EKS-GAA-00197

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00197

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	479.0	4.0E-144	148	406	259

Status

Unreviewed

Ensembl Protein

ENSGACP00000002402

UniProt Accession

G3NAQ7;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000001849	ENSGACP00000002402	ENSGACT00000002409

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

457

Protein Sequence
(FASTA)

EYYDKGEHVI REGEEGSTFY IIAQGKVKVT QTTEDHQLPQ TINTLQKGDY FGEKALISDD 60

VRSANIIAEE NGVECLVIDR ETFNQTVGTF NELQKYLEGY VATLDRDDKK RHARRSVSRH 120

QSQPLSADVI QLKDRVSAFP PSRPFEHLEV IATLGVGGFG RVELVKVQDE DVTFALKVIK 180

KKHIVDNRQE EHIHSERKIL TEARSPFVVK LYRTFKDNKY VYMLLEACLG GEIWSLLRDR 240

GSFDEPTAKF CVGCVTEAFD YLHRKGVLYR DLKPENLMLD AEGYIKLVDF GFAKKIRCGQ 300

KTWTFCGTPE YVAPEIILNK GHNFSVDFWS LGILVFELLT GSPPFTGSDQ MMTYTFILKG 360

IEKMDFPKKV TKRPEDLIRK LCRRNPSERL GNLKNGITDI KKHRWFNGFN WEGLKAMTLP 420

SPLKRELTGP TDHSYFDSYP PDEDSPPDEL SGWDMDF 457

Nucleotide Sequence
(FASTA)

GAATACTATG ACAAGGGAGA GCACGTCATC CGGGAGGGAG AGGAGGGCAG CACCTTCTAC 60

ATCATCGCAC AGGGGAAGGT GAAGGTGACT CAGACCACCG AGGACCACCA GCTGCCGCAG 120

ACCATCAACA CGCTGCAGAA GGGAGACTAC TTTGGAGAGA AAGCCCTAAT AAGCGATGAT 180

GTCCGGTCGG CTAACATCAT AGCCGAGGAG AACGGGGTGG AGTGCCTCGT CATCGACAGA 240

GAGACATTTA ACCAGACGGT GGGGACCTTC AATGAGCTGC AGAAGTACCT CGAGGGCTAC 300

GTGGCCACGC TGGATCGCGA CGACAAGAAG AGACACGCCA GGAGGTCGGT GTCCCGTCAC 360

CAGAGCCAGC CGCTGTCGGC GGACGTCATC CAGCTGAAGG ACAGGGTGTC GGCGTTTCCT 420

CCGTCCAGGC CCTTCGAGCA CCTGGAGGTC ATCGCCACCC TCGGGGTCGG CGGCTTCGGG 480

CGAGTAGAAC TGGTGAAGGT GCAGGACGAG GACGTCACCT TTGCTCTAAA GGTCATCAAG 540

AAAAAGCACA TCGTGGACAA CAGGCAGGAG GAGCACATCC ACTCGGAGAG GAAGATCCTC 600

ACGGAGGCCC GCTCGCCGTT CGTTGTCAAA CTGTATCGCA CATTTAAGGA CAACAAGTAC 660

GTGTACATGC TGCTGGAGGC CTGTCTGGGG GGGGAGATCT GGAGTCTGCT CAGAGACAGG 720

GGGAGTTTTG ACGAGCCCAC CGCCAAATTC TGCGTCGGTT GCGTCACTGA GGCGTTCGAT 780

TACCTCCATC GCAAAGGGGT CCTCTACAGA GACCTGAAGC CTGAGAATCT CATGCTGGAC 840

GCTGAGGGGT ACATCAAGCT GGTTGACTTT GGTTTTGCCA AGAAGATCCG ATGCGGCCAA 900

AAGACCTGGA CCTTCTGCGG GACACCGGAG TACGTGGCCC CCGAGATCAT CCTCAACAAA 960

GGCCACAACT TCAGTGTGGA CTTCTGGTCT CTGGGCATCC TGGTGTTTGA GCTCCTCACC 1020

GGCAGTCCCC CGTTCACCGG AAGTGACCAG ATGATGACGT ACACCTTCAT CTTGAAGGGA 1080

ATCGAGAAAA TGGACTTTCC CAAGAAGGTC ACAAAGAGAC CCGAGGACCT CATACGGAAG 1140

CTGTGCAGGC GGAATCCCTC AGAGCGACTG GGAAACCTCA AAAACGGAAT AACTGATATC 1200

AAGAAGCACC GGTGGTTTAA CGGCTTCAAC TGGGAGGGAC TGAAGGCCAT GACTTTACCA 1260

TCACCTCTGA AAAGAGAACT CACGGGACCG ACAGATCACA GCTATTTCGA CAGCTACCCT 1320

CCGGACGAGG ACAGTCCTCC AGATGAGCTG TCCGGTTGGG ACATGGACTT C 1371

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l+viatlgvggfgrvelvkv++ e  +falk++kkkhivd++q+eh+ se++il+ea+s+

Q: 148   LEVIATLGVGGFGRVELVKVQD-EDVTFALKVIKKKHIVDNRQEEHIHSERKILTEARSP  206

         689*****************98.899**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         f+vklyrtfkd+kyvy+lleaclgge+w++lrdrgsfd+ takf+v+cv+ea++ylh+k+

Q: 207   FVVKLYRTFKDNKYVYMLLEACLGGEIWSLLRDRGSFDEPTAKFCVGCVTEAFDYLHRKG  266

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         ++yrdlkpenl+ld+egy+klvdfgfakk++ g+ktwtfcgtpeyvapeiilnkgh++sv

Q: 267   VLYRDLKPENLMLDAEGYIKLVDFGFAKKIRCGQKTWTFCGTPEYVAPEIILNKGHNFSV  326

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilv+elltg+ppf+g+d+++ty+ ilkgi+k+++p+k+tk++edli+klcr np

Q: 327   DFWSLGILVFELLTGSPPFTGSDQMMTYTFILKGIEKMDFPKKVTKRPEDLIRKLCRRNP  386

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dikkh+wf

Q: 387   SERLGNLKNGITDIKKHRWF  406

         *******************9

Domain Sequence
(FASTA)

LEVIATLGVG GFGRVELVKV QDEDVTFALK VIKKKHIVDN RQEEHIHSER KILTEARSPF 60

VVKLYRTFKD NKYVYMLLEA CLGGEIWSLL RDRGSFDEPT AKFCVGCVTE AFDYLHRKGV 120

LYRDLKPENL MLDAEGYIKL VDFGFAKKIR CGQKTWTFCG TPEYVAPEII LNKGHNFSVD 180

FWSLGILVFE LLTGSPPFTG SDQMMTYTFI LKGIEKMDFP KKVTKRPEDL IRKLCRRNPS 240

ERLGNLKNGI TDIKKHRWF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 1.
PS00889	; CNMP_BINDING_2; 1.
PS50042	; CNMP_BINDING_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013