EKS-GAA-00396
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00396
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20341.25.2E-10215272258
StatusUnreviewed
Ensembl ProteinENSGACP00000001059
UniProt AccessionG3N6Y2;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K2
Gene Synonyms/Alias MAP4K2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000000819ENSGACP00000001059ENSGACT00000001059
ENSGACG00000000819ENSGACP00000001057ENSGACT00000001057
OrganismGasterosteus aculeatus
Functional Description
Protein Length398
Protein Sequence
(FASTA)
MNRIGVSFLD PLDDYELVYR IGCGTYGDVF KARNIETSEL AAIKIVKLDP GDDITSIQQE 60
ITMMKECKHK NIVAYFGSYH RNTRLWICME YCGGGSLQDI YHVTGPLKEK QIAYVCRETL 120
QGLYHLHETG KMHRDIKGAN ILLTERGDVK LADFGVAAEI SASVAKRKSF IGTPYWMAPE 180
VAAVEKKGGY NHLCDIWAVG ITAIELAELQ PPMFDLHPMR ALMLMSKSSF QPPRLKDKSK 240
WSAGFQSFVK MSLIKSPRKR PSAETLLQHP FVTQLLTRNL VIELLDTANN PELHSSHTHS 300
MDDNELEVGE VAPDKIQSAG KRLPVERTLS EEQFDQVKFG PPLRKVTEPY PGLGSYDDDW 360
SLSGDEDNSP SLLECVEQAL QLRSLTIKRT PSTDVSAN 398
Nucleotide Sequence
(FASTA)
ATGAACCGGA TAGGGGTGTC GTTCCTGGAC CCTTTGGACG ACTACGAGCT GGTCTACCGG 60
ATTGGATGCG GTACCTACGG AGATGTGTTC AAGGCTCGTA ACATCGAGAC GTCTGAACTG 120
GCAGCAATCA AGATTGTCAA GCTAGACCCT GGCGATGACA TCACGTCCAT CCAGCAGGAG 180
ATCACCATGA TGAAGGAATG CAAGCACAAA AACATCGTGG CCTACTTCGG CAGCTACCAC 240
AGGAACACCA GGCTGTGGAT TTGCATGGAG TACTGCGGTG GAGGGTCTCT TCAAGATATT 300
TACCACGTGA CGGGCCCTCT GAAGGAGAAG CAGATAGCGT ATGTGTGCAG AGAAACCCTC 360
CAGGGTTTGT ACCACCTGCA TGAAACTGGC AAAATGCACA GAGACATAAA GGGAGCCAAC 420
ATCCTCTTGA CAGAGAGAGG CGATGTGAAA CTGGCTGACT TCGGAGTGGC AGCAGAGATC 480
AGCGCCTCCG TAGCCAAAAG GAAGTCTTTT ATCGGCACTC CCTACTGGAT GGCTCCGGAG 540
GTGGCTGCCG TCGAGAAGAA AGGTGGCTAC AACCACCTGT GTGACATCTG GGCCGTCGGC 600
ATCACCGCCA TCGAGCTGGC CGAGCTACAG CCGCCCATGT TTGACCTCCA CCCAATGAGG 660
GCGCTGATGT TGATGTCCAA GAGCAGTTTC CAGCCTCCAA GACTAAAGGA CAAAAGCAAG 720
TGGTCGGCTG GTTTCCAAAG CTTTGTGAAG ATGTCTCTGA TTAAAAGCCC CCGTAAACGA 780
CCCTCAGCGG AGACGCTGCT GCAGCATCCG TTTGTGACAC AGCTCCTGAC CCGCAACCTG 840
GTAATTGAGC TGCTGGACAC GGCCAACAAC CCTGAGCTCC ACAGCAGCCA CACGCACAGC 900
ATGGACGACA ACGAGCTGGA GGTTGGGGAA GTGGCTCCTG ACAAGATTCA GTCAGCAGGG 960
AAACGCCTGC CTGTAGAGAG GACCCTGTCT GAGGAACAAT TCGACCAGGT GAAGTTTGGG 1020
CCTCCACTGA GGAAAGTCAC TGAGCCATAT CCTGGTTTGG GCTCCTATGA TGATGACTGG 1080
AGTCTGTCTG GAGACGAAGA CAACTCACCG AGCCTGTTGG AATGTGTGGA GCAAGCTCTG 1140
CAGCTGAGAA GTTTAACCAT TAAAAGGACG CCATCTACTG ATGTAAGTGC TAAC 1194
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         yel+ +ig G++g+v++ar+++t+el+aik+++l+  ++++++q+ei+++k++kh+niv+
Q: 15    YELVYRIGCGTYGDVFKARNIETSELAAIKIVKLDPGDDITSIQQEITMMKECKHKNIVA  74
         899*********************************************************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s+ ++++lw++mey+ gGsl+d+++  ++ +lkE+qiay++re+l++L +lH+ +++
Q: 75    YFGSYHRNTRLWICMEYCGGGSLQDIYH--VTGPLKEKQIAYVCRETLQGLYHLHETGKM  132
         ****************************..******************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179
         Hrdik++niLlte+g+VkL+dfgvaa+++++++krk+++gtpywmAPEv a+e + gY++
Q: 133   HRDIKGANILLTERGDVKLADFGVAAEISASVAKRKSFIGTPYWMAPEVAAVEkKGGYNH  192
         ****************************************************98889***
S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237
          +Diw++GItaielae +pP++dl+p++al++++k++  pp+lk+k+k+s  f++fv+  
Q: 193   LCDIWAVGITAIELAELQPPMFDLHPMRALMLMSKSSfqPPRLKDKSKWSAGFQSFVKMS  252
         **********************************99988*********************
S: 238   lqknpekRpsasellkhkFl  257
         l k+p+kRpsa++ll+h+F+
Q: 253   LIKSPRKRPSAETLLQHPFV  272
         *******************7
Domain Sequence
(FASTA)
YELVYRIGCG TYGDVFKARN IETSELAAIK IVKLDPGDDI TSIQQEITMM KECKHKNIVA 60
YFGSYHRNTR LWICMEYCGG GSLQDIYHVT GPLKEKQIAY VCRETLQGLY HLHETGKMHR 120
DIKGANILLT ERGDVKLADF GVAAEISASV AKRKSFIGTP YWMAPEVAAV EKKGGYNHLC 180
DIWAVGITAI ELAELQPPMF DLHPMRALML MSKSSFQPPR LKDKSKWSAG FQSFVKMSLI 240
KSPRKRPSAE TLLQHPFV 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Mus musculus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00310
EKS-BOT-00321
EKS-CAJ-00329
EKS-CAF-00324
EKS-CAP-00353
EKS-DAR-00668
EKS-DIO-00040
EKS-GOG-00316
EKS-HOS-00329
EKS-ICT-00315
EKS-MUM-00354
EKS-ORN-00418
EKS-ORL-00381
EKS-PAT-00304
EKS-POA-00311
EKS-PTV-00073
EKS-SUS-00279
EKS-TAR-00416
EKS-TEN-00412
EKS-XIM-00410
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013