EKS-GAA-00373
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00373
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR405.89.4E-122659915257
StatusUnreviewed
Ensembl ProteinENSGACP00000000966
UniProt AccessionG3N6P1;
Protein Name
Protein Synonyms/Alias
Gene NameERBB3 (1 of 2)
Gene Synonyms/Alias ERBB3 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000000747ENSGACP00000000966ENSGACT00000000966
OrganismGasterosteus aculeatus
Functional Description
Protein Length1303
Protein Sequence
(FASTA)
LYVCITICEV NTTLSVETFI VVVCYGTKNG LSTTGDSELQ YTLMKDMYTG CEIVMGNLEI 60
TMMDHTRDFS FLGSIREVTG YILFAVNEFR RLPLDHLRVI RGTTLYEDKY ALAVMVNYQK 120
GGQYGLEELG LTRLTEILEG GVKIIQNEYL SYVKRVNWED IVNSADIVIE DNGPEKPCNE 180
ACGDLPCWDS GNDTCQILTK TVCAPQCNRR CFGKNPSECC HNECAGGCTG RLDTDCFACR 240
NFNNSGACVP LCPQTLIYNK HTFKLEPNPN AKYQYGSICV AQCPSNFVVD ESSCVSNCPS 300
DKMEVEKNGV KRCDPCGGLC PKACQGTGSS SRQTVDALNI DSFINCTTIQ GSLHFLVTGI 360
KGDEYNGVPA LDPEKLKIFN TVREITDSDI LSIQSWPENL SDLSVFSNLQ TIQGRTLNKC 420
YSLLVMKIPS LTSLGLRSLQ KMNDGGVYIT GNKKLCYQRT INWTRILTAV SRPQRRQKHI 480
KIEENRPLNE CGLLGAGAKP VHVVVSIIKK KNGVCLNVPL SFKGADQCVA CARLQDGPHC 540
VSECPEGLMG GEGFIFKYPN KQGSCEPCHI NCTKGLCNVS SSFSSVIRQA TTGIVLGVIA 600
FLFTSFSVFV LTVLYRRGLA IRRKRAMRRY MESGESFEPL DPGEKGSKAH ARILKPSELR 660
QIKLLGSGVF GSVHKGIWIP EGDTVKLPVA IKTIHDRTKR QTFHQMTDHM VTIGSMNHIN 720
VVRTLGICPG TSLQLVTQLS SQGSLLEHVR NSKNKLSPQR LLNWCVQIAK GMYYLEENKM 780
VHRNLAARNV LLKNNYTVQI SDYGIADLLY PDDKKYFYNE VKTPIKWMAL ESILFRRYTH 840
QSDVWSYGVT VWEMMSNGAE PYTAMRPQEV PDLLEKGERL SQPQICTIDV YMVMVKCWMI 900
DENVRPTFKE LANEFTRMAR DPPRYLVIKE YRDQQDSALD DLGHRSADLD DLDDLDFQLE 960
DQEEEEEVDG VIQAPHRSLS RLSRIDTHRV IISPSNGEGY LPMTPGVENP GQAMWQSRSR 1020
LNSARTVSES SEGCSTAVEL EMIEAGSLKK RRQREDSAYI SQRGSLSGGP PETPSPRMEE 1080
EDQNGYVLPG DSPEKDTLLF PSRAGTGRMG KSHSLGIFDD PDEEEYEYMN KQKFVKSVSP 1140
RHNSHRSRPS KKRTSSTSSQ VTACSGDTTS SVEVRSIHNS DSEQQESNEG EYEYMDIRGN 1200
ENDKKELKIE GREEDEDEDE AYEYEDMDSF AALRPGEAVV YHNLQRDGEG AVGGTKAHQS 1260
GFESYVKVRT GVGVGEPPVG DRSFDNPNYW HSRMFLKSNA VPT 1303
Nucleotide Sequence
(FASTA)
TTGTATGTTT GTATCACAAT ATGTGAAGTC AATACAACTT TGTCTGTAGA GACCTTTATA 60
GTGGTCGTTT GTTACGGCAC CAAAAACGGC CTGAGCACGA CGGGAGACTC GGAGCTCCAG 120
TACACCCTGA TGAAGGACAT GTACACCGGC TGCGAGATCG TGATGGGCAA CCTTGAGATT 180
ACCATGATGG ATCACACCAG GGACTTCTCC TTCCTGGGGT CTATCAGGGA GGTGACGGGC 240
TACATTCTTT TCGCCGTCAA TGAGTTTCGC CGCCTGCCCC TCGATCACCT GCGCGTCATC 300
AGAGGCACCA CGCTGTATGA GGACAAGTAC GCGTTGGCCG TGATGGTCAA CTACCAGAAG 360
GGCGGGCAGT ACGGCCTGGA GGAACTGGGC CTCACGCGCC TCACAGAGAT ACTGGAGGGA 420
GGAGTCAAGA TAATCCAGAA TGAGTACCTG AGCTACGTCA AGCGGGTGAA CTGGGAGGAC 480
ATTGTGAACA GTGCTGATAT CGTGATCGAG GACAATGGGC CTGAGAAGCC TTGTAATGAA 540
GCATGTGGAG ACCTCCCGTG TTGGGATTCA GGAAACGACA CGTGCCAGAT CTTGACAAAG 600
ACTGTGTGCG CCCCTCAGTG TAACAGACGA TGCTTTGGTA AAAACCCAAG CGAGTGCTGT 660
CACAATGAGT GTGCTGGAGG CTGCACTGGA CGCCTGGATA CAGATTGCTT TGCATGCAGG 720
AACTTCAACA ACTCGGGCGC CTGCGTGCCT CTGTGTCCCC AGACCCTAAT CTACAACAAG 780
CACACGTTCA AACTTGAGCC CAATCCCAAT GCCAAGTACC AGTATGGCTC CATCTGTGTG 840
GCCCAGTGCC CTTCTAACTT TGTGGTGGAC GAAAGCTCAT GCGTCAGCAA TTGTCCGTCT 900
GATAAAATGG AGGTGGAGAA AAATGGAGTG AAAAGATGTG ACCCCTGCGG AGGCCTCTGT 960
CCAAAAGCTT GCCAAGGCAC AGGAAGTTCC TCCAGACAGA CAGTAGATGC TCTTAACATC 1020
GACAGTTTCA TAAACTGCAC TACGATCCAG GGCAGTCTGC ACTTCCTGGT GACCGGGATT 1080
AAAGGTGATG AGTACAACGG TGTGCCAGCT CTCGATCCAG AGAAACTAAA GATCTTCAAC 1140
ACTGTTCGGG AAATTACAGA TTCAGACATC CTAAGCATCC AGTCGTGGCC TGAAAACTTG 1200
TCGGACCTGT CAGTCTTCTC CAACCTCCAA ACCATCCAGG GCAGAACACT TAACAAGTGC 1260
TACTCTCTTC TGGTGATGAA GATCCCCTCT TTGACCTCGC TGGGGTTACG CTCGCTGCAA 1320
AAGATGAACG ACGGCGGCGT CTACATCACG GGAAACAAGA AGCTCTGCTA CCAACGCACC 1380
ATTAACTGGA CGCGCATCCT CACCGCCGTC TCTCGCCCAC AGCGACGCCA GAAGCACATC 1440
AAGATCGAGG AGAACAGACC GCTAAACGAG TGCGGGCTGT TGGGGGCCGG GGCCAAACCA 1500
GTGCATGTCG TGGTGAGTAT TATAAAAAAA AAAAACGGTG TTTGTCTTAA TGTTCCTCTG 1560
TCTTTTAAGG GAGCGGATCA GTGTGTTGCA TGTGCCCGCC TGCAGGACGG TCCACACTGT 1620
GTCTCTGAGT GTCCAGAGGG CTTGATGGGA GGGGAGGGAT TTATCTTTAA ATACCCCAAC 1680
AAGCAAGGCA GCTGTGAACC GTGCCACATC AACTGCACCA AAGGATTATG TAACGTCTCT 1740
TCTTCTTTTT CATCCGTCAT CAGACAAGCG ACCACAGGCA TCGTCCTTGG AGTGATCGCC 1800
TTTCTCTTTA CTTCATTCTC TGTTTTTGTG CTGACTGTTC TGTACCGACG AGGTCTTGCC 1860
ATTCGTCGCA AACGAGCCAT GAGGAGATAC ATGGAGAGTG GAGAGAGTTT TGAACCTCTG 1920
GATCCCGGAG AGAAAGGGTC AAAGGCCCAT GCTCGGATCC TAAAGCCGTC AGAGCTCCGT 1980
CAGATCAAGC TGCTGGGTAG TGGAGTGTTT GGATCAGTGC ATAAGGGCAT TTGGATTCCT 2040
GAGGGCGATA CGGTGAAACT TCCCGTGGCT ATAAAGACGA TTCATGATCG CACCAAACGG 2100
CAGACCTTCC ATCAGATGAC AGATCACATG GTGACCATTG GAAGCATGAA CCATATCAAC 2160
GTAGTCAGGA CCCTGGGCAT CTGCCCCGGG ACCAGCTTGC AGCTCGTCAC CCAGCTCAGC 2220
AGCCAGGGCT CCCTGCTGGA GCACGTCAGG AACTCCAAGA ACAAACTCAG CCCACAACGG 2280
CTGCTCAACT GGTGTGTTCA AATCGCAAAG GGGATGTATT ACCTGGAGGA GAACAAGATG 2340
GTCCACAGGA ACCTGGCCGC GAGAAATGTG CTCCTGAAGA ATAATTACAC AGTACAGATC 2400
TCCGACTACG GCATTGCAGA CCTGCTTTAC CCTGATGACA AGAAATACTT TTACAATGAG 2460
GTTAAGACAC CAATCAAATG GATGGCTCTG GAAAGCATCT TGTTTCGCAG GTATACCCAC 2520
CAGAGCGATG TCTGGAGTTA CGGTGTGACA GTATGGGAGA TGATGTCCAA TGGGGCTGAG 2580
CCGTACACTG CGATGCGTCC ACAGGAGGTT CCTGATCTAT TGGAAAAGGG CGAGCGTCTG 2640
TCTCAACCTC AAATTTGCAC CATTGACGTC TACATGGTCA TGGTCAAGTG TTGGATGATT 2700
GATGAGAATG TCCGTCCAAC ATTCAAAGAG CTGGCAAACG AATTCACCAG AATGGCCAGA 2760
GACCCGCCTC GCTACCTGGT GATCAAAGAG TACCGCGACC AACAGGACTC AGCCCTGGAT 2820
GATCTTGGAC ATCGAAGTGC AGACCTGGAC GACCTGGATG ATCTTGACTT TCAGTTGGAG 2880
GACCAAGAGG AGGAGGAGGA GGTGGATGGT GTGATTCAAG CCCCTCACAG GAGCCTAAGT 2940
CGCCTCTCCC GGATCGACAC TCACAGAGTG ATTATTTCTC CATCAAACGG GGAGGGTTAC 3000
CTGCCTATGA CCCCAGGTGT TGAGAACCCA GGACAGGCCA TGTGGCAGTC ACGCTCTCGA 3060
CTTAACTCAG CCCGGACTGT GTCTGAGAGC TCGGAGGGCT GCAGCACGGC AGTTGAGCTG 3120
GAGATGATAG AGGCAGGTAG CCTCAAGAAA CGGCGTCAAC GCGAGGACAG CGCTTACATC 3180
TCTCAGAGAG GCAGCTTGTC CGGCGGGCCA CCAGAGACTC CATCACCAAG GATGGAGGAA 3240
GAGGATCAGA ATGGATATGT GCTTCCTGGA GACAGTCCAG AGAAAGATAC CCTACTTTTC 3300
CCATCTCGTG CCGGTACTGG CAGGATGGGC AAGTCTCATT CGTTGGGCAT CTTCGACGAC 3360
CCCGATGAAG AAGAGTATGA GTATATGAAC AAGCAGAAAT TTGTAAAATC TGTCTCACCA 3420
AGGCATAACA GTCACCGGTC GAGGCCGAGC AAGAAGCGCA CTTCCTCCAC GTCGTCACAA 3480
GTGACTGCGT GCTCAGGTGA CACCACATCG TCCGTGGAAG TCAGAAGCAT TCACAACTCT 3540
GATTCAGAGC AGCAGGAATC TAATGAAGGT GAATATGAAT ACATGGACAT CAGGGGTAAT 3600
GAAAATGATA AGAAGGAGCT AAAGATAGAG GGAAGGGAAG AGGACGAGGA CGAGGACGAG 3660
GCATACGAGT ATGAGGACAT GGACTCCTTT GCTGCCTTAC GGCCCGGAGA AGCTGTGGTG 3720
TACCACAACC TGCAGAGAGA TGGGGAGGGA GCAGTAGGGG GCACAAAGGC ACATCAATCT 3780
GGGTTTGAAT CCTACGTGAA AGTGCGAACT GGAGTCGGGG TTGGGGAACC TCCAGTTGGC 3840
GACAGGTCTT TTGACAATCC AAACTACTGG CACAGCAGGA TGTTTCTGAA ATCAAACGCA 3900
GTGCCTACAT GA 3912
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+++k lGsG+fG+v+kGiwipeg++vk+pvaik ++++t+++++++++d++++++s++h
Q: 659   LRQIKLLGSGVFGSVHKGIWIPEGDTVKLPVAIKTIHDRTKRQTFHQMTDHMVTIGSMNH  718
         6899********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
          n+vr lg+c  ++lqlvtql   G+ll++vr+ k+kl +q llnwcvqiakGm+ylee+
Q: 719   INVVRTLGICPGTSLQLVTQLSSQGSLLEHVRNSKNKLSPQRLLNWCVQIAKGMYYLEEN  778
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         ++vhr+laarnvl+k+   v+i+d+G+a+ll  d+k++ +++ k+pikw+alesil+r+y
Q: 779   KMVHRNLAARNVLLKNNYTVQISDYGIADLLYPDDKKYFYNEVKTPIKWMALESILFRRY  838
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwe+++ Ga+py +++ +e+pdllekGerl+qp+ictidvymv+vkcw
Q: 839   THQSDVWSYGVTVWEMMSNGAEPYTAMRPQEVPDLLEKGERLSQPQICTIDVYMVMVKCW  898
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela+ef
Q: 899   MIDENVRPTFKELANEF  915
         ****************9
Domain Sequence
(FASTA)
LRQIKLLGSG VFGSVHKGIW IPEGDTVKLP VAIKTIHDRT KRQTFHQMTD HMVTIGSMNH 60
INVVRTLGIC PGTSLQLVTQ LSSQGSLLEH VRNSKNKLSP QRLLNWCVQI AKGMYYLEEN 120
KMVHRNLAAR NVLLKNNYTV QISDYGIADL LYPDDKKYFY NEVKTPIKWM ALESILFRRY 180
THQSDVWSYG VTVWEMMSNG AEPYTAMRPQ EVPDLLEKGE RLSQPQICTI DVYMVMVKCW 240
MIDENVRPTF KELANEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Danio rerio"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-DAR-00647
EKS-ORN-00391
EKS-ORL-00362
EKS-TAR-00394
EKS-TEN-00390
EKS-XIM-00382
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 2.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013