EKS-GAA-00175
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00175
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR518.83.5E-156424692269
StatusUnreviewed
Ensembl ProteinENSGACP00000004504
UniProt AccessionG3NGP8;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR2
Gene Synonyms/Alias FGFR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000003443ENSGACP00000004504ENSGACT00000004518
OrganismGasterosteus aculeatus
Functional Description
Protein Length709
Protein Sequence
(FASTA)
PTLCSVHPGE LLKLSCPLSP PGTITWTKDG SSVGTNNRTV IEQEVLQIRD ATAKDSGLYT 60
CTSVGKKTVC FIVNVTDAIS SGDDEDDSER SEDTGVDEEQ ISAPFWTSTA KMEKRLHAVP 120
AANTVKFRCA AGGNPRPKMR WLKNSRPFRQ EDRMGGYKVR SQHWTLIMES VVPSDKGNYT 180
CLVENEFGAI NHTYTLDVVE RSPHRPILQA GLPANITVHV GEDARFVCKV YSDAQPHIQW 240
LKHISRNGSR YGPDGHPYVQ VLKTAGVNTT DKEIEALYLP NVTFEDSGEY TCLAGNSIGI 300
SYHTAWLTVL PAIEKSIGPF SPDYVEIAIY CAGVFLIACM VGIVVVCRMR NTAKKPDFGG 360
QPAVHKLSKQ IPLRRQVSAD SSSSMNSSTP LVRITTRRSS AHDDRIPEYD LPEDPCWEFS 420
RDRLTLGKPL GEGCFGQVVM AEALGIDKDK TKDAVTVAVK MLKDDATEKD LSDLVSEMEM 480
MKMIGKHKNI INLLGACTQE GPLYVIVEYA SKGNLREYME YSYDIARVSD EQLTFKDLVS 540
CTYQVARGME YLASQKCIHR DLAARNVLVT ESNFMKIADF GLARDVHNID YYKKTTNGRL 600
PVKWMAPEAL FDRVYTHQSD VWSFGVLMWE IFTLGGSPYP GIPVEELFKL LKEGHRMDKP 660
GNCTNELYMM MKDCWHAISS HRPTFKQLVE DLDRILSLNT NEEESVDLC 709
Nucleotide Sequence
(FASTA)
CCCACGTTGT GCTCAGTGCA CCCGGGGGAG TTGCTGAAGC TGAGCTGCCC TCTGTCGCCG 60
CCGGGGACCA TCACCTGGAC CAAAGACGGC AGCTCAGTGG GCACCAACAA TCGCACGGTC 120
ATAGAGCAGG AGGTGCTGCA GATCCGTGAC GCCACGGCCA AGGATTCAGG CCTGTACACC 180
TGCACCAGCG TGGGCAAAAA AACAGTCTGC TTCATAGTGA ATGTCACAGA TGCCATCTCG 240
TCGGGGGATG ACGAGGACGA CAGTGAGCGA TCGGAGGACA CCGGGGTGGA CGAAGAGCAG 300
ATAAGCGCTC CGTTTTGGAC CTCGACAGCG AAGATGGAGA AGAGGCTGCA CGCGGTGCCG 360
GCCGCCAACA CGGTGAAGTT CCGCTGTGCC GCAGGAGGCA ACCCCCGGCC CAAGATGCGC 420
TGGCTTAAAA ACAGCAGGCC TTTCCGCCAA GAGGACCGCA TGGGAGGGTA TAAGGTGCGT 480
AGCCAGCACT GGACCCTGAT CATGGAGAGC GTGGTGCCCT CGGACAAGGG CAACTACACC 540
TGTCTGGTGG AGAACGAGTT CGGCGCCATC AACCACACCT ACACCCTGGA TGTAGTGGAA 600
CGGTCCCCTC ACCGGCCCAT CCTCCAGGCC GGTCTCCCGG CCAACATCAC GGTTCACGTC 660
GGGGAGGACG CCCGCTTCGT CTGCAAGGTC TACAGCGACG CCCAACCTCA CATCCAGTGG 720
TTGAAACACA TCAGCCGGAA CGGCAGTCGC TACGGCCCTG ACGGACACCC GTATGTCCAA 780
GTGTTGAAGA CCGCAGGTGT TAACACCACA GATAAGGAGA TAGAAGCTCT CTACTTGCCC 840
AATGTAACAT TTGAAGATTC TGGGGAGTAT ACGTGCTTGG CGGGTAATTC TATTGGGATC 900
TCCTATCACA CTGCTTGGTT GACGGTGCTT CCAGCGATCG AGAAATCCAT CGGGCCCTTT 960
TCTCCAGACT ATGTGGAGAT CGCAATCTAC TGCGCAGGCG TCTTCCTCAT CGCCTGCATG 1020
GTGGGGATTG TGGTTGTTTG CCGCATGAGG AACACCGCCA AGAAACCCGA CTTTGGGGGC 1080
CAACCAGCTG TCCACAAACT GAGCAAGCAG ATCCCTCTGC GCCGCCAGGT GTCGGCTGAC 1140
TCCAGCTCTT CCATGAACTC CAGTACGCCG CTGGTACGCA TCACGACGCG GCGGAGCTCA 1200
GCGCACGACG ACCGGATCCC CGAGTATGAC CTCCCCGAGG ACCCGTGCTG GGAGTTTTCC 1260
CGAGACAGGC TGACCCTGGG CAAGCCCCTA GGTGAGGGTT GCTTCGGCCA AGTTGTGATG 1320
GCCGAGGCCC TGGGCATCGA CAAGGACAAA ACCAAGGACG CTGTAACGGT CGCTGTCAAG 1380
ATGCTGAAAG ACGATGCCAC TGAGAAAGAC CTGTCTGACC TGGTGTCAGA GATGGAAATG 1440
ATGAAGATGA TCGGCAAACA TAAGAACATT ATTAATCTGT TGGGGGCTTG TACACAAGAA 1500
GGTCCTCTCT ACGTGATAGT GGAGTACGCC TCCAAAGGCA ACCTGAGGGA GTACATGGAG 1560
TACTCCTACG ACATCGCCCG GGTCTCAGAT GAACAGCTTA CTTTCAAAGA TCTGGTCTCC 1620
TGCACTTATC AGGTGGCCCG GGGCATGGAG TACCTCGCAT CCCAGAAGTG TATACACAGA 1680
GATCTGGCAG CCAGGAACGT CCTGGTCACA GAGAGCAACT TTATGAAGAT TGCTGATTTC 1740
GGGCTGGCCA GGGACGTCCA TAACATCGAC TACTATAAAA AGACAACCAA CGGTCGCCTC 1800
CCGGTGAAAT GGATGGCTCC GGAGGCGTTG TTTGACCGGG TCTACACACA CCAGAGTGAC 1860
GTCTGGTCAT TCGGGGTGCT GATGTGGGAG ATCTTCACCC TCGGGGGATC CCCCTATCCT 1920
GGCATCCCTG TCGAAGAGCT CTTCAAGTTG CTCAAAGAGG GACATCGCAT GGATAAGCCT 1980
GGCAACTGCA CCAACGAGCT GTACATGATG ATGAAAGACT GTTGGCATGC CATCTCATCG 2040
CACAGACCCA CCTTCAAGCA GCTAGTAGAG GATCTGGATC GCATCCTTTC CCTCAACACA 2100
AACGAGGAGG AAAGTGTGGA CCTGTGT 2127
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 424   LTLGKPLGEGCFGQVVMAEALGIDKDKTKDAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  483
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactqeGplyviveya+kGnlre++        e+s+d +++s+eqlt+
Q: 484   IGKHKNIINLLGACTQEGPLYVIVEYASKGNLREYM--------EYSYDIARVSDEQLTF  535
         ***********************************6........799*************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs++yqvarGmeylas+kcihrdlaarnvlvte n +kiadfGlardvh+idyykkt
Q: 536   KDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNFMKIADFGLARDVHNIDYYKKT  595
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 596   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  655
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp +ct+ely++m++cwha +s+rptfkqlvedl
Q: 656   RMDKPGNCTNELYMMMKDCWHAISSHRPTFKQLVEDL  692
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA LGIDKDKTKD AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQEGPL YVIVEYASKG NLREYMEYSY DIARVSDEQL TFKDLVSCTY 120
QVARGMEYLA SQKCIHRDLA ARNVLVTESN FMKIADFGLA RDVHNIDYYK KTTNGRLPVK 180
WMAPEALFDR VYTHQSDVWS FGVLMWEIFT LGGSPYPGIP VEELFKLLKE GHRMDKPGNC 240
TNELYMMMKD CWHAISSHRP TFKQLVEDL 269
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00139
EKS-ANC-00140
EKS-BOT-00148
EKS-CAJ-00155
EKS-CAF-00154
EKS-DAR-00432
EKS-EQC-00145
EKS-FEC-00140
EKS-GAM-00078
EKS-GAG-00125
EKS-GOG-00147
EKS-HOS-00152
EKS-ICT-00144
EKS-LAC-00158
EKS-LOA-00149
EKS-MOD-00147
EKS-MUP-00151
EKS-NOL-00141
EKS-ORN-00182
EKS-ORC-00138
EKS-ORL-00170
EKS-OTG-00152
EKS-PAT-00137
EKS-PES-00132
EKS-PEM-00080
EKS-PTV-00139
EKS-RAN-00145
EKS-SAH-00142
EKS-TAG-00176
EKS-TAR-00191
EKS-TEN-00183
EKS-XET-00137
EKS-XIM-00176
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013