EKS-GAA-00336

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00336

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	466.3	4.7E-140	205	491	287

Status

Unreviewed

Ensembl Protein

ENSGACP00000001253

UniProt Accession

G3N7H2;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000000970	ENSGACP00000001253	ENSGACT00000001254

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

VTLALTSSHR SIVPLVIISS DLQALIGGLQ CYCDRCSANS SCTTDGVCFI SIRRSGSQPS 60

TEQRQCVHNN ELIPRDRPFI CSPSVTQDTG IYPLCCNTDY CNKEPNLDIP PVHPEKTPPL 120

GPVALAAVIA GPVCVLCLLL VLAFYVCHSQ RDHHHRVPNE EDPSIDHPFI TVGTTLKDLI 180

YDMTTSGSGS GLPLLVQRTI ARTIILQESI GKGRFGEVWR GKWRGEEVAV KIFSSREERS 240

WFREAEIYQT VMLRHENILG FIAADNKDNG TWTQLWLVSD YHEHGSLFDY LNRYTVTVEG 300

MIKLSLSTAS GLAHLHMEIV GTQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVRHDSA 360

TDTIDIAPNH RVGTKRYMAP EVLDDSINMK HFESFKRADI YAMGLVFWEI ASRCSMGGIH 420

EDYQLPYYDL VQSDPSVEEM RKVVCEQKLR PNIPNRWQSC EALRVMAKIM RECWYANSAA 480

RLTALRIKKT LSQLSQQEGI KM 502

Nucleotide Sequence
(FASTA)

GTCACATTGG CACTTACTTC CTCCCACAGG AGCATCGTTC CTCTTGTTAT AATATCATCT 60

GACCTCCAAG CACTGATTGG AGGCCTGCAG TGTTACTGCG ACCGCTGCAG CGCCAACTCC 120

AGCTGCACGA CGGATGGCGT CTGCTTCATC TCCATCCGCA GGTCGGGCAG CCAGCCCTCC 180

ACGGAGCAGC GGCAGTGTGT GCACAACAAC GAGCTGATCC CCAGGGACCG GCCCTTCATC 240

TGCTCCCCGT CAGTCACGCA GGACACGGGC ATCTACCCGC TCTGCTGCAA CACGGACTAC 300

TGCAACAAGG AGCCCAACCT GGACATCCCG CCCGTCCACC CCGAGAAGAC CCCCCCTCTG 360

GGGCCCGTGG CCCTCGCGGC GGTCATCGCC GGCCCTGTGT GCGTGCTGTG TCTGCTGCTG 420

GTCCTGGCGT TCTATGTTTG CCACAGCCAG AGGGACCACC ACCACCGGGT GCCCAACGAA 480

GAGGACCCCT CGATTGACCA CCCCTTCATC ACCGTGGGAA CGACGCTGAA GGATCTCATC 540

TATGACATGA CCACCTCGGG CTCTGGATCA GGCCTGCCGC TGCTGGTCCA GAGGACCATC 600

GCCAGGACCA TCATCCTCCA GGAGAGCATC GGGAAGGGCC GCTTCGGGGA AGTGTGGCGC 660

GGCAAGTGGC GCGGCGAGGA GGTGGCCGTG AAGATCTTCT CCTCCCGCGA GGAGCGCTCC 720

TGGTTCCGCG AGGCTGAGAT CTACCAGACG GTGATGCTAA GGCACGAGAA CATCCTGGGC 780

TTCATCGCCG CCGACAACAA AGATAACGGG ACGTGGACTC AGCTGTGGCT GGTGTCGGAC 840

TACCACGAGC ACGGCTCCCT GTTTGACTAC CTGAACCGCT ACACCGTGAC CGTGGAGGGT 900

ATGATCAAGC TGTCCCTGTC CACAGCCAGC GGCCTCGCCC ACCTCCACAT GGAGATAGTG 960

GGAACACAAG GGAAGCCGGC CATCGCACAC AGAGACCTGA AGTCAAAGAA CATTCTGGTG 1020

AAGAAGAACG GGACGTGCTG CATCGCGGAC CTCGGCCTGG CCGTCCGCCA CGACTCCGCC 1080

ACGGACACCA TCGACATCGC TCCCAACCAC CGAGTGGGGA CCAAAAGGTA CATGGCTCCG 1140

GAGGTCCTGG ACGACTCCAT AAACATGAAA CACTTTGAGT CTTTCAAGAG GGCCGACATC 1200

TACGCCATGG GCCTGGTGTT CTGGGAGATC GCCAGCCGCT GCTCTATGGG AGGCATCCAT 1260

GAGGACTACC AGCTGCCCTA CTACGACCTG GTTCAGTCCG ATCCGTCAGT GGAGGAGATG 1320

AGGAAGGTGG TGTGCGAGCA GAAGCTTCGC CCCAACATTC CCAACCGCTG GCAGAGCTGT 1380

GAGGCCTTGC GGGTGATGGC GAAGATAATG AGGGAGTGTT GGTACGCCAA CAGCGCCGCC 1440

CGACTCACCG CTCTCCGAAT CAAGAAGACC CTGTCTCAGC TCAGCCAACA GGAAGGAATC 1500

AAGATGTAG 1509

Domain Profile

S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61

          l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fiaa

Q: 205   ILQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAA  264

         58899*******************************************************

S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121

         d+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++l ls+asGlahLH+eivgt+g

Q: 265   DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQG  324

         ************************************************************

S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181

           KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPEv

Q: 325   --KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEV  382

         ..**********************************************************

S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241

         l++++n+k+fe+fkraD+Y++gLv+WE+asRc++ ++++e+y+lp+++ v+sdPs+eem+

Q: 383   LDDSINMKHFESFKRADIYAMGLVFWEIASRCSM-GGIHEDYQLPYYDLVQSDPSVEEMR  441

         **********************************.*************************

S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 442   KVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANSAARLTALRIKKTL  491

         ************************************************97

Domain Sequence
(FASTA)

ILQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE AEIYQTVMLR HENILGFIAA 60

DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMIKL SLSTASGLAH LHMEIVGTQG 120

KPAIAHRDLK SKNILVKKNG TCCIADLGLA VRHDSATDTI DIAPNHRVGT KRYMAPEVLD 180

DSINMKHFES FKRADIYAMG LVFWEIASRC SMGGIHEDYQ LPYYDLVQSD PSVEEMRKVV 240

CEQKLRPNIP NRWQSCEALR VMAKIMRECW YANSAARLTA LRIKKTL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013