EKS-GAA-00325

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00325

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	462.5	9.9E-139	181	494	314

Status

Unreviewed

Ensembl Protein

ENSGACP00000000925

UniProt Accession

G3N6J9;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK2

Gene Synonyms/Alias

DYRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000000712	ENSGACP00000000925	ENSGACT00000000925
ENSGACG00000000712	ENSGACP00000000924	ENSGACT00000000923

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

570

Protein Sequence
(FASTA)

GSQTASPGAL PRLRNHNLTT LIVQHLYGGP RAAMSQAVQL SSQSQVTQLY EENTNKRPVL 60

TSQPNGLAPL GSTRPGLPLP DRQSSAPEPP NHCRQGSASS NKSTEGKPKP SSLSPEQAMK 120

QFMSKMSSLE HHEVFSYPEV YFVGPNAKKR SGVPGGANNG GYDDDQGSYI HVPHDHIAYR 180

YEVLKVIGKG SFGQVVKAFD HRSQTHLALK MVRNEKRFHR QAAEEIRILE HLRKQDKDSS 240

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDSLHK 300

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGSRYGM 360

PIDMWSLGCI LAELLTGYPL LPGEDEADQL ACIIELLGMP SQKLLDASKR AKNFVSSKGY 420

PRYCTVTTLP DGTAMLNAGR SRRGKVRGTP GSKDWSVALK GADDPLFLDF LKQCLEWDPA 480

LRMTPSQALR HPWLRRRLPK PPTGTTPGDK TSSSKRGAAT TADGAITSLS KLATTSSTTA 540

SSSKTRTNLA AITDANGNIQ PRTVLPKLVS 570

Nucleotide Sequence
(FASTA)

GGCTCTCAGA CGGCGTCGCC CGGCGCGCTG CCGCGACTCC GCAACCACAA CCTGACGACT 60

CTGATAGTCC AGCATTTATA TGGAGGCCCT AGAGCTGCCA TGTCGCAGGC CGTCCAGCTG 120

TCGTCTCAGT CTCAGGTCAC CCAGCTGTAC GAGGAGAACA CCAACAAGCG TCCGGTGCTG 180

ACCTCCCAGC CCAACGGCCT GGCTCCTCTC GGCTCCACCC GGCCGGGCCT CCCGCTGCCA 240

GACCGCCAGT CCTCGGCCCC GGAGCCCCCC AACCACTGCC GGCAGGGCAG CGCCTCTTCC 300

AACAAGTCGA CGGAGGGCAA GCCGAAGCCG TCCTCCCTGT CACCGGAGCA GGCCATGAAG 360

CAGTTCATGT CCAAGATGTC GTCTCTGGAG CACCACGAGG TCTTCAGCTA CCCCGAAGTG 420

TATTTCGTCG GCCCAAATGC GAAGAAGAGG TCAGGGGTCC CGGGCGGAGC CAACAACGGC 480

GGCTACGATG ACGATCAGGG ATCCTACATC CACGTTCCAC ACGACCACAT CGCCTACCGC 540

TACGAGGTCC TGAAGGTCAT TGGCAAGGGC AGCTTTGGAC AGGTGGTGAA GGCCTTCGAC 600

CACCGGTCTC AGACCCACTT AGCCCTGAAG ATGGTCCGCA ATGAGAAGCG CTTCCACCGG 660

CAGGCGGCTG AGGAGATCCG CATCCTGGAG CACCTAAGGA AGCAAGACAA GGACTCCAGC 720

ATGAACGTCA TCCACATGCT GGAGAACTTC ACCTTCCGGA ACCACATCTG CATGACCTTC 780

GAGCTGCTCA GCATGAACCT GTACGAGCTC ATCAAGAAAA ACAAGTTCCA GGGCTTTAGC 840

CTCCCGCTGG TCAGGAAGTT TGCCCACTCC ATCCTGCAGT GCCTGGACTC GCTGCACAAG 900

AACCGCATCA TCCACTGCGA CCTGAAGCCC GAGAACATCC TGCTGAAGCA GCAGGGACGC 960

AGCGGCATCA AGGTCATAGA TTTTGGTTCG AGCTGTTACG AACATCAGAG AGTTTACACC 1020

TACATCCAGT CCAGGTTCTA CAGAGCGCCG GAGGTCATTC TAGGCTCCAG GTACGGGATG 1080

CCGATCGACA TGTGGTCCCT GGGCTGCATT CTGGCCGAGC TGTTGACCGG TTACCCGCTG 1140

CTGCCGGGCG AGGACGAGGC CGACCAGCTG GCGTGCATCA TCGAGCTGCT GGGAATGCCG 1200

AGCCAGAAGC TCCTCGACGC CTCCAAGAGG GCCAAGAACT TTGTGTCATC CAAGGGCTAC 1260

CCGCGCTACT GCACCGTCAC CACGCTGCCC GACGGCACCG CCATGCTCAA CGCCGGCCGC 1320

TCACGGCGGG GGAAGGTGCG CGGCACGCCC GGCAGCAAGG ACTGGAGCGT GGCGCTGAAG 1380

GGCGCAGACG ACCCGCTGTT CTTGGACTTC CTGAAGCAGT GCCTGGAGTG GGACCCGGCG 1440

CTCAGGATGA CGCCCAGCCA GGCGCTGCGC CACCCGTGGC TGAGAAGACG ACTCCCCAAG 1500

CCACCGACGG GCACCACGCC AGGGGACAAG ACCTCCTCCT CTAAACGCGG CGCCGCCACA 1560

ACCGCCGACG GCGCCATAAC CTCTTTATCC AAGCTCGCCA CCACCTCCTC AACCACCGCC 1620

TCTTCCTCCA AAACCAGGAC TAACTTGGCG GCAATCACCG ACGCCAACGG GAACATCCAG 1680

CCCAGGACGG TGCTGCCCAA GCTGGTCAGC TGA 1713

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqVvka d++ ++++a+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 181   YEVLKVIGKGSFGQVVKAFDHRSQTHLALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSS  240

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L+ L++

Q: 241   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDSLHK  300

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg +y

Q: 301   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGSRYG  359

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+i+e+lg+p++kll+++k+ak+f+++k+

Q: 360   MPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKLLDASKRAKNFVSSKG  419

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+  d +  l+ ++++++k r +p+sk+++ alk  +d lf d+lk++le+dp

Q: 420   YPRYCTVTTLPDGTAMLNAGRSRRGKVRGTPGSKDWSVALKGADDPLFLDFLKQCLEWDP  479

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a R+tp++al+hp++

Q: 480   ALRMTPSQALRHPWL  494

         **************6

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVVKAFD HRSQTHLALK MVRNEKRFHR QAAEEIRILE HLRKQDKDSS 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDSLHK 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGSRYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEADQL ACIIELLGMP SQKLLDASKR AKNFVSSKGY 240

PRYCTVTTLP DGTAMLNAGR SRRGKVRGTP GSKDWSVALK GADDPLFLDF LKQCLEWDPA 300

LRMTPSQALR HPWL 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013