EKS-GAA-00348
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00348
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR366.51.3E-109204496293
StatusUnreviewed
Ensembl ProteinENSGACP00000004968
UniProt AccessionG3NI05;
Protein Name
Protein Synonyms/Alias
Gene NameTGFBR2 (2 of 2)
Gene Synonyms/Alias TGFBR2 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000003781ENSGACP00000004968ENSGACT00000004982
ENSGACG00000003781ENSGACP00000004965ENSGACT00000004979
OrganismGasterosteus aculeatus
Functional Description
Protein Length526
Protein Sequence
(FASTA)
MNQLCKFCDV ELTSCSGTGT CVSNCSITSI CTDRVEVCVS IWRKNETDLS LETLCHNPSK 60
PLYGVMLDDY NSSTCVMKKK NTTSGMAEIC SCRDVEECND KVLFIPVGPQ KIVDPTPDDA 120
LLSVILVSLL PLLTMGVVVA GMFYWYRAYR QRVSQEWERS AKKRKTKAGG LDCDACAIMM 180
DDDGSDSSST HANHLNHNTE PLPIELDMLV GKGRFAQVYK AKLKQTTSDQ FETVAVKIFP 240
YEEYASWKNE KDIFSYMDLR HENIVHFLTA EERKVEKQYW LITAFHPRGN LQEHLTRHVI 300
SWEELQVLGL SLARGVAHLH SDRLLCGRPK VPIVHRDLKS SNILVKNDLT LCLCDFGLGL 360
RLDSTLSVDD LANSGQVGTA RYMAPEVLEA RLNLENMESF KQTDIYSMAL VLWEMTSRCE 420
AVGEVKEYEP AYGSKVREHP CVESMKDSVL RDRGRPEIPD TWLRHKGLAQ ICGTIMECWD 480
HDPEARLTAL CVAERILELE DEMDKLSSRS SSAEKIPAEL KIPMEV 526
Nucleotide Sequence
(FASTA)
ATGAATCAGC TCTGTAAGTT CTGCGACGTG GAGCTTACCT CCTGCAGCGG CACGGGGACC 60
TGCGTGTCCA ACTGCTCTAT CACATCCATC TGTACGGACC GCGTCGAGGT CTGCGTCTCC 120
ATCTGGAGAA AGAACGAGAC CGACCTCTCC CTTGAAACCT TGTGCCACAA CCCATCCAAG 180
CCGCTCTACG GGGTCATGCT GGACGACTAC AACAGCTCCA CCTGCGTGAT GAAAAAGAAG 240
AACACCACGA GCGGGATGGC TGAAATCTGC TCCTGTAGAG ACGTGGAAGA GTGTAACGAC 300
AAAGTCTTAT TCATCCCCGT GGGTCCCCAG AAAATCGTGG ATCCAACCCC GGACGATGCT 360
TTGCTGTCCG TGATCCTGGT GAGCCTGCTC CCCCTGCTGA CGATGGGGGT TGTGGTTGCC 420
GGAATGTTCT ATTGGTACCG AGCCTACCGG CAACGCGTGA GCCAAGAGTG GGAGAGAAGC 480
GCGAAGAAGC GTAAGACAAA AGCCGGTGGG TTGGACTGTG ATGCGTGCGC CATCATGATG 540
GACGACGACG GGTCGGACAG CAGCTCGACG CACGCCAACC ACCTGAACCA CAACACCGAG 600
CCACTGCCTA TAGAGCTGGA TATGCTGGTG GGTAAGGGTC GCTTTGCCCA GGTGTACAAA 660
GCAAAGCTGA AACAGACCAC CTCGGATCAG TTTGAGACGG TGGCCGTGAA GATCTTCCCT 720
TACGAGGAGT ACGCCTCCTG GAAAAACGAG AAAGACATCT TCTCCTATAT GGACCTCCGG 780
CATGAGAACA TCGTCCACTT CCTGACGGCT GAGGAGCGGA AGGTGGAGAA GCAGTACTGG 840
CTCATCACCG CCTTCCACCC CAGAGGAAAC CTACAGGAGC ACCTGACGCG TCATGTGATC 900
AGCTGGGAGG AGCTGCAGGT GCTCGGCTTG TCTCTGGCCC GGGGCGTCGC CCACCTGCAC 960
AGCGACCGCC TCCTCTGTGG GCGCCCTAAG GTGCCCATAG TCCATCGCGA CCTGAAGAGC 1020
TCCAACATCC TGGTGAAGAA CGACCTGACG TTGTGCCTGT GTGACTTTGG GCTCGGACTC 1080
CGTTTGGACA GCACTCTGTC TGTGGACGAC CTGGCCAACA GTGGACAGGT GGGTACGGCG 1140
CGCTACATGG CTCCAGAAGT GCTGGAGGCC CGACTCAACC TGGAGAACAT GGAGTCCTTC 1200
AAACAGACCG ACATCTACTC CATGGCCCTT GTGCTCTGGG AGATGACGTC CAGGTGTGAA 1260
GCCGTTGGAG AGGTGAAGGA GTACGAGCCG GCCTATGGCT CCAAGGTTCG AGAGCACCCC 1320
TGCGTGGAGA GCATGAAGGA CAGCGTGCTG AGGGACAGAG GACGACCCGA GATCCCGGAC 1380
ACCTGGCTGA GGCATAAGGG CCTGGCACAG ATCTGCGGCA CCATCATGGA GTGCTGGGAC 1440
CACGACCCAG AGGCGCGCCT CACCGCCCTC TGCGTCGCCG AGCGCATCTT GGAGCTGGAG 1500
GACGAGATGG ACAAGCTGTC CAGCCGCAGC TCCTCGGCGG AGAAGATCCC CGCCGAGCTG 1560
AAGATCCCCA TGGAGGTG 1578
Domain Profile
S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54
         ++l  l+gkGr+++V+kakl++      e+vAvKif++e+ aswk+Ek+i++ + lrhen
Q: 204   IELDMLVGKGRFAQVYKAKLKQttsdqfETVAVKIFPYEEYASWKNEKDIFSYMDLRHEN  263
         567889****************999999********************************
S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114
         i++f++a++++  ++++++l+t++h++g+L+++L+r+++++eel  l lsla+G+ahLH+
Q: 264   IVHFLTAEERK--VEKQYWLITAFHPRGNLQEHLTRHVISWEELQVLGLSLARGVAHLHS  321
         ********977..779********************************************
S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174
         +    +g+ K  i+HRDlks Nilvk+dlt c++D+GL l+l+++ ++ dla++ qvGt 
Q: 322   DR-LLCGRPKVPIVHRDLKSSNILVKNDLTLCLCDFGLGLRLDSTLSVDDLANSGQVGTA  380
         *6.56699****************************************************
S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234
         RYmaPEvle +lnl+++e+fk++D+Ys++LvlWE++sRce+  +ev+ey++++ ++v+++
Q: 381   RYMAPEVLEARLNLENMESFKQTDIYSMALVLWEMTSRCEA-VGEVKEYEPAYGSKVREH  439
         *****************************************.999***************
S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         P++e+mk+ v++++ rP+ip++w +++ l++++ ++ ecWd+dpeaRltal+v++r+
Q: 440   PCVESMKDSVLRDRGRPEIPDTWLRHKGLAQICGTIMECWDHDPEARLTALCVAERI  496
         *****************************************************9985
Domain Sequence
(FASTA)
IELDMLVGKG RFAQVYKAKL KQTTSDQFET VAVKIFPYEE YASWKNEKDI FSYMDLRHEN 60
IVHFLTAEER KVEKQYWLIT AFHPRGNLQE HLTRHVISWE ELQVLGLSLA RGVAHLHSDR 120
LLCGRPKVPI VHRDLKSSNI LVKNDLTLCL CDFGLGLRLD STLSVDDLAN SGQVGTARYM 180
APEVLEARLN LENMESFKQT DIYSMALVLW EMTSRCEAVG EVKEYEPAYG SKVREHPCVE 240
SMKDSVLRDR GRPEIPDTWL RHKGLAQICG TIMECWDHDP EARLTALCVA ERI 293
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Danio rerio"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Meleagris gallopavo"; ?>Oreochromis niloticus"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-DAR-00626
EKS-GAM-00178
EKS-GAG-00237
EKS-MEG-00224
EKS-ORN-00367
EKS-PES-00253
EKS-SAH-00266
EKS-SUS-00252
EKS-TAG-00296
EKS-TAR-00368
EKS-TEN-00368
EKS-XET-00356
EKS-XIM-00362
Gene Ontology
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0005026; F:transforming growth factor beta receptor activity, type II
GO:0023014; P:signal transduction by phosphorylation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR017194; Transform_growth_fac-b_typ-2.
IPR015013; Transforming_GF_b_rcpt_2_ecto.
Pfam
PF08917; ecTbetaR2; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013