQAKRAKNFINSKG  431

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+  ++  + +++l+ ++++++k r +p+ske++ alk +ed +f+d++k++l++dp

Q: 432   HPRYCGANTLPTGATVLTGSRSRRGKMRGPPGSKEWSAALKGCEDPTFTDFIKKCLDWDP  491

         ************************************************************

S: 301   akRitpkealkhpfv  315

         ++R+tp++al+hp++

Q: 492   SSRLTPTQALRHPWL  506

         **************6

Domain Sequence
(FASTA)

YEFLKIIGKG SFGQVAKVYD HKLQQHLALK MVRNEKRFHR QAQEEIRILE HLRKQDRNGT 60

MNVVHMLENF TFRNHICMTF ELLSMNLYEL IKRNKFQGFS LPLVRKFAHS ILQCLEALSK 120

HRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCFEHQRVYT YIQSRFYRAP EVILGSRYGL 180

PIDMWSFGCI LAELLTGYPL FPGEDEGDQL ACVMELLGMP PQKVLEQAKR AKNFINSKGH 240

PRYCGANTLP TGATVLTGSR SRRGKMRGPP GSKEWSAALK GCEDPTFTDF IKKCLDWDPS 300

SRLTPTQALR HPWL 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Danio rerio"; ?>Gadus morhua"; ?>Latimeria chalumnae"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013