EKS-GAA-00350

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00350

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	358.8	2.7E-107	227	520	294

Status

Unreviewed

Ensembl Protein

ENSGACP00000004123

UniProt Accession

G3NFM0;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2 (1 of 2)

Gene Synonyms/Alias

TGFBR2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000003140	ENSGACP00000004123	ENSGACT00000004137
ENSGACG00000003140	ENSGACP00000004125	ENSGACT00000004139

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

550

Protein Sequence
(FASTA)

MELLGFCALC CAAALFGGGA LEEAEASILK PKMLCKFCDV RPTSCTGKGS CKVECEITAI 60

CPNDEDVCVS TWRKEGDNFT IDTVCHNRFH KLHGLALEDY NNSKCEMKER KGMGSQFFIC 120

SCSEDECNEH VFFNSYSPHP LNPPDMDSQV VAVILVSLVP LLVMAVVVIT SFYCYRVYHQ 180

RRASSGRKRG CLDFSDARAI MIDDEGSDSS STHANNLNHN TELLPIELEV QVGKGRFAEV 240

YKAKLKRSSS VREEQGFETV AVKIFQYEEY ASWKNEKEIF SDADLRHENV LHFLTAEDRK 300

AQRQCWLITA YQPRGNLQEF LIHHIVSWHD LWLLGGSLAR GVAHLHSDLS PCGRYKVPIA 360

HRDIKSSNIL VKGDLTCCLC DFGLALRLDN ALSVDELANS GQVGTARYMA PEVLESRINL 420

ENIESFKQAD VYSMALVLWE IISRCSAIGE VKEYEPPFGN LREHPCVESM KDSVLRDRGR 480

PEVPNSWIDH TGIQMVCASI DECWDHDPEA RLTAQCVAER FSDMEYLDKL SDRSDSEEKI 540

PEEILMVDEK 550

Nucleotide Sequence
(FASTA)

ATGGAGCTAC TTGGGTTTTG CGCGCTGTGC TGCGCGGCGG CGCTGTTCGG CGGCGGCGCG 60

CTGGAGGAGG CCGAAGCCAG TATTCTTAAG CCCAAAATGC TGTGCAAGTT CTGTGATGTG 120

CGTCCCACCA GCTGCACGGG CAAAGGGAGC TGCAAGGTCG AGTGTGAAAT CACGGCCATT 180

TGCCCCAACG ACGAGGACGT GTGTGTCAGT ACCTGGAGGA AGGAGGGCGA CAATTTCACC 240

ATCGACACAG TCTGCCACAA CCGATTCCAC AAGCTGCACG GCCTGGCCCT GGAGGATTAC 300

AACAACAGCA AGTGTGAGAT GAAGGAGAGG AAGGGCATGG GCTCCCAGTT CTTTATCTGC 360

TCCTGCTCTG AGGACGAGTG CAACGAGCAC GTCTTCTTCA ACTCCTATTC TCCTCATCCT 420

CTCAATCCCC CAGACATGGA TTCCCAGGTG GTGGCGGTCA TCTTAGTGAG CCTGGTGCCT 480

CTGCTGGTGA TGGCCGTGGT CGTCATCACT TCCTTCTACT GCTATCGCGT CTACCACCAG 540

CGGCGGGCCA GCTCCGGGCG CAAGAGGGGC TGCCTGGACT TCAGCGACGC CCGCGCCATC 600

ATGATCGACG ACGAGGGCTC CGACAGCAGC TCCACGCACG CCAACAACCT CAACCACAAC 660

ACGGAGCTGC TGCCCATCGA GCTGGAGGTC CAGGTCGGGA AGGGCCGCTT CGCCGAGGTT 720

TACAAAGCCA AGCTGAAGCG GAGCTCCTCC GTCCGCGAGG AGCAGGGTTT CGAGACGGTG 780

GCCGTGAAGA TCTTCCAGTA CGAGGAGTAC GCCTCCTGGA AGAACGAGAA GGAGATTTTC 840

TCCGACGCCG ACCTGCGGCA CGAGAACGTG CTTCACTTCC TGACGGCGGA GGACCGGAAG 900

GCGCAGAGGC AGTGCTGGCT GATCACGGCC TACCAGCCCC GAGGGAACCT GCAGGAGTTC 960

TTGATCCACC ACATCGTCAG CTGGCACGAC CTGTGGCTGC TGGGGGGGTC GCTGGCGCGC 1020

GGCGTGGCGC ACCTCCACAG CGACCTCAGC CCCTGCGGCC GCTACAAGGT GCCCATCGCG 1080

CACAGGGACA TTAAGAGCTC CAACATCCTG GTGAAAGGCG ACCTGACCTG CTGCCTGTGT 1140

GACTTCGGCC TCGCCCTGCG CCTGGACAAC GCTCTGTCTG TGGACGAGCT GGCCAACAGT 1200

GGGCAGGTGG GCACTGCCAG GTACATGGCC CCGGAGGTCT TGGAGTCCAG AATCAACCTG 1260

GAAAACATTG AGTCTTTCAA ACAGGCCGAC GTTTACTCCA TGGCTCTTGT GCTGTGGGAG 1320

ATCATCTCCA GGTGCAGCGC AATAGGAGAG GTGAAAGAGT ACGAGCCGCC CTTTGGGAAC 1380

CTGAGGGAGC ACCCGTGTGT GGAGAGCATG AAGGACAGCG TCCTCCGAGA CAGAGGAAGA 1440

CCTGAGGTCC CCAACAGCTG GATCGACCAC ACAGGCATCC AGATGGTGTG CGCCTCCATA 1500

GACGAGTGCT GGGACCACGA CCCGGAGGCC CGTCTGACAG CCCAGTGTGT CGCCGAGCGC 1560

TTCAGCGACA TGGAGTACCT GGACAAGCTG TCGGATCGCT CCGACTCAGA GGAGAAGATC 1620

CCCGAGGAAA TCTTGATGGT GGATGAGAAG TAG 1653

Domain Profile

S: 2     klleligkGrygeVwkaklrg..........eevAvKifstedeaswkrEkeiyqtvllr  51

         +l  ++gkGr++eV+kakl+           e+vAvKif++e+ aswk+Ekei++   lr

Q: 227   ELEVQVGKGRFAEVYKAKLKRsssvreeqgfETVAVKIFQYEEYASWKNEKEIFSDADLR  286

         67778***************999*************************************

S: 52    henilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlah  111

         hen+l+f++a+ ++   + + +l+t+y+++g+L+++L ++++++++l  l  sla+G+ah

Q: 287   HENVLHFLTAEDRK--AQRQCWLITAYQPRGNLQEFLIHHIVSWHDLWLLGGSLARGVAH  344

         **********9876..5689****************************************

S: 112   LHeeivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqv  171

         LH+++   +g++K  iaHRD+ks Nilvk dltcc++D+GLal+l+++ ++ +la++ qv

Q: 345   LHSDL-SPCGRYKVPIAHRDIKSSNILVKGDLTCCLCDFGLALRLDNALSVDELANSGQV  403

         ****7.56799*************************************************

S: 172   GtkRYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevv  231

         Gt RYmaPEvle+++nl+++e+fk+aDvYs++LvlWE++sRc++  +ev+ey++pf   +

Q: 404   GTARYMAPEVLESRINLENIESFKQADVYSMALVLWEIISRCSA-IGEVKEYEPPF-GNL  461

         ********************************************.999********.779

S: 232   gsdPsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +++P++e+mk+ v++++ rP++p++w ++  +++++  ++ecWd+dpeaRlta++v++r

Q: 462   REHPCVESMKDSVLRDRGRPEVPNSWIDHTGIQMVCASIDECWDHDPEARLTAQCVAER  520

         ********************************************************987

Domain Sequence
(FASTA)

ELEVQVGKGR FAEVYKAKLK RSSSVREEQG FETVAVKIFQ YEEYASWKNE KEIFSDADLR 60

HENVLHFLTA EDRKAQRQCW LITAYQPRGN LQEFLIHHIV SWHDLWLLGG SLARGVAHLH 120

SDLSPCGRYK VPIAHRDIKS SNILVKGDLT CCLCDFGLAL RLDNALSVDE LANSGQVGTA 180

RYMAPEVLES RINLENIESF KQADVYSMAL VLWEIISRCS AIGEVKEYEP PFGNLREHPC 240

VESMKDSVLR DRGRPEVPNS WIDHTGIQMV CASIDECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013