EKS-GAA-00555

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00555

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	475.5	6.8E-143	27	305	279

Status

Unreviewed

Ensembl Protein

ENSGACP00000003905

UniProt Accession

G3NF04;

Protein Name

Protein Synonyms/Alias

Gene Name

PIK3R4

Gene Synonyms/Alias

PIK3R4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000002977	ENSGACP00000003905	ENSGACT00000003919

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1364

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVDSYF SDIHDHEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

SLPLTSYKQE LEELKIRLHS CQNCLPFQKT SLTEKAAILF RQYVRDNLYD RISTRPFLNN 120

VEKRWLAFQI LNAVDQAHKA GVRHGDIKTE NVMVTSWNWV LLTDFASFKP TFLPEDNPAD 180

FNYFFDTSRR RTCYIAPERF VDGSMFTAEN DQNTPLVDLT NNNQRSRGEL RAAMDIFSAG 240

CVIAELFTEG VPLFDLSQLL AYRKGHFLTE QVLLKIEDLS VRELVAQMVQ REPEKRLTAE 300

EYLRQQRGKA FPDIFYTFLQ PYMAQFAKET FQSADERVLV IRKDLDNILL NLRGGSSSSL 360

DGSHGAPSSR EEQGLMVLVS VITSCLQTLH SCDSKLAALE LVLHLAPRLA VDVLLDRITP 420

FLLHFCNDPV PRMRAQAVRT LTKVLALIKE VPRNDVNIYP EYILPGIAHL AQDDATIVRL 480

AYAENIAHLA ECALRFLELV QENNVNTEQQ DLIGEDVEEI LHPNENYDSE LQALHEMVQQ 540

KVVTLLSDSE NIVKQSLMEN GITRLCVFFG RQKANDVLLS HMITFLNDKN DWHLRGAFFD 600

SIVGVAAYVG WQSSSILKPL LQQGLSDTEE FVIYKALNSL TCMCQLGLLQ KPHIYEFVSD 660

IAPFLCHPNL WIRYGAVGFI TVIAQHLNVA DVYCKLMPHL NAFITQPIIQ IDKELVLLSV 720

LKEPVSRSIF DYALRSKDIS SLFRHLLLRQ KKRMGSIPEC FTPDDPAIAQ LLKKLLSQGM 780

TEAEEDQLLA LKDFMLKSNK AKATMGEQGH LGGEAHSGFI DLATLGITGR QVDLVKAKVE 840

LEDKRARKHT KQDSTMNEEW KSMFGSQEPP STVTPRSASL ELLGSSLPPG NEWYKMLARV 900

FRAAEGPAGQ NLRSASVPAV PVLQSVASGP AYHRRINTCK VELQQLVQQK REQCSAERMA 960

KQMMESAEWE SRPPPPGWHP KGLLVAHLHE HKASVNRIRV SDEHSIFATA SNDGTVKVWD 1020

SQKMEGKTTT TRSVLTYSRI GGHVKTLTFC QGSHYLAVAS DNGSIQLLAV EANKPPKSPK 1080

VQPFQTRLLD PQEDGCAVDI HHFNSGAQSV LAYATVNGSL VGWDLRSNSN AWTLRHDLRL 1140

GLITSFSVDM HQCWLCLGTS SGTMACWDMR FQLPISNHSH PARARIRRLL MHPLYQSSII 1200

AAVQGNNEVS MWDMETGDRK FTLWASSAPP LSEVVCLQPS PHSVHGIYCS PADGNPLLLT 1260

AGSDMRIRFW DLAYPERSYI VVGGANDSLH CPSVLYSRKI IEGTEVVQEI HSKQKSGAVE 1320

DSPRRGPESL PVGHHDIITD IATFQTTQGF IVTSSRDGIV KVWK 1364

Nucleotide Sequence
(FASTA)

ATGGGGAACC AGCTGGCGGG CATTGCCCCC TCTCAGATCC TGTCTGTGGA CAGCTACTTC 60

TCAGACATCC ACGACCACGA GTATGACAAG AGCTTGGGCA GCACCCGCTT CTTCAAGGTG 120

GCCCGTGCCA AACACCGCGA GGGCCTCGTC GTGGTCAAGG TGTTCGCCAT CCAGGACCCC 180

TCGCTGCCCC TGACCAGCTA CAAGCAGGAG CTGGAGGAGC TAAAGATCCG GCTGCACTCC 240

TGCCAGAACT GCCTGCCCTT CCAGAAGACC TCGCTGACGG AGAAGGCGGC CATCTTGTTC 300

CGCCAGTACG TGCGGGACAA CTTGTACGAC CGCATCAGCA CTCGGCCCTT CCTCAACAAC 360

GTGGAGAAGC GCTGGCTGGC CTTCCAGATC CTCAACGCTG TGGACCAGGC GCACAAGGCT 420

GGTGTCCGCC ACGGCGACAT CAAGACGGAG AATGTGATGG TCACCAGCTG GAATTGGGTG 480

CTGCTCACTG ACTTCGCCAG CTTCAAGCCC ACCTTTCTGC CCGAAGACAA TCCTGCCGAC 540

TTCAACTACT TCTTCGATAC GTCCCGGCGC AGGACGTGCT ACATTGCCCC CGAGAGGTTT 600

GTGGACGGGA GCATGTTCAC TGCCGAGAAC GACCAGAACA CACCGCTGGT GGACCTGACC 660

AATAACAACC AGAGGAGCCG AGGGGAGCTG AGAGCTGCAA TGGACATCTT CTCTGCAGGC 720

TGCGTGATAG CTGAGCTCTT CACTGAGGGC GTTCCTCTCT TCGATCTGTC GCAGCTGCTG 780

GCCTATCGTA AAGGACACTT TCTGACAGAG CAGGTCCTCC TGAAGATCGA AGACCTGAGC 840

GTCCGAGAGC TGGTGGCTCA GATGGTGCAG AGGGAACCAG AGAAGCGTCT GACAGCTGAA 900

GAGTACCTGA GGCAGCAGAG AGGGAAAGCC TTCCCTGACA TCTTCTACAC CTTCCTGCAG 960

CCATACATGG CTCAGTTTGC TAAAGAGACC TTCCAGTCCG CAGACGAGCG GGTGCTCGTG 1020

ATCCGCAAAG ACCTGGACAA CATCCTGCTC AACCTGCGAG GAGGCTCCTC CTCCTCTCTG 1080

GATGGTAGCC ATGGGGCGCC GAGCTCCAGG GAGGAACAGG GCCTCATGGT CCTAGTGTCC 1140

GTCATCACCT CCTGCCTGCA GACGCTGCAC TCCTGCGACT CCAAGCTGGC GGCGTTGGAG 1200

CTGGTCCTGC ACCTGGCGCC GCGACTGGCC GTGGATGTCC TGCTGGACCG CATCACACCT 1260

TTCCTGCTGC ACTTTTGCAA TGACCCGGTG CCCCGCATGC GCGCTCAGGC CGTGAGAACA 1320

CTGACCAAAG TACTGGCGCT GATCAAGGAG GTACCGAGGA ACGACGTGAA CATCTACCCA 1380

GAGTACATCC TGCCGGGCAT TGCCCACCTC GCACAGGACG ACGCCACCAT CGTCAGGCTG 1440

GCCTATGCAG AGAACATCGC CCATCTGGCG GAGTGTGCGC TGCGTTTCCT GGAGTTGGTT 1500

CAGGAGAACA ATGTGAACAC AGAGCAGCAG GACCTGATCG GAGAGGACGT GGAGGAGATC 1560

CTCCACCCAA ACGAGAACTA CGACTCAGAG CTGCAGGCTC TGCACGAGAT GGTGCAGCAG 1620

AAGGTGGTGA CGCTGCTGAG CGACTCGGAG AACATAGTCA AACAGTCGCT GATGGAGAAC 1680

GGAATCACCA GACTCTGCGT CTTCTTCGGC CGGCAGAAAG CCAACGACGT GCTTCTGTCT 1740

CACATGATCA CCTTCCTCAA CGACAAGAAC GACTGGCACC TACGGGGGGC CTTTTTCGAC 1800

AGCATCGTGG GTGTAGCTGC TTACGTGGGC TGGCAGAGCT CCTCCATCCT GAAGCCCCTC 1860

CTCCAGCAGG GTTTGAGTGA CACCGAGGAG TTTGTCATCT ACAAAGCTCT GAACTCTCTC 1920

ACCTGTATGT GTCAGCTGGG TCTTCTGCAG AAACCTCATA TCTACGAGTT TGTCAGTGAC 1980

ATCGCTCCGT TCTTGTGTCA CCCCAACCTG TGGATCCGAT ACGGGGCGGT GGGCTTCATC 2040

ACCGTCATCG CTCAGCACCT CAACGTGGCC GACGTCTACT GCAAGCTGAT GCCCCACCTC 2100

AACGCCTTCA TCACCCAGCC CATCATCCAG ATTGACAAGG AGCTGGTCCT GCTCAGCGTG 2160

CTGAAGGAGC CGGTGAGTCG CTCCATCTTT GACTACGCCC TTCGCTCTAA AGACATCTCC 2220

AGTCTCTTCC GTCATCTGTT GCTGAGGCAG AAGAAGCGCA TGGGATCAAT CCCAGAATGC 2280

TTCACTCCCG ATGACCCAGC CATTGCTCAG CTACTGAAGA AGCTGCTCTC ACAGGGCATG 2340

ACGGAGGCAG AGGAGGACCA GCTGCTGGCC CTCAAAGACT TCATGCTGAA GTCCAACAAG 2400

GCCAAAGCCA CCATGGGGGA GCAGGGTCAC CTGGGGGGGG AGGCTCACAG TGGGTTTATT 2460

GACCTGGCAA CACTCGGCAT CACCGGGCGC CAAGTGGACC TCGTGAAGGC CAAGGTGGAG 2520

CTGGAGGACA AGAGGGCGAG GAAGCACACC AAGCAGGACT CCACCATGAA TGAGGAGTGG 2580

AAGAGCATGT TCGGGTCTCA GGAACCGCCC TCCACGGTAA CACCACGCAG TGCCAGTCTG 2640

GAGCTTTTGG GTTCCTCTCT TCCTCCAGGA AACGAGTGGT ATAAAATGTT AGCACGCGTG 2700

TTTAGGGCGG CTGAAGGGCC GGCGGGTCAG AACCTGAGAA GCGCCTCAGT GCCAGCTGTT 2760

CCCGTCCTGC AGTCTGTGGC GAGCGGCCCC GCTTACCACC GACGCATCAA CACCTGCAAG 2820

GTGGAGCTGC AGCAGCTGGT GCAGCAGAAG AGGGAGCAGT GTAGCGCAGA GAGGATGGCC 2880

AAGCAGATGA TGGAGAGTGC AGAGTGGGAG AGTCGCCCTC CTCCACCAGG GTGGCACCCC 2940

AAAGGACTGC TGGTTGCTCA CCTCCACGAG CACAAAGCGT CTGTGAACCG CATCAGAGTC 3000

TCAGACGAAC ACTCTATCTT CGCCACGGCC TCCAATGACG GAACTGTTAA GGTCTGGGAC 3060

AGTCAGAAGA TGGAGGGAAA GACCACCACC ACCAGGTCGG TCTTGACCTA TTCCCGTATC 3120

GGGGGTCACG TGAAGACCTT GACCTTCTGT CAGGGGTCAC ATTATCTGGC GGTGGCTTCA 3180

GACAACGGAT CCATCCAGCT GCTGGCAGTG GAAGCAAACA AACCGCCCAA GTCTCCCAAA 3240

GTTCAGCCCT TCCAGACAAG GTTACTTGAC CCGCAGGAAG ACGGCTGTGC GGTGGACATC 3300

CACCACTTCA ACTCTGGCGC CCAGTCGGTG CTGGCCTACG CCACCGTCAA CGGCTCGCTG 3360

GTCGGCTGGG ACCTTCGCTC CAACTCCAAC GCCTGGACGC TGAGGCACGA CCTCCGCCTG 3420

GGACTCATTA CCTCCTTCAG CGTGGACATG CACCAGTGCT GGCTCTGCCT AGGTACCAGC 3480

AGTGGCACTA TGGCATGCTG GGATATGCGG TTTCAGCTCC CCATCTCAAA CCACTCCCAC 3540

CCTGCACGTG CACGAATCAG ACGACTGCTG ATGCATCCAC TCTACCAATC ATCCATCATC 3600

GCAGCTGTCC AGGGGAATAA TGAAGTGTCC ATGTGGGACA TGGAAACCGG AGATCGTAAA 3660

TTCACCCTGT GGGCGAGTTC TGCGCCCCCA CTCTCCGAGG TTGTGTGTCT GCAGCCGTCC 3720

CCTCACAGCG TTCATGGGAT CTATTGTAGT CCTGCTGATG GGAACCCCCT GCTGCTGACT 3780

GCCGGGTCGG ACATGAGGAT CAGGTTCTGG GATTTGGCCT ATCCTGAGAG GTCTTACATC 3840

GTGGTCGGAG GAGCCAACGA CTCGCTGCAC TGTCCTTCGG TCCTCTACAG CAGGAAGATC 3900

ATTGAAGGCA CTGAAGTTGT CCAGGAGATC CACAGCAAAC AGAAGAGCGG CGCAGTGGAG 3960

GACTCGCCCC GCCGCGGCCC AGAATCCCTC CCTGTGGGCC ACCATGACAT CATCACTGAT 4020

ATCGCCACCT TCCAGACCAC GCAGGGCTTC ATCGTCACCT CTTCCAGGGA CGGAATCGTT 4080

AAGGTGTGGA AGTGA 4095

Domain Profile

S: 2     eyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqnclp  61

         ey+k+lgstrf+kva+ak++eG++vvkvf++qdp+l+l+s+kq+leelk++l++ qnclp

Q: 27    EYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPSLPLTSYKQELEELKIRLHSCQNCLP  86

         79**********************************************************

S: 62    fqkvlekekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvvhGd  121

         fqk +++ekaa+l+rqyv+dnlydr+strPfln++ek+w+afq+l+a+dq+hk+gv+hGd

Q: 87    FQKTSLTEKAAILFRQYVRDNLYDRISTRPFLNNVEKRWLAFQILNAVDQAHKAGVRHGD  146

         ************************************************************

S: 122   iktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsalas  181

         iktenv+vtswnWvlltdfasfkPt+lpednPadf+yffdtsrrrtcyiaPerfv++ ++

Q: 147   IKTENVMVTSWNWVLLTDFASFKPTFLPEDNPADFNYFFDTSRRRTCYIAPERFVDGSMF  206

         ***********************************************************9

S: 182   deklrdgstelvdl.dsiqrlrgelkkamdifsaGcvilelftegrplfelsqllayrsg  240

           +  d +t+lvdl +++qr rgel+ amdifsaGcvi+elfteg+plf+lsqllayr+g

Q: 207   TAEN-DQNTPLVDLtNNNQRSRGELRAAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRKG  265

         8875.5699999963789******************************************

S: 241   eflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         +fl+e+vl kied ++r+lv+q++q+epekr+ ae++l++

Q: 266   HFLTEQVLLKIEDLSVRELVAQMVQREPEKRLTAEEYLRQ  305

         **************************************87

Domain Sequence
(FASTA)

EYDKSLGSTR FFKVARAKHR EGLVVVKVFA IQDPSLPLTS YKQELEELKI RLHSCQNCLP 60

FQKTSLTEKA AILFRQYVRD NLYDRISTRP FLNNVEKRWL AFQILNAVDQ AHKAGVRHGD 120

IKTENVMVTS WNWVLLTDFA SFKPTFLPED NPADFNYFFD TSRRRTCYIA PERFVDGSMF 180

TAENDQNTPL VDLTNNNQRS RGELRAAMDI FSAGCVIAEL FTEGVPLFDL SQLLAYRKGH 240

FLTEQVLLKI EDLSVRELVA QMVQREPEKR LTAEEYLRQ 279

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 5.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013