EKS-GAA-00117

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00117

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	327.2	1.6E-97	3687	4032	346

Status

Unreviewed

Ensembl Protein

ENSGACP00000002585

UniProt Accession

G3NB89;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKDC

Gene Synonyms/Alias

PRKDC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000001974	ENSGACP00000002585	ENSGACT00000002594
ENSGACG00000001974	ENSGACP00000002590	ENSGACT00000002599

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

4096

Protein Sequence
(FASTA)

AAGGVHGLLL KLHNSLSDED TRAAALKCHD IVGDLGQECM LTPTENELAL QMSLLFSKDY 60

GLLGFLRKSL GSEELRDTRV DILVFLEKFL DRISPRVKGW ERTCANDDTC MVVYTKDKTA 120

KCRTLVLELL IKVLQTTKAS SVVAELRICE LFNRYYGELC QKSKLPDSVL GKIYELLGVL 180

AEVHPSEMSS NSDKLYKAYL GELKEQMTSL TKEPKLFVVA GCLRGLASLM VNFTKTMDED 240

PATSKEIFQY ALKAISPQMS MTRYAVIFAG LRLLAKHASQ FSSCLMDHYR ALFEVMSSLC 300

GHINSEMKKT SYHALEAFLK QVAMVVAENI EEHKGKLKFF MQKFCGIIRN MDSTHKELSI 360

AIRGYGFFAT PCKKVCPQDV DLMYTELIQR CKQMYLTESD GEDESFYQLP SFLDSIASVL 420

IHLDKIPEVY TPLLERLLVV QIDSFPQYSE KMQTACCRSI LKVLVAMASK GPVLWGFISS 480

VVHQGLIRVC SKPALLSEDK DNGRSESPQL HTGKWKVPSS HNYLALFKSL LDCDRLKDSG 540

FLDGAFESQN AALVSLSRLL YDELVKSILK IVEKLDLSVQ KVNTGGEALD DAAHVLPSSD 600

PTAHLLPNKI KDFTAFINLV DFCSELLLTK HLEYFQFWMY CLSHELILHS IRNPLVSGFY 660

KLLSVTMKVA NRIKFYQGVC PRSSTSPQSD TGKSACFALF SKFGKEVCVR MKQYKDELLA 720

SCLTFVLSLH YNMVALDLKA YCPALEAALK LGLSHVPLAN TALDALEDWS SHIPLDTMQH 780

CYTSILPLLD GYLKTSSDDK DDSNWEVMAS LSSRSDKGYS RVMTRLLKKS KQLPTEDAPL 840

VAVRLRVVKL LGHLGGKLNR NLVTGVSSEE TMKKFVAWDS EKRLSFAVPF ADMKPVIYLD 900

PFLPHISELA LSTSDRQTKV AACELLHSLV VYMVGKSAQM VEGDNSLPPM YKLHKRLFPV 960

LLRLCDVDQV TRQLFEPLVM QLIHWFTNNK KFESKDTVAI LEAIMDGVVD PMDSTLRDFC 1020

GRCIEEFVKW SIKQTTPKQQ EKSPTNMKSL FKRIYSLALH PNGFKRLGAA LAFNSIYRQF 1080

REEASLVEQF IFEVLVIFVE SLALAHSDEP SMGTLQQCSS AIDHVKRIIN QKAPSLNRHN 1140

TKIRVPRGFP PDEKLCLSDM VLWLLEQCGR PQTACRHKCM YLFYEFIPLL PGKESPSQWV 1200

DGKLKDHGKG FLISRFEGGG LFSQPTLRGL TVPSSVRATL QWMDVLLAAL DCYNTFIQLH 1260

IIKPPLMLST REKSSFLKAI CFFLTELATG NLAAAESCFS HGQKTSHFSP REVEQYNFSK 1320

CTIIVRLLEF VTRILVKGDK EFWKLLEQDI FVPNLFELTA LVVCEPSTVG FNMADVEVMR 1380

KLPEVCVPLL KALLASPYRT RLEGSLRTKI SRKSVEELCT VDFYHSSTQR HHDQMEMVLS 1440

SCKQIHKADF LSSILHSQDG ACAKSIGSRL LMTVYKGIAP GENRNALPSL DIITKSLADG 1500

LLQLAFSLNQ QSEPLVDLLL NTILLTVPIS GSHCHNVLSF SHGEYFYSLF QMTINTELLK 1560

DLNTTVPCLM LASSQNPSMV SVLLNGMLDH SFRERSVRKT QGKQLVEEVL RRWNSLQSWW 1620

KGHSSTPESK TATLLLLSKL LQIDSSVCSD TNHEAFRPVF STFTMLLVDM DLPLNLKSQA 1680

LLVLPFFTTL PEEPLGELQE ALDALVASHF PMQSDEFAKG SLHRNNYMDC IRKLLDALEL 1740

SQSPLLLKLM AGILCRDRKH IMEEPFQTCF QRIARRSSSE RQLQLLCTVY RGVQQGDVPM 1800

SSMLQAAMER VLLPLASHCS TKALNDFFVA NVSDMMVVLL SRFTKSNEME FEIQLMKKSG 1860

CYKLMELLYS QLPKEEVYSK ESRINQAYCC SDKTEGNELS KTLIKLCFDA FTENMAGETQ 1920

LLELRRQYRC AAYNCAIAAI SCSFSEPKFY QGFLFSEKPE KNQFILENII DVERTYNFPI 1980

EIEVPLERKK KYVMIRKEVS EENGVPTEAP VYLSSQSYMA DSSLSEEMSQ FDFSTGVQSF 2040

SFSSQNPEGP RRTVAKRETE ETNPSQDAMV DLEMDELNQH ECMTTMTALI GHMLRNNITP 2100

KIEQGNVPGE LPPWMKFLHG KLSNPATPLN IRLFISKLII NTEEVFRPYA KHWLGPLLQL 2160

VVSGNNGGEG IHFMVVEIIV TVLSWTSLAS PKGNPRDEVL ANRLLEFLMK HCFHSKRAVF 2220

RHNLEIIRTL VECWKDCLHV PYSLIHERFC GNDPNSKDNS VGLQLLGIIL GNNLPPYDAS 2280

CGIEYDRYIQ SLTNNVSFVR YKDVYAAAAE IIGLILKNMT EHRQQLLSLA ASKITNLKKK 2340

DMDDKFIICL NKVSKHFPPF MDRFVNYVFS LLPKLHGILK THCLECVLSR ADVIPDIFLH 2400

LKTTGFIQMM GHRDEARQRV CLDIIHKIVA CLTPAQLQEI LGAVISFVSH PSPVCRERMY 2460

DVLMWIQDNY SDAESMEDNT SVEVLNSAKE ALLQGLSEEN QGLQLYVRNF WSQEKRLPTT 2520

TLERMLTVLS SLYSCQIEKS FLSLATNLLL ERTSQSPDFI RNIFEYPLSE CTFQDYVIDS 2580

NWRFRSTVMT PMFVETQSSQ GPESVMASQS GGIKGKLRAT QSSLEFSQTQ TTGRRTAYNW 2640

LTGSSVDTLA EYTLSSESLS SLLAFDKKPA RQNAVRRPVG EGFGLRRLTA STDEVDSRTR 2700

AAANEQRNNI LRLRRRFIKD QEKVSLNFAQ KEIQQQRQKK VDKADQRLRK EAQVTLYRNY 2760

RAGDFPDIQI PYSSLIAPLQ ALAQRDPILA KQLFSALFDG ILQEMETHKA RGESGRIKEE 2820

LRRCMNTFLS KSTVCFPPFI ACIQDMCHQH KELHHLDPAA ISSTCLMSLQ QPSGILLLEE 2880

GLLHSGGQEE PAAKRSRGRK EIPPDTNKWI HLARLYRSLE DYDVVRGIFG GKVGTRSITC 2940

AALQAEANSD FAEAVKLYNE ALNTEHWTDG EPTESEKDFW EIAAMDAYSH LTEWKSLRYC 3000

STLYVDMMWS EPLYQEMYLR HMIRSMLKQL QLGEADQTLL SFIDAAMAVE ERKKLLESHY 3060

SQELSLLYIL QEDYDRATYY TNYAMQLFMQ NYSSVDTLLT QSRLTILQSV QALTEIQDFL 3120

QFIKGEVSMR SLTRLIGLWA ERYPDAKADP VNLWDDIITS RCFFLDKIRI KLGGHAPSDS 3180

MEVDGSEDQA GAIDTLVNDC KFSMKLQMAD SALKQNNFPV ATKMLKELHK EAKTNRGWLL 3240

RWVHGFSRYN HKRSQTQGPV EQISAMLKTI PFLDDLQADC QSATAKVFRC QKILEGKSFH 3300

IMATAVGRSP SVLGTMEAEK AGRVAQLSGA AWPDENAKKV EVGLQLKALN LLCDATRKAD 3360

EELQSYTQEC VESSSIIETY MTLANFCDKL LRGAEQSDTE NQFPNMLALP VHILENLLKA 3420

LKMNSEEARL KFPRLLQIIE LYPSETLDLM MKEMMSVPCW MLIGWISQMV ALLDKPEAVA 3480

VQRCVEQIAD CYPQALVYAL MISSESYQFE DSATGHQQRG FVDRLNSVLD KEGPVKNFVN 3540

SLQQLTNPEM LFRDWWDCMK NELDKPGFDE KRMGRMYEEM HSSLGNCNTG GHGMFRARFI 3600

RKFAKDVEKL LGSNGSKLFQ KRKDKSFLKQ VDELAASMRG FQKEPGNLKE YSPWLSGFKA 3660

DTFSNELEIP GQYDGRSKPL PEYHAKITGF DERVMVMSSI RRPKRLIIRG DDERDHPFLV 3720

KGGEDLRQDQ RIEQLFAVMN IMLSHDAACT HRGMQLRTYQ VIPITTRIGV IEWMENTCTL 3780

KEFLHGTMTK EEKKSSERCA EYHNSWLQKF AVSKKDPNLF SLYGKAYEKA ARNETVTYFL 3840

KALQCVPSDL LKRAFLKMCN SPEAFLSLRS HFIGSHALLC VSQWILGIGD RHLSNFMINM 3900

ETGGMIGIDF GHAFGSATQF LCVPELMPFR LTQQFVNLMQ PLRESGLIQS IMVHSLRAYS 3960

AEPDLLLNTM DVFVKEPSLD WKNFELKQMK KGGTWTDSVN TKEINWYPLQ KVDFARRKLE 4020

GANPAAITSE ELKLGFEKDP AFQGMQSVAL GSAEHNIRAR LPLAGLSVEK QVDCLLDQAM 4080

DPNVLGRVWV GWEPWF 4096

Nucleotide Sequence
(FASTA)

GCCGCTGGAG GCGTTCACGG GCTTCTTCTG AAACTCCACA ATTCCCTCTC AGACGAAGAC 60

ACCCGAGCTG CGGCTTTGAA ATGTCACGAT ATTGTCGGGG ACTTGGGACA GGAGTGCATG 120

CTAACTCCAA CCGAGAACGA ACTTGCCTTG CAGATGTCCT TATTGTTCTC TAAAGACTAC 180

GGCTTGCTCG GCTTCCTCAG GAAGTCGCTG GGATCAGAGG AGTTGCGGGA CACGCGAGTT 240

GACATTCTGG TTTTTCTGGA GAAGTTCTTG GACAGGATCT CACCAAGAGT CAAAGGTTGG 300

GAGAGGACAT GCGCCAATGA CGACACATGC ATGGTTGTGT ACACGAAGGA CAAAACAGCC 360

AAGTGTAGGA CTCTCGTGCT GGAGCTCCTC ATCAAGGTTC TCCAAACAAC AAAGGCTTCC 420

AGTGTCGTCG CAGAGCTTCG TATCTGTGAA CTATTCAACA GATATTACGG TGAGCTCTGT 480

CAGAAGAGCA AACTGCCAGA TTCAGTCCTC GGCAAAATCT ATGAGTTGCT GGGAGTTCTG 540

GCCGAGGTCC ACCCCAGCGA GATGTCCAGT AACTCCGACA AACTCTACAA GGCGTATCTG 600

GGAGAGCTCA AAGAGCAGAT GACCTCTTTG ACGAAGGAAC CCAAACTTTT TGTTGTAGCT 660

GGATGTTTGA GAGGACTCGC GTCTCTTATG GTCAACTTCA CTAAAACGAT GGACGAAGAC 720

CCTGCAACAT CCAAGGAGAT TTTTCAATAT GCCCTAAAGG CCATCAGCCC TCAGATGTCA 780

ATGACTCGCT ACGCCGTCAT ATTCGCCGGG CTCCGATTGC TCGCCAAACA CGCGTCCCAG 840

TTCAGCAGCT GCCTCATGGA CCACTACAGA GCTCTGTTCG AGGTCATGTC CAGTCTCTGT 900

GGACACATCA ACAGCGAGAT GAAGAAGACG AGTTACCACG CGCTCGAGGC CTTCCTCAAG 960

CAGGTTGCAA TGGTGGTGGC AGAAAATATT GAGGAGCACA AAGGCAAGTT GAAGTTCTTC 1020

ATGCAGAAGT TCTGCGGCAT CATAAGAAAC ATGGACTCGA CGCACAAGGA GCTGTCCATC 1080

GCTATACGAG GATATGGATT CTTTGCCACC CCATGCAAGA AGGTCTGCCC ACAAGACGTG 1140

GACTTGATGT ACACAGAGCT GATTCAGCGC TGTAAGCAGA TGTACCTGAC GGAGTCTGAT 1200

GGGGAGGACG AAAGCTTCTA CCAGCTGCCC AGCTTCCTGG ACTCCATAGC CAGTGTCTTG 1260

ATTCACCTGG ACAAGATTCC AGAGGTGTAC ACGCCACTGC TGGAGCGTCT CCTCGTGGTG 1320

CAGATCGACA GCTTCCCCCA GTACAGCGAG AAAATGCAGA CCGCGTGTTG CAGGTCCATC 1380

CTGAAGGTGC TGGTGGCCAT GGCCTCTAAA GGACCTGTCC TTTGGGGGTT CATCAGCTCT 1440

GTGGTTCACC AGGGCTTGAT TCGTGTCTGC TCAAAACCCG CCCTGCTTTC TGAGGACAAA 1500

GACAACGGTC GCTCGGAGTC TCCCCAGCTG CACACTGGAA AATGGAAAGT TCCATCCAGT 1560

CACAACTACC TCGCCCTGTT TAAAAGCCTT CTAGACTGTG ATCGGCTGAA GGATTCAGGA 1620

TTTTTAGATG GAGCTTTTGA AAGTCAGAAC GCCGCCCTGG TGTCTCTGAG CCGCCTGCTT 1680

TATGACGAGT TGGTGAAATC AATTCTCAAA ATTGTGGAGA AGTTGGACTT GTCTGTGCAG 1740

AAAGTGAATA CGGGAGGAGA GGCTCTAGAT GATGCGGCCC ATGTCCTGCC GTCCTCGGAC 1800

CCCACAGCTC ACCTGCTGCC CAATAAGATC AAAGATTTCA CGGCCTTCAT CAACCTAGTG 1860

GACTTCTGCA GCGAGTTGTT GCTGACTAAA CACCTGGAGT ATTTTCAGTT CTGGATGTAT 1920

TGCTTAAGCC ACGAGCTAAT CCTCCACTCC ATACGAAATC CACTCGTCAG TGGCTTTTAC 1980

AAGCTGCTCT CTGTCACCAT GAAAGTTGCC AATAGAATCA AGTTCTACCA GGGAGTCTGC 2040

CCGAGAAGCT CCACGTCCCC CCAGAGTGAC ACGGGGAAGA GCGCTTGTTT CGCTCTCTTC 2100

TCTAAGTTTG GAAAAGAGGT GTGTGTGAGA ATGAAGCAGT ACAAAGATGA GCTGCTGGCA 2160

TCCTGCTTGA CATTCGTCCT CTCGCTGCAC TACAACATGG TAGCGCTGGA CCTCAAGGCC 2220

TACTGTCCCG CCCTTGAGGC TGCTCTGAAG TTGGGTCTGA GCCACGTTCC TTTGGCCAAC 2280

ACAGCGCTGG ATGCCCTCGA GGACTGGTCC TCCCACATTC CCCTGGACAC GATGCAGCAC 2340

TGCTACACCA GCATCCTTCC CCTTCTTGAT GGCTACCTGA AAACCAGCTC CGACGACAAA 2400

GACGACAGCA ACTGGGAGGT GATGGCCTCC TTGTCCTCGA GAAGTGACAA AGGATACAGC 2460

CGAGTGATGA CGAGGCTCTT GAAAAAATCC AAACAGCTCC CCACGGAAGA CGCCCCTCTC 2520

GTCGCTGTGA GGCTCCGAGT GGTGAAGTTG CTCGGCCACC TGGGAGGAAA GCTGAACAGG 2580

AACCTCGTAA CCGGGGTGTC TTCGGAGGAG ACGATGAAGA AATTTGTTGC CTGGGACTCT 2640

GAGAAAAGGC TCAGCTTTGC AGTGCCGTTC GCTGACATGA AGCCGGTCAT CTACCTCGAC 2700

CCATTTCTGC CTCACATCAG TGAACTGGCT CTGTCCACGA GTGACCGACA AACCAAAGTA 2760

GCGGCGTGTG AGCTGCTCCA CAGCCTGGTG GTCTACATGG TTGGGAAGAG TGCTCAGATG 2820

GTGGAGGGAG ACAATAGTTT GCCGCCCATG TACAAGCTGC ACAAGAGGCT GTTTCCTGTG 2880

CTGCTGCGTC TGTGCGATGT GGATCAGGTG ACCAGACAGC TCTTTGAACC ACTGGTCATG 2940

CAGCTGATTC ACTGGTTCAC AAACAACAAG AAGTTTGAGA GCAAAGACAC GGTAGCCATT 3000

CTGGAGGCCA TCATGGACGG CGTGGTTGAC CCGATGGACA GCACTCTCAG AGACTTCTGC 3060

GGCCGCTGCA TTGAAGAGTT TGTCAAATGG TCAATCAAAC AAACAACCCC CAAGCAGCAG 3120

GAGAAGAGCC CGACCAACAT GAAGTCCTTG TTTAAGCGCA TCTACAGCTT GGCTCTCCAC 3180

CCGAACGGCT TCAAAAGGCT TGGTGCGGCC TTGGCATTCA ATAGCATCTA CAGACAATTC 3240

AGGGAGGAGG CGTCCTTGGT GGAGCAGTTC ATTTTTGAAG TTCTCGTCAT ATTTGTGGAA 3300

AGTCTGGCTC TTGCGCACTC GGATGAGCCA TCTATGGGTA CATTGCAGCA GTGTAGCAGT 3360

GCCATTGATC ACGTGAAAAG AATCATCAAC CAAAAGGCTC CCAGTCTGAA TCGGCACAAC 3420

ACAAAGATAC GTGTCCCGAG GGGCTTTCCC CCTGATGAAA AGCTGTGCCT CTCTGACATG 3480

GTTTTATGGC TTCTGGAACA ATGTGGCCGA CCTCAGACAG CGTGTCGCCA CAAATGCATG 3540

TACCTATTCT ATGAGTTCAT ACCTCTCCTC CCAGGAAAGG AGTCTCCATC TCAGTGGGTC 3600

GACGGCAAGC TGAAGGATCA TGGAAAAGGT TTTCTGATCT CCCGTTTTGA GGGTGGAGGC 3660

CTCTTCTCTC AGCCCACTCT CAGGGGCCTG ACGGTCCCTT CTAGTGTCAG AGCCACGCTG 3720

CAGTGGATGG ACGTGCTGCT GGCGGCCCTG GACTGCTACA ACACCTTCAT CCAGTTGCAC 3780

ATAATCAAGC CTCCGCTCAT GCTTAGCACC AGAGAGAAAT CGAGCTTTCT CAAAGCCATA 3840

TGCTTCTTTT TGACGGAACT GGCAACGGGC AATCTGGCAG CAGCAGAAAG CTGCTTCTCA 3900

CACGGCCAGA AGACCTCGCA CTTCAGCCCG AGAGAGGTGG AGCAGTACAA CTTCAGCAAG 3960

TGCACCATCA TTGTCCGCCT CCTGGAGTTT GTCACCAGGA TTCTTGTCAA AGGAGACAAA 4020

GAATTTTGGA AGCTTCTCGA ACAAGACATT TTTGTCCCCA ATCTGTTTGA GCTGACCGCG 4080

CTGGTGGTGT GTGAGCCATC CACCGTGGGG TTCAACATGG CAGATGTGGA GGTGATGAGG 4140

AAACTACCAG AAGTGTGCGT TCCTTTACTA AAGGCGCTGC TGGCCTCCCC TTACCGCACT 4200

CGCCTGGAAG GCAGTTTGCG GACAAAAATC TCCCGTAAAA GTGTGGAGGA GCTGTGTACT 4260

GTAGACTTCT ATCACTCGAG CACCCAGAGA CACCATGACC AGATGGAAAT GGTTCTGTCG 4320

TCCTGTAAGC AGATCCACAA AGCCGACTTT CTCAGCTCTA TTCTGCACAG TCAGGACGGC 4380

GCCTGTGCCA AATCCATTGG GTCCCGACTT CTAATGACGG TGTATAAAGG AATAGCACCG 4440

GGTGAGAACC GCAACGCACT TCCATCCTTG GACATAATTA CCAAAAGTTT GGCGGACGGT 4500

CTGCTTCAGC TTGCCTTCTC TCTGAACCAA CAGAGTGAGC CGCTGGTGGA CCTGTTGTTG 4560

AACACCATCC TGCTCACTGT GCCGATCTCT GGAAGTCATT GCCATAACGT CCTGAGCTTC 4620

TCACACGGCG AGTACTTCTA CAGCCTCTTC CAGATGACCA TCAACACTGA GCTGCTGAAG 4680

GATTTGAACA CCACAGTGCC ATGCCTCATG TTGGCATCCT CTCAGAACCC CAGCATGGTG 4740

AGCGTGTTGC TGAATGGCAT GCTGGACCAC AGCTTTAGAG AGCGCTCCGT GAGGAAGACT 4800

CAGGGAAAAC AGCTGGTTGA AGAGGTGCTA CGGAGATGGA ATAGCCTGCA GTCGTGGTGG 4860

AAAGGACACT CCTCTACTCC AGAGAGCAAA ACTGCCACTC TGCTACTGCT CTCCAAGCTC 4920

CTACAGATTG ACTCCTCCGT CTGCTCTGAT ACCAACCACG AAGCGTTCAG ACCGGTTTTC 4980

TCCACTTTCA CCATGCTGCT GGTCGACATG GATCTGCCGC TGAATCTCAA GAGTCAGGCT 5040

TTGCTGGTGT TACCGTTCTT CACAACCCTC CCAGAGGAGC CGCTCGGTGA GCTGCAGGAA 5100

GCCCTCGACG CCCTGGTGGC GTCCCATTTC CCCATGCAGT CGGATGAGTT CGCTAAGGGC 5160

TCACTGCACC GCAACAACTA CATGGACTGC ATCCGAAAGT TGCTAGATGC CCTAGAGCTT 5220

TCTCAGAGTC CACTTCTCCT CAAACTGATG GCGGGGATTC TGTGTCGCGA TAGAAAACAC 5280

ATCATGGAGG AGCCCTTCCA AACCTGCTTC CAAAGAATTG CCAGACGATC AAGCAGTGAG 5340

CGGCAGCTGC AGCTGCTGTG CACTGTGTAC CGGGGGGTCC AGCAGGGTGA CGTGCCGATG 5400

AGCTCCATGC TGCAGGCCGC GATGGAGAGG GTCCTGCTAC CTCTCGCCTC CCACTGTAGC 5460

ACCAAGGCTC TGAATGACTT CTTTGTGGCG AATGTCTCTG ACATGATGGT TGTACTGCTC 5520

AGTCGCTTCA CAAAGTCAAA TGAAATGGAA TTTGAGATCC AGTTGATGAA GAAGAGCGGC 5580

TGCTACAAGC TGATGGAGCT CCTGTATTCT CAGCTTCCCA AAGAAGAGGT TTACTCCAAG 5640

GAGTCCCGCA TTAACCAAGC CTACTGTTGT TCAGACAAAA CCGAGGGGAA TGAGTTGTCC 5700

AAGACCTTGA TCAAGTTGTG TTTTGATGCC TTCACTGAGA ACATGGCCGG GGAAACTCAG 5760

CTCCTTGAGC TTCGGAGACA ATATCGCTGC GCTGCATACA ATTGTGCCAT CGCCGCAATC 5820

AGCTGCAGCT TCAGTGAGCC CAAATTCTAC CAAGGCTTCC TCTTCAGTGA GAAACCAGAA 5880

AAGAATCAGT TCATTCTGGA GAATATTATC GACGTTGAAA GGACCTACAA CTTTCCAATT 5940

GAAATTGAGG TCCCACTTGA GAGAAAAAAG AAATATGTCA TGATTCGGAA AGAAGTGAGC 6000

GAGGAGAATG GAGTTCCCAC AGAGGCGCCA GTGTATCTGT CCTCCCAGTC TTACATGGCG 6060

GACAGCAGCC TGAGTGAGGA GATGAGCCAG TTTGATTTCT CCACCGGAGT CCAAAGCTTT 6120

TCCTTCAGCT CCCAAAACCC TGAAGGACCC CGGCGCACTG TTGCAAAAAG AGAGACAGAG 6180

GAGACAAACC CCTCCCAGGA CGCAATGGTG GATCTAGAAA TGGACGAGCT AAACCAGCAT 6240

GAATGCATGA CGACCATGAC TGCTCTTATT GGTCACATGC TGAGGAACAA CATAACCCCC 6300

AAAATTGAGC AGGGAAACGT GCCTGGTGAA CTTCCTCCAT GGATGAAGTT TCTACATGGC 6360

AAACTATCAA ATCCAGCTAC ACCTCTGAAT ATTCGACTGT TCATCTCAAA GCTGATCATC 6420

AACACGGAGG AGGTTTTCCG ACCATACGCC AAGCACTGGC TGGGGCCCCT CCTGCAGCTC 6480

GTCGTTTCTG GAAACAACGG TGGAGAGGGG ATCCATTTCA TGGTGGTGGA AATAATCGTC 6540

ACAGTGCTCT CTTGGACGAG CCTGGCCAGC CCCAAGGGAA ACCCCAGAGA TGAAGTGCTC 6600

GCCAACCGGC TTTTAGAGTT CCTGATGAAG CATTGCTTCC ATTCCAAAAG GGCGGTTTTC 6660

CGGCACAATC TGGAAATCAT TCGCACCCTG GTTGAGTGCT GGAAAGACTG TCTGCATGTG 6720

CCTTACAGTT TGATACACGA GCGATTTTGT GGCAACGACC CAAATAGCAA AGACAACTCT 6780

GTTGGACTTC AGCTGCTGGG AATCATCCTG GGAAACAACC TCCCTCCATA CGATGCCTCA 6840

TGTGGAATTG AATACGACAG GTACATCCAG TCTCTCACAA ACAACGTGTC CTTCGTAAGA 6900

TACAAAGACG TCTACGCAGC AGCTGCTGAG ATTATTGGCC TCATCCTGAA GAACATGACT 6960

GAACATCGTC AGCAGCTTCT CAGTCTCGCT GCAAGTAAGA TCACCAATCT GAAGAAAAAA 7020

GACATGGATG ACAAGTTCAT TATTTGCTTG AACAAAGTTT CAAAGCACTT TCCTCCATTT 7080

ATGGATCGGT TTGTCAACTA CGTGTTCTCC CTCCTGCCAA AGTTGCACGG CATCTTGAAG 7140

ACGCACTGTT TGGAGTGCGT GCTGAGCCGT GCTGATGTCA TCCCAGATAT ATTTCTGCAT 7200

CTGAAAACCA CAGGCTTCAT TCAAATGATG GGCCACAGGG ATGAAGCCAG GCAGAGAGTG 7260

TGTCTGGATA TCATCCACAA GATTGTTGCC TGCTTGACTC CAGCTCAGCT TCAGGAGATC 7320

CTGGGAGCTG TGATTTCCTT TGTCTCCCAT CCCTCCCCGG TGTGCAGGGA GAGGATGTAT 7380

GACGTCCTCA TGTGGATCCA GGACAACTAC AGTGATGCAG AGAGCATGGA AGACAACACC 7440

TCAGTCGAGG TTTTGAACTC TGCTAAAGAA GCACTTCTTC AGGGGCTCTC TGAAGAAAAC 7500

CAAGGCCTTC AGCTTTATGT CCGTAACTTC TGGAGTCAGG AGAAGCGCCT CCCAACCACG 7560

ACCCTCGAGC GAATGTTGAC GGTGCTCAGT TCTCTGTACT CCTGTCAAAT TGAGAAGTCT 7620

TTTCTAAGCC TGGCTACCAA TCTTCTGCTG GAAAGGACCA GCCAGAGTCC GGACTTCATA 7680

CGGAACATTT TTGAGTACCC GCTGTCAGAG TGTACCTTCC AGGACTATGT GATCGACTCC 7740

AACTGGCGCT TCAGGAGCAC AGTGATGACG CCGATGTTTG TCGAAACCCA AAGCTCTCAA 7800

GGCCCGGAGA GTGTGATGGC GTCGCAGTCT GGAGGCATAA AGGGGAAGCT CCGAGCCACG 7860

CAGAGCTCAT TAGAGTTCAG CCAGACACAA ACCACAGGTC GGCGTACAGC GTATAACTGG 7920

CTGACTGGCA GCAGTGTGGA CACGCTGGCA GAGTACACTC TCAGCTCTGA GTCTCTGTCT 7980

TCGTTGCTGG CGTTTGATAA GAAACCAGCG AGGCAAAATG CAGTCAGGAG ACCAGTGGGA 8040

GAAGGTTTTG GGCTGAGGCG CCTCACAGCA TCAACCGACG AGGTGGACAG TCGCACTAGA 8100

GCAGCGGCGA ATGAGCAACG CAATAACATC CTAAGACTGA GACGCAGATT CATCAAGGAT 8160

CAGGAGAAAG TCAGCTTGAA TTTTGCGCAA AAAGAAATCC AACAACAAAG ACAGAAAAAG 8220

GTGGACAAAG CAGATCAAAG GCTGCGAAAA GAGGCTCAGG TGACTCTCTA TCGTAACTAC 8280

AGAGCGGGAG ACTTCCCGGA CATCCAGATC CCATACAGTA GCCTCATTGC CCCGCTTCAA 8340

GCACTGGCCC AGAGAGATCC AATTTTAGCC AAACAGCTGT TCAGCGCGCT GTTTGATGGA 8400

ATCCTGCAAG AAATGGAGAC GCACAAAGCA AGAGGGGAGA GCGGGAGAAT TAAAGAGGAG 8460

CTGCGTCGCT GCATGAATAC ATTCCTGAGC AAGAGCACCG TGTGCTTCCC TCCATTCATA 8520

GCATGTATTC AGGACATGTG CCACCAGCAT AAGGAGCTCC ATCACCTAGA TCCAGCGGCC 8580

ATCAGCTCCA CGTGCCTGAT GAGCCTCCAG CAGCCATCGG GCATCCTGCT GCTGGAAGAG 8640

GGCTTGTTGC ATTCCGGTGG CCAGGAGGAG CCTGCTGCCA AGCGGTCCCG AGGACGCAAA 8700

GAGATCCCCC CTGACACCAA TAAATGGATC CACCTAGCAA GGCTTTACAG GTCTCTGGAG 8760

GATTATGATG TCGTACGCGG CATCTTTGGT GGTAAAGTCG GGACCAGGTC GATCACTTGC 8820

GCCGCGCTTC AAGCTGAAGC AAACTCCGAC TTCGCAGAAG CCGTGAAGCT TTACAATGAG 8880

GCCCTGAACA CTGAGCACTG GACAGATGGC GAGCCCACAG AGTCTGAGAA GGACTTCTGG 8940

GAAATAGCTG CCATGGACGC CTACAGTCAT CTGACTGAGT GGAAGTCTCT TCGGTACTGC 9000

TCCACCTTGT ACGTAGATAT GATGTGGTCG GAGCCACTCT ACCAGGAAAT GTACCTGCGG 9060

CACATGATTC GCAGCATGCT GAAGCAGCTG CAGCTGGGTG AAGCAGACCA AACTCTCCTC 9120

AGCTTCATTG ACGCAGCCAT GGCGGTGGAG GAGCGCAAAA AGCTGCTGGA AAGTCATTAC 9180

AGCCAAGAGC TCAGCCTGCT GTACATCCTG CAGGAGGACT ATGACCGCGC GACATACTAC 9240

ACCAACTACG CCATGCAGCT CTTCATGCAG AATTACTCCA GTGTGGATAC GTTGTTGACT 9300

CAGAGTCGGC TGACCATCCT TCAGTCAGTG CAGGCCTTGA CTGAAATCCA AGACTTCCTG 9360

CAGTTCATCA AAGGAGAAGT GTCTATGCGC TCGCTCACAC GGCTCATCGG TCTGTGGGCC 9420

GAACGGTATC CTGATGCTAA AGCGGATCCA GTGAATTTAT GGGATGACAT CATCACATCT 9480

CGATGTTTCT TCTTGGACAA GATCAGGATA AAACTAGGAG GCCACGCCCC CAGTGACAGT 9540

ATGGAGGTGG ACGGTTCAGA AGATCAAGCG GGAGCCATCG ACACATTAGT AAATGACTGC 9600

AAGTTCAGCA TGAAGTTACA AATGGCCGAC AGCGCTTTGA AGCAGAATAA CTTTCCTGTG 9660

GCCACCAAGA TGCTGAAGGA ACTTCACAAA GAAGCCAAGA CAAACAGAGG GTGGTTGCTG 9720

CGGTGGGTCC ACGGTTTCAG CCGCTACAAC CACAAGCGCA GCCAGACACA GGGTCCTGTT 9780

GAACAAATCA GTGCCATGCT GAAGACTATT CCATTCCTGG ACGACCTTCA GGCTGACTGT 9840

CAGAGTGCAA CAGCTAAAGT ATTCAGATGC CAAAAGATAC TTGAGGGGAA ATCCTTCCAC 9900

ATCATGGCCA CAGCGGTAGG CAGGAGCCCC TCGGTCCTGG GAACCATGGA AGCTGAGAAA 9960

GCAGGCAGAG TTGCCCAGCT TTCTGGAGCT GCTTGGCCAG ATGAGAATGC AAAGAAAGTG 10020

GAAGTGGGGC TGCAGTTGAA AGCGTTGAAC TTGCTGTGTG ATGCTACCAG AAAGGCTGAT 10080

GAAGAGCTTC AGTCTTACAC GCAGGAATGT GTGGAAAGCA GCAGCATCAT TGAGACATAC 10140

ATGACTCTGG CTAACTTCTG TGACAAACTG CTGCGAGGGG CGGAGCAGAG TGATACTGAA 10200

AACCAATTTC CAAACATGTT GGCACTGCCT GTTCATATAT TGGAGAACTT GTTGAAAGCA 10260

CTGAAGATGA ACTCTGAGGA AGCTCGCCTC AAGTTCCCAC GTCTGCTGCA GATCATTGAG 10320

TTGTACCCCT CCGAGACCCT GGACCTGATG ATGAAAGAAA TGATGTCAGT TCCCTGCTGG 10380

ATGCTGATTG GCTGGATCAG TCAAATGGTC GCCCTACTGG ACAAGCCGGA AGCGGTGGCC 10440

GTGCAGCGCT GCGTTGAGCA GATAGCGGAC TGCTACCCTC AAGCTCTGGT TTACGCTCTG 10500

ATGATCAGCA GTGAGAGTTA CCAGTTTGAG GACTCGGCTA CGGGCCACCA GCAGCGGGGA 10560

TTTGTCGACA GGCTCAACAG CGTGCTGGAT AAGGAAGGAC CTGTGAAGAA CTTTGTGAAT 10620

TCCCTGCAGC AGCTGACAAA CCCTGAGATG CTTTTCAGGG ATTGGTGGGA TTGCATGAAA 10680

AATGAATTGG ACAAACCAGG CTTTGACGAG AAGCGGATGG GCCGCATGTA TGAGGAGATG 10740

CACTCCTCAC TCGGGAATTG TAACACAGGC GGTCATGGAA TGTTCCGCGC AAGATTCATC 10800

AGAAAGTTTG CTAAAGATGT GGAGAAGCTG CTGGGATCTA ACGGCAGCAA GCTTTTTCAG 10860

AAGAGGAAGG ATAAAAGCTT TTTGAAGCAG GTGGACGAAC TGGCAGCATC CATGCGTGGT 10920

TTTCAGAAGG AACCAGGGAA CCTTAAGGAA TACTCGCCCT GGCTGAGTGG ATTCAAAGCG 10980

GACACATTCA GTAATGAGCT GGAGATCCCA GGACAATACG ATGGCAGATC CAAACCATTG 11040

CCAGAATATC ATGCAAAAAT AACTGGCTTT GACGAAAGGG TGATGGTGAT GTCGTCCATC 11100

CGTCGCCCCA AACGCCTGAT CATCCGCGGG GATGATGAAC GGGACCACCC CTTTCTGGTG 11160

AAGGGTGGAG AAGACCTCCG CCAGGACCAA CGCATTGAGC AGCTCTTTGC TGTCATGAAC 11220

ATTATGCTGA GTCATGACGC GGCGTGCACA CACAGAGGCA TGCAGCTGCG CACCTATCAA 11280

GTCATTCCCA TAACCACAAG GATTGGTGTA ATTGAATGGA TGGAGAATAC CTGTACTCTG 11340

AAAGAGTTCC TTCATGGTAC AATGACCAAA GAGGAAAAGA AAAGCTCAGA GAGGTGTGCT 11400

GAATACCACA ATAGCTGGCT CCAGAAATTT GCCGTTTCCA AGAAAGATCC AAATCTTTTT 11460

TCACTGTATG GAAAGGCTTA TGAGAAAGCG GCTCGTAACG AGACTGTCAC CTACTTTTTG 11520

AAAGCGTTGC AGTGTGTGCC CAGCGACCTG CTGAAGAGAG CTTTTCTGAA GATGTGCAAC 11580

AGTCCTGAGG CATTTCTCTC CTTGCGCTCC CACTTTATCG GCTCGCATGC CTTGCTGTGT 11640

GTCAGCCAAT GGATTCTTGG AATTGGTGAT CGTCATCTCT CCAACTTCAT GATCAACATG 11700

GAAACGGGAG GCATGATCGG CATCGACTTC GGTCATGCAT TCGGTTCAGC CACACAGTTC 11760

CTCTGTGTGC CTGAGCTCAT GCCTTTCCGG CTGACCCAGC AGTTTGTGAA CCTCATGCAA 11820

CCCTTGAGGG AGTCGGGTTT GATCCAAAGT ATCATGGTCC ACTCCCTCCG AGCTTACAGC 11880

GCTGAGCCGG ACCTTTTGCT AAACACCATG GATGTGTTCG TCAAAGAGCC CTCGTTGGAC 11940

TGGAAGAACT TTGAGCTAAA ACAGATGAAG AAAGGAGGCA CATGGACCGA CAGCGTAAAC 12000

ACCAAAGAAA TCAACTGGTA TCCCCTACAA AAGGTCGACT TTGCCAGAAG AAAACTAGAA 12060

GGAGCAAATC CAGCGGCTAT AACCAGTGAG GAGCTGAAGC TGGGCTTTGA GAAGGACCCG 12120

GCCTTCCAGG GGATGCAGTC TGTGGCCCTG GGGTCTGCGG AGCACAATAT TCGTGCAAGG 12180

CTTCCACTTG CAGGCTTGTC GGTGGAGAAG CAGGTGGACT GTCTGCTTGA CCAAGCCATG 12240

GATCCAAATG TGCTTGGCAG AGTTTGGGTC GGCTGGGAAC CGTGGTTCTG A 12291

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i gfderv +++s ++pk+l++rG d++ +p+Lvkg eDlrqd+r++qlf ++N +L +d

Q: 3687  ITGFDERVMVMSSIRRPKRLIIRGDDERDHPFLVKGGEDLRQDQRIEQLFAVMNIMLSHD  3746

         789*********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +++++r +++rty+V+p++tr+g+iew+ent +Lke+l+ ++ k++ + +++   + + +

Q: 3747  AACTHRGMQLRTYQVIPITTRIGVIEWMENTCTLKEFLHGTMTKEEKKSSERCAEYHNSW  3806

         *****************************************9999999988888888888

S: 121   stvqar...........kpklkhlkls..........levfkevlenlvpkdllkkllle  159

          ++ a            +        +          ++ f ++l+  vp dllk+++l+

Q: 3807  LQKFAVskkdpnlfslyG--------KayekaarnetVTYFLKALQC-VPSDLLKRAFLK  3857

         877766555555555553........045555555789999999998.9***********

S: 160   kfpspeewfelrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafeka  219

         ++ spe++++lr+++  s+A+ +++++iLg+gdrhl+n++i++etg ++ idfg+af++a

Q: 3858  MCNSPEAFLSLRSHFIGSHALLCVSQWILGIGDRHLSNFMINMETGGMIGIDFGHAFGSA  3917

         ************************************************************

S: 220   ktqlkvpekvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydp  279

         +++l vpe +PFRLT+++vn+++++ ++G++++++++ lr+   +++ ll++++vf+++p

Q: 3918  TQFLCVPELMPFRLTQQFVNLMQPLRESGLIQSIMVHSLRAYSAEPDLLLNTMDVFVKEP  3977

         ************************************************************

S: 280   lvdwkk......kkktsketeeelaekakaealkikkllskvekaenavatrdll  328

         ++dwk+      kk++++ ++ + +e ++++ +k+  + +k+e+a++a +t ++l

Q: 3978  SLDWKNfelkqmKKGGTWTDSVNTKEINWYPLQKVDFARRKLEGANPAAITSEEL  4032

         ***********99999********************************9998776

Domain Sequence
(FASTA)

ITGFDERVMV MSSIRRPKRL IIRGDDERDH PFLVKGGEDL RQDQRIEQLF AVMNIMLSHD 60

AACTHRGMQL RTYQVIPITT RIGVIEWMEN TCTLKEFLHG TMTKEEKKSS ERCAEYHNSW 120

LQKFAVSKKD PNLFSLYGKA YEKAARNETV TYFLKALQCV PSDLLKRAFL KMCNSPEAFL 180

SLRSHFIGSH ALLCVSQWIL GIGDRHLSNF MINMETGGMI GIDFGHAFGS ATQFLCVPEL 240

MPFRLTQQFV NLMQPLRESG LIQSIMVHSL RAYSAEPDLL LNTMDVFVKE PSLDWKNFEL 300

KQMKKGGTWT DSVNTKEINW YPLQKVDFAR RKLEGANPAA ITSEEL 346

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0003677	; F:DNA binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0006303	; P:double-strand break repair via nonhomologous end joining

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR012582	; NUC194.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF08163	; NUC194; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013