EKS-GAA-00451
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00451
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src429.35.9E-129241491251
StatusUnreviewed
Ensembl ProteinENSGACP00000004798
UniProt AccessionG3NHI9;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000003658ENSGACP00000004798ENSGACT00000004812
OrganismGasterosteus aculeatus
Functional Description
Protein Length506
Protein Sequence
(FASTA)
MGCVGSKKEQ EPMGKGTDDG DQQSHTLTTH YVKDPTVGIP GSKPVSSSGS VVLGQGAVGE 60
SIAMALYDYE AIHEGDLGFK KGDKLRILTE SGEWWKAKLI SSGQEGFIPS NYVAKDTLEA 120
EEWFFKGVSR KDAERQLLAP GNRAGSFMIR DSETTRGSYS LSVRDGDPQS GDTVKHYKIR 180
TLDNGGFYIS PRNTFTTLQE LVTHYKKQGD GLCQNLTSPC LSPKPEKPWE KDAWEIPRSS 240
LKMDKKLGAG QFGEVWMATY NKHTKVAVKT MKPGTMSVEA FMGEANLMKT LQHDKLVRLN 300
AVVTKEEPIY IITEYMEKGS LLDFLKSDEG NRLQLPKLID FSAQTAEGMA YIEQRNYIHR 360
DLRAANILVN KALVCKIADF GLARIIEDNE YTAREGAKFP IKWTAPEAIN YGSFTIKSDV 420
WSFGVLLTEI ISYGRTPYPG MTNPEVIRAL EKGYRMQRQE SCPTELYDIM LECWKNKPED 480
RPTFDYLQSV LEDFYTATES QYQQQP 506
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGGGCTCGAA GAAGGAGCAG GAGCCTATGG GCAAAGGGAC GGACGACGGC 60
GACCAGCAGA GCCACACACT GACCACCCAC TACGTCAAAG ACCCTACCGT AGGAATCCCT 120
GGGAGCAAAC CTGTAAGCAG TAGTGGCAGT GTGGTTCTGG GCCAAGGCGC CGTAGGTGAG 180
AGCATCGCCA TGGCGCTGTA CGACTACGAA GCCATCCACG AGGGCGACCT TGGCTTCAAG 240
AAGGGAGATA AGCTCCGAAT CCTAACAGAA TCGGGGGAGT GGTGGAAAGC TAAGTTAATT 300
AGTTCGGGTC AGGAGGGCTT CATCCCCAGT AATTATGTGG CCAAAGATAC TCTGGAGGCT 360
GAGGAGTGGT TCTTTAAGGG CGTGAGCAGG AAAGATGCGG AGAGGCAGCT GCTGGCCCCG 420
GGGAACAGAG CGGGATCCTT CATGATCCGA GACAGCGAGA CCACCAGGGG CAGCTACTCC 480
TTGTCTGTGA GGGATGGCGA TCCCCAGTCC GGGGACACGG TCAAACACTA CAAGATACGT 540
ACGCTGGACA ACGGAGGATT CTACATCTCT CCGCGCAACA CCTTCACCAC CCTGCAGGAG 600
CTGGTCACCC ATTACAAGAA GCAGGGAGAT GGCCTCTGCC AAAACCTCAC CAGCCCGTGC 660
TTGAGCCCCA AACCGGAGAA GCCATGGGAG AAAGACGCCT GGGAAATCCC GAGATCCTCA 720
CTCAAAATGG ACAAGAAGCT TGGTGCCGGC CAGTTTGGAG AAGTCTGGAT GGCTACATAC 780
AACAAGCACA CCAAAGTGGC AGTGAAGACC ATGAAGCCTG GCACCATGTC AGTAGAAGCC 840
TTCATGGGCG AGGCCAACCT GATGAAGACT CTGCAGCATG ACAAACTGGT CCGTCTCAAT 900
GCTGTGGTCA CCAAGGAGGA GCCCATCTAT ATCATCACTG AGTACATGGA GAAAGGGAGT 960
TTATTGGACT TCCTGAAGAG TGATGAGGGC AACCGCCTTC AGCTGCCAAA GCTCATCGAC 1020
TTCTCTGCCC AAACCGCAGA GGGTATGGCC TACATCGAGC AGAGGAATTA CATCCACCGA 1080
GACTTGAGAG CTGCCAACAT CCTGGTCAAC AAGGCTTTGG TTTGCAAAAT CGCAGACTTT 1140
GGCCTAGCTC GCATCATTGA GGACAACGAG TACACGGCCA GGGAAGGAGC CAAGTTTCCC 1200
ATAAAATGGA CAGCCCCGGA GGCCATCAAT TATGGCTCTT TCACCATCAA ATCTGACGTC 1260
TGGTCCTTTG GCGTCTTGCT GACTGAGATT ATCAGCTATG GACGTACACC ATACCCAGGG 1320
ATGACCAACC CGGAGGTGAT CCGTGCCCTG GAGAAGGGCT ACCGGATGCA GCGCCAGGAG 1380
AGCTGTCCCA CCGAACTCTA TGACATCATG CTGGAGTGCT GGAAGAATAA GCCCGAGGAC 1440
CGCCCCACTT TTGATTACCT GCAGAGTGTC CTGGAGGATT TCTACACCGC CACAGAGAGC 1500
CAGTACCAGC AGCAGCCATG A 1521
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lk+ kklG+GqfGevw++++++++kvavkt+k+gt+s eaf+ ea+++k+l+h+klv+l 
Q: 241   LKMDKKLGAGQFGEVWMATYNKHTKVAVKTMKPGTMSVEAFMGEANLMKTLQHDKLVRLN  300
         5789********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++eePiyi+te+m+kGslldflk++eg++l+lpkl+d++aq aeGmay+e++n+ihr
Q: 301   AVVTKEEPIYIITEYMEKGSLLDFLKSDEGNRLQLPKLIDFSAQTAEGMAYIEQRNYIHR  360
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv++ lv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 361   DLRAANILVNKALVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDV  420
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfG+lltei+++G++PypGmtn ev++++e+gyr+ r e+cp+ely+++lecwk++pe+
Q: 421   WSFGVLLTEIISYGRTPYPGMTNPEVIRALEKGYRMQRQESCPTELYDIMLECWKNKPED  480
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++lq+vl
Q: 481   RPTFDYLQSVL  491
         ********986
Domain Sequence
(FASTA)
LKMDKKLGAG QFGEVWMATY NKHTKVAVKT MKPGTMSVEA FMGEANLMKT LQHDKLVRLN 60
AVVTKEEPIY IITEYMEKGS LLDFLKSDEG NRLQLPKLID FSAQTAEGMA YIEQRNYIHR 120
DLRAANILVN KALVCKIADF GLARIIEDNE YTAREGAKFP IKWTAPEAIN YGSFTIKSDV 180
WSFGVLLTEI ISYGRTPYPG MTNPEVIRAL EKGYRMQRQE SCPTELYDIM LECWKNKPED 240
RPTFDYLQSV L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-TUT-00099
EKS-XIM-00467
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013