EKS-GAA-00489
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00489
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl302.14.6E-90626868243
StatusUnreviewed
Ensembl ProteinENSGACP00000001015
UniProt AccessionG3N6U0;
Protein Name
Protein Synonyms/Alias
Gene Name
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000000790ENSGACP00000001015ENSGACT00000001015
OrganismGasterosteus aculeatus
Functional Description
Protein Length883
Protein Sequence
(FASTA)
SCPVVLHPLL LVFGTPSFLP SHLTSTGPDM KDGGLQDQMR RMGDYIVPYP SHQREKIKSG 60
NENTCPIQDI KDYNLNPATD NHWVTGMLIR WMERKGARHL LMDVSFAQEE EPSHQLTPLK 120
VYLFDSNTPI ARFQNTQAVL DLQTSKAFPV TVPPNQVSRY LNRSRALSLG SVSSRGFHLA 180
LSYSGRCVLI ASIRLYYRRC PYTVANLASF EATGAASGPL KGSCVKGAVE LFPPVRECDV 240
DGVWSPVQGG CNCKAGHQVM EDTCQVCRMG FYKPINGSGE CRPCPQNSRT HGEGTEKCDC 300
LQDFNRLPTD PYELGCTKPP SAPVNLTVYY PNVSVLMVTW DPPQDWGGRH EIKYSIKCEW 360
EADSGHRWKA CGDDVIFLPY SAGLTNTSVS ITEVNPQLNY RLTVQAQNDL SDLRGTLASS 420
TATITIHRYV FNTLNHPGKD CKKQATSSQG WPVFVRVMQW QKFYFGNTTC SNDQSYTSLK 480
SQHLNVTPGH CKYGDFSLLE KSQMATAGKV PPVEITVTSD LNVSKHHIVP AAEPSRLYMW 540
LTVGVLFGLL LLGAVFPFAV CVLRSHYTKL RQETINFVFD SQNRMLKSPR IRAFAHECTF 600
QPTSTAAGGC TSDVQHVTPR FLAVSSAGEF GSVYEGVFTL DEGGDIKVAV KTMRVGIHSQ 660
EDLHEFLREA DIMKNFDHEN VVGLLENIQT CYPEILIASY LRSHPSPTFF QFVPHQSLLR 720
FGIDIAAGMA YLSAKGFLHR DLAARNCMLG DDLRVCVADF GLSKKIYSSN YYRQKATIRV 780
PIKWMAIESL SESIYSSKSD VWSFGVTMWE IVSRGRTPYP GVHNHELLEL LLSGHRLKPP 840
EDCDHNLYEV MQSCWDKEPS RRPDFKELGE ILKGLLSELP ALK 883
Nucleotide Sequence
(FASTA)
TCTTGTCCTG TAGTCCTGCA TCCCCTTCTT CTGGTCTTTG GTACCCCATC CTTCCTTCCT 60
TCTCATCTGA CCAGTACAGG ACCAGATATG AAAGATGGGG GATTACAGGA CCAGATGAGA 120
AGGATGGGGG ACTACATAGT CCCCTATCCT TCCCATCAGA GAGAAAAAAT AAAAAGCGGA 180
AATGAGAACA CTTGCCCAAT CCAGGATATA AAAGACTACA ATTTGAATCC AGCCACAGAC 240
AACCATTGGG TCACGGGGAT GTTGATCAGA TGGATGGAGC GGAAAGGTGC CCGCCATCTA 300
CTGATGGATG TTTCATTTGC CCAAGAAGAG GAGCCGTCTC ATCAGCTCAC CCCGCTAAAA 360
GTTTACCTGT TTGATTCAAA CACACCTATT GCAAGATTTC AAAACACTCA GGCTGTTTTG 420
GACCTTCAGA CCTCCAAGGC ATTCCCTGTA ACAGTCCCTC CAAACCAGGT ATCCAGGTAT 480
CTGAACCGCA GCCGGGCTCT GAGCCTGGGC TCCGTGAGCA GCAGGGGCTT CCATCTGGCC 540
CTCTCCTATT CAGGAAGGTG TGTGCTAATA GCTTCCATCA GACTGTACTA CAGGAGGTGC 600
CCTTACACCG TGGCAAACCT TGCCTCGTTT GAGGCAACCG GGGCCGCGTC TGGTCCATTA 660
AAGGGTTCCT GCGTGAAGGG CGCCGTGGAG CTTTTCCCAC CTGTTAGAGA GTGTGATGTG 720
GATGGAGTTT GGAGTCCAGT GCAGGGTGGG TGTAACTGTA AGGCTGGCCA TCAAGTCATG 780
GAGGACACCT GTCAAGTGTG TAGAATGGGC TTCTACAAAC CAATCAATGG GAGTGGAGAA 840
TGCCGGCCAT GCCCGCAGAA TAGCAGGACG CATGGGGAGG GAACAGAGAA GTGCGACTGT 900
CTGCAAGATT TCAACAGACT GCCAACTGAC CCCTATGAGC TCGGCTGCAC CAAGCCGCCC 960
TCTGCCCCCG TGAATCTAAC GGTCTATTAT CCCAATGTCT CTGTGCTGAT GGTGACGTGG 1020
GATCCTCCGC AGGACTGGGG CGGCAGACAT GAAATTAAGT ATTCCATCAA GTGTGAGTGG 1080
GAAGCGGATT CTGGCCATCG GTGGAAGGCA TGTGGGGACG ATGTGATTTT CCTTCCATAC 1140
TCGGCAGGCC TGACCAACAC GTCAGTCAGC ATCACAGAAG TGAATCCGCA GCTCAACTAC 1200
AGACTTACAG TGCAAGCCCA GAATGACCTA TCCGATCTGC GGGGAACGCT GGCTTCATCC 1260
ACCGCCACCA TCACCATCCA TAGATATGTC TTCAACACGT TGAATCATCC AGGAAAAGAC 1320
TGTAAAAAAC AGGCTACCTC ATCACAGGGG TGGCCAGTGT TTGTAAGAGT CATGCAATGG 1380
CAAAAGTTCT ATTTTGGGAA TACAACATGC AGCAATGACC AGAGCTATAC ATCCCTAAAG 1440
TCTCAACATC TCAACGTCAC TCCCGGACAT TGCAAATATG GTGACTTCTC TTTATTGGAA 1500
AAATCCCAAA TGGCGACAGC AGGGAAAGTT CCACCTGTGG AGATCACTGT GACATCGGAC 1560
TTAAACGTCT CAAAGCACCA CATAGTGCCG GCTGCTGAGC CGAGTCGCCT CTACATGTGG 1620
CTAACAGTCG GAGTCTTGTT TGGCCTCCTG CTGCTCGGGG CTGTTTTCCC CTTTGCTGTG 1680
TGTGTCCTGC GCAGCCACTA CACCAAACTC AGGCAGGAGA CCATCAATTT TGTCTTTGAT 1740
AGTCAGAATC GAATGTTAAA ATCACCCAGA ATTAGAGCTT TTGCCCATGA ATGCACCTTC 1800
CAGCCCACCT CCACAGCAGC TGGAGGCTGC ACCTCAGACG TCCAACATGT CACACCGAGG 1860
TTCCTAGCAG TTAGCTCTGC AGGAGAATTT GGCTCAGTCT ACGAAGGTGT TTTTACACTA 1920
GATGAAGGCG GGGACATCAA GGTGGCCGTG AAGACCATGA GAGTTGGAAT CCACAGTCAA 1980
GAAGACTTAC ATGAGTTTTT GAGAGAGGCA GATATCATGA AGAACTTTGA TCATGAAAAT 2040
GTGGTTGGAC TACTTGAAAA TATACAGACA TGTTACCCAG AAATCCTCAT TGCATCATAT 2100
TTAAGATCAC ATCCTTCTCC CACCTTCTTC CAGTTTGTGC CCCATCAGAG TCTCCTGCGC 2160
TTTGGGATCG ACATTGCAGC AGGGATGGCC TATCTGAGCG CGAAGGGGTT CCTGCACAGA 2220
GATCTAGCTG CACGCAACTG CATGCTGGGC GATGACCTCA GGGTGTGTGT GGCTGACTTC 2280
GGCCTGTCAA AGAAAATCTA CAGCAGCAAT TATTATCGTC AAAAGGCAAC TATCCGTGTG 2340
CCAATTAAGT GGATGGCCAT CGAGAGCCTG TCTGAGTCCA TCTACTCTTC CAAAAGTGAC 2400
GTGTGGTCAT TTGGGGTGAC CATGTGGGAG ATTGTGTCCC GAGGTCGGAC CCCCTATCCA 2460
GGAGTTCACA ACCACGAGCT GCTAGAGCTG CTGCTGTCTG GACACAGGCT CAAACCCCCG 2520
GAGGACTGTG ACCACAATCT TTATGAAGTG ATGCAGAGCT GCTGGGACAA GGAGCCGAGC 2580
CGTAGGCCTG ACTTCAAGGA ACTGGGCGAG ATACTTAAAG GTCTTCTCTC TGAGCTGCCA 2640
GCGCTGAAG 2649
Domain Profile
S: 8     gegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdhpnvirlv  67
           gefgsv eg +  ++g  +kvavkt+++ i +++++ efl+ea  mk+fdh nv+ l+
Q: 626   SAGEFGSVYEGVFTLDEGGDIKVAVKTMRVGIHSQEDLHEFLREADIMKNFDHENVVGLL  685
         579*****************************************************9887
S: 68    gvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmvdiasgme  127
               + +   p+ ++i  +++     +f          +++p q l++f +dia+gm 
Q: 686   E-----NIQTCYPE-ILIASYLRSHPSPTF---------FQFVPHQSLLRFGIDIAAGMA  730
         5.....33444555.455566655555555.........4789*****************
S: 128   ylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvkwiaiesl  187
         yls++ f+hrdlaarncml +d+ vcvadfglskkiys +yyrq    ++p+kw+aiesl
Q: 731   YLSAKGFLHRDLAARNCMLGDDLRVCVADFGLSKKIYSSNYYRQKATIRVPIKWMAIESL  790
         ************************************************************
S: 188   adrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedcldelydl  247
         ++ +y+sksdvw+fgvtmwei++rg+tpy+gv+n+e+ + ll g+rlk pedc ++ly++
Q: 791   SESIYSSKSDVWSFGVTMWEIVSRGRTPYPGVHNHELLELLLSGHRLKPPEDCDHNLYEV  850
         ************************************************************
S: 248   myrcweadpkdrpsfsvl  265
         m++cw+ +p  rp f +l
Q: 851   MQSCWDKEPSRRPDFKEL  868
         ***************987
Domain Sequence
(FASTA)
SAGEFGSVYE GVFTLDEGGD IKVAVKTMRV GIHSQEDLHE FLREADIMKN FDHENVVGLL 60
ENIQTCYPEI LIASYLRSHP SPTFFQFVPH QSLLRFGIDI AAGMAYLSAK GFLHRDLAAR 120
NCMLGDDLRV CVADFGLSKK IYSSNYYRQK ATIRVPIKWM AIESLSESIY SSKSDVWSFG 180
VTMWEIVSRG RTPYPGVHNH ELLELLLSGH RLKPPEDCDH NLYEVMQSCW DKEPSRRPDF 240
KEL 243
KeywordATP-binding; Complete proteome; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0048013; P:ephrin receptor signaling pathway
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013