EKS-GAA-00087

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00087

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	337.5	7.7E-101	26	335	310

Status

Unreviewed

Ensembl Protein

ENSGACP00000004137

UniProt Accession

G3NFN2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK8

Gene Synonyms/Alias

CDK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000003151	ENSGACP00000004143	ENSGACT00000004157
ENSGACG00000003151	ENSGACP00000004137	ENSGACT00000004151

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

464

Protein Sequence
(FASTA)

MDYDFKVRLT GERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS 60

MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 120

LQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF 180

NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED 240

IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH 300

KVKPDSKAFH LLQKLLTMDP IRRITSEQAM QDPYFLEEPL PTSDVFAGCQ IPYPKREFLT 360

EEEPEDKADK KNQQQQQGNN HTNGAGHTGN PDNSHAQGPP QKKVRVVPPT TTSGGLIMNS 420

DYQRSNPHAA YQNPGPSASL PQSSMGYSST SQQPPQYSHQ THRY 464

Nucleotide Sequence
(FASTA)

ATGGACTATG ACTTCAAGGT GAGGCTGACC GGCGAAAGAG AGCGCGTCGA GGACCTGTTC 60

GAGTACGAAG GATGCAAAGT GGGACGAGGC ACTTACGGCC ATGTATACAA GGCGAAGAGA 120

AAAGATGGGA AGGATGACAA GGACTACGCC CTCAAGCAGA TTGAAGGCAC TGGCATCTCC 180

ATGTCAGCCT GCAGGGAGAT CGCACTGCTG CGGGAGCTGA AGCACCCCAA CGTCATCTCG 240

CTGCAGAAGG TTTTTCTGTC ACACGCCGAC CGTAAAGTTT GGCTGCTCTT TGACTACGCC 300

GAACACGATC TCTGGCACAT TATTAAGTTC CACAGAGCGT CCAAGGCCAA CAAGAAGCCA 360

CTTCAGCTGC CGAGAGGAAT GGTCAAGTCT CTGCTCTACC AGATCCTGGA TGGCATCCAT 420

TACCTTCACG CCAACTGGGT CCTCCACAGA GACCTTAAAC CAGCAAACAT TTTAGTGATG 480

GGGGAAGGGC CGGAGAGGGG CCGAGTAAAG ATTGCGGACA TGGGATTCGC CCGCCTCTTC 540

AATTCACCGC TGAAGCCTTT AGCCGATCTC GACCCTGTGG TGGTCACCTT CTGGTACAGG 600

GCGCCCGAAC TGCTGCTCGG GGCTCGGCAC TACACCAAAG CCATCGACAT CTGGGCGATT 660

GGCTGCATCT TTGCCGAGCT GCTGACGTCG GAGCCCATAT TCCACTGTCG CCAGGAGGAC 720

ATCAAGACCA GTAACCCTTA CCACCACGAC CAATTGGACC GCATCTTCAA CGTCATGGGC 780

TTCCCTGCTG ATAAAGACTG GGAGGACATC AAAAAGATGC CAGAACACTC AACGCTGATG 840

AAAGACTTTA GAAGGAACAC ATACACAAAC TGCAGCCTTA TAAAATACAT GGAGAAACAC 900

AAAGTCAAGC CAGACAGCAA AGCGTTCCAC TTGCTGCAGA AGCTGTTGAC CATGGACCCC 960

ATCCGGAGAA TCACATCCGA GCAGGCCATG CAGGACCCTT ACTTTTTGGA GGAGCCGTTG 1020

CCCACCTCTG ATGTGTTTGC AGGTTGCCAG ATTCCTTACC CCAAGAGGGA GTTCCTGACC 1080

GAGGAGGAGC CGGAGGACAA AGCAGACAAA AAAAACCAGC AGCAGCAACA GGGAAACAAC 1140

CACACAAACG GGGCGGGGCA CACCGGTAAC CCTGACAACA GCCATGCCCA GGGCCCGCCC 1200

CAGAAGAAGG TGCGAGTTGT CCCGCCGACC ACTACCTCAG GTGGCCTCAT CATGAACTCA 1260

GACTACCAGC GCTCCAATCC ACATGCTGCT TACCAGAACC CCGGACCAAG TGCGTCACTG 1320

CCCCAGAGCA GCATGGGATA CTCCTCTACC TCCCAGCAGC CGCCCCAGTA CTCCCACCAA 1380

ACCCACCGCT ACTGA 1395

Domain Profile

S: 6     kigeGtygkvykakdke..tgevvAlKkirlekekegvpitalrEisllkelkhknivkL  63

         k+g+Gtyg+vykak+k+  +++ +AlK+i    e +g++++a+rEi+ll+elkh+n+++L

Q: 26    KVGRGTYGHVYKAKRKDgkDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL  81

         79************986447778******....999************************

S: 64    levva.kdkkklyLvfefleqdLkkllkkkkkk.......klsleevkslllqlleglay  115

         ++v+  ++++k++L+f+++e+dL++++k ++++       +l++ +vksll+q+l+g++y

Q: 82    QKVFLsHADRKVWLLFDYAEHDLWHIIKFHRASkankkplQLPRGMVKSLLYQILDGIHY  141

         ****94555*********************9999999*9*********************

S: 116   lHsnkilHRDlKpqNlLiske....gklklaDfGlarafssplk...tytkevvTlwYra  168

         lH+n++lHRDlKp+N+L++ e    g++k+aD+G+ar f+splk   +++++vvT+wYra

Q: 142   LHANWVLHRDLKPANILVMGEgperGRVKIADMGFARLFNSPLKplaDLDPVVVTFWYRA  201

         *******************9988889*************99999665699**********

S: 169   PelLlgakeYstavDiWsvgcilaelltrkplfqgkse.........idqlerifkllgt  219

         PelLlga++Y++a+DiW++gci+aellt++p+f++++e         +dql+rif+++g

Q: 202   PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEdiktsnpyhHDQLDRIFNVMGF  261

         ************************************************************

S: 220   psekvwpevsklpeyk...ksfpkkkkk..klkekvkklk....ekaldllekllaldpk  270

         p +k+w++++k+pe++   k+f++++++  +l ++++k k    +ka++ll+kll++dp

Q: 262   PADKDWEDIKKMPEHStlmKDFRRNTYTncSLIKYMEKHKvkpdSKAFHLLQKLLTMDPI  321

         ***************96644777777764455666644333354679*************

S: 271   kRisakealqhkyf  284

         +Ri++++a+q++yf

Q: 322   RRITSEQAMQDPYF  335

         *************9

Domain Sequence
(FASTA)

KVGRGTYGHV YKAKRKDGKD DKDYALKQIE GTGISMSACR EIALLRELKH PNVISLQKVF 60

LSHADRKVWL LFDYAEHDLW HIIKFHRASK ANKKPLQLPR GMVKSLLYQI LDGIHYLHAN 120

WVLHRDLKPA NILVMGEGPE RGRVKIADMG FARLFNSPLK PLADLDPVVV TFWYRAPELL 180

LGARHYTKAI DIWAIGCIFA ELLTSEPIFH CRQEDIKTSN PYHHDQLDRI FNVMGFPADK 240

DWEDIKKMPE HSTLMKDFRR NTYTNCSLIK YMEKHKVKPD SKAFHLLQKL LTMDPIRRIT 300

SEQAMQDPYF 310

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013