EKS-GAA-00177

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00177

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	481.1	1.0E-144	433	707	275

Status

Unreviewed

Ensembl Protein

ENSGACP00000005985

UniProt Accession

G3NKX2;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR3

Gene Synonyms/Alias

FGFR3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000004533	ENSGACP00000005985	ENSGACT00000006002

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

772

Protein Sequence
(FASTA)

DSVSSETAFL EDDVLGIGDT LEMSCDLEDH SEPVAWFKDG AGLLPSNRTR LGQRVLRVVN 60

VSYEDSGVYS CRLARSNALL SNYTIRVTED SLSSGDDEDY DEDPEDAGNG NAEAPYWTRP 120

DRMDKKLLAV PAANTAKFRC AASGNPTPTI HWLKNGKEFK GEQRMGGIKV RGRRIAASGE 180

SGLPEEPRSF TTSYRRKLYG DLPHLLPADQ QQLSPSLCLL MCKLPLKLTI TRFAERLNHP 240

EISTMESPPL STVCHLLLSA IRSAPEGAPK KSHGKKTAGI NTTDKELEVL LLTNVSFEDA 300

GEYTCLAGNS IGIAHHSAWL EVLPAVSPEK EDYYADILIY VTGCVLFILA VVIVMLCRMR 360

MTTQKTLPTP PVQKLSKFPL KRQVSLDSNS SMNSNTPLVR IARLSSSDGP MLANVSELEL 420

PSDPKWEFPR TRLTLGKPLG EGCFGQVVMA EAIGIDKEKP NKPLDVAAKM LKDDATDKDL 480

SDLVSEMEMM KMIGKHKNII NLLGACTQDG PLYVLVEYAS KGNLREYLRA RRPPGMDYSF 540

DTCKIPDEQL TFKDLVSCAY QVARGMEYLA SQKCIHRDRA RNVLVTEDNI MKIADFGLAR 600

DVHNIDYYKK TTNSQTPCPQ RSHPSQTRRP LSTRAAVWSY GVLLWEIFTL GGSPYPGIPV 660

EELFKLLKEG HRMDKPANCT HELYMIMREC WHAVPSQRPT FRQLVEDHDR VLSMTSTDEY 720

LDLAVPFEQY SPTCQDSNST CSSGDDSVFA HDPLPEEPCL PKPAPSNGVI RT 772

Nucleotide Sequence
(FASTA)

GACTCCGTGT CCAGCGAGAC GGCCTTCCTG GAGGACGACG TCCTGGGCAT CGGGGACACC 60

CTGGAGATGT CCTGTGACCT GGAGGACCAC TCGGAGCCCG TCGCCTGGTT CAAAGACGGC 120

GCCGGGCTGT TGCCTAGCAA CCGGACGCGG CTGGGCCAGA GGGTCCTGCG CGTCGTCAAC 180

GTGTCCTACG AGGACTCGGG TGTCTACTCC TGCCGGCTCG CCCGCAGCAA CGCGCTGCTC 240

AGCAACTACA CCATCCGGGT CACAGAAGAT TCTCTGTCGT CTGGGGACGA TGAAGATTAT 300

GACGAAGACC CAGAAGATGC AGGTAATGGA AATGCAGAAG CTCCGTATTG GACGAGGCCC 360

GACCGGATGG ACAAGAAGCT CCTCGCCGTC CCGGCCGCCA ACACCGCCAA GTTCCGCTGC 420

GCCGCGTCCG GCAACCCGAC GCCGACCATC CACTGGCTGA AGAACGGCAA GGAGTTCAAA 480

GGAGAGCAGA GGATGGGCGG CATCAAGGTG AGAGGACGCA GAATTGCTGC GTCGGGGGAA 540

AGCGGCCTGC CCGAGGAGCC CCGTAGCTTT ACAACGTCTT ACAGACGGAA ACTTTACGGA 600

GATCTCCCAC ATCTGCTCCC AGCAGACCAA CAGCAGTTGT CTCCCTCCCT CTGCTTGTTA 660

ATGTGCAAAT TACCACTAAA GCTGACGATA ACAAGGTTTG CAGAACGACT CAATCACCCA 720

GAGATCAGCA CAATGGAGTC GCCTCCACTC AGCACAGTTT GTCATTTGCT CTTAAGTGCC 780

ATCAGATCTG CACCAGAAGG GGCACCCAAA AAAAGCCATG GAAAAAAGAC GGCCGGCATT 840

AACACCACAG ATAAGGAGCT AGAGGTTCTC CTCTTGACCA ATGTGTCTTT TGAGGATGCG 900

GGCGAGTACA CTTGTCTGGC TGGGAACTCT ATCGGCATTG CTCACCACTC TGCCTGGCTG 960

GAGGTGCTTC CAGCAGTGAG CCCGGAGAAG GAGGACTACT ACGCCGACAT CCTCATCTAC 1020

GTGACGGGCT GCGTGCTCTT CATCCTCGCC GTGGTCATCG TCATGCTTTG CCGCATGAGG 1080

ATGACGACGC AGAAGACGCT GCCCACGCCG CCCGTGCAGA AGCTGTCAAA GTTCCCCCTC 1140

AAGAGACAGG TGTCCTTGGA TTCCAACTCC TCCATGAACT CCAACACGCC GCTGGTCCGG 1200

ATCGCCCGCC TGTCCTCCAG CGACGGGCCG ATGCTGGCCA ACGTCTCCGA GCTGGAGCTG 1260

CCCTCCGACC CCAAGTGGGA GTTTCCCCGG ACACGGCTGA CTCTGGGTAA GCCTCTGGGC 1320

GAGGGCTGCT TCGGCCAGGT GGTGATGGCC GAGGCCATCG GCATCGACAA GGAGAAGCCC 1380

AACAAGCCTC TCGACGTGGC CGCGAAAATG CTCAAAGATG ACGCCACGGA CAAAGACTTG 1440

TCGGACTTGG TGTCGGAGAT GGAGATGATG AAGATGATCG GGAAACACAA GAACATCATC 1500

AACCTGCTGG GGGCGTGCAC GCAGGACGGT CCCCTGTACG TGCTGGTGGA GTACGCCTCC 1560

AAAGGCAACC TGAGGGAGTA CCTGCGGGCG CGGCGCCCAC CGGGCATGGA CTACTCCTTC 1620

GACACCTGTA AGATCCCCGA CGAGCAGCTC ACCTTCAAAG ACCTGGTGTC CTGCGCCTAC 1680

CAGGTGGCCC GAGGCATGGA GTACCTCGCC TCGCAGAAGT GTATCCACAG AGACCGGGCC 1740

AGAAACGTCC TCGTGACGGA GGACAACATC ATGAAGATCG CCGACTTCGG TCTCGCCAGA 1800

GATGTGCACA ATATAGACTA CTACAAAAAG ACCACCAACA GCCAGACGCC GTGTCCCCAG 1860

CGCAGCCATC CAAGCCAAAC ACGGCGGCCC TTGTCAACAC GGGCCGCCGT GTGGTCCTAC 1920

GGGGTGCTGC TGTGGGAGAT CTTCACCCTG GGGGGCTCGC CGTACCCTGG GATCCCCGTA 1980

GAGGAACTCT TCAAGCTGCT GAAGGAGGGA CATCGGATGG ACAAACCTGC CAACTGCACC 2040

CATGAACTGT ACATGATCAT GAGGGAGTGC TGGCACGCCG TGCCGTCCCA GAGGCCGACC 2100

TTCAGGCAGC TGGTGGAAGA TCACGACCGG GTCTTATCCA TGACCTCCAC CGACGAGTAC 2160

CTGGACCTGG CGGTGCCCTT CGAGCAGTAC TCGCCCACCT GCCAGGACTC CAACAGCACC 2220

TGCTCCTCGG GGGACGACTC TGTGTTCGCC CACGACCCGC TGCCCGAGGA GCCCTGCCTC 2280

CCCAAGCCGG CCCCCAGCAA CGGGGTGATC AGGACG 2316

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aeaig+dk+k++k   va kmlk+datdkdl+dlvseme++k+

Q: 433   LTLGKPLGEGCFGQVVMAEAIGIDKEKPNKPLDVAAKMLKDDATDKDLSDLVSEMEMMKM  492

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyv+veya+kGnlre+lrarrp+g+++s d++k+++eqlt+

Q: 493   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPDEQLTF  552

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylas+kcihrd  arnvlvtedn++kiadfGlardvh+idyykkt

Q: 553   KDLVSCAYQVARGMEYLASQKCIHRDR-ARNVLVTEDNIMKIADFGLARDVHNIDYYKKT  611

         **************************6.7*******************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tn + p    +  + + r  ++++ vws+Gvllwei+tlGgspypgi+veelfkllkeGh

Q: 612   TNSQTPCPQRSHPSQTRRPLSTRAAVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  671

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlved  276

         rm+kpa+ct+ely++mrecwha++s+rptf+qlved

Q: 672   RMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVED  707

         **********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA IGIDKEKPNK PLDVAAKMLK DDATDKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT CKIPDEQLTF 120

KDLVSCAYQV ARGMEYLASQ KCIHRDRARN VLVTEDNIMK IADFGLARDV HNIDYYKKTT 180

NSQTPCPQRS HPSQTRRPLS TRAAVWSYGV LLWEIFTLGG SPYPGIPVEE LFKLLKEGHR 240

MDKPANCTHE LYMIMRECWH AVPSQRPTFR QLVED 275

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Danio rerio"; ?>Gallus gallus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 1.
PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013